CORDIS OpenAire Sygma Archivio della ricerca - Università degli studi di Napoli Federico II HAL INRAE Bielefeld Academic Search Engine (BASE) UnpayWall FEDOA - IRIS Università degli Studi Napoli Federico II Crossref Hal Microsoft Academic Graph Europe PubMed Central European Union Open Data Portal https://www.iris.unina.it/bitstream/11588/757589/1/Post-print%20for%20IRIS.pdf https://hal.inrae.fr/hal-02623443/file/S0043135419307067.pdf https://doi.org/10.1016/j.watres.2019.114932 Water Research Open Access 2019-07-30 2021-12-20 2019-08-07 High-solids anaerobic digestion (HS-AD) of the organic fraction of municipal solid waste (OFMSW) is operated at a total solid (TS) content ≥ 10% to enhance the waste treatment economy, though it might be associated to free ammonia (NH3) inhibition. This study aimed to calibrate and cross-validate a HS-AD model for homogenized reactors in order to assess the effects of high NH3 levels in HS-AD of OFMSW, but also to evaluate the suitability of the reversible non-competitive inhibition function to reproduce the effect of NH3 on the main acetogenic and methanogenic populations. The practical identifiability of structural/biochemical parameters (i.e. 35) and initial conditions (i.e. 32) was evaluated using batch experiments at different TS and/or inoculum-to-substrate ratios. Variance-based global sensitivity analysis and approximate Bayesian computation were used for parameter optimization. The experimental data in this study permitted to estimate up to 8 biochemical parameters, whereas the rest of parameters and biomass contents were poorly identifiable. The study also showed the relatively high levels of NH3 (i.e. up to 2.3 g N/L) and ionic strength (i.e. up to 0.9 M) when increasing TS in HS-AD of OFMSW. However, the NH3 non-competitive function was unable to capture the acetogenic/methanogenic inhibition. Therefore, the calibration emphasized the need for target-oriented experimental data to enhance the practical identifiability and the predictive capabilities of structured HS-AD models, but also the need for further testing the NH3 inhibition function used in these simulations. [SDE] Environmental Sciences [SDV]Life Sciences [q-bio] 0207 environmental engineering high-solids anaerobic digestion model Bayes Theorem 02 engineering and technology Solid Waste 01 natural sciences 7. Clean energy 6. Clean water Refuse Disposal 12. Responsible consumption [SDV] Life Sciences [q-bio] High-solids anaerobic digestion model, ammonia inhibition, ionic strength, global sensitivity analysis, approximate bayesian computation Bioreactors global sensitivity analysis [SDE]Environmental Sciences Calibration High-solids anaerobic digestion model Anaerobiosis ionic strength Methane ammonia inhibition approximate bayesian computation 0105 earth and related environmental sciences Renaud Escudié, Eric Trably, Jérôme Harmand, Jean-Philippe Steyer, Vicente Pastor-Poquet, Vicente Pastor-Poquet, Giovanni Esposito, Stefano Papirio, 2019-11-01 journalpaper High-solids anaerobic digestion (HS-AD) of the organic fraction of municipal solid waste (OFMSW) is operated at a total solid (TS) content ≥ 10% to enhance the waste treatment economy, though it might be associated to free ammonia (NH3) inhibition. This study aimed to calibrate and cross-validate a HS-AD model for homogenized reactors in order to assess the effects of high NH3 levels in HS-AD of OFMSW, but also to evaluate the suitability of the reversible non-competitive inhibition function to reproduce the effect of NH3 on the main acetogenic and methanogenic populations. The practical identifiability of structural/biochemical parameters (i.e. 35) and initial conditions (i.e. 32) was evaluated using batch experiments at different TS and/or inoculum-to-substrate ratios. Variance-based global sensitivity analysis and approximate Bayesian computation were used for parameter optimization. The experimental data in this study permitted to estimate up to 8 biochemical parameters, whereas the rest of parameters and biomass contents were poorly identifiable. The study also showed the relatively high levels of NH3 (i.e. up to 2.3 g N/L) and ionic strength (i.e. up to 0.9 M) when increasing TS in HS-AD of OFMSW. However, the NH3 non-competitive function was unable to capture the acetogenic/methanogenic inhibition. Therefore, the calibration emphasized the need for target-oriented experimental data to enhance the practical identifiability and the predictive capabilities of structured HS-AD models, but also the need for further testing the NH3 inhibition function used in these simulations. Assessing practical identifiability during calibration and cross-validation of a structured model for high-solids anaerobic digestion 10.1016/j.watres.2019.114932