{"type": "FeatureCollection", "features": [{"id": "10.1186/s12916-021-01913-w", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:00:08Z", "type": "Journal Article", "created": "2021-02-11", "title": "High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome", "description": "Abstract Background

Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.

Methods

Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts.

Results

Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q\uffe2\uff80\uff89<\uffe2\uff80\uff890.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet.

Conclusion

A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella.

Trial registration

The ClinicalTrials.gov registration identifier is NCT03479866.

", "keywords": ["Adult", "Male", "0301 basic medicine", "610", "Leukocyte Count", "03 medical and health sciences", "RNA", " Ribosomal", " 16S", "Leukocytes", "Humans", "Lymphocyte Count", "White blood cell", " Gut microbiome", " Diet", " Vegetable intake", " Chronic inflammation", "White blood cell", "Clostridium", "2. Zero hunger", "Gut microbiome", "Clostridiales", "0303 health sciences", "Mediation Analysis", "Interleukin-6", "R", "COVID-19", "Chronic inflammation; Diet; Gut microbiome; Vegetable intake; White blood cell", "Chronic inflammation", "General Medicine", "Fasting", "Middle Aged", "Diet", "Gastrointestinal Microbiome", "3. Good health", "Actinobacteria", "Vegetable intake", "Fruit", "Medicine", "Female", "Biomarkers", "Research Article"]}, "links": [{"href": "https://air.unimi.it/bitstream/2434/1101012/2/s12916-021-01913-w.pdf"}, {"href": "https://iris.unitn.it/bitstream/11572/329112/1/s12916-021-01913-w.pdf"}, {"href": "http://link.springer.com/content/pdf/10.1186/s12916-021-01913-w.pdf"}, {"href": "https://doi.org/10.1186/s12916-021-01913-w"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1186/s12916-021-01913-w", "name": "item", "description": "10.1186/s12916-021-01913-w", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1186/s12916-021-01913-w"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-02-11T00:00:00Z"}}, {"id": "10.1007/s13127-020-00465-w", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T06:56:09Z", "type": "Journal Article", "created": "2020-11-03", "title": "Integrative taxonomy confirms two new West-Palaearctic species allied with Chrysotoxum vernale Loew, 1841 (Diptera: Syrphidae)", "description": "\u00a9 2020, Gesellschaft f\u00fcr Biologische Systematik. The taxonomy of the syrphid genus Chrysotoxum Meigen, 1803 (Diptera: Syrphidae), is complex and currently under scrutiny. Two new species allied with Chrysotoxum vernale, one from the Western Mediterranean, Chrysotoxum hispanicum sp. n. and the other from the Eastern Mediterranean, Chysotoxum anatolicum sp. n., are described and illustrated. Chrysotoxum hispanicum sp. n. is distinguished from the similar C. vernale Loew by the size of the yellow abdominal fasciae and shape of surstyli. Chrysotoxum anatolicum sp. n., known only from females, possesses an almost entirely yellow-pigmented wing, unusual amongst the other studied species of the C. vernale group. Additionally, C. hispanicum sp. n. and C. anatolicum sp. n. are separated from each other, as well as from other species of the C. vernale group by COI and ITS2 gene markers. An identification key to the West Palaearctic species of the C. vernale group is provided.", "keywords": ["COI", "0106 biological sciences", "adult morphology", " COI", " ITS2", " Chrysotoxum hispanicum sp.n.", " Chrysotoxum anatolicum sp.n.", " Identification key", "ITS2", "Adultmorphology", "Zoolog\u00eda", "Chrysotoxum anatolicum sp. n.", "01 natural sciences", "Chrysotoxum hispanicum sp. n.", "Identification key"], "contacts": [{"organization": "Zorica Nedeljkovi\u0107, Zorica Nedeljkovi\u0107, M\u00aa \u00c1ngeles Marcos-Garc\u00eda, Ante Vuji\u0107, R\u00fcstem Hayat, Antonio Ricarte, Ljiljana \u0160a\u0161i\u0107 Zori\u0107, Mihajla Djan,", "roles": ["creator"]}]}, "links": [{"href": "http://link.springer.com/content/pdf/10.1007/s13127-020-00465-w.pdf"}, {"href": "https://doi.org/10.1007/s13127-020-00465-w"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Organisms%20Diversity%20%26amp%3B%20Evolution", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s13127-020-00465-w", "name": "item", "description": "10.1007/s13127-020-00465-w", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s13127-020-00465-w"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-11-03T00:00:00Z"}}, {"id": "10.1016/j.cub.2020.09.063", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T06:56:45Z", "type": "Journal Article", "created": "2020-10-15", "title": "Newly explored\u00a0Faecalibacterium\u00a0diversity is connected to age, lifestyle, geography, and disease.", "description": "Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.", "keywords": ["Adult", "0301 basic medicine", "pangenome", "Adolescent", "gut microbiome", "Datasets as Topic", "General Biochemistry", " Genetics and Molecular Biology", "Innovation action", "Feces", "03 medical and health sciences", "Animals", "Humans", "biotherapeutics", "European Commission", "Child", "Life Style", "Faecalibacterium", "Aged", "Aurora Universities Network", "Horizon 2020", "0303 health sciences", "EC", "Geography", "Faecalibacterium prausnitzii", "H2020", "Age Factors", "Infant", "Middle Aged", "Gastrointestinal Microbiome", "Faecalibacterium prausnitzii", " gut microbiome", " strain diversity", " pangenome", " novel probiotics", " biotherapeutics", "Child", " Preschool", "novel probiotics", "Dysbiosis", "Macaca", "Metagenome", "strain diversity", "Metagenomics", "General Agricultural and Biological Sciences"]}, "links": [{"href": "https://www.iris.unina.it/bitstream/11588/819607/1/PIIS0960982220314330.pdf"}, {"href": "https://doi.org/10.1016/j.cub.2020.09.063"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Current%20Biology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.cub.2020.09.063", "name": "item", "description": "10.1016/j.cub.2020.09.063", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.cub.2020.09.063"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-12-01T00:00:00Z"}}, {"id": "10.1016/j.foodres.2024.114342", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T06:57:01Z", "type": "Journal Article", "created": "2024-04-23", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.The World Health Organization recommends the use of the microscopy-based Kato-Katz thick smear for diagnosing soil-transmitted helminth (STH) infections. Despite its simplicity and cost-effectiveness, the Kato-Katz method faces challenges, including reader subjectivity and reduced sensitivity. Real-time polymerase chain reaction (qPCR) technology offers standardized readouts and higher sensitivity, making it suitable for STH diagnosis and monitoring the treatment efficacy of emodepside within the framework of randomized controlled trials.

Methodology/Principal findings

We evaluated the performance of Kato-Katz versus qPCR for assessing treatment efficacy in terms of cure rates, of single doses of 5, 10, 15, 20, 25 and 30\uffe2\uff80\uff89mg of emodepside compared to 400\uffe2\uff80\uff89mg albendazole. Spearman\uffe2\uff80\uff99s rank correlation coefficient examined the correlation between STH eggs per gram in stool samples and qPCR Ct values. Diagnostic sensitivity of qPCR was calculated using a Bayesian latent class modelling approach with data from Ascaris lumbricoides infections. Agreement between Kato-Katz and qPCR at baseline was 93.57% for Trichuris trichiura, and 73.49% for both hookworm and A. lumbricoides. For the latter helminth qPCR demonstrated higher sensitivity (85.00% vs. 47.70%) and slightly lower specificity (93.40% vs. 99.40%) compared to Kato-Katz. We observed a fair to moderate agreement with negative correlation between Ct values and Kato-Katz egg counts. Treatment efficacy, as assessed by qPCR, was lower for all doses of emodepside and albendazole compared to Kato-Katz. Nonetheless, emodepside demonstrated higher cure rates against T. trichiura and A. lumbricoides infections compared to albendazole.

Conclusion/ Significance

Our study confirmed that qPCR is a sensitive diagnostic method for diagnosing STH infections compared to Kato-Katz and serves as a valuable tool for determining treatment efficacy in clinical trials. Furthermore, qPCR confirmed the better treatment efficacy of emodepside compared to albendazole, despite indicating lower cure rates than Kato-Katz.

The Food and Drug Administration (FDA) can regulate the introduction of new tobacco products and some changes to existing products. Cigarette packs have been used as a marketing tool to target specific groups and priority populations. Research has shown that sexual and gender minority (SGM) adults are substantially more likely to use tobacco products than their straight and cisgender counterparts. However, research to inform the FDA\u2019s regulatory decisions regarding cigarette packs targeting priority populations is nascent. To fill this gap, we conducted an online experiment in 2018, randomizing U.S. adults who reported current smoking ( N = 954, 52% were SGM) to view one of three cigarette packs. A graphic designer developed \u201cGlacier\u201d branded packs with three levels of SGM imagery: (1) no targeting, (2) subtle targeting, and (3) a rainbow \u201cpride edition.\u201d Participants viewed and rated the pack using cognitive, affective, and behavioral measures informed by theory. We used a linear model framework to compare the two SGM-targeted packs with the not targeted version and tested interactions between pack and SGM identity for the dependent variables. We stratified results by SGM status. SGM status was a significant moderator of the relationship between the pack and ratings of appeal, positive affect, feeling shocked, and intent to try with a coupon. Findings from this study revealed that packs designed for SGM populations can disproportionately change cognitive, affective, and behavioral intention responses for SGM smokers. Products entering the market should be assessed by FDA for the appeal of their packs to vulnerable populations.

", "keywords": ["Adult", "Male", "Marketing", "Adolescent", "Vaping", "Tobacco Products", "Electronic Nicotine Delivery Systems", "Risk Assessment", "Transgender Persons", "United States", "3. Good health", "Sexual and Gender Minorities", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Socioeconomic Factors", "Surveys and Questionnaires", "Humans", "Female", "10. No inequality", "Designed for LGBT", "Cigarette Packs", "Potential Impact", "Minority Groups"]}, "links": [{"href": "https://doi.org/10342/9526"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Health%20Promotion%20Practice", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10342/9526", "name": "item", "description": "10342/9526", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10342/9526"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "11577/3480910", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:05:33Z", "type": "Journal Article", "created": "2014-09-20", "title": "The representativeness of a European multi-center network for influenza-like-illness participatory surveillance", "description": "The Internet is becoming more commonly used as a tool for disease surveillance. Similarly to other surveillance systems and to studies using online data collection, Internet-based surveillance will have biases in participation, affecting the generalizability of the results. Here we quantify the participation biases of Influenzanet, an ongoing European-wide network of Internet-based participatory surveillance systems for influenza-like-illness.In 2011/2012 Influenzanet launched a standardized common framework for data collection applied to seven European countries. Influenzanet participants were compared to the general population of the participating countries to assess the representativeness of the sample in terms of a set of demographic, geographic, socio-economic and health indicators.More than 30,000 European residents registered to the system in the 2011/2012 season, and a subset of 25,481 participants were selected for this study. All age classes (10\u00a0years brackets) were represented in the cohort, including under 10 and over 70\u00a0years old. The Influenzanet population was not representative of the general population in terms of age distribution, underrepresenting the youngest and oldest age classes. The gender imbalance differed between countries. A counterbalance between gender-specific information-seeking behavior (more prominent in women) and Internet usage (with higher rates in male populations) may be at the origin of this difference. Once adjusted by demographic indicators, a similar propensity to commute was observed for each country, and the same top three transportation modes were used for six countries out of seven. Smokers were underrepresented in the majority of countries, as were individuals with diabetes; the representativeness of asthma prevalence and vaccination coverage for 65+ individuals in two successive seasons (2010/2011 and 2011/2012) varied between countries.Existing demographic and national datasets allowed the quantification of the participation biases of a large cohort for influenza-like-illness surveillance in the general population. Significant differences were found between Influenzanet participants and the general population. The quantified biases need to be taken into account in the analysis of Influenzanet epidemiological studies and provide indications on populations groups that should be targeted in recruitment efforts.", "keywords": ["Influenza; Internet data collection; Participation bias; Representativeness; Selection bias; Surveillance", "Adult", "Male", "0301 basic medicine", "Adolescent", "Health Status", "Young Adult", "03 medical and health sciences", "Age Distribution", "0302 clinical medicine", "Influenza", " Human", "11. Sustainability", "Prevalence", "Humans", "Child", "Representativeness", "Aged", "Selection bias", "Internet", "Surveillance", "Internet data collection", "Public Health", " Environmental and Occupational Health", "Infant", " Newborn", "Participation bias", "Infant", "Middle Aged", "16. Peace & justice", "Influenza", "3. Good health", "Europe", "Socioeconomic Factors", "[SDV.SPEE] Life Sciences [q-bio]/Sant\u00e9 publique et \u00e9pid\u00e9miologie", "13. Climate action", "Child", " Preschool", "Population Surveillance", "Female", "Research Article"]}, "links": [{"href": "https://researchonline.lshtm.ac.uk/id/eprint/2017934/1/12889_2014_7121_MOESM2_ESM.pdf"}, {"href": "https://air.unimi.it/bitstream/2434/240039/2/cantarelli-colizza.pdf"}, {"href": "https://www.research.unipd.it/bitstream/11577/3480910/1/Cantarelli_BMC-PubHealth_2014.pdf"}, {"href": "https://doi.org/11577/3480910"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Public%20Health", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11577/3480910", "name": "item", "description": "11577/3480910", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11577/3480910"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-09-20T00:00:00Z"}}, {"id": "19462205", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:05:46Z", "type": "Journal Article", "created": "2009-05-21", "title": "Modifiable surgical and anesthesiologic risk factors for the development of cardiac and pulmonary complications after laparoscopic colorectal surgery", "description": "In contrast to patient-related risk factors, which are difficult to influence, factors relating to surgery and anesthesia that can be influenced have hardly been investigated. This study aimed to identify such risk factors.Pre- and intraoperative surgical and anesthesiologic factors of 388 colonic and 112 rectal procedures performed by a single surgeon within 50 months were recorded and analyzed for correlations with postoperative complications requiring treatment.Higher American Society of Anesthesiology (ASA) emergency interventions and intraoperative factors (bleeding, long operating time) had an elevated risk for general complications. Furthermore, patients benefited from the clinical experience of the anesthesiologist, especially in terms of emergency procedures, hemorrhagic complications, and a longer operating time.Standardization of the surgical technique, 'bloodless' surgery, standardization of intraoperative monitoring, and the use of board-certified anesthesiologists for high-risk cases, emergency procedures, and patients with high ASA stages are able to reduce postoperative morbidity.", "keywords": ["Adult", "Aged", " 80 and over", "Lung Diseases", "Male", "Intraoperative Care", "Adolescent", "Heart Diseases", "Middle Aged", "3. Good health", "Colonic Diseases", "03 medical and health sciences", "Postoperative Complications", "0302 clinical medicine", "Anesthesiology", "Preoperative Care", "Humans", "Female", "Laparoscopy", "Clinical Competence", "Prospective Studies", "Emergencies", "Anesthesia", " Inhalation", "Aged"], "contacts": [{"organization": "Th C, B\u00f6ttger, S, Hermeneit, M, M\u00fcller, A, Terzic, A, Rodehorst, L, Elad, M, Schamberger,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/19462205"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Surgical%20Endoscopy", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "19462205", "name": "item", "description": "19462205", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/19462205"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2009-05-22T00:00:00Z"}}, {"id": "20440493", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:06:02Z", "type": "Journal Article", "created": "2010-05-03", "title": "Mechanotransduction: The Missing Link in the Facial Aging Puzzle?", "description": "Craniofacial bony remodeling has been recognized as an important contributor to the facial aging process. Multiple studies have demonstrated significant craniofacial skeletal changes with age. However, no review has assembled this information in a concise, cogent fashion. Furthermore, the etiology of these skeletal changes has not been elucidated. This information is important for understanding the mechanisms of facial aging and for further development of facial rejuvenation.A literature review of all articles discussing remodeling of the craniofacial skeleton with age was performed. Studies that used objective measurements of craniofacial skeletal parameters for different age groups were collected and analyzed.The studies demonstrated consistent morphologic changes in the craniofacial skeleton with age. These changes included trends toward increased facial bony width in women; contour changes of the orbit, anterior maxilla, and mandibular body; and decreased dimensions of the glabellar, pyriform, and maxillary angles.The craniofacial skeleton remodels with aging. Many of the observed changes in soft tissue contour and position reflect these skeletal changes. Changes in facial muscle function through the process of mechanotransduction may be responsible for these skeletal changes.", "keywords": ["Adult", "Aged", " 80 and over", "Male", "Aging", "Adolescent", "Skull", "Middle Aged", "Biophysical Phenomena", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Face", "Humans", "Female", "Aged"], "contacts": [{"organization": "Safa E, Sharabi, Daniel A, Hatef, John C, Koshy, Larry H, Hollier, Michael J, Yaremchuk,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/20440493"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Aesthetic%20Plastic%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "20440493", "name": "item", "description": "20440493", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/20440493"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2010-05-04T00:00:00Z"}}, {"id": "23892191", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:06:13Z", "type": "Journal Article", "created": "2013-07-24", "title": "The Efficacy of the T-Shunt Procedure and Intracavernous Tunneling (Snake Maneuver) for Refractory Ischemic Priapism", "description": "The current management of ischemic priapism that is refractory to conventional medical therapy is a form of shunt procedure that diverts blood away from the corpus cavernosum. We assessed the outcome of the T-shunt and intracavernous tunneling for the management of ischemic priapism.During a 36-month period 45 patients presented with prolonged ischemic priapism. Patients were divided into subgroups according to the duration of priapism. All patients had an unsuccessful primary treatment, and underwent a T-shunt and intracavernous tunneling with cavernous muscle biopsies. All patients completed an IIEF-5 (International Index of Erectile Function-5) questionnaire preoperatively and 6 months postoperatively.Resolution of the priapism using a T-shunt and snake maneuver occurred in all patients with a priapism duration of less than 24 hours and in only 30% of those with priapism lasting more than 48 hours. After a 6-month median followup the IIEF-5 score was significantly reduced from a mean of 24 (range 23 to 25) preoperatively to 7.7 (range 5 to 24), which was related to the duration of the priapism (p <0.0005). All patients with priapism for more than 48 hours had necrotic cavernous smooth muscle on biopsy and had severe erectile dysfunction requiring the insertion of a penile prosthesis. Those patients with moderate and mild erectile dysfunction were treated with phosphodiesterase type 5 inhibitors.The success of the T-shunt with snake tunneling is dependent on the duration of priapism. When it is less than 24 hours the results are favorable, although erectile dysfunction is still present in 50% of patients. In those with a priapism duration greater than 48 hours the technique usually fails to resolve the priapism and all patients end up with erectile dysfunction due to smooth muscle necrosis.", "keywords": ["Adult", "Male", "03 medical and health sciences", "Time Factors", "Treatment Outcome", "0302 clinical medicine", "Ischemia", "Humans", "Middle Aged", "Priapism", "Aged", "Penis", "3. Good health"], "contacts": [{"organization": "Zacharakis, E., Raheem, A.A., Freeman, A., Skolarikos, A., Garaffa, G., Christopher, A.N., Muneer, A., Ralph, D.J.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/23892191"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Urology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "23892191", "name": "item", "description": "23892191", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/23892191"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-01-01T00:00:00Z"}}, {"id": "25031029", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:06:15Z", "type": "Journal Article", "created": "2014-07-17", "title": "Maternal Reported Indicators and Causes of Insufficient Milk Supply", "description": "Background:

Although the breastfeeding initiation rate is high in China, exclusivity is low. Not having enough breast milk has been frequently reported as a reason for supplementing and weaning.

Objective:

The objective was to explore maternal perception of indicators and causes of self-reported insufficient milk supply (IMS) among a sample of southwestern Chinese mothers.

Methods:

This was a cross-sectional study, conducted in a hospital in Chengdu, China.

Results:

The majority of mothers were of Han ethnicity and primiparous. Most initiated breastfeeding (n = 325, 95.3%). Among mothers who had weaned by the time of questionnaire completion, more than half (n = 52) reported IMS as a reason, and 53.8% of these mothers reported this occurring during the first 2 days postpartum. Mothers often identified IMS by using less sensitive indicators of adequate intake such as receiving a hungry look from the infant after nursing (34.6%) and not feeling the presence of milk (28.8%). More sensitive indicators of adequate intake, such as the number of wet/soiled diapers, were not reported. More than a third of mothers (39.2%) could not express a reason for the occurrence of IMS. Among those who identified reasons, nearly one-fourth of mothers attributed IMS, at least partially, to dietary factors such as poor appetite (23.5%).

Conclusion:

Self-reported IMS appears to be a common barrier to breastfeeding continuation among this sample of Chinese mothers. Culturally appropriate intervention, designed to inform mothers how to correctly identify and address IMS, might be an effective strategy to support optimal infant-feeding behaviors in China. To evaluate whether the administration of desmopressin alters the risk for renal biopsy complications.

Methods

A multicenter registry containing 576 native kidney biopsies (NKb) with a serum creatinine above 150\uffc2\uffa0\uffce\uffbcmol/L in 527 patients (372 men and 155 women, median age 61\uffc2\uffa0years) was used. Most of the data were prospective. At one of the hospitals all biopsies with creatinine above 150\uffc2\uffa0\uffce\uffbcmol/L received desmopressin before biopsies (NKb 204). These were compared to outcome of biopsy complications against other centres where desmopressin was not given (NKb 372). Fisher's exact test, \uffcf\uff872 analyses, univariate and multiple binary logistic regression were used. Data were given as odds ratio (OR) and confidence interval (CI). A two sided P\uffe2\uff80\uff90value of <0.05 was considered significant.

Results

In NKb with creatinine >150\uffc2\uffa0\uffce\uffbcmol/L, those with desmopressin had less overall (3.4% vs 8.4%, OR 0.39, CI 0.17\uffe2\uff80\uff930.90) whereas major or minor complications were not different. While desmopressin did not exhibit difference in complications in men, women received less major (0% vs 8.6%, P\uffc2\uffa0=\uffc2\uffa00.03) and overall complications (0% vs 12.1%, P\uffc2\uffa0=\uffc2\uffa00.006). A multiple logistic regression revealed that, after adjusting for BMI, age and sex, prophylaxis with desmopressin showed less major (OR 0.38, CI 0.15\uffe2\uff80\uff930.96) and overall complications (OR 0.36, CI 0.15\uffe2\uff80\uff930.85).

Conclusion

Desmopressin given before a native kidney biopsy in patients with impaired renal function can reduce the risk for complications.The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder.

Methods

A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measured with a VAS from 0 to 100 (VAS based), and somnolence frequency was recorded according to incident report (incidence based) at each visit. The rates of VAS-based and incidence-based somnolence and changes in somnolence severity from baseline to the end of study were compared between the lithium and quetiapine groups. Longitudinal changes in somnolence severity were analyzed with linear regression analysis.

Results

Of 42 patients randomized, only 3 scored 0 on the VAS at baseline. The rates of incidence-based and VAS-based somnolence were similar in the lithium and quetiapine-IR groups. The VAS change scores from baseline to each visit varied in both groups with significant decreases at weeks 6 and 12 in the quetiapine-IR group only. The decrease at week 6 in the quetiapine-IR group was significantly different from that in the lithium group. Patterns of changes in somnolence severity were inconsistent in both groups. A significant interaction between time course and the decrease in VAS scores was observed in the quetiapine-IR group, but not in the lithium group.

Conclusions

Baseline somnolence was highly prevalent in patients with bipolar disorder. The change in somnolence severity was different between lithium-treated and quetiapine-treated patients. Quantifying somnolence longitudinally is important in clinical trials and practice.

", "keywords": ["Adult", "Male", "Bipolar Disorder", "Sleepiness", "Visual Analog Scale", "Middle Aged", "Severity of Illness Index", "Quetiapine Fumarate", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Antimanic Agents", "Lithium Compounds", "Humans", "Female", "Longitudinal Studies", "Antipsychotic Agents"], "contacts": [{"organization": "Keming, Gao, Meilei, Su, Stephen J, Ganocy, Toyomi, Goto, Chengmei, Yuan, Fang, Fang, Carla, Conroy, Brittany, Brownrigg, Mary Beth, Serrano, Joseph R, Calabrese,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/30932950"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Clinical%20Psychopharmacology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "30932950", "name": "item", "description": "30932950", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/30932950"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-05-01T00:00:00Z"}}, {"id": "36811616", "type": "Feature", "geometry": null, "properties": {"license": "unspecified", "updated": "2026-05-31T07:06:59Z", "type": "Journal Article", "created": "2023-02-22", "title": "Single-incision, off-pump repair of a right aortic arch with an aberrant left subclavian artery and diverticulum of Kommerell in an adult", "description": "

Repairing a complete vascular ring in adults can be challenging. A right aortic arch with an aberrant retro-oesophageal left subclavian artery and persistent diverticulum of Kommerell represents one of the most common variants seen in adults, and the ring is completed by the left-sided ligamentum arteriosum. Most presentations in adults occur secondary to oesophageal compression, resulting in varying degrees of dysphagia. Owing to the difficulty and challenges associated with exposure in adults, it is not unusual for surgeons to offer a two-incision approach or to stage the procedure. We present a detailed surgical technique for a single-incision repair of a right aortic arch with an aberrant retro-oesophageal left subclavian artery via a left posterolateral thoracotomy.

", "keywords": ["Adult", "Diverticulum", "Cardiovascular Abnormalities", "Subclavian Artery", "Humans", "Aorta", " Thoracic"]}, "links": [{"href": "https://doi.org/36811616"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Multimedia%20Manual%20of%20Cardio-Thoracic%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "36811616", "name": "item", "description": "36811616", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/36811616"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-02-22T00:00:00Z"}}, {"id": "37195942", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-05-31T07:07:00Z", "type": "Journal Article", "created": "2023-05-17", "title": "Emodepside for Trichuris trichiura and Hookworm Infection", "description": "Current treatments for soil-transmitted helminth infections in humans have low efficacy against Trichuris trichiura. Emodepside - a drug in veterinary use and under development for the treatment of onchocerciasis in humans - is a leading therapeutic candidate for soil-transmitted helminth infection.We conducted two phase 2a, dose-ranging, randomized, controlled trials to evaluate the efficacy and safety of emodepside against T. trichiura and hookworm infections. We randomly assigned, in equal numbers, adults 18 to 45 years of age in whom T. trichiura or hookworm eggs had been detected in stool samples to receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo. The primary outcome was the percentage of participants who were cured of T. trichiura or hookworm infection (the cure rate) with emodepside 14 to 21 days after treatment, determined with the use of the Kato-Katz thick-smear technique. Safety was assessed 3, 24, and 48 hours after the receipt of treatment or placebo.A total of 266 persons were enrolled in the T. trichiura trial and 176 in the hookworm trial. The predicted cure rate against T. trichiura in the 5-mg emodepside group (85% [95% confidence interval {CI}, 69 to 93]; 25 of 30 participants) was higher than the predicted cure rate in the placebo group (10% [95% CI, 3 to 26]; 3 of 31 participants) and the observed cure rate in the albendazole group (17% [95% CI, 6 to 35]; 5 of 30 participants). A dose-dependent relationship was shown in participants with hookworm: the observed cure rate was 32% (95% CI, 13 to 57; 6 of 19 participants) in the 5-mg emodepside group and 95% (95% CI, 74 to 99.9; 18 of 19 participants) in the 30-mg emodepside group; the observed cure rates were 14% (95% CI, 3 to 36; 3 of 21 participants) in the placebo group and 70% (95% CI, 46 to 88; 14 of 20 participants) in the albendazole group. In the emodepside groups, headache, blurred vision, and dizziness were the most commonly reported adverse events 3 and 24 hours after treatment; the incidence of events generally increased in a dose-dependent fashion. Most adverse events were mild in severity and were self-limited; there were few moderate and no serious adverse events.Emodepside showed activity against T. trichiura and hookworm infections. (Funded by the European Research Council; ClinicalTrials.gov number, NCT05017194.).", "keywords": ["Adult", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Administration", " Oral", "Middle Aged", "Albendazole", "16. Peace & justice", "3. Good health", "03 medical and health sciences", "Feces", "Hookworm Infections", "Soil", "Young Adult", "0302 clinical medicine", "Trichuris", "Depsipeptides", "Animals", "Humans", "Trichuriasis"]}, "links": [{"href": "https://doi.org/37195942"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "37195942", "name": "item", "description": "37195942", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/37195942"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-05-18T00:00:00Z"}}, {"id": "38763635", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:07:02Z", "type": "Journal Article", "created": "2024-04-22", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.To assess the association of Life's Essential 8 (LE8) and the presence of abdominal aortic calcification (AAC) with mortality among middle\uffe2\uff80\uff90aged and older individuals.

Methods

Participants aged older than 40\uffe2\uff80\uff89years were enrolled from the National Health and Nutrition Examination Survey 2013\uffe2\uff80\uff902014. AAC was assessed using dual\uffe2\uff80\uff90energy X\uffe2\uff80\uff90ray absorptiometry. Mortality data were ascertained through linkage with the National Death Index until 31 December 2019. The LE8 score incorporates eight components: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose and blood pressure. The total LE8 score, an unweighted average of all components, was categorized into low (0\uffe2\uff80\uff9049), medium (50\uffe2\uff80\uff9079) and high (80\uffe2\uff80\uff90100) scores.

Results

This study included 2567 individuals, with a mean LE8 score of 67.28\uffe2\uff80\uff89\uffc2\uffb1\uffe2\uff80\uff890.48 and an AAC prevalence of 28.28%. Participants with low LE8 scores showed a significantly higher prevalence of AAC (odds ratio\uffe2\uff80\uff89=\uffe2\uff80\uff892.12 [1.12\uffe2\uff80\uff904.19]) compared with those with high LE8 scores. Over a median 6\uffe2\uff80\uff90year follow\uffe2\uff80\uff90up, there were 222 all\uffe2\uff80\uff90cause deaths, and 55 cardiovascular deaths occurred. Participants with AAC had an increased risk of all\uffe2\uff80\uff90cause (hazard ratio [HR]\uffe2\uff80\uff89=\uffe2\uff80\uff892.17 [1.60\uffe2\uff80\uff902.95]) and cardiovascular (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.35 [1.40\uffe2\uff80\uff903.93]) mortality. Moreover, individuals with AAC and low or medium LE8 scores exhibited a 137% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.37 [1.58\uffe2\uff80\uff903.54]) and 119% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.19 [1.61\uffe2\uff80\uff902.99]) higher risk of all\uffe2\uff80\uff90cause mortality, as well as a 224% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff893.24 [1.73\uffe2\uff80\uff906.04]) and 125% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.25 [1.24\uffe2\uff80\uff904.09]) increased risk of cardiovascular mortality, respectively.

Conclusions

The LE8 score correlates with AAC prevalence in middle\uffe2\uff80\uff90aged and older individuals and serves as a valuable tool for evaluating the risk of all\uffe2\uff80\uff90cause and cardiovascular mortality in individuals with AAC.

", "keywords": ["Male", "Adult", "Aged", " 80 and over", "2. Zero hunger", "Aortic Diseases", "Middle Aged", "Nutrition Surveys", "United States", "Body Mass Index", "Diet", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Risk Factors", "Prevalence", "Humans", "Female", "Aorta", " Abdominal", "Mortality", "Vascular Calcification", "Exercise", "Aged"]}, "links": [{"href": "https://doi.org/39165042"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Diabetes%2C%20Obesity%20and%20Metabolism", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "39165042", "name": "item", "description": "39165042", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/39165042"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-20T00:00:00Z"}}, {"id": "PMC4416083", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:08:47Z", "type": "Journal Article", "created": "2014-10-14", "title": "Clinical characteristics of RA patients with secondary SS and association with joint damage", "description": "Secondary SS (sSS) is a common extra-articular manifestation of RA. There are conflicting data regarding the association of sSS with worse joint damage. This study aims to characterize sSS patients in an RA cohort and study the association between sSS and joint damage.We conducted a cross-sectional study of RA patients with \u22651 year of follow-up at a large academic centre. Subjects with co-morbid diseases that can also result in sicca symptoms were excluded from the analysis. Subjects were considered to have sSS if they were reported as having sSS by their rheumatologist at recruitment into the cohort and had the diagnosis confirmed by chart review. The primary outcome was Sharp score using bilateral hand radiographs at recruitment. We constructed a linear regression model to determine the association of sSS status and Sharp score adjusted by age, gender, disease duration and ACPA and RF status.We studied 829 RA subjects, mean age 57 years, 83% female, mean RA duration 13 years, 74% seropositive; 85 subjects (10.3%) had sSS. We observed a female predominance (95.3%), longer mean disease duration (16.9 years) and higher frequency of RF or ACPA positive among patients with sSS and RA. Having sSS at baseline was associated with higher Sharp scores (P = 0.03), independent of age, gender, RA disease duration and seropositive disease.In our RA cohort, RA subjects with sSS had worse joint damage, suggesting that sSS is a marker of more aggressive disease.", "keywords": ["Adult", "Male", "2. Zero hunger", "Comorbidity", "Middle Aged", "Severity of Illness Index", "Antibodies", "Arthritis", " Rheumatoid", "03 medical and health sciences", "Cross-Sectional Studies", "Sjogren's Syndrome", "0302 clinical medicine", "Rheumatoid Factor", "Disease Progression", "Linear Models", "Humans", "Female", "Joints", "Arthrography", "10. No inequality", "Aged", "Follow-Up Studies"], "contacts": [{"organization": "Lindsay E, Brown, Michelle L, Frits, Christine K, Iannaccone, Michael E, Weinblatt, Nancy A, Shadick, Katherine P, Liao,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/PMC4416083"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Rheumatology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC4416083", "name": "item", "description": "PMC4416083", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC4416083"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-10-13T00:00:00Z"}}, {"id": "PMC11322291", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:08:45Z", "type": "Journal Article", "created": "2024-08-13", "title": "Insights into the ecology of the infant gut plasmidome", "description": "Plasmids are small DNA molecules that enable bacteria to share beneficial traits, influencing microbial communities. However, their role within the human gut microbiome remains largely unknown. In this study, we investigate the gut microbiomes of 34 mother-child cohorts, employing a plasmid analysis workflow to understand the impact of plasmids on the gut microbiome. We create a plasmid phylogenetic tree, devise a method for assigning plasmid hosts, and examine potential plasmid transfer networks. Our research discovers a wide variety of previously unidentified plasmid sequences, indicating that current databases do not fully represent the gut plasmidome. Interestingly, infants display greater plasmid diversity compared to mothers and other healthy adults. We find that Bacteroidota, a major bacterial phylum, serves as the primary host for gut plasmids and plays a dominant role in gut plasmid transfer events. Additionally, plasmids broaden the genetic capabilities of bacteria, with their influence on bacterial function becoming more apparent as children's gut microbiomes develop. This study sheds light on the role of plasmids in the infant gut microbiome, making a significant contribution to our understanding of plasmid biology.", "keywords": ["Adult", "Male", "0301 basic medicine", "0303 health sciences", "Bacteria", "Bacteroidetes", "Science", "Q", "Infant", " Newborn", "Infant", "Article", "Gastrointestinal Microbiome", "Feces", "03 medical and health sciences", "Humans", "Female", "Phylogeny", "Plasmids"]}, "links": [{"href": "https://doi.org/PMC11322291"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Communications", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11322291", "name": "item", "description": "PMC11322291", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11322291"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-13T00:00:00Z"}}, {"id": "PMC11542457", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:08:46Z", "type": "Journal Article", "created": "2024-11-07", "title": "Graduate reflections on Community Service: a view of roles in practice", "description": "In South Africa, newly qualified physiotherapists transition to the workplace during community service, often in diverse healthcare settings, attending to patients with complex ailments. The transition is complicated by the shortage of rehabilitation personnel, especially in rural and peri-urban areas. While higher education curricula should prepare students for the workplace, the roles and expectations of new therapists remain unclear. Assessing how well current curricula, built around the CanMEDS framework, equip students with the competencies needed for entry-level community service practice will help to improve physiotherapy training practices. This study investigated the experiences of community service physiotherapists to inform curriculum design and graduate outcomes.A descriptive qualitative study was conducted. Graduates were purposefully sampled during their community service year via a class group contact, with a snowball approach to recruit diverse participants. Semi-structured interviews were conducted over MS Teams, recorded, and transcribed. Reflexive deductive coding was used to interpret the data, which was analysed around the CanMEDS roles and graduate outcomes, as well as curriculum constraints and enablers to the workplace transition.Ten community service physiotherapists placed in five different provinces participated. Most identified strongly with their core role as clinicians and felt prepared in terms of clinical skills. However, aspects of roles linked to advocacy, leadership, and professionalism were more complex to navigate. The contexts of placements and the nuances of how the healthcare system operated in each province impacted their experience.The study highlighted varied readiness levels among community service physiotherapists. While many felt competent in specific clinical tasks, there are significant gaps in their preparation for broader community practice challenges. Participants noted their undergraduate training adequately prepared them for the clinician role but not for roles integrating collaboration, communication, patient and professional advocacy. Quality clinical placements and the role of educators were crucial, yet the protective nature of these placements limited exposure to real-world scenarios. Insufficient mentorship and support contributed to feelings of isolation. To enhance preparedness, the curriculum should integrate more experiences addressing real-world challenges, which value multiple competencies and outcomes. Future research should examine the development of context-appropriate competency frameworks and long-term effects of community service on career development.", "keywords": ["Male", "Adult", "LC8-6691", "Attitude of Health Personnel", "Research", "R", "Competencies", "Special aspects of education", "Physical Therapists", "South Africa", "03 medical and health sciences", "Professional Role", "0302 clinical medicine", "Graduate roles", "Physiotherapist", "Medicine", "Humans", "Community service", "Female", "Curriculum", "Clinical Competence", "Community Health Services", "Education", " Graduate", "Qualitative Research", "Entry level practice"]}, "links": [{"href": "https://doi.org/PMC11542457"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Medical%20Education", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11542457", "name": "item", "description": "PMC11542457", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11542457"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-11-07T00:00:00Z"}}, {"id": "PMC11835329", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:08:46Z", "type": "Journal Article", "created": "2025-02-18", "title": "Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials", "description": "Background

The World Health Organization recommends the use of the microscopy-based Kato-Katz thick smear for diagnosing soil-transmitted helminth (STH) infections. Despite its simplicity and cost-effectiveness, the Kato-Katz method faces challenges, including reader subjectivity and reduced sensitivity. Real-time polymerase chain reaction (qPCR) technology offers standardized readouts and higher sensitivity, making it suitable for STH diagnosis and monitoring the treatment efficacy of emodepside within the framework of randomized controlled trials.

Methodology/Principal findings

We evaluated the performance of Kato-Katz versus qPCR for assessing treatment efficacy in terms of cure rates, of single doses of 5, 10, 15, 20, 25 and 30\uffe2\uff80\uff89mg of emodepside compared to 400\uffe2\uff80\uff89mg albendazole. Spearman\uffe2\uff80\uff99s rank correlation coefficient examined the correlation between STH eggs per gram in stool samples and qPCR Ct values. Diagnostic sensitivity of qPCR was calculated using a Bayesian latent class modelling approach with data from Ascaris lumbricoides infections. Agreement between Kato-Katz and qPCR at baseline was 93.57% for Trichuris trichiura, and 73.49% for both hookworm and A. lumbricoides. For the latter helminth qPCR demonstrated higher sensitivity (85.00% vs. 47.70%) and slightly lower specificity (93.40% vs. 99.40%) compared to Kato-Katz. We observed a fair to moderate agreement with negative correlation between Ct values and Kato-Katz egg counts. Treatment efficacy, as assessed by qPCR, was lower for all doses of emodepside and albendazole compared to Kato-Katz. Nonetheless, emodepside demonstrated higher cure rates against T. trichiura and A. lumbricoides infections compared to albendazole.

Conclusion/ Significance

Our study confirmed that qPCR is a sensitive diagnostic method for diagnosing STH infections compared to Kato-Katz and serves as a valuable tool for determining treatment efficacy in clinical trials. Furthermore, qPCR confirmed the better treatment efficacy of emodepside compared to albendazole, despite indicating lower cure rates than Kato-Katz.An important consideration in the treatment of patients with psoriatic arthritis (PsA) is whether the addition of methotrexate (MTX) to biologics has greater efficacy than biologic monotherapy with respect to efficacy outcomes in these patients.

Objectives

To conduct a network meta-analysis (NMA) comparing biologics by treatment class with and without MTX for treatment of adults with active PsA.

Methods

A systematic literature review (SLR) identified randomised, double-blinded, controlled trials, and a Bayesian NMA compared biologics with and without MTX by treatment class (tumour necrosis factor inhibitors (TNFi), interleukin-23 inhibitors (IL-23i) and IL-17i). Efficacy outcomes included American College of Rheumatology 20%, 50% and 70% (ACR20, ACR50 and ACR70) improvement response.

Results

The SLR initially identified 31 studies, of which 17 met feasibility criteria for the NMA by containing the \uffe2\uff80\uff98without MTX\uffe2\uff80\uff99 subgroup. For ACR20 efficacy (the most robust assessment examined), all active treatments were significantly better than placebo. No statistically significant differences were demonstrated between biologic monotherapy (for all classes examined) and biologics in combination with MTX for ACR20/50. IL-17i were comparable to IL-23i, and IL-17i were significantly better than TNFi for ACR20. Although limited by fewer trials, TNFi, IL-23i and IL-17i were not statistically different for ACR50/70.

Conclusions

Concomitant use of MTX and biologics did not improve ACR efficacy outcomes versus biologic monotherapy. MTX does not appear to be necessary as a background therapy when biologics are used for the achievement of ACR20/50 responses in patients with PsA.

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