{"type": "FeatureCollection", "features": [{"id": "10.11591/.v3i4.4696", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:38Z", "type": "Journal Article", "created": "2019-11-04", "title": "Factors associated with Institutional delivery in Boricha district of Sidama zone, southern Ethiopia", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>&lt;p style='color: #000000; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 10px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;'&gt;Every year, 40 million women give birth at home without the help of a&lt;br /&gt;skilled birth attendant. In 2011, 287,000 women died during pregnancy or childbirth. Almost all these deaths occur in developing countries where mothers and children lack access to basic health care. Reports showed the low utilization of health facility for delivery service in Ethiopia. This study aimed to determine the utilization and factors influencing institutional delivery. Community based cross sectional study was conducted from January to February 2013/14 in Boricha District of Southern Ethiopia among mothers who gave birth in the last 1 year. Multistage sampling techniques were used to collect data from 546 mothers. Taking in to account place of birth for the last child, only 4.9% women gave birth in a health facility. Women\u2019s education level (AOR=4.4 (95% CI=1.36-14.33)), timing of firstANC visit (AOR= .03 (95% CI=0.004 - 0.205)), women\u2019s advice to deliver in a health facility during ANC (AOR = 31.15 (95% CI=2.02-479.52)), women\u2019s knowledge of birth related complications (AOR= 12.4 (95% CI=2.67-57.16)) and decision making power (AOR=0.2 (95% CI=0.060.82)) showed significant association with institutionional delivery. Institutional delivery in the study area was found to be very low. Raising\u00a0awareness on institutional delivery to maximize delivery service utilization and strengthening provision of education and counseling to deliver in health facility during antenatal care visits at individual and community level should be given due emphasis.&lt;/p&gt;</p></article>", "keywords": ["2. Zero hunger", "03 medical and health sciences", "0302 clinical medicine", "1. No poverty", "3. Good health"]}, "links": [{"href": "https://doi.org/10.11591/.v3i4.4696"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/International%20Journal%20of%20Public%20Health%20Science%20%28IJPHS%29", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.11591/.v3i4.4696", "name": "item", "description": "10.11591/.v3i4.4696", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.11591/.v3i4.4696"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-12-01T00:00:00Z"}}, {"id": "sun,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sun,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sun,2007", "name": "item", "description": "sun,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sun,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "10.1001/archinte.165.5.551", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:13:58Z", "type": "Journal Article", "created": "2005-03-14", "title": "The Effects of Cyclooxygenase-2 [COX-2] Inhibitors and Nonsteroidal Anti-inflammatory Therapy on 24-Hour Blood Pressure in Patients With Hypertension, Osteoarthritis, and Type 2 Diabetes Mellitus\u2014Correction", "keywords": ["03 medical and health sciences", "0302 clinical medicine"]}, "links": [{"href": "https://doi.org/10.1001/archinte.165.5.551"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Internal%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1001/archinte.165.5.551", "name": "item", "description": "10.1001/archinte.165.5.551", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1001/archinte.165.5.551"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2005-03-14T00:00:00Z"}}, {"id": "10.1007/bf03040379", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:14:23Z", "type": "Journal Article", "created": "2009-05-12", "title": "Une forme de t\u00e9ratozoospermie monomorphe: Le syndrome des spermatozo\u00efdes macroc\u00e9phales et ses variants", "description": "Les teratozoospermies monomorphes refletent une anomalie de structure des spermatozoides rare, mais sont souvent source de discussion lorsqu\u2019il faut envisager une prise en charge therapeutique. Nous proposons donc de faire le point des donnees actuelles de la litterature concernant le syndrome des spermatozoides macrocephales et ses variants. D\u2019un point de vue pratique, en dehors de la forme homogene du syndrome, l\u2019assistance medicale a la procreation (AMP) peut etre proposee. Apres evaluation des taux d\u2019anomalies chromosomiques dans les spermatozoides de ces patients, une discussion multidisciplinaire et une information claire du couple sont necessaires avant toute prise en charge en AMP.", "keywords": ["0301 basic medicine", "03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Catherine Metzler-Guillemain, Vincent Achard, Georges Mercier, Marie -Roberte Guichaoua,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/bf03040379"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Andrologie", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/bf03040379", "name": "item", "description": "10.1007/bf03040379", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/bf03040379"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2008-03-01T00:00:00Z"}}, {"id": "10.1007/s00268-003-1016-4", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:14:27Z", "type": "Journal Article", "created": "2003-11-19", "title": "Invited Commentary", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Abdallah S. Daar", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/s00268-003-1016-4"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/World%20Journal%20of%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s00268-003-1016-4", "name": "item", "description": "10.1007/s00268-003-1016-4", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s00268-003-1016-4"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2003-06-18T00:00:00Z"}}, {"id": "10.1016/j.envpol.2021.117220", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:16:41Z", "type": "Journal Article", "created": "2021-05-04", "title": "Trade-offs between short-term mortality attributable to NO2 and O3 changes during the COVID-19 lockdown across major Spanish cities", "description": "The emergence of the COVID-19 pandemic forced most countries to put in place lockdown measures to slow down the transmission of the virus. These lockdowns have led to temporal improvements in air quality. Here, we evaluate the changes in NO2 and O3 levels along with the associated impact upon premature mortality during the COVID-19 lockdown and deconfinement periods along the first epidemic wave across the provincial capital cities of Spain. We first quantify the change in pollutants solely due to the lockdown as the difference between business-as-usual (BAU) pollution levels, estimated with a machine learning-based meteorological normalization technique, and observed concentrations. Second, instead of using exposure-response functions between the pollutants and mortality reported in the literature, we fit conditional quasi-Poisson regression models to estimate city-specific associations between daily pollutant levels and non-accidental mortality during the period 2010-2018. Significant relative risk values are observed at lag 1 for NO2 (1.0047 [95% CI: 1.0014 to 1.0081]) and at lag 0 for O3 (1.0039 [1.0013 to 1.0065]). On average NO2 changed by -51% (intercity range -65.7 to -30.9%) and -36.4% (-53.7 to -11.6%), and O3 by -1.1% (-20.2 to 23.8%) and 0.6% (-12.4 to 23.0%), during the lockdown (57 days) and deconfinement (42 days) periods, respectively. We obtain a reduction in attributable mortality associated with NO2 changes of -119 (95% CI: -273 to -24) deaths over the lockdown, and of -53 (-114 to -10) deaths over the deconfinement. This was partially compensated by an increase in the attributable number of deaths, 14 (-72 to 99) during the lockdown, and 8 (-27 to 50) during the deconfinement, associated with the rise in O3 levels in the most populous cities during the analysed period, despite the overall small average reductions. Our study shows that the potential trade-offs between multiple air pollutants should be taken into account when evaluating the health impacts of environmental exposures.", "keywords": ["Air Pollutants", "SARS-CoV-2", "Nitrogen Dioxide", "COVID-19", "01 natural sciences", "Article", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "13. Climate action", "Air Pollution", "Communicable Disease Control", "Humans", "Particulate Matter", "Cities", "Pandemics", "Environmental Monitoring", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.1016/j.envpol.2021.117220"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Environmental%20Pollution", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.envpol.2021.117220", "name": "item", "description": "10.1016/j.envpol.2021.117220", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.envpol.2021.117220"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-10-01T00:00:00Z"}}, {"id": "10.1007/s11192-011-0558-8", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:15:15Z", "type": "Journal Article", "created": "2011-11-18", "title": "Equal contributions and credit given to authors in anesthesiology journals during a 10-year period", "description": "To investigate the prevalence and characteristics of the practice of explicitly giving authors equal credit in publications of major anesthesiology journals. Four major anesthesiology journals (Anesthesia and Analgesia (AA), Anesthesiology, British Journal of Anaesthesia (BJA) and Pain) were searched manually to identify original research articles published between January 1st, 2001 and December 31st, 2010 with respect to equally credited authors (ECAs). It was found that all journals explicitly gave authors equal credit, and articles with ECAs accounted for a greater proportion of the total number of articles published in each journal in 2010 versus that in 2000 (AA: 3.3% vs. 0%; Anesthesiology: 7.1% vs. <1%; BJA: 5.7% vs. 0%; Pain: 11.0% vs. <1%). The number of ECAs articles tended to increase significantly yearly in all journals (P < 0.0001 for each journal). The first two authors in the byline received equal credit in most cases. Furthermore, the ECAs articles involved institutions from different countries and regions and were sponsored by various funds. However, no specific guidance concerning this practice was provided in the instructions to authors in the four journals. It is increasingly common to give authors equal credit in original research articles in major anesthesiology journals. Detailed guidelines regarding this practice are warranted in future.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "05 social sciences", "0509 other social sciences", "3. Good health"], "contacts": [{"organization": "Tianzhu Tao, Lulong Bo, Fei Wang, Jinbao Li, Xiaoming Deng,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/s11192-011-0558-8"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Scientometrics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s11192-011-0558-8", "name": "item", "description": "10.1007/s11192-011-0558-8", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s11192-011-0558-8"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2011-11-19T00:00:00Z"}}, {"id": "10.1007/s11255-019-02331-x", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:15:15Z", "type": "Journal Article", "created": "2019-11-19", "title": "Holmium laser enucleation of the prostate in Jehovah\u2019s Witness patients", "description": "To evaluate if HoLEP is a viable option for male patients with medication-refractory urinary symptoms due to an enlarged prostate who are surgical candidates, but do not accept blood product transfusion.Between August 2008 and March 2019, nine Jehovah's Witness patients were undergoing HoLEP for relief of lower urinary tract symptoms and urinary retention. We described change in hemoglobin, change in PSA, enucleated prostate weight, enucleation and morcellation times, length of stay, and postoperative retention rate.The average age was 71.4\u00a0years (range 53-87). Urinary retention requiring catheterization was present in seven patients (78%). Two patients had a known diagnosis of prostate cancer preoperatively. The mean preoperative PSA on average was 21.6\u00a0ng/dL. Patients had a wide range of gland sizes, with a mean enucleated weight of 141\u00a0g (range 18-344\u00a0g). Mean reduction in hemoglobin was 16.9% following HoLEP. All patients managed to void postoperatively. All but one patient went home on postoperative day 1, and this patient went home on postoperative day 2. No patients required blood product transfusion or return to the operating room for clot irrigation postoperatively.HoLEP is a reasonable option for Jehovah's Witness and other patients with contraindications to blood product transfusion requiring surgical management of urinary symptoms due to enlarged prostate.", "keywords": ["Male", "Blood Loss", " Surgical", "Prostate", "Prostatic Hyperplasia", "Lasers", " Solid-State", "Organ Size", "Urinary Retention", "3. Good health", "03 medical and health sciences", "Outcome and Process Assessment", " Health Care", "Postoperative Complications", "0302 clinical medicine", "Lower Urinary Tract Symptoms", "Humans", "Laser Therapy", "Urinary Catheterization", "Jehovah's Witnesses", "Aged"], "contacts": [{"organization": "Ashraf Selim, Charles U. Nottingham, Nadya E. York, Casey A. Dauw, Michael S. Borofsky, Ronald S. Boris, James E. Lingeman,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/s11255-019-02331-x"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/International%20Urology%20and%20Nephrology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s11255-019-02331-x", "name": "item", "description": "10.1007/s11255-019-02331-x", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s11255-019-02331-x"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-11-19T00:00:00Z"}}, {"id": "10.1007/s11418-006-0129-0", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:15:22Z", "type": "Journal Article", "created": "2007-02-02", "title": "Hypoglycaemic effect of Eriosema kraussianum N. E. Br. [Fabaceae] rootstock hydro-alcohol extract in rats", "description": "Erectile dysfunction (ED) is a common medical condition in men with cardiovascular disorders such as ischaemic heart disease, hypertension and peripheral vascular diseases. It is also common in men with diabetes mellitus, probably because of the shared factors that impair haemodynamic mechanisms in the penile and ischaemic vasculature. In an attempt to scientifically appraise the efficacy, ethnomedical significance and contribution of Eriosema kraussianum rootstock to its Zulu folkloric use as \u201cuBangalala\u201d and \u201cViagra substitute\u201d, the present study was undertaken to investigate the hypoglycaemic effect of E. kraussianum rootstock hydro-alcohol extract in normoglycaemic (normal) and hyperglycaemic (diabetic) rat experimental paradigms, using glibenclamide, a \u2018second-generation\u2019 sulphonylurea, as the reference oral hypoglycaemic drug for comparison. E. kraussianum rootstock hydro-alcohol extract (EKE, 40\u2013320 mg/kg p.o.) produced dose-dependent, significant (P < 0.05\u20130.001) hypoglycaemia in the normoglycaemic and diabetic rats used. Glibenclamide (10 mg/kg p.o.) also induced marked, significant reductions (P < 0.001) in the blood glucose concentrations of the normoglycaemic and diabetic rats used. The contribution of this hypoglycaemic activity to the folkloric use of the plant\u2019s rootstock as a remedy for the management and/or treatment of ED among Zulu men of South Africa still remains an unresolved scientific nightmare.", "keywords": ["2. Zero hunger", "0301 basic medicine", "03 medical and health sciences", "0302 clinical medicine", "3. Good health"], "contacts": [{"organization": "John A. O. Ojewole, Siegfried E. Drewes,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/s11418-006-0129-0"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Natural%20Medicines", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s11418-006-0129-0", "name": "item", "description": "10.1007/s11418-006-0129-0", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s11418-006-0129-0"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2007-02-01T00:00:00Z"}}, {"id": "10.1007/s40265-021-01505-1", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:15:31Z", "type": "Journal Article", "created": "2021-04-30", "title": "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review", "description": "Soil-transmitted helminths (Ascaris lumbricoides, hookworm and Trichuris trichiura) infect about one-fifth of the world's population. The currently available drugs are all highly efficacious against A. lumbricoides. However, they are only moderately efficacious against hookworm and poorly efficacious against T. trichiura. Oxantel, a tetrahydropyrimidine derivative discovered in the 1970s, has recently been brought back to our attention given its high efficacy against T. trichiura infections (estimated 76% cure rate and 85% egg reduction rate at a 20 mg/kg dose). This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. Oxantel pamoate acts locally in the human gastrointestinal tract and binds to the parasite's nicotinic acetylcholine receptor (nAChR), leading to a spastic paralysis of the worm and subsequent expulsion. The drug is metabolically stable, shows low permeability and low systemic bioavailability after oral use. Oxantel pamoate was found to be safe in humans, with only a few mild adverse events reported. Several clinical trials have investigated the efficacy of this drug against T. trichiura\u00a0and suggest that oxantel pamoate is more efficacious against T. trichiura than the currently recommended drugs, which makes it a strong asset to the depleted drug armamentarium and could help delay or even prevent the development of resistance to existing drugs. We highlight existing data to support the use of oxantel pamoate against T. trichiura infections.", "keywords": ["Hookworm Infections", "03 medical and health sciences", "Trichuris", "0302 clinical medicine", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Pyrantel Pamoate", "Animals", "Humans", "Drug Interactions", "Review Article", "3. Good health"]}, "links": [{"href": "https://link.springer.com/content/pdf/10.1007/s40265-021-01505-1.pdf"}, {"href": "https://doi.org/10.1007/s40265-021-01505-1"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Drugs", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s40265-021-01505-1", "name": "item", "description": "10.1007/s40265-021-01505-1", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s40265-021-01505-1"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-04-30T00:00:00Z"}}, {"id": "10.1016/0958-2592(94)90048-5", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:15:33Z", "type": "Journal Article", "created": "2004-04-20", "title": "Skin tumours of the foot", "description": "In little more than a decade there has been a greater than 2-fold increase in the incidence of both melanoma and non-melanoma skin cancer.\u2019 This has been matched by an increased public awareness of skin malignancy, resulting in an even greater rise of benign tumours being removed in dermatology departments. Ultraviolet light exposure is widely accepted as the most significant aetiological factor in skin cancer.2 In most people, for most of the time, the foot is protected from ultraviolet light exposure, and is in consequence not a major site of skin malignancy. Nonetheless, a wide variety of both benign and malignant tumours may affect the skin of the foot and be the subject of enquiry by patients to health care workers. As illustrated in Figure 1, any of the cells of the skin may give rise to both benign and malignant neoplasms, which will be discussed in relation to their histogenesis.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"], "contacts": [{"organization": "A.G. Smith", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/0958-2592(94)90048-5"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20Foot", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/0958-2592(94)90048-5", "name": "item", "description": "10.1016/0958-2592(94)90048-5", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/0958-2592(94)90048-5"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1994-12-01T00:00:00Z"}}, {"id": "10.1016/j.ando.2022.09.014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:16:00Z", "type": "Journal Article", "created": "2022-12-12", "title": "Infertility revealing juvenile haemochromatosis", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Ioana Ruxandra Calapod, Marie-Christine Vantyghem,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.ando.2022.09.014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Annales%20d%27Endocrinologie", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.ando.2022.09.014", "name": "item", "description": "10.1016/j.ando.2022.09.014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.ando.2022.09.014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-12-01T00:00:00Z"}}, {"id": "10.1016/j.cropro.2009.09.006", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:16:26Z", "type": "Journal Article", "created": "2009-11-04", "title": "Efficacies Of Habitat Management Techniques In Managing Maize Stem Borers In Ethiopia", "description": "Habitat management techniques to control maize stem borers were tested in eastern (Melkassa and Mieso) and western (Sibu-Sire) Ethiopia. These techniques consisted of using mixed cropping of maize with haricot beans at different maize:bean ratios and a \u2018\u2018push\u2013pull\u2019\u2019 (PP) strategy utilizing Napier grass as a trap plant around maize plots as the \u2018\u2018pull\u2019\u2019 and Desmodium in between maize rows as a deterrent or \u2018\u2018push\u2019\u2019. In Melkassa, pest infestations were too low for the cropping system to significantly affect pests, plant damage and yields while in Mieso, where the pest densities were high, intercropping of maize with beans at ratios of 1:1 to 2:1 significantly decreased borer densities compared to pure maize stands. Chilo partellus (Swinhoe) and Cotesia flavipes (Cameron) were the major stem borer and parasitoid species, respectively, recorded both at Melkassa and Mieso. Borer parasitism was higher at Mieso than at Melkassa and it tended to increase with the increase of haricot bean ratio in the intercropping system. Land equivalent ratios of >1 indicated higher land use efficiency in mixed compared to sole cropping, even if pest densities were low. Establishment of Desmodium and Napier grass in PP trials varied from site to site, and poor establishment was observed in plots with low soil pH. Where yields varied significantly, they were lower in the PP than the sole maize plots. Borer densities were low and mostly not affected by the cropping system. However, in the second season when borer density was relatively high, higher levels of infestation and leaf feeding scores were recorded in the control than push\u2013pull plots. Published by Elsevier Ltd.", "keywords": ["2. Zero hunger", "0106 biological sciences", "Desmodium", "Push\u00e2\u20ac\u201cpull", "Life Sciences", "Agriculture", "15. Life on land", "01 natural sciences", "630", "Maize", "03 medical and health sciences", "Intercropping", "0302 clinical medicine", "Stem borers", "Entomology", "Napier grass"], "contacts": [{"organization": "Difabachew K. Belay, Difabachew K. Belay, John E. Foster,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.cropro.2009.09.006"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Crop%20Protection", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.cropro.2009.09.006", "name": "item", "description": "10.1016/j.cropro.2009.09.006", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.cropro.2009.09.006"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2010-05-01T00:00:00Z"}}, {"id": "10.1016/j.foodres.2017.03.045", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:16:47Z", "type": "Journal Article", "created": "2018-08-22", "title": "Past, present and future: The strength of plant-based dairy substitutes based on gluten-free raw materials", "description": "As the pace of vaccine uptake accelerates globally, there is a need to document low-income country experiences with vaccine introductions. Over the course of five years, the government of Rwanda rolled out vaccines against pneumococcus, human papillomavirus, rotavirus, and measles & rubella, achieving over 90% coverage for each. To carry out these rollouts, Rwanda's Ministry of Health engaged in careful review of disease burden information and extensive, cross-sectoral planning at least one year before introducing each vaccine. Rwanda's local leaders, development partners, civil society organizations and widespread community health worker network were mobilized to support communication efforts. Community health workers were also used to confirm target population size. Support from Gavi, UNICEF and WHO was used in combination with government funds to promote country ownership and collaboration. Vaccination was also combined with additional community-based health interventions. Other countries considering rapid consecutive or simultaneous rollouts of new vaccines may consider lessons from Rwanda's experience while tailoring the strategies used to local context.", "keywords": ["Plant-based milk substitutes", "Measles Vaccine", "Plant Proteins", " Dietary", "Pneumococcal Vaccines", "Diet", " Gluten-Free", "03 medical and health sciences", "0404 agricultural biotechnology", "0302 clinical medicine", "Protein-high foods", "Food Quality", "Humans", "Rubella Vaccine", "Protein requirement", "Papillomavirus Vaccines", "Vaccines", " Combined", "Milk alternatives", "Plant-based dairy substitutes", "Food", " Formulated", "Community Health Workers", "Population Density", "2. Zero hunger", "Vaccines", "Immunization Programs", "Protein", "Diet", " Vegetarian", "Communication", "Vaccination", "Rotavirus Vaccines", "Rwanda", "1. No poverty", "04 agricultural and veterinary sciences", "Diets", "plant-based milk substitutes; protein requirement; milk alternatives; protein-high foods; protein; diets; plant-based dairy substitutes", "3. Good health", "Food Technology", "Dairy Products", "0405 other agricultural sciences", "Forecasting"], "contacts": [{"organization": "Gatera, Maurice, Bhatt, Sunil, Ngabo, Fidele, Utamuliza, Mathilde, Sibomana, Hassan, Karema, Corine, Mugeni, Cathy, Nutt, Cameron T., Nsanzimana, Sabin, Wagner, Claire M., Binagwaho, Agnes,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.foodres.2017.03.045"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Food%2C%20Nutrition%20and%20Population%20Health", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.foodres.2017.03.045", "name": "item", "description": "10.1016/j.foodres.2017.03.045", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.foodres.2017.03.045"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2016-06-01T00:00:00Z"}}, {"id": "10.1016/j.ijcard.2007.01.085", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:07Z", "type": "Journal Article", "created": "2007-05-01", "title": "Austrian syndrome: A clinical rarity", "description": "We present a case of classical Austrian syndrome in a 55-year-old man with a history of alcoholism. The rapid destruction in aortic valve cusps caused perforations with severe aortic insufficiency, acute pulmonary edema, and determined an urgent aortic valve substitution with good postoperative evolution. The review of the literature suggests cardiac surgery in this syndrome to improve the poor survival with conservative treatment. We recommend early surgery in these cases because of the fast impairment of the patient and valvular tissue destruction detected in intraoperatory examination.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"]}, "links": [{"href": "https://doi.org/10.1016/j.ijcard.2007.01.085"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/International%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.ijcard.2007.01.085", "name": "item", "description": "10.1016/j.ijcard.2007.01.085", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.ijcard.2007.01.085"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2008-07-01T00:00:00Z"}}, {"id": "10.1016/j.jenvman.2021.112861", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:14Z", "type": "Journal Article", "created": "2021-06-01", "title": "Looking into individual choices and local realities to define adaptation options to drought and climate change", "description": "Climate change adaptation choices defined by local communities reflect individual risk perception and contextual factors. This study examines how local contextual environmental factors contribute to individual choices for adapting to water scarcity in three locations in central Spain. The study evaluates citizens' choices by audience segmentation and explore the role of geographical location in segments' engagement with adaptation and adaptation measure preference. The results of the analysis of the effect of local experience support the findings of other studies that suggest that local experience is linked to risk perception but does not necessarily drive adaptive behaviour. The results suggest that respondents from most degraded areas show a higher local risk perception, but do not show homogeneous commitment to adaptation. The results also indicate differences over adaptation measure preferences across locations. Respondents of less degraded areas have a lower risk perception and show individualistic responses as compared to respondents in water stressed communities. These results highlight the relevance of local experience-driven risk perception in support to adaptation actions. Spain exemplifies many countries in southern Europe and North Africa, where drought is already a challenge to society and it is affecting an increasing number of people.", "keywords": ["Europe", "03 medical and health sciences", "0302 clinical medicine", "Africa", " Northern", "Spain", "13. Climate action", "Climate Change", "11. Sustainability", "1. No poverty", "Humans", "15. Life on land", "6. Clean water", "Droughts"]}, "links": [{"href": "https://doi.org/10.1016/j.jenvman.2021.112861"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Environmental%20Management", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.jenvman.2021.112861", "name": "item", "description": "10.1016/j.jenvman.2021.112861", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.jenvman.2021.112861"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-09-01T00:00:00Z"}}, {"id": "10.1016/j.jflm.2018.03.016", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:15Z", "type": "Journal Article", "created": "2018-03-28", "title": "Poisoning histories in the Italian renaissance: The case of Pico Della Mirandola and Angelo Poliziano", "description": "Giovanni Pico della Mirandola and Angelo Poliziano were two of the most important humanists of the Italian Renaissance. They died suddenly in 1494 and their deaths have been for centuries a subject of debate. The exhumation of their remains offered the opportunity to study the cause of their death through a multidisciplinary research project. Anthropological analyses, together with documentary evidences, radiocarbon dating and ancient DNA analysis supported the identification of the remains attributed to Pico. Macroscopic examination did not reveal paleopathological lesions or signs related to syphilis. Heavy metals analysis, carried out on bones and mummified tissues, showed that in Pico's remains there were potentially lethal levels of arsenic, supporting the philosopher's poisoning theory reported by documentary sources. The arsenic concentrations obtained from analysis of Poliziano's remains, are probably more related to an As chronic exposure or diagenetic processes rather than poisoning.", "keywords": ["Male", "Microscopy", "Spectrum Analysis", "Environmental Exposure", "Mummies", "06 humanities and the arts", "Bone and Bones", "Arsenic", "Forensic Toxicology", "03 medical and health sciences", "0302 clinical medicine", "Italy", "Arsenic Poisoning", "Microscopy", " Electron", " Scanning", "Humans", "0601 history and archaeology", "Carbon Radioisotopes", "Ancient DNA; Angelo Poliziano; Arsenic poisoning; Girolamo benivieni; Pico della Mirandola; Radiocarbon dating", "DNA", " Ancient", "History", " 15th Century"]}, "links": [{"href": "https://doi.org/10.1016/j.jflm.2018.03.016"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Forensic%20and%20Legal%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.jflm.2018.03.016", "name": "item", "description": "10.1016/j.jflm.2018.03.016", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.jflm.2018.03.016"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-05-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2017.12.004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2017-12-16", "title": "Luminescence properties of natural muscovite relevant to optical dating of contaminated quartz samples", "description": "Muscovite is a mineral commonly found along quartz in sediments, where the latter is the mineral of choice in numerous optically stimulated luminescence (OSL) dating studies. Since muscovite cannot be efficiently eliminated following standard laboratory treatments, it is important to assess its luminescence properties. This study is focused on the investigation of muscovite hand-picked from a quartz sample extracted from loess and of museum specimens of muscovite in order to evaluate their potential implication in the OSL dating of quartz samples contaminated with muscovite grains. The obtained results show that generally applicable luminescence characteristics cannot be described for muscovite. In terms of the thermoluminescence (TL) response, all samples investigated display the same wide peak at 200\u202f\u00b0C. The blue light and infrared (IR) sensitivities differ between the samples: 3 out of 5 samples present no or negligible level of OSL and IRSL response, while the other 2 samples are characterised by both blue light (2000\u20133400 counts in 0.31\u202fs of stimulation for 10\u202fmg of muscovite after irradiation with a dose of 136\u202fGy) and IR sensitivity (265\u2013320 counts in 0.31\u202fs of stimulation for 10\u202fmg of muscovite after irradiation with a dose of 136\u202fGy). Based on the samples analysed in this study, aliquots of quartz contaminated with optically (blue light) sensitive muscovite would also be IR sensitive. Hence, potentially problematic aliquots can be identified via the IRSL purity test usually used in the OSL dating of quartz samples for detection of feldspar contamination. The impact of muscovite on dose determination for quartz was also tested and it was concluded that at least in the case of bright quartz, muscovite minerals do not influence the OSL measurements.", "keywords": ["690", "03 medical and health sciences", "0302 clinical medicine", "13. Climate action", "F800", "6. Clean water", "620"]}, "links": [{"href": "https://nrl.northumbria.ac.uk/id/eprint/38081/1/1-s2.0-S1350448716303821-main.pdf"}, {"href": "https://eprints.soton.ac.uk/419707/1/1_s2.0_S1350448716303821_main.pdf"}, {"href": "https://doi.org/10.1016/j.radmeas.2017.12.004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2017.12.004", "name": "item", "description": "10.1016/j.radmeas.2017.12.004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2017.12.004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-02-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2018.06.023", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2018-06-28", "title": "Electron spin resonance characterisation of sedimentary quartz of different grain sizes", "description": "Abstract   Different optically stimulated luminescence (OSL) single aliquot regenerative (SAR) saturation characteristics have been previously reported for quartz of diverse grain sizes. This preliminary electron spin resonance (ESR) study documents on paramagnetic signals in natural sedimentary quartz extracts of different grain sizes (4\u201311\u202f\u03bcm, 63\u201390\u202f\u03bcm, 90\u2013125\u202f\u03bcm, 125\u2013180\u202f\u03bcm, 180\u2013250\u202f\u03bcm) extracted from loess and sand samples that are amendable to OSL and ESR dating. Spectra recorded at room temperature and low power ( 63\u202f\u03bcm) titanium-lithium [TiO4/Li+]0 signals increase with increasing grain size. Aluminium-hole ([AlO4]0) signals are observed in all natural and laboratory irradiated investigated samples when spectra are recorded at low temperature (90\u202fK). The intensity of these signals appears to decrease with increasing grain size, however, room temperature measurements show that these signals are highly interfered by a variety of signals tentatively attributed to peroxy (g\u202f\u2248\u202f2.007 and g\u202f\u2248\u202f2.004) with significantly higher intensities in fine grains (4\u201311\u202f\u03bcm). A decrease of their intensity is reported when grain size increases and partial evidence that these defects are preferentially located in damaged regions of the grains is presented. A dose dependent paramagnetic signal at g\u202f\u2248\u202f2.011 was detected only in 4\u201311\u202f\u03bcm quartz. The stronger signature of the [TiO4/Li+]0 signals in larger grains coupled with the weaker signals of peroxy signals interfering with [AlO4]0 signal measurement is suggesting that coarser fractions should be preferred for conventional ESR dating using aluminium-hole and titanium signals. The understanding of the implication of these defects in OSL dating alongside with their concentration dependency on grain size requires further investigations.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "01 natural sciences", "0105 earth and related environmental sciences"], "contacts": [{"organization": "Timar-Gabor, A.", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.radmeas.2018.06.023"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2018.06.023", "name": "item", "description": "10.1016/j.radmeas.2018.06.023", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2018.06.023"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-12-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2010.05.029", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2010-05-27", "title": "Assessment of undesirable dose to eye-melanoma patients after proton radiotherapy", "description": "Abstract   Radiotherapy with a proton beam of initial energy 55\u201380\u00a0MeV is presently the clinically recommended therapy for some cases of intraocular melanoma such as large melanomas or tumours adjacent to critical organs. Evaluation and optimization of radiation doses outside the treatment volume may contribute to reducing undesirable side-effects and decreasing the risk of occurrence of secondary cancers, particularly for paediatric patients. In this work the undesired doses to organs were assessed basing on Monte Carlo calculation of secondary radiation transport and on results of measurements of neutron and \u03b3-ray doses at the proton therapy facility of the Institute of Nuclear Physics at Krakow. Dosimetry was performed using a He-3-based FHT 762 neutron monitor (Wendi II), a FH40G proportional counter (for \u03b3-rays), and MTS-7 (LiF:Mg,Ti) thermoluminescence detectors (TLDs). Organ doses were calculated in the ADAM anthropomorphic phantom using the MCNPX Monte Carlo transport code and partly verified, for \u03b3-ray doses, with TLD measurements in the RANDO Anderson anthropomorphic phantom. The effective dose due to undesired radiation, including exposure from scattered radiation during the entire process of proton radiotherapy and patient positioning using X-rays, does not exceed 1\u00a0mSv.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"]}, "links": [{"href": "https://doi.org/10.1016/j.radmeas.2010.05.029"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2010.05.029", "name": "item", "description": "10.1016/j.radmeas.2010.05.029", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2010.05.029"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2010-12-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2018.06.008", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2018-06-05", "title": "Single and multi-grain OSL investigations in the high dose range using coarse quartz", "description": "Abstract   There is evidence that optically stimulated luminescence (OSL) dating of quartz using the single-aliquot regenerative-dose (SAR) protocol underestimates the equivalent dose (De) for paleodoses above 100\u2013200\u202fGy. Additionally, \u2018infinitely\u2019 old samples found not to be in laboratory saturation were reported. We present single and multi-grain SAR-OSL investigations for a coarse-grained (180\u2013250\u202f\u03bcm) quartz sample extracted from loess collected below the Brunhes/Matuyama transition at the Roksolany site (Ukraine). The sample was dated to more than 1000 ka by electron spin resonance using a multi center approach (Al and Ti signals), confirming that the De (\u223c2000\u202fGy) falls beyond the limit of standard OSL De measurement techniques. However, the natural signal measured using multi-grain aliquots of quartz was found to be below the laboratory saturation level. A comparison was made between synthetic dose response curves (DRCs) generated from single-grain and multi-grain aliquot data, respectively; the natural signal was found to be closer to the latoratory saturation level (92%) in the case of the single-grain synthetic DRC than for the multi-grain synthetic DRC where the signal was 86% of the saturation level. This difference could not be attributed to stimulation with different wavelengths, i.e. blue and green light stimulation for multi and single-grain measurements, respectively. By analysing synthetic data obtained by grouping grains according to their brightness, it was observed that brighter grains give a natural signal closer to the laboratory saturation level. This trend was confirmed for multi-grain aliquot data. Based on these findings we infer that variability in the contribution from populations of grains with different levels of brightness may represent a controlling factor in the closeness of the natural signal to laboratory saturation level for infinitely old samples.", "keywords": ["Multi-grain aliquots", "03 medical and health sciences", "0302 clinical medicine", "Quartz dose response", "\u2018Infinitely\u2019 old", "Optically stimulated luminescence (OSL)", "Saturation", "Single grains", "01 natural sciences", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.1016/j.radmeas.2018.06.008"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2018.06.008", "name": "item", "description": "10.1016/j.radmeas.2018.06.008", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2018.06.008"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-12-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2019.106187", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2019-09-16", "title": "Phenomenological model of aluminium-hole ([AlO4/h+]0) defect formation in sedimentary quartz upon room temperature irradiation: electron spin resonance (ESR) study", "description": "Abstract   The mechanism governing the production of the paramagnetic [AlO4/h+]0 centres (denoted also as Al-hole or Al-h) in quartz as a function of given dose is of great importance in electron spin resonance (ESR) dating, as the analytical function used to characterise the evolution of this centre with accumulated dose is used to derive the equivalent dose by extrapolation to the abscissa-axis. The single saturating exponential model fails to accurately represent the dose response curve especially at high doses, and consequently, empirical functions, such as a saturating exponential plus a linear term, are widely used in the dating community. Herein, a physical phenomenological model is presented to describe the Al-hole formation under gamma irradiation in sedimentary quartz. Based on previous studies it is known that the Al-hole centre is formed via the dissociation of the Al centres compensated with alkali ions [AlO4/M+]0 (generally denoted as Al-M) where M+ could be Li+, Na+ or K+, as well as by the dissociation of Al compensated with hydrogen ions [AlO4/H+]0, (denoted as Al\u2013H). When irradiation moves interstitial alkali ions away from the aluminium ions, they can be replaced by H+ ions beside the conversion to Al-hole centres. By assuming that the rate of the dissociation process is proportional to the concentration of the defects themselves, a sum of saturating exponential functions is obtained for describing the growth of Al-hole with dose. The model is applied on data obtained on sedimentary quartz specimens of different origins for describing the dose response of the paramagnetic Al-hole ESR signal. We are showing that the signal of Al-hole does not reach full saturation at doses even as high as 100\u00a0kGy and can it be well represented by two exponential components as predicted by the model. As such, the additional linear term reported by other works when describing the dose response is just a first order approximation of one of the saturating exponential functions.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "ESR dating Al-hole centres ([AlO4/h+]0)Production mechanism Dose response curve", "01 natural sciences", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.1016/j.radmeas.2019.106187"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2019.106187", "name": "item", "description": "10.1016/j.radmeas.2019.106187", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2019.106187"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "10.1016/j.radmeas.2019.106221", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:17:24Z", "type": "Journal Article", "created": "2019-11-19", "title": "Bleaching studies on Al-hole ([AlO4/h]0) electron spin resonance (ESR) signal in sedimentary quartz", "description": "Abstract   Electron spin resonance (ESR) dating of sediments using quartz is most commonly used for older sediments (>100 ka), since large residuals render the ESR signal unsuitable for dating young sediments. The multiple-centre approach (utilising both Ti and [AlO4/h]0 signals) is usually used to test the resetting of the signals used for ESR dating. Here we work towards a better understanding of, and correction for, the residual signal in ESR samples of sedimentary quartz. We undertook multiple-centre ESR measurements using quartz [AlO4/h]0 and Ti signals on young aeolian samples of different grain sizes which have been independently dated using optically stimulated luminescence (OSL). Our results demonstrate that [AlO4/h]0 signal yields residuals indicating equivalent doses of about 500\u00a0Gy, substantially older than expected for the known OSL equivalent doses in the range of 8\u201337\u00a0Gy. The decay of [AlO4/h]0 signal as function of bleaching time can be represented by an exponential function. We investigate the dependence of the residual magnitude of the ESR signal as a function of the previous given dose and observe an exponential increase in the residual signal with dose. Such observations are consistent with the results of luminescence process modelling conducted for a model comprising two luminescence centres and several traps, one of which is a so-called deep disconnected trap that cannot be emptied during optical stimulation. We propose that bleaching occurs through an electron-hole recombination process with electrons released from optically sensitive traps. In addition to our new insights into the bleaching mechanisms of the [AlO4/h]0 ESR signal, we discuss the implications for the procedures used for performing residual dose corrections in ESR dating. We recommend that modern analogues be used in addition to laboratory-bleached samples when performing residual dose corrections.", "keywords": ["ESR dating", "Sedimentary quartz", "03 medical and health sciences", "0302 clinical medicine", "Residual", "Sedimentary quartz ESR dating[AlO4/h]0 Residual Bleaching Modelling", "[AlO4/h]0", "Bleaching", "01 natural sciences", "Modelling", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.1016/j.radmeas.2019.106221"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Radiation%20Measurements", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.radmeas.2019.106221", "name": "item", "description": "10.1016/j.radmeas.2019.106221", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.radmeas.2019.106221"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "10.1016/j.ygyno.2013.04.038", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:08Z", "type": "Journal Article", "created": "2013-10-02", "title": "Abstract 8: Continuing routine cardiac surveillance in long-term use of pegylated liposomal doxorubicin: Is it necessary?", "keywords": ["0301 basic medicine", "03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "S. Gill, K. Savage, D. Blackhurst, J. Eggert, K. Smith, W. Wysham, W. Winter, L. Puls,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.ygyno.2013.04.038"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Gynecologic%20Oncology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.ygyno.2013.04.038", "name": "item", "description": "10.1016/j.ygyno.2013.04.038", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.ygyno.2013.04.038"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2013-10-01T00:00:00Z"}}, {"id": "10.1016/s0015-0282(02)03702-0", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:08Z", "type": "Journal Article", "created": "2002-10-08", "title": "Assessing the clinical utility of in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) in human immunodeficiency virus-1 (HIV-1) serodiscordant couples: report of 103 consecutive cycles", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Joseph E Pena, Melvin H Thornton, Jane Ruman, Jeff Klein, Suzanne Kavic, Mark V Sauer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/s0015-0282(02)03702-0"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Fertility%20and%20Sterility", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/s0015-0282(02)03702-0", "name": "item", "description": "10.1016/s0015-0282(02)03702-0", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/s0015-0282(02)03702-0"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2002-09-01T00:00:00Z"}}, {"id": "10.1016/s0149-7944(99)00191-9", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:09Z", "type": "Journal Article", "created": "2002-07-26", "title": "Carpal tunnel syndrome: an update", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Chris D Tzarnas", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/s0149-7944(99)00191-9"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Current%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/s0149-7944(99)00191-9", "name": "item", "description": "10.1016/s0149-7944(99)00191-9", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/s0149-7944(99)00191-9"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1999-11-01T00:00:00Z"}}, {"id": "10.1016/s0168-9002(04)01697-3", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:09Z", "type": "Journal Article", "created": "2008-01-25", "title": "Development of 2nd prototype of novel silicon Stripixel detector for PHENIX upgrade", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "0103 physical sciences", "01 natural sciences"]}, "links": [{"href": "https://doi.org/10.1016/s0168-9002(04)01697-3"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nuclear%20Instruments%20and%20Methods%20in%20Physics%20Research%20Section%20A%3A%20Accelerators%2C%20Spectrometers%2C%20Detectors%20and%20Associated%20Equipment", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/s0168-9002(04)01697-3", "name": "item", "description": "10.1016/s0168-9002(04)01697-3", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/s0168-9002(04)01697-3"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2004-12-11T00:00:00Z"}}, {"id": "10.1016/s0895-4356(98)00145-0", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:09Z", "type": "Journal Article", "created": "2002-07-25", "title": "The Validity of the Routine Mortality Statistics on Coronary Heart Disease in Finland", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"]}, "links": [{"href": "https://doi.org/10.1016/s0895-4356(98)00145-0"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Clinical%20Epidemiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/s0895-4356(98)00145-0", "name": "item", "description": "10.1016/s0895-4356(98)00145-0", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/s0895-4356(98)00145-0"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1999-02-01T00:00:00Z"}}, {"id": "10.1016/s2542-5196(20)30148-0", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:09Z", "type": "Journal Article", "created": "2020-07-15", "title": "Reduction in air pollution and attributable mortality due to COVID-19 lockdown", "description": "Correspondence", "keywords": ["China", "SARS-CoV-2", "Pneumonia", " Viral", "COVID-19", "01 natural sciences", "Betacoronavirus", "03 medical and health sciences", "0302 clinical medicine", "Air Pollution", "Correspondence", "Humans", "Coronavirus Infections", "Pandemics", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.1016/s2542-5196(20)30148-0"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20Lancet%20Planetary%20Health", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/s2542-5196(20)30148-0", "name": "item", "description": "10.1016/s2542-5196(20)30148-0", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/s2542-5196(20)30148-0"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-07-01T00:00:00Z"}}, {"id": "10.1023/a:1008916026143", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:21Z", "type": "Journal Article", "title": "Spike-Frequency Adaptation Of A Generalized Leaky Integrate-And-Fire Model Neuron", "description": "Although spike-frequency adaptation is a commonly observed property of neurons, its functional implications are still poorly understood. In this work, using a leaky integrate-and-fire neural model that includes a Ca2+-activated K+ current (IAHP), we develop a quantitative theory of adaptation temporal dynamics and compare our results with recent in vivo intracellular recordings from pyramidal cells in the cat visual cortex. Experimentally testable relations between the degree and the time constant of spike-frequency adaptation are predicted. We also contrast the IAHP model with an alternative adaptation model based on a dynamical firing threshold. Possible roles of adaptation in temporal computation are explored, as a a time-delayed neuronal self-inhibition mechanism. Our results include the following: (1) given the same firing rate, the variability of interspike intervals (ISIs) is either reduced or enhanced by adaptation, depending on whether the IAHP dynamics is fast or slow compared with the mean ISI in the output spike train; (2) when the inputs are Poisson-distributed (uncorrelated), adaptation generates temporal anticorrelation between ISIs, we suggest that measurement of this negative correlation provides a probe to assess the strength of IAHP in vivo; (3) the forward masking effect produced by the slow dynamics of IAHP is nonlinear and effective at selecting the strongest input among competing sources of input signals.", "keywords": ["0301 basic medicine", "Neurons", "03 medical and health sciences", "0302 clinical medicine", "Potassium Channels", "Time Factors", "Models", " Neurological", "Electric Conductivity", "Reaction Time", "Action Potentials", "Differential Threshold", "Calcium", "Adaptation", " Physiological"], "contacts": [{"organization": "Ying-Hui Liu, Xiao Jing Wang,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1023/a:1008916026143"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20computational%20neuroscience", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1023/a:1008916026143", "name": "item", "description": "10.1023/a:1008916026143", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1023/a:1008916026143"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2001-01-01T00:00:00Z"}}, {"id": "10.1055/a-1175-6408", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:58Z", "type": "Journal Article", "created": "2020-06-26", "title": "Die Pflege von Menschen mit Diabetes interdisziplin\u00e4r abgestimmt, evidenzbasiert und rechtssicher gestalten", "description": "ZUSAMMENFASSUNG<p>In der Pflege von Menschen mit Diabetes geht es vor allem darum, die berufsgruppen\uffc3\uffbcbergreifende Zusammenarbeit abgestimmt und koordiniert zu gestalten. Dabei ist es wichtig, den Informationsaustausch zwischen den unterschiedlichen Versorgungsorten vor Informationsverlusten und Missverst\uffc3\uffa4ndnissen zu sch\uffc3\uffbctzen, um \uffc3\uff9cber-, Unter- und Fehlversorgung zu vermeiden. F\uffc3\uffbcr Pflege, Medizin und Therapieberufe sollten Versorgungsleitlinien der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (AWMF) sowie Expertenstandards des Deutschen Netzwerks f\uffc3\uffbcr Qualit\uffc3\uffa4tsentwicklung in der Pflege (DNQP) ein gemeinsamer Orientierungsrahmen sein. Auf dieser Grundlage k\uffc3\uffb6nnen Assessmentstrategien abgestimmt, ver\uffc3\uffa4nderte Versorgungsbedarfe sowie Akut- und Folgekomplikationen standardisiert erfasst und in einer \uffe2\uff80\uff9egemeinsamen Sprache\uffe2\uff80\uff9c \uffc3\uffbcbermittelt werden. So gelingen die gemeinsame Patientenversorgung, das Entlass- und \uffc3\uff9cberleitungsmanagement sowie auch die Abstimmung der Beratungs-/Schulungsinhalte f\uffc3\uffbcr Patienten in abgestimmter Kooperation auf dem Fundament eines gemeinsamen wissenschaftsfundierten Orientierungsrahmens. Dies mit einem Ziel: Patientensicherheit.</p", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Susanne Grundke", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1055/a-1175-6408"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Diabetes%20aktuell", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1055/a-1175-6408", "name": "item", "description": "10.1055/a-1175-6408", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1055/a-1175-6408"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-06-01T00:00:00Z"}}, {"id": "10.1056/nejmoa2212825", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:58Z", "type": "Journal Article", "created": "2023-05-17", "title": "Emodepside for             Trichuris trichiura             and Hookworm Infection", "description": "Current treatments for soil-transmitted helminth infections in humans have low efficacy against Trichuris trichiura. Emodepside - a drug in veterinary use and under development for the treatment of onchocerciasis in humans - is a leading therapeutic candidate for soil-transmitted helminth infection.We conducted two phase 2a, dose-ranging, randomized, controlled trials to evaluate the efficacy and safety of emodepside against T. trichiura and hookworm infections. We randomly assigned, in equal numbers, adults 18 to 45 years of age in whom T. trichiura or hookworm eggs had been detected in stool samples to receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo. The primary outcome was the percentage of participants who were cured of T. trichiura or hookworm infection (the cure rate) with emodepside 14 to 21 days after treatment, determined with the use of the Kato-Katz thick-smear technique. Safety was assessed 3, 24, and 48 hours after the receipt of treatment or placebo.A total of 266 persons were enrolled in the T. trichiura trial and 176 in the hookworm trial. The predicted cure rate against T. trichiura in the 5-mg emodepside group (85% [95% confidence interval {CI}, 69 to 93]; 25 of 30 participants) was higher than the predicted cure rate in the placebo group (10% [95% CI, 3 to 26]; 3 of 31 participants) and the observed cure rate in the albendazole group (17% [95% CI, 6 to 35]; 5 of 30 participants). A dose-dependent relationship was shown in participants with hookworm: the observed cure rate was 32% (95% CI, 13 to 57; 6 of 19 participants) in the 5-mg emodepside group and 95% (95% CI, 74 to 99.9; 18 of 19 participants) in the 30-mg emodepside group; the observed cure rates were 14% (95% CI, 3 to 36; 3 of 21 participants) in the placebo group and 70% (95% CI, 46 to 88; 14 of 20 participants) in the albendazole group. In the emodepside groups, headache, blurred vision, and dizziness were the most commonly reported adverse events 3 and 24 hours after treatment; the incidence of events generally increased in a dose-dependent fashion. Most adverse events were mild in severity and were self-limited; there were few moderate and no serious adverse events.Emodepside showed activity against T. trichiura and hookworm infections. (Funded by the European Research Council; ClinicalTrials.gov number, NCT05017194.).", "keywords": ["Adult", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Administration", " Oral", "Middle Aged", "Albendazole", "16. Peace & justice", "3. Good health", "03 medical and health sciences", "Feces", "Hookworm Infections", "Soil", "Young Adult", "0302 clinical medicine", "Trichuris", "Depsipeptides", "Animals", "Humans", "Trichuriasis"]}, "links": [{"href": "https://doi.org/10.1056/nejmoa2212825"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1056/nejmoa2212825", "name": "item", "description": "10.1056/nejmoa2212825", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1056/nejmoa2212825"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-05-18T00:00:00Z"}}, {"id": "10.1063/5.0005161", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:00Z", "type": "Journal Article", "created": "2020-07-20", "title": "The compensation effect (Meyer\u2013Neldel rule) on [AlO 4 /h + ] 0 and [TiO 4 /M + ] 0 paramagnetic centers in irradiated sedimentary quartz", "description": "<p>The effect of thermal excitation on paramagnetic defects in natural sedimentary quartz irradiated with different doses of gamma radiation was studied using electron spin resonance (ESR) spectroscopy. We report a variation in the activation energy and the frequency factor for [AlO4/h+]0 and [TiO4/M+]0 paramagnetic defects with the gamma dose, for a dose range investigated between \uffe2\uff88\uffbc100 Gy and \uffe2\uff88\uffbc40 000 Gy. Our results indicate that both [AlO4/h+]0 and [TiO4/M+]0 defects are less thermally stable above 1 kGy\uffe2\uff80\uff932 kGy than below this dose range. The correlation between the two kinetic parameters (activation energy and frequency factor) satisfies the Meyer\uffe2\uff80\uff93Neldel rule. A linear correlation was found between the amplitude of the ESR signals of [AlO4/h+]0 and [TiO4/M+]0 paramagnetic defects corresponding to different doses after the application of thermal treatments in the pulse annealing procedure. We propose a mechanism involving the exchange of the cation, assigned mainly to Li+ here, between the two defects. Under irradiation, the cation is removed from [AlO4/M+]0 (forming [AlO4/h+]0) to [TiO4]\uffe2\uff88\uff92 (forming [TiO4/M+]0), while under heating, the reverse mechanism takes place. The migration energy of the cation from one defect to another was found to be about 51 meV, corresponding to a temperature of about 325 \uffc2\uffb0C.</p>", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "Physics", "QC1-999", "01 natural sciences", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://pubs.aip.org/aip/adv/article-pdf/doi/10.1063/5.0005161/12913546/075114_1_online.pdf"}, {"href": "https://doi.org/10.1063/5.0005161"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/AIP%20Advances", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1063/5.0005161", "name": "item", "description": "10.1063/5.0005161", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1063/5.0005161"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-07-01T00:00:00Z"}}, {"id": "10.1080/03610910802556106", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:20Z", "type": "Journal Article", "created": "2009-01-14", "title": "The Effects Of Imputing The Missing Standard Deviations On The Standard Error Of Meta Analysis Estimates", "description": "A common problem in the meta analysis of continuous data is that some studies do not report sufficient information to calculate the standard deviation (SDs) of the treatment effect. One of the approaches in handling this problem is through imputation. This article examines the empirical implications of imputing the missing SDs on the standard error (SE) of the overall meta analysis estimate. The simulation results show that if the SDs are missing under Missing Completely at Random and Missing at Random mechanism, imputation is recommended. With non random missing, imputation can lead to overestimation of the SE of the estimate.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "330", "0101 mathematics", "Probabilities. Mathematical statistics", "01 natural sciences", "510"], "contacts": [{"organization": "Idris, N.R.N., Robertson, C.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1080/03610910802556106"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Communications%20in%20Statistics%20-%20Simulation%20and%20Computation", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1080/03610910802556106", "name": "item", "description": "10.1080/03610910802556106", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1080/03610910802556106"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2009-02-19T00:00:00Z"}}, {"id": "10.1080/17515831.2015.1125984", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:25Z", "type": "Journal Article", "created": "2016-02-22", "title": "Analysis on stress and micromotion on various peg fixation at glenoid implant", "description": "Six commercially available implant designs were simulated via finite element analysis. The objectives of this study are (1) to determine the effect of peg numbers and orientations to the stress distribution at the implant and cement (2) to compare the micromotion between fully cemented and partially cemented implant. An applied load of 750\u00a0N was subjected to the implant at inferior location in which pegs were distributed. The result showed, by increasing the peg numbers, implant stress decreased and increased maximum stress at cement. While, fully cemented implant had higher micromotion compared to partially cemented implant. There are no significant differences between four-fins and six-fins implants under both load conditions. In conclusion, increase in peg numbers results in decreased stress at implant and partially cemented implant can provide better stability in terms of micromotion than fully cemented as it allows bone in-growth between fins. While, adding more fins in partially cemented implant doe...", "keywords": ["2. Zero hunger", "03 medical and health sciences", "0302 clinical medicine", "QD Chemistry"]}, "links": [{"href": "https://doi.org/10.1080/17515831.2015.1125984"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Tribology%20-%20Materials%2C%20Surfaces%20%26amp%3B%20Interfaces", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1080/17515831.2015.1125984", "name": "item", "description": "10.1080/17515831.2015.1125984", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1080/17515831.2015.1125984"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2016-01-02T00:00:00Z"}}, {"id": "10.1093/jpe/rtac075", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:31Z", "type": "Journal Article", "created": "2022-07-26", "title": "Effects of land use on soil microbial community structure and diversity in the Yellow River floodplain", "description": "Abstract                <p>Soil microorganisms and their diversity are important bioindicators of soil carbon and nutrient cycling. Land use type is a major determining factor that influences soil microbial community composition in floodplain ecosystems. However, how the structure and diversity of soil microbial communities respond to specific changes in land use, as well as the main drivers of these changes, are still unclear. This study was conducted in the Yellow River floodplain to examine the effects of land use type on soil microbial communities. Four land use types (shrubland, farmland, grassland and forest) were selected, wherein shrubland served as the baseline. We measured soil microbial structure and diversity using phospholipid fatty acids (PLFAs). Land use type significantly affected total, bacterial and fungal PLFAs, and the gram-positive/negative bacterial PLFAs. Compared with shrubland, peanut farmland had higher total and bacterial PLFAs and forest had higher fungal PLFAs. Soil pH and phosphorus were the predominate drivers of microbial PLFAs, explaining 37% and 26% of the variability, respectively. Soil total nitrogen and nitrate nitrogen were the main factors increasing microbial community diversity. Peanut farmland had the highest soil carbon content, soil carbon stock, total PLFAs and microbial diversity, suggesting that farmland has great potential as a carbon sink. Our findings indicated that peanut farmland in the Yellow River floodplain is critical for maintaining soil microbial communities and soil carbon sequestration.</p", "keywords": ["2. Zero hunger", "03 medical and health sciences", "0302 clinical medicine", "microbial community diversity", "Yellow River floodplain", "13. Climate action", "fungi", "15. Life on land", "bacteria", "6. Clean water", "soil carbon stock", "land use type"]}, "links": [{"href": "https://doi.org/10.1093/jpe/rtac075"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Plant%20Ecology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1093/jpe/rtac075", "name": "item", "description": "10.1093/jpe/rtac075", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1093/jpe/rtac075"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-07-26T00:00:00Z"}}, {"id": "10.1093/toxsci/kfae051", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:34Z", "type": "Journal Article", "created": "2024-04-18", "title": "Parameter grouping and co-estimation in physiologically based kinetic models using genetic algorithms", "description": "Abstract                <p>Physiologically based kinetic (PBK) models are widely used in pharmacology and toxicology for predicting the internal disposition of substances upon exposure, voluntarily or not. Due to their complexity, a large number of model parameters need to be estimated, either through in silico tools, in vitro experiments, or by fitting the model to in vivo data. In the latter case, fitting complex structural models on in vivo data can result in overparameterization and produce unrealistic parameter estimates. To address these issues, we propose a novel parameter grouping approach, which reduces the parametric space by co-estimating groups of parameters across compartments. Grouping of parameters is performed using genetic algorithms and is fully automated, based on a novel goodness-of-fit metric. To illustrate the practical application of the proposed methodology, two case studies were conducted. The first case study demonstrates the development of a new PBK model, while the second focuses on model refinement. In the first case study, a PBK model was developed to elucidate the biodistribution of titanium dioxide (TiO2) nanoparticles in rats following intravenous injection. A variety of parameter estimation schemes were employed. Comparative analysis based on goodness-of-fit metrics demonstrated that the proposed methodology yields models that outperform standard estimation approaches, while utilizing a reduced number of parameters. In the second case study, an existing PBK model for perfluorooctanoic acid (PFOA) in rats was extended to incorporate additional tissues, providing a more comprehensive portrayal of PFOA biodistribution. Both models were validated through independent in vivo studies to ensure their reliability.</p", "keywords": ["Titanium", "Male", "0301 basic medicine", "Fluorocarbons", "Models", " Biological", "Biotransformation", " Toxicokinetics", " and Pharmacokinetics", "Rats", "Kinetics", "03 medical and health sciences", "0302 clinical medicine", "Animals", "Nanoparticles", "Tissue Distribution", "Computer Simulation", "Caprylates", "Algorithms"]}, "links": [{"href": "https://academic.oup.com/toxsci/article-pdf/200/1/31/58318724/kfae051.pdf"}, {"href": "https://doi.org/10.1093/toxsci/kfae051"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Toxicological%20Sciences", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1093/toxsci/kfae051", "name": "item", "description": "10.1093/toxsci/kfae051", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1093/toxsci/kfae051"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-04-19T00:00:00Z"}}, {"id": "10.1097/00005768-199705001-00580", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:37Z", "type": "Journal Article", "created": "2003-11-19", "title": "SHOULDER PAIN: FOOTBALL 581", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "E. G. McFarland, S. Bliven, A. Medina, J. Martire,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1097/00005768-199705001-00580"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Medicine%20%26amp%3Bamp%20Science%20in%20Sports%20%26amp%3Bamp%20Exercise", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1097/00005768-199705001-00580", "name": "item", "description": "10.1097/00005768-199705001-00580", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1097/00005768-199705001-00580"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1997-05-01T00:00:00Z"}}, {"id": "10.1097/00006454-200009000-00007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:37Z", "type": "Journal Article", "created": "2003-04-24", "title": "Etiology of community-acquired pediatric viral diarrhea: a prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998", "description": "Objective. To determine the viral etiology of community-acquired diarrhea in children admitted to hospitals and presenting in emergency departments, pediatric practices and child care centers from November 1, 1997, to June 30, 1998. Study design. Children with diarrhea were identified in a prospective multisite cohort study and analyzed according to age, gender and duration of hospitalization. Stools were tested for rotavirus by enzyme immunoassay and for all other enteric viruses by electron microscopy. Results. Of the 2524 children identified with diarrhea, stools of 1386 (55%) were tested by enzyme immunoassay for rotavirus, and of these 1365 (54%) were screened by electron microscopy for all identifiable enteric viruses. Rotavirus was found in 32% (n = 437), adenovirus in 4% (n = 55), torovirus in 3% (n = 44), Norwalk-like viruses in 2% (n = 25) and astrovirus (n = 14) and calicivirus (n = 7) in fewer than 1% of the specimens tested. The proportion of rotavirus was significantly higher in children 12 to 23 months of age (43% of tested stools, n = 159) and 24 to 35 months of age (38% of tested stools, n = 64) (P < 0.001) than in any other age group. Toroviruses were found to approximately the same extent in children \u226536 months of age (6% of tested stools, n = 19) as those <36 months of age. Rotavirus (36% of tested stools, n = 375, P < 0.0005) and torovirus (4% of tested stools, n = 43, P < 0.004) were most often found in hospitalized patients. In contrast Norwalk-like viruses (P < 0.001) and astroviruses (P < 0.01) were more commonly detected in specimens from patients who presented to physicians' offices and who were symptomatic for gastroenteritis in child care centers. Conclusion. This study demonstrates that although all known gastroenteritis viruses were diagnosed in symptomatic children, rotavirus was the etiologic agent in most cases of diarrhea managed in the community and in the hospital.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"], "contacts": [{"organization": "VALERIE WATERS, E. LEE FORD-JONES, MARTIN PETRIC, MARGARET FEARON, PAUL COREY, RAHIM MOINEDDEIN,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1097/00006454-200009000-00007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20Pediatric%20Infectious%20Disease%20Journal", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1097/00006454-200009000-00007", "name": "item", "description": "10.1097/00006454-200009000-00007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1097/00006454-200009000-00007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2000-09-01T00:00:00Z"}}, {"id": "10.1097/00006250-200204001-00040", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:37Z", "type": "Journal Article", "created": "2012-03-29", "title": "Outpatient Management of Missed Abortion with Vaginal Misoprostol*", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Michael J. Heard, Gayle M. Stewart, John E. Buster, Sandra A. Carson, Harold J. Miller,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1097/00006250-200204001-00040"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Obstetrics%20%26amp%3B%20Gynecology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1097/00006250-200204001-00040", "name": "item", "description": "10.1097/00006250-200204001-00040", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1097/00006250-200204001-00040"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2002-04-01T00:00:00Z"}}, {"id": "10.1097/00115514-201101000-00002", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:37Z", "type": "Journal Article", "created": "2017-12-07", "title": "Interview with Eugene S. Schneller, PhD, Professor and Dean\u02bcs Council of 100 Distinguished Scholars, W. P. Carey School of Business, Arizona State University", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "0305 other medical science"]}, "links": [{"href": "https://doi.org/10.1097/00115514-201101000-00002"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Healthcare%20Management", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1097/00115514-201101000-00002", "name": "item", "description": "10.1097/00115514-201101000-00002", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1097/00115514-201101000-00002"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2011-01-01T00:00:00Z"}}, {"id": "10.1097/hjh.0b013e32834786f0", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:19:38Z", "type": "Journal Article", "created": "2011-05-10", "title": "Albumin Overload Activates Intrarenal Renin\u2013Angiotensin System Through Protein Kinase C And Nadph Oxidase-Dependent Pathway", "description": "Inappropriate activation of the intrarenal renin-angiotensin system (RAS) plays an important role in the pathogenesis of hypertension and renal injury. However, the underlying mechanisms remain elusive. Proteinuria has been shown to elicit the renal activation of RAS. The present study was performed to test the intracellular signal pathway involved in albumin-triggered activation of RAS.NRK52E cells, a rat renal proximal tubular cell line, were incubated with increased levels of albumin. The rat model of protein overload was established in female Wistar-Kyoto rats that were subjected to unilateral nephrectomy followed by daily intraperitoneal injection of BSA at various doses (0.5, 1.0, and 5.0 g/kg) or combination with intragastric administration of apocynin (100 mg/kg per day), an inhibitor of NADPH oxidase.Exposure of the cells to high levels of albumin activated the RAS through the endocytic receptors megalin and cubilin. High levels of albumin triggered the production of intracellular reactive oxygen species by a protein kinase C (PKC)-NADPH oxidase-dependent pathway and this, in turn, led to activation of nuclear factor-\u03baB (NF-\u03baB) and activation protein-1 (AP-1). Inhibition of PKC or NADPH oxidase abolished albumin-induced activation of RAS. In a protein overload rat model, activation of RAS in renal proximal tubular cells was significantly increased, coincident with activation of PKC, NADPH oxidase, NF-\u03baB, and AP-1. Chronic inhibition of NADPH oxidase by apocynin largely ameliorated intrarenal activation of RAS.Exposure of renal tubular epithelial cells with high levels of albumin triggers activation of RAS via a PKC-NADPH oxidase-dependent pathway.", "keywords": ["Kidney Tubules", " Proximal", "Renin-Angiotensin System", "03 medical and health sciences", "0302 clinical medicine", "Albumins", "Animals", "NADPH Oxidases", "Female", "Rats", " Inbred WKY", "Protein Kinase C", "Cell Line", "Rats", "3. Good health"]}, "links": [{"href": "https://doi.org/10.1097/hjh.0b013e32834786f0"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Hypertension", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1097/hjh.0b013e32834786f0", "name": "item", "description": "10.1097/hjh.0b013e32834786f0", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1097/hjh.0b013e32834786f0"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2011-07-01T00:00:00Z"}}, {"id": "10.11150/kansenshogakuzasshi1970.74.1023", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:27Z", "type": "Journal Article", "created": "2014-12-03", "title": "Virucidal Activity of Disinfectants", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"], "contacts": [{"organization": "Masahiro NODA, Shunji MATSUDA, Masao KOBAYASHI,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.11150/kansenshogakuzasshi1970.74.1023"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20the%20Japanese%20Association%20for%20Infectious%20Diseases", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.11150/kansenshogakuzasshi1970.74.1023", "name": "item", "description": "10.11150/kansenshogakuzasshi1970.74.1023", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.11150/kansenshogakuzasshi1970.74.1023"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2000-01-01T00:00:00Z"}}, {"id": "10.1117/12.2624516", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:28Z", "type": "Journal Article", "created": "2022-05-19", "title": "Plastic scintillator-based fibre dosimeters for measurement of X-ray pulses in a clinical setting", "description": "This work presents the development of plastic scintillator (BCF-10) based optical fibre sensors for medical radiotherapy dosimetry. Two different designs of BCF10 joined to PMMA (Polymethyl methacrylate) fibre were considered, based on simple Plug and Play designs for the rapid and effective assembly of radiation sensors. The first design was a simple butt-coupling arrangement sheathed in tubing, with an outer diameter of <2 mm. The second design explored the coupling joint of a cylindrical protrusion and hollow part of BCF10-PMMA that were achieved using femtosecond laser machining; the purpose of which was to maintain the original 1-mm fibre diameter for the sensor probe. The two fibres were pressed together and sealed with UV curing, hence the reference to a Plug and Play architecture. Both sensors exhibit higher output counts at the higher dose rate (due to the higher number of radiation pulses), although a discernible signal is observed at 50 MU/min for 6 MV, 15 MV energies and both sensors. When comparing both sensors with the different joint coupling designs, the flat surface connection of BCF-10 to PMMA demonstrates slightly higher photon counts compared with the micro-machined sensor (Plug n Play). However, the difference is small and the Plug n Play sensor benefits from the smaller sensor diameter (1 mm diameter), which is suitable for inserting into a small applicator or in-vivo monitoring. In the second section, micro-pulses of X-Ray radiation from Siemens Linear Accelerator (linac) were obtained and compared for two different energies and dose rates. Both of the sensors demonstrate the feasibility to be used for characterisation of X-ray pulses from a clinical linac.", "keywords": ["Plastic scintillator", "03 medical and health sciences", "0302 clinical medicine", "fibre dosimeters", "Engineering and Technology", "Electrical Engineering - Electronic Engineering - Information Engineering", "X-ray pulses"]}, "links": [{"href": "https://doi.org/10.1117/12.2624516"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Micro-Structured%20and%20Specialty%20Optical%20Fibres%20VII", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1117/12.2624516", "name": "item", "description": "10.1117/12.2624516", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1117/12.2624516"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-05-19T00:00:00Z"}}, {"id": "10.1185/135525707x183012", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:41Z", "type": "Journal Article", "created": "2007-05-23", "title": "Survey of off-label prescribing in learning disability", "keywords": ["03 medical and health sciences", "0302 clinical medicine"], "contacts": [{"organization": "Indermeet Sawhney, John Morgan, Prakash Chandra,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1185/135525707x183012"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Primary%20Care%20and%20Community%20Psychiatry", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1185/135525707x183012", "name": "item", "description": "10.1185/135525707x183012", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1185/135525707x183012"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2006-12-31T00:00:00Z"}}, {"id": "10.1183/13993003.congress-2020.2899", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:41Z", "type": "Journal Article", "created": "2020-11-05", "title": "Degeneration of nerve fibers in chronic obstructive lung disease and usual interstitial pneumonia", "description": "Hyperreactivity is known in bronchial asthma and chronic obstructive pulmonary disease (COPD), however, the mechanisms are not fully understood. In chronic bronchitis micronodular proliferations of Schwann cells were found, pointing to a degenerative process, but the affected nerves are unknown. Degeneration of nerves probably occur in usual interstitial pneumonia (UIP) too.  Nerves are either adrenergic or cholinergic, and those with non-adrenergic, non-cholinergic (NANC) receptors. Mediators can be excitatory, or inhibitory. Sensory nerves are stretch-sensitive, and touch-sensitive nociceptors and C-fibers.  We analyzed nerves in tissues from COPD and UIP cases. Cases of asthma served as controls. Antibodies for different nerve types and receptors were used: nicotinic acetylcholine receptor a (NARa), NMDAR1, tyrosine hydrolase (TH), dopamine transporter, a1adrenergic receptor (aAR), CGRP, iNOS, GABA transporter1 (GABA1), substance P (SP). The presence of nerve fibers was demonstrated by immunohistochemistry for S100 protein and neurofilament.  Vacuolar degeneration of nerves with micronodular proliferation of Schwann cells was seen in asthma and COPD but not in UIP. Nerve fibers in COPD and asthma stained for NARa, NMDAR1, TH, and GABA1. In degenerated nerves NARa, aAR, and GABA1 were positive in asthma, whereas aAR was negative in COPD. Positivity for SP was seen in COPD, but not in asthma. In UIP no degeneration of nerves was seen in the central bronchial system, but a loss in the periphery. There are differences and similarities between COPD and asthma, well known in the clinics, however different nerves are affected by degeneration in these diseases.", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "3. Good health"]}, "links": [{"href": "https://doi.org/10.1183/13993003.congress-2020.2899"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Airway%20pharmacology%20and%20treatment", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1183/13993003.congress-2020.2899", "name": "item", "description": "10.1183/13993003.congress-2020.2899", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1183/13993003.congress-2020.2899"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-09-07T00:00:00Z"}}, {"id": "10.1186/1477-7525-12-60", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:41Z", "type": "Journal Article", "created": "2014-04-27", "title": "Health-Related Quality Of Life And Related Factors Of Military Police Officers", "description": "The present study aimed to determine the effect of demographic characteristics, occupation, anthropometric indices, and leisure-time physical activity levels on coronary risk and health-related quality of life among military police officers from the State of Santa Catarina, Brazil.The sample included 165 military police officers who fulfilled the study\u2019s inclusion criteria. The International Physical Activity Questionnaire and the Short Form Health Survey were used, in addition to a spreadsheet of socio-demographic, occupational and anthropometric data. Statistical analyses were performed using descriptive analysis followed by Spearman Correlation and multiple linear regression analysis using the backward method.The waist-to-height ratio was identified as a risk factor low health-related quality of life. In addition, the conicity index, fat percentage, years of service in the military police, minutes of work per day and leisure-time physical activity levels were identified as risk factors for coronary disease among police officers.These findings suggest that the Military Police Department should adopt an institutional policy that allows police officers to practice regular physical activity in order to maintain and improve their physical fitness, health, job performance, and quality of life.", "keywords": ["Adult", "Male", "Health Status", "Coronary Disease", "Motor Activity", "Young Adult", "03 medical and health sciences", "Leisure Activities", "0302 clinical medicine", "Risk Factors", "Surveys and Questionnaires", "Humans", "10. No inequality", "Research", "Public Health", " Environmental and Occupational Health", "Middle Aged", "Body Height", "Police", "3. Good health", "Skinfold Thickness", "Military Personnel", "8. Economic growth", "Quality of Life", "Female", "Waist Circumference", "0305 other medical science", "Brazil"]}, "links": [{"href": "https://doi.org/10.1186/1477-7525-12-60"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Health%20and%20Quality%20of%20Life%20Outcomes", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1186/1477-7525-12-60", "name": "item", "description": "10.1186/1477-7525-12-60", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1186/1477-7525-12-60"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-01-01T00:00:00Z"}}, {"id": "10.1186/s12934-021-01520-7", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:42Z", "type": "Journal Article", "created": "2021-01-11", "title": "Multi-pathogen Infections and Alzheimer&rsquo;s Disease", "description": "<p>Alzheimer&amp;rsquo;s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-&amp;beta; peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechanism of AD pathogenesis, the underlying cause of AD remains poorly understood. No disease-modifying therapies currently exist, and numerous clinical trials have failed to demonstrate any benefits. The recent discovery that the amyloid-&amp;beta; peptide has antimicrobial activities supports the possibility of an infectious aetiology of AD and suggests that amyloid-&amp;beta; plaque formation might be induced by infection. AD patients have a weakened blood-brain barrier and immune system and are thus at elevated risk of microbial infections. Such infections can cause chronic neuroinflammation, production of the antimicrobial amyloid-&amp;beta; peptide, and neurodegeneration. Various pathogens, including viruses, bacteria, fungi, and parasites have been associated with AD. Most research in this area has focused on individual pathogens, with herpesviruses and periodontal bacteria being most frequently implicated. The purpose of this review is to highlight the potential role of multi-pathogen infections in AD. Recognition of the potential coexistence of multiple pathogens and biofilms in AD's aetiology may stimulate the development of novel approaches to its diagnosis and treatment. Multiple diagnostic tests could be applied simultaneously to detect major pathogens, followed by anti-microbial treatment using antiviral, antibacterial, antifungal, and anti-biofilm agents.</p>", "keywords": ["0301 basic medicine", "Bacteria", "Review", "Antifungal", "Microbiology", "Antiviral Agents", "QR1-502", "3. Good health", "Antibacterial", "Anti-biofilm", "03 medical and health sciences", "0302 clinical medicine", "Anti-Infective Agents", "Alzheimer Disease", "Biofilms", "Animals", "Humans", "Antiviral", "Alzheimer\u2019s disease"]}, "links": [{"href": "http://link.springer.com/content/pdf/10.1186/s12934-021-01520-7.pdf"}, {"href": "https://doi.org/10.1186/s12934-021-01520-7"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Microbial%20Cell%20Factories", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1186/s12934-021-01520-7", "name": "item", "description": "10.1186/s12934-021-01520-7", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1186/s12934-021-01520-7"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-01-11T00:00:00Z"}}, {"id": "10.3389/fmicb.2021.652173", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:22:19Z", "type": "Journal Article", "created": "2021-06-11", "title": "Assessing METland\u00ae Design and Performance Through LCA: Techno-Environmental Study With Multifunctional Unit Perspective", "description": "<p>Conventional wastewater treatment technologies are costly and energy demanding; such issues are especially remarkable when small communities have to clean up their pollutants. In response to these requirements, a new variety of nature-based solution, so-called METland\uffc2\uffae, has been recently develop by using concepts from Microbial Electrochemical Technologies (MET) to outperform classical constructed wetland regarding wastewater treatment. Thus, the current study evaluates two operation modes (aerobic and aerobic\uffe2\uff80\uff93anoxic) of a full-scale METland\uffc2\uffae, including a Life Cycle Assessment (LCA) conducted under a Net Environmental Balance perspective. Moreover, a combined technical and environmental analysis using a Net Eutrophication Balance (NEuB) focus concluded that the downflow (aerobic) mode achieved the highest removal rates for both organic pollutant and nitrogen, and it was revealed as the most environmentally friendly design. Actually, aerobic configuration outperformed anaero/aero-mixed mode in a fold-range from 9 to 30%. LCA was indeed recalculated under diverse Functional Units (FU) to determine the influence of each FU in the impacts. Furthermore, in comparison with constructed wetland, METland\uffc2\uffae showed a remarkable increase in wastewater treatment capacity per surface area (0.6 m2/pe) without using external energy. Specifically, these results suggest that aerobic\uffe2\uff80\uff93anoxic configuration could be more environmentally friendly under specific situations where high N removal is required. The removal rates achieved demonstrated a robust adaptation to influent variations, revealing a removal average of 92% of Biology Oxygen Demand (BOD), 90% of Total Suspended Solids (TSS), 40% of total nitrogen (TN), and 30% of total phosphorus (TP). Moreover, regarding the global warming category, the overall impact was 75% lower compared to other conventional treatments like activated sludge. In conclusion, the LCA revealed that METland\uffc2\uffae appears as ideal solution for rural areas, considering the low energy requirements and high efficiency to remove organic pollutants, nitrogen, and phosphates from urban wastewater.</p>", "keywords": ["Funtional Unit", "treatment wetlands", "Net Environmental Balance", "QS Ecology", "15. Life on land", "Microbiology", "01 natural sciences", "QR1-502", "6. Clean water", "12. Responsible consumption", "wastewater treatment", "03 medical and health sciences", "0302 clinical medicine", "life cycle assessment", "13. Climate action", "11. Sustainability", "TD Environmental technology. Sanitary engineering", "METland", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://doi.org/10.3389/fmicb.2021.652173"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Frontiers%20in%20Microbiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3389/fmicb.2021.652173", "name": "item", "description": "10.3389/fmicb.2021.652173", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3389/fmicb.2021.652173"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-06-11T00:00:00Z"}}, {"id": "10.1371/journal.pone.0184198", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:20:54Z", "type": "Journal Article", "created": "2017-09-01", "title": "Portfolio optimization for seed selection in diverse weather scenarios", "description": "The aim of this work was to develop a method for selection of optimal soybean varieties for the American Midwest using data analytics. We extracted the knowledge about 174 varieties from the dataset, which contained information about weather, soil, yield and regional statistical parameters. Next, we predicted the yield of each variety in each of 6,490 observed subregions of the Midwest. Furthermore, yield was predicted for all the possible weather scenarios approximated by 15 historical weather instances contained in the dataset. Using predicted yields and covariance between varieties through different weather scenarios, we performed portfolio optimisation. In this way, for each subregion, we obtained a selection of varieties, that proved superior to others in terms of the amount and stability of yield. According to the rules of Syngenta Crop Challenge, for which this research was conducted, we aggregated the results across all subregions and selected up to five soybean varieties that should be distributed across the network of seed retailers. The work presented in this paper was the winning solution for Syngenta Crop Challenge 2017.", "keywords": ["Crops", " Agricultural", "2. Zero hunger", "Models", " Statistical", "Glycine max", "Science", "Climate Change", "Q", "R", "Uncertainty", "Agriculture", "04 agricultural and veterinary sciences", "15. Life on land", "Portfolio optimisation", "Yield prediction", "Midwestern United States", "03 medical and health sciences", "0302 clinical medicine", "Seeds", "Medicine", "Regression Analysis", "0401 agriculture", " forestry", " and fisheries", "data analytics", "Weather", "Research Article"]}, "links": [{"href": "https://doi.org/10.1371/journal.pone.0184198"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PLOS%20ONE", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1371/journal.pone.0184198", "name": "item", "description": "10.1371/journal.pone.0184198", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1371/journal.pone.0184198"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-09-01T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=0302+clinical+medicine&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=0302+clinical+medicine&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=0302+clinical+medicine&", "hreflang": "en-US"}, {"rel": "next", "type": "application/geo+json", "title": "items (next)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=0302+clinical+medicine&offset=50", "hreflang": "en-US"}], "numberMatched": 240, "numberReturned": 50, "distributedFeatures": [], "timeStamp": "2026-04-04T08:59:24.572041Z"}