The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/li,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "li,2014", "name": "item", "description": "li,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/li,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "li,2016", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:25Z", "type": "Journal Article", "created": "2017-12-22", "description": "Effects of sodium nitrate were compared with sodium chloride loading on transport of electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron, the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1%, urinary sodium excretion (UNaV) of 1,126 mueq/min, and urinary chloride excretion (UClV) of 848 mueq/min during nitrate loading compared with an increase in CNa/GFR of 37.6%, UNaV of 2,362 mueq/min, and UClV of 2,397 mueq/min during saline loading. The smaller diuretic-induced increment in Na and Cl excretion in the nitrate studies suggests, as do the hydrated studies, that less Cl and Na are reabsorbed in the distal nephron during nitrate than saline loading. At every level of UNaV, fractional bicarbonate reabsorption was higher, urine pH was lower, and urinary potassium excretion (UKV) was higher in the nitrate studies. Thus, compared with saline loading, sodium nitrate decreases chloride and sodium reabsorption in the distal nephron. The higher hydrogen and potassium secretion in the nitrate studies may be consequent to the decreased ability of the distal nephron to reabsorb chloride.
", "keywords": ["0301 basic medicine", "0303 health sciences", "Nitrates", "Sodium", "Biological Transport", "Chlorothiazide", "Hydrogen-Ion Concentration", "Sodium Chloride", "Urine", "6. Clean water", "Diuresis", "3. Good health", "Bicarbonates", "Electrolytes", "03 medical and health sciences", "Dogs", "Ethacrynic Acid", "Kidney Tubules", "Chlorides", "Potassium", "Animals", "Glomerular Filtration Rate"], "contacts": [{"organization": "Marvin F. Levitt, T Kahn, J. P. Bosch, MH Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/li,2016"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "li,2016", "name": "item", "description": "li,2016", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/li,2016"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "ma,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:27Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/ma,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "ma,2015", "name": "item", "description": "ma,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ma,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "mao,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:27Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/mao,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "mao,2015", "name": "item", "description": "mao,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/mao,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "ou,y.,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:48Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/ou,y.,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "ou,y.,2015", "name": "item", "description": "ou,y.,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ou,y.,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "sun,2016", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2017-12-22", "description": "Effects of sodium nitrate were compared with sodium chloride loading on transport of electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron, the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1%, urinary sodium excretion (UNaV) of 1,126 mueq/min, and urinary chloride excretion (UClV) of 848 mueq/min during nitrate loading compared with an increase in CNa/GFR of 37.6%, UNaV of 2,362 mueq/min, and UClV of 2,397 mueq/min during saline loading. The smaller diuretic-induced increment in Na and Cl excretion in the nitrate studies suggests, as do the hydrated studies, that less Cl and Na are reabsorbed in the distal nephron during nitrate than saline loading. At every level of UNaV, fractional bicarbonate reabsorption was higher, urine pH was lower, and urinary potassium excretion (UKV) was higher in the nitrate studies. Thus, compared with saline loading, sodium nitrate decreases chloride and sodium reabsorption in the distal nephron. The higher hydrogen and potassium secretion in the nitrate studies may be consequent to the decreased ability of the distal nephron to reabsorb chloride.
", "keywords": ["0301 basic medicine", "0303 health sciences", "Nitrates", "Sodium", "Biological Transport", "Chlorothiazide", "Hydrogen-Ion Concentration", "Sodium Chloride", "Urine", "6. Clean water", "Diuresis", "3. Good health", "Bicarbonates", "Electrolytes", "03 medical and health sciences", "Dogs", "Ethacrynic Acid", "Kidney Tubules", "Chlorides", "Potassium", "Animals", "Glomerular Filtration Rate"], "contacts": [{"organization": "Marvin F. Levitt, T Kahn, J. P. Bosch, MH Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sun,2016"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sun,2016", "name": "item", "description": "sun,2016", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sun,2016"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "su,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/su,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "su,2014", "name": "item", "description": "su,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/su,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "villanueva-lopez,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:10Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/villanueva-lopez,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "villanueva-lopez,2015", "name": "item", "description": "villanueva-lopez,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/villanueva-lopez,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "vonreis,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:10Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/vonreis,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "vonreis,2014", "name": "item", "description": "vonreis,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/vonreis,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "wang,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:11Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/wang,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "wang,2014", "name": "item", "description": "wang,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/wang,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "xuan,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/xuan,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "xuan,2014", "name": "item", "description": "xuan,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/xuan,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "xiao,j.,2016", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "Effects of sodium nitrate were compared with sodium chloride loading on transport of electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron, the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1%, urinary sodium excretion (UNaV) of 1,126 mueq/min, and urinary chloride excretion (UClV) of 848 mueq/min during nitrate loading compared with an increase in CNa/GFR of 37.6%, UNaV of 2,362 mueq/min, and UClV of 2,397 mueq/min during saline loading. The smaller diuretic-induced increment in Na and Cl excretion in the nitrate studies suggests, as do the hydrated studies, that less Cl and Na are reabsorbed in the distal nephron during nitrate than saline loading. At every level of UNaV, fractional bicarbonate reabsorption was higher, urine pH was lower, and urinary potassium excretion (UKV) was higher in the nitrate studies. Thus, compared with saline loading, sodium nitrate decreases chloride and sodium reabsorption in the distal nephron. The higher hydrogen and potassium secretion in the nitrate studies may be consequent to the decreased ability of the distal nephron to reabsorb chloride.
", "keywords": ["0301 basic medicine", "0303 health sciences", "Nitrates", "Sodium", "Biological Transport", "Chlorothiazide", "Hydrogen-Ion Concentration", "Sodium Chloride", "Urine", "6. Clean water", "Diuresis", "3. Good health", "Bicarbonates", "Electrolytes", "03 medical and health sciences", "Dogs", "Ethacrynic Acid", "Kidney Tubules", "Chlorides", "Potassium", "Animals", "Glomerular Filtration Rate"], "contacts": [{"organization": "Marvin F. Levitt, T Kahn, J. P. Bosch, MH Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/xiao,j.,2016"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "xiao,j.,2016", "name": "item", "description": "xiao,j.,2016", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/xiao,j.,2016"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "yu,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/yu,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "yu,2014", "name": "item", "description": "yu,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/yu,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zhao,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhao,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhao,2014", "name": "item", "description": "zhao,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhao,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zheng,2016", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "Effects of sodium nitrate were compared with sodium chloride loading on transport of electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron, the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1%, urinary sodium excretion (UNaV) of 1,126 mueq/min, and urinary chloride excretion (UClV) of 848 mueq/min during nitrate loading compared with an increase in CNa/GFR of 37.6%, UNaV of 2,362 mueq/min, and UClV of 2,397 mueq/min during saline loading. The smaller diuretic-induced increment in Na and Cl excretion in the nitrate studies suggests, as do the hydrated studies, that less Cl and Na are reabsorbed in the distal nephron during nitrate than saline loading. At every level of UNaV, fractional bicarbonate reabsorption was higher, urine pH was lower, and urinary potassium excretion (UKV) was higher in the nitrate studies. Thus, compared with saline loading, sodium nitrate decreases chloride and sodium reabsorption in the distal nephron. The higher hydrogen and potassium secretion in the nitrate studies may be consequent to the decreased ability of the distal nephron to reabsorb chloride.
", "keywords": ["0301 basic medicine", "0303 health sciences", "Nitrates", "Sodium", "Biological Transport", "Chlorothiazide", "Hydrogen-Ion Concentration", "Sodium Chloride", "Urine", "6. Clean water", "Diuresis", "3. Good health", "Bicarbonates", "Electrolytes", "03 medical and health sciences", "Dogs", "Ethacrynic Acid", "Kidney Tubules", "Chlorides", "Potassium", "Animals", "Glomerular Filtration Rate"], "contacts": [{"organization": "Marvin F. Levitt, T Kahn, J. P. Bosch, MH Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zheng,2016"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zheng,2016", "name": "item", "description": "zheng,2016", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zheng,2016"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zhong,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhong,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhong,2015", "name": "item", "description": "zhong,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhong,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zhouandwang,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.
", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhouandwang,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhouandwang,2014", "name": "item", "description": "zhouandwang,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhouandwang,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zhu,2015", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "It has been established that H+ secretion can be maintained in frog stomach in the absence of exogenous CO2 by using a nutrient bathing fluid containing 25 mM H2PO4 (pH approximately equal to 4.5) or by lowering the pH of a nonbuffered nutrient solution to about 3.0-3.6. Exogenous CO2 in the presence of these nutrient solutions uniformly caused a marked decrease in H+ secretion, PD, adn short-circuit current (Isc) and an increase in transmucosal resistance (R). Elevation of nutrient [k+] to 83 mM reduced R significantly but transiently without change in H+ when nutrient pH less than 5.0, whereas R returned to base line and H+ increased when nutrient pH greater than 5.0. Acidification of the nutrient medium in the presence of exogenous CO2 results in inhibition of the secretory pump, probably by decreasing intracellular pH, and also interferes with conductance at the nutrient membrane. Removal of exogenous CO2 from standard bicarbonate nutrient solution reduced by 50% the H+, PD, and Isc without change in R; K+-free nutrient solutions reverse these changes in Isc and PD but not in H+. The dropping PD and rising R induced by K+-free nutrient solutions in 5% CO2 - 95% O2 are returned toward normal by 100% O2. Our findings support an important role for exogenous CO2 in maintaining normal acid-base balance in frog mucosa by acting as an acidifying agent.
", "keywords": ["Acid-Base Equilibrium", "0301 basic medicine", "Rana catesbeiana", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Phosphates", "Electrophysiology", "Solutions", "Bicarbonates", "03 medical and health sciences", "0302 clinical medicine", "Gastric Mucosa", "Potassium", "Animals", "Anura"], "contacts": [{"organization": "William Silen, JG Forte, T E Machen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhu,2015"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhu,2015", "name": "item", "description": "zhu,2015", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhu,2015"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?facets=true&offset=50&soil_chemical_properties=potassium&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?facets=true&offset=50&soil_chemical_properties=potassium&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "prev", "title": "items (prev)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?facets=true&soil_chemical_properties=potassium&offset=0", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?facets=true&soil_chemical_properties=potassium&offset=68", "hreflang": "en-US"}], "numberMatched": 68, "numberReturned": 18, "distributedFeatures": [], "timeStamp": "2026-04-04T15:08:24.166232Z"}