{"type": "FeatureCollection", "features": [{"id": "10.1038/nature02048", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:16:44Z", "type": "Journal Article", "created": "2003-10-29", "title": "Neuroanatomy Of Flying Reptiles And Implications For Flight, Posture And Behaviour", "description": "Comparison of birds and pterosaurs, the two archosaurian flyers, sheds light on adaptation to an aerial lifestyle. The neurological basis of control holds particular interest in that flight demands on sensory integration, equilibrium, and muscular coordination are acute. Here we compare the brain and vestibular apparatus in two pterosaurs based on high-resolution computed tomographic (CT) scans from which we constructed digital endocasts. Although general neural organization resembles birds, pterosaurs had smaller brains relative to body mass than do birds. This difference probably has more to do with phylogeny than flight, in that birds evolved from nonavian theropods that had already established trends for greater encephalization. Orientation of the osseous labyrinth relative to the long axis of the skull was different in these two pterosaur species, suggesting very different head postures and reflecting differing behaviours. Their enlarged semicircular canals reflect a highly refined organ of equilibrium, which is concordant with pterosaurs being visually based, aerial predators. Their enormous cerebellar floccular lobes may suggest neural integration of extensive sensory information from the wing, further enhancing eye- and neck-based reflex mechanisms for stabilizing gaze.", "keywords": ["0301 basic medicine", "0303 health sciences", "Behavior", " Animal", "Fossils", "Body Weight", "Posture", "Skull", "Brain", "Reptiles", "Feeding Behavior", "Organ Size", "Birds", "Neuroanatomy", "03 medical and health sciences", "Flight", " Animal", "Animals", "Head"], "contacts": [{"organization": "Sankar Chatterjee, Lawrence M. Witmer, Timothy B. Rowe, Jonathan Franzosa,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1038/nature02048"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1038/nature02048", "name": "item", "description": "10.1038/nature02048", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1038/nature02048"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2003-10-01T00:00:00Z"}}, {"id": "10.1109/TMI.2017.2743819", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:17:22Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/10.1109/TMI.2017.2743819"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1109/TMI.2017.2743819", "name": "item", "description": "10.1109/TMI.2017.2743819", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1109/TMI.2017.2743819"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "10.1109/tmi.2017.2743819", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:17:23Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/10.1109/tmi.2017.2743819"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1109/tmi.2017.2743819", "name": "item", "description": "10.1109/tmi.2017.2743819", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1109/tmi.2017.2743819"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "10.3390/bios12121071", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:19:03Z", "type": "Journal Article", "created": "2022-11-24", "title": "One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>A novel photochemical technological route for one-step functionalization of a graphene surface with an azide-modified DNA aptamer for biomarkers is developed. The methodology is demonstrated for the functionalization of a DNA aptamer for an N-terminal B-type natriuretic peptide (NT-proBNP) heart failure biomarker on the surface of a graphene channel within a system based on a liquid-gated graphene field effect transistor (GFET). The limit of detection (LOD) of the aptamer-functionalized sensor is 0.01 pg/mL with short response time (75 s) for clinically relevant concentrations of the cardiac biomarker, which could be of relevance for point-of-care (POC) applications. The novel methodology could be applicable for the development of different graphene-based biosensors for fast, stable, real-time, and highly sensitive detection of disease markers.</p></article>", "keywords": ["azide modification", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "point-of-care diagnostic", "Article", "Peptide Fragments", "graphene biosensor; heart failure; field-effect transistor; point-of-care diagnostic; aptamer; azide modification; photochemistry", "Natriuretic Peptide", " Brain", "graphene biosensor", "Graphite", "0210 nano-technology", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "http://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://doi.org/10.3390/bios12121071"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/bios12121071", "name": "item", "description": "10.3390/bios12121071", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/bios12121071"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-11-23T00:00:00Z"}}, {"id": "10.3390/bios14050215", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:19:03Z", "type": "Journal Article", "created": "2024-04-26", "title": "Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Graphene-based materials are actively being investigated as sensing elements for the detection of different analytes. Both graphene grown by chemical vapor deposition (CVD) and graphene oxide (GO) produced by the modified Hummers\u2019 method are actively used in the development of biosensors. The production costs of CVD graphene- and GO-based sensors are similar; however, the question remains regarding the most efficient graphene-based material for the construction of point-of-care diagnostic devices. To this end, in this work, we compare CVD graphene aptasensors with the aptasensors based on reduced GO (rGO) for their capabilities in the detection of NT-proBNP, which serves as the gold standard biomarker for heart failure. Both types of aptasensors were developed using commercial gold interdigitated electrodes (IDEs) with either CVD graphene or GO formed on top as a channel of liquid-gated field-effect transistor (FET), yielding GFET and rGO-FET sensors, respectively. The functional properties of the two types of aptasensors were compared. Both demonstrate good dynamic range from 10 fg/mL to 100 pg/mL. The limit of detection for NT-proBNP in artificial saliva was 100 fg/mL and 1 pg/mL for rGO-FET- and GFET-based aptasensors, respectively. While CVD GFET demonstrates less variations in parameters, higher sensitivity was demonstrated by the rGO-FET due to its higher roughness and larger bandgap. The demonstrated low cost and scalability of technology for both types of graphene-based aptasensors may be applicable for the development of different graphene-based biosensors for rapid, stable, on-site, and highly sensitive detection of diverse biochemical markers.</p></article>", "keywords": ["Transistors", " Electronic", "graphene", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "01 natural sciences", "point-of-care diagnostic", "Article", "Peptide Fragments", "0104 chemical sciences", "Limit of Detection", "Natriuretic Peptide", " Brain", "graphene oxide", "Humans", "Graphite", "Gold", "0210 nano-technology", "Electrodes", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/5/215/pdf"}, {"href": "https://doi.org/10.3390/bios14050215"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/bios14050215", "name": "item", "description": "10.3390/bios14050215", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/bios14050215"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-04-26T00:00:00Z"}}, {"id": "17190727", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:02Z", "type": "Journal Article", "created": "2006-12-27", "title": "Long-Acting Calcium Channel Blocker, Azelnidipine, Increases Endothelial Nitric Oxide Synthase in the Brain and Inhibits Sympathetic Nerve Activity", "description": "Nitric oxide (NO) in the central nervous system inhibits sympathetic nerve activity, thereby decreasing blood pressure. It is unknown, however, whether orally administered antihypertensive treatment alters NO synthase (NOS) expression, particularly in the brain, and how changes in NOS expression affects sympathetic nerve activity. Azelnidipine, a recently developed long-acting dihydropyridine calcium channel blocker, does not cause baroreflex-induced tachycardia. The aim of the present study was to determine whether antihypertensive treatment with azelnidipine alters endothelial NOS (eNOS), neuronal NOS (nNOS), or inducible NOS (iNOS) expression in the brain, and how changes in NOS affect sympathetic nerve activity. Azelnidipine (20 mg/kg/day) or hydralazine (20 mg/kg/day) was orally administered for 30 days in stroke-prone spontaneously hypertensive rats (SHRSP). Blood pressure and heart rate were measured by the tail cuff method. Urinary norepinephrine excretion was measured as a marker of sympathetic nerve activity. Western blot analysis was performed to examine eNOS, nNOS, or iNOS expression levels in the brain (cortex, cerebellum, hypothalamus, and the brain stem), heart, and aorta. The extent of blood pressure reduction was similar between the two groups. Heart rate increased in the hydralazine-treated group but did not change in the azelnidipine-treated group. Urinary norepinephrine excretion was significantly increased only in the hydralazine-treated group. Treatment with azelnidipine significantly increased eNOS expression levels in the brain, heart, and aorta, but did not alter nNOS or iNOS expression levels. Treatment with hydralazine did not change any of the NOS expression levels. These results suggest that antihypertensive treatment with azelnidipine attenuates reflex-induced sympathetic activation and enhances eNOS expression levels in the brain as well as in the heart and aorta.", "keywords": ["Male", "Dihydropyridines", "Sympathetic Nervous System", "Nitric Oxide Synthase Type III", "Myocardium", "Brain", "Nitric Oxide Synthase Type II", "Blood Pressure", "Rats", " Inbred Strains", "Nitric Oxide Synthase Type I", "Calcium Channel Blockers", "Rats", "3. Good health", "Enzyme Activation", "Norepinephrine", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Rats", " Inbred SHR", "Animals", "Azetidinecarboxylic Acid", "Aorta"], "contacts": [{"organization": "Yoshikuni, Kimura, Yoshitaka, Hirooka, Yoji, Sagara, Kenji, Sunagawa,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/17190727"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Clinical%20and%20Experimental%20Hypertension", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "17190727", "name": "item", "description": "17190727", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/17190727"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2007-01-01T00:00:00Z"}}, {"id": "27236510", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:30Z", "type": "Journal Article", "created": "2016-05-14", "title": "Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes", "description": "The clinical application of trans resveratrol (RSV) in glioma treatment is largely limited because of its rapid metabolism, fast elimination from systemic circulation and low biological half life. Therefore, the objectives of this study were to enhance the circulation time, biological half life and passive brain targeting of RSV using d-\u03b1-tocopheryl polyethylene glycol 1000 succinate (TPGS) coated liposomes (RSV-TPGS-Lipo). In addition to basic liposomal characterizations, in vitro anticancer potential against C6 glioma cell lines and cellular internalization of liposomes were carried out by MTT assay and confocal laser scanning microscopy (CLSM), respectively. Pharmacokinetics and tissue distribution studies were also carried out after intravenous administration in Charles Foster rats. RSV-TPGS-Lipo 2 showed significantly higher cytotoxicity than RSV-Lipo (uncoated liposomes) and RSV. Both uncoated and TPGS coated liposomes showed excellent cellular uptake. RSV, RSV-Lipo and RSV-TPGS-Lipo 2 were found to be haemocompatible and safe after i.v. administration. Area under the curve (AUC) and plasma half life (t1/2) after i.v. administration of RSV-TPGS-Lipo 2 was found to be approximately 5.73 and 6.72 times higher than that of RSV-Lipo as well as 29.94 and 29.66 times higher than that of RSV, respectively. Thus, the outcome indicates that RSV-TPGS-Lipo 2 is a promising carrier for glioma treatment with improved pharmacokinetic parameters. Moreover, brain accumulation of RSV-Lipo and RSV-TPGS-Lipo 2 was found to be significantly higher than that of RSV (P<0.05). Results are suggesting that both RSV-Lipo and RSV-TPGS-Lipo 2 are the promising tools of RSV for the treatment of brain cancer.", "keywords": ["Male", "Drug Carriers", "Brain Neoplasms", "Antineoplastic Agents", "04 agricultural and veterinary sciences", "Polyethylene Glycols", "Rats", "3. Good health", "Nanomedicine", "0404 agricultural biotechnology", "Resveratrol", "Cell Line", " Tumor", "Liposomes", "Stilbenes", "Animals", "Vitamin E", "0405 other agricultural sciences"]}, "links": [{"href": "https://doi.org/27236510"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Colloids%20and%20Surfaces%20B%3A%20Biointerfaces", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "27236510", "name": "item", "description": "27236510", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/27236510"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2016-09-01T00:00:00Z"}}, {"id": "2750197518", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:31Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/2750197518"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "2750197518", "name": "item", "description": "2750197518", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/2750197518"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "28858789", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:33Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/28858789"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "28858789", "name": "item", "description": "28858789", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/28858789"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "8130083", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:23:47Z", "type": "Journal Article", "created": "2003-02-11", "title": "Inhibition of cell growth by K+ channel modulators is due to interference with agonist-induced Ca2+ release", "description": "The effects of K+ channel modulators, tetraethylammonium, 4-aminopyridine and diazoxide, and high extracellular K+ on cell growth and agonist-induced intracellular Ca2+ mobilization were investigated. Two human brain tumour cell lines, U-373 MG astrocytoma and SK-N-MC neuroblastoma, were used as model cellular systems. K+ channel modulators and increased extracellular K+ concentration inhibited tumour cell growth in a dose-related fashion in both cell lines. In addition, agonist (carbachol or serum)-induced intracellular Ca2+ mobilization was also blocked by the pretreatment of growth-inhibitory concentrations of K+ channel modulators and high extracellular K+. Thus, these results suggest that K+ channel modulators are effective inhibitors of brain tumour cell growth and that their growth regulation may be due to the interference with the intracellular Ca2+ signalling mechanisms.", "keywords": ["0301 basic medicine", "0303 health sciences", "Potassium Channels", "Brain Neoplasms", "Diazoxide", "Tetraethylammonium", "Astrocytoma", "In Vitro Techniques", "Tetraethylammonium Compounds", "Sodium Channels", "Neuroblastoma", "03 medical and health sciences", "Tumor Cells", " Cultured", "Humans", "Calcium", "4-Aminopyridine", "Cell Division", "Signal Transduction", "Sodium Channel Blockers"], "contacts": [{"organization": "Y S, Lee, M M, Sayeed, R D, Wurster,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/8130083"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cellular%20Signalling", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "8130083", "name": "item", "description": "8130083", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/8130083"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1993-11-01T00:00:00Z"}}, {"id": "PMC11117807", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:24:19Z", "type": "Journal Article", "created": "2024-04-26", "title": "Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Graphene-based materials are actively being investigated as sensing elements for the detection of different analytes. Both graphene grown by chemical vapor deposition (CVD) and graphene oxide (GO) produced by the modified Hummers\u2019 method are actively used in the development of biosensors. The production costs of CVD graphene- and GO-based sensors are similar; however, the question remains regarding the most efficient graphene-based material for the construction of point-of-care diagnostic devices. To this end, in this work, we compare CVD graphene aptasensors with the aptasensors based on reduced GO (rGO) for their capabilities in the detection of NT-proBNP, which serves as the gold standard biomarker for heart failure. Both types of aptasensors were developed using commercial gold interdigitated electrodes (IDEs) with either CVD graphene or GO formed on top as a channel of liquid-gated field-effect transistor (FET), yielding GFET and rGO-FET sensors, respectively. The functional properties of the two types of aptasensors were compared. Both demonstrate good dynamic range from 10 fg/mL to 100 pg/mL. The limit of detection for NT-proBNP in artificial saliva was 100 fg/mL and 1 pg/mL for rGO-FET- and GFET-based aptasensors, respectively. While CVD GFET demonstrates less variations in parameters, higher sensitivity was demonstrated by the rGO-FET due to its higher roughness and larger bandgap. The demonstrated low cost and scalability of technology for both types of graphene-based aptasensors may be applicable for the development of different graphene-based biosensors for rapid, stable, on-site, and highly sensitive detection of diverse biochemical markers.</p></article>", "keywords": ["Transistors", " Electronic", "graphene", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "01 natural sciences", "point-of-care diagnostic", "Article", "Peptide Fragments", "0104 chemical sciences", "Limit of Detection", "Natriuretic Peptide", " Brain", "graphene oxide", "Humans", "Graphite", "Gold", "0210 nano-technology", "Electrodes", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/5/215/pdf"}, {"href": "https://doi.org/PMC11117807"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11117807", "name": "item", "description": "PMC11117807", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11117807"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-04-26T00:00:00Z"}}, {"id": "PMC5778340", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:24:22Z", "type": "Journal Article", "created": "2017-12-30", "title": "Pneumonia diagnosis in childhood and incidence of leukaemia, lymphoma and brain cancer: a Danish nationwide cohort study", "description": "Objectives<p>There is an ongoing debate on the possible association between infections in early childhood and subsequent cancer risk, but it remains unclear if a hospital admission for infection is associated with risk of childhood cancer diagnosis. We examined if a hospital-based diagnosis of pneumonia was a clinical marker of the three most common childhood cancers.</p>Design<p>Population-based cohort study.</p>Setting<p>Denmark, hospital diagnoses, 1994\uffe2\uff80\uff932013.</p>Methods<p>Using national health registries, we compared the observed incidence of leukaemia, lymphoma and brain cancer among 83\uffe2\uff80\uff89935 children with a hospital-based pneumonia diagnosis with that expected among children in the general population. We calculated absolute cancer risks and standardised incidence ratios (SIRs) as a measure of relative risk.</p>Results<p>The cancer SIRs were substantially increased during the first 6 months of follow-up; lymphoid leukaemia: 6.2 (95% CI 3.5 to 10.3); myeloid leukaemia: 14.8 (95% CI 6.0 to 30.6); Hodgkin\uffe2\uff80\uff99s lymphoma: 60.8 (95% CI 26.2 to 120), non-Hodgkin\uffe2\uff80\uff99s lymphoma: 15.9 (95% CI 5.2 to 37.2) and brain cancer: 4.4 (95% CI 1.9 to 8.7). The 6-month absolute risks of leukaemia, lymphoma and brain cancer were all low, reaching 0.05% when combined. An increased risk persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the 5-year absolute cancer risk was 0.14%.</p>Conclusions<p>The short-term incidence of leukaemia, lymphoma and brain cancer was higher than expected and persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the absolute cancer risk was low.</p", "keywords": ["Risk", "Male", "Adolescent", "Lymphoma", "Epidemiology", "Denmark", "Cohort Studies", "03 medical and health sciences", "0302 clinical medicine", "Journal Article", "Leukaemia", "Humans", "Child", "Leukemia", "Brain Neoplasms", "Incidence", "Lymphoma", " Non-Hodgkin", "Infant", " Newborn", "Infant", "Paediatrics", "Pneumonia", "Hodgkin Disease", "Leukemia", " Lymphoid", "3. Good health", "Brain Cancer", "Hospitalization", "Leukemia", " Myeloid", "Child", " Preschool", "Female"]}, "links": [{"href": "https://doi.org/PMC5778340"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMJ%20Open", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC5778340", "name": "item", "description": "PMC5778340", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC5778340"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-12-01T00:00:00Z"}}, {"id": "PMC9775241", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:24:26Z", "type": "Journal Article", "created": "2022-11-24", "title": "One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>A novel photochemical technological route for one-step functionalization of a graphene surface with an azide-modified DNA aptamer for biomarkers is developed. The methodology is demonstrated for the functionalization of a DNA aptamer for an N-terminal B-type natriuretic peptide (NT-proBNP) heart failure biomarker on the surface of a graphene channel within a system based on a liquid-gated graphene field effect transistor (GFET). The limit of detection (LOD) of the aptamer-functionalized sensor is 0.01 pg/mL with short response time (75 s) for clinically relevant concentrations of the cardiac biomarker, which could be of relevance for point-of-care (POC) applications. The novel methodology could be applicable for the development of different graphene-based biosensors for fast, stable, real-time, and highly sensitive detection of disease markers.</p></article>", "keywords": ["azide modification", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "point-of-care diagnostic", "Article", "Peptide Fragments", "graphene biosensor; heart failure; field-effect transistor; point-of-care diagnostic; aptamer; azide modification; photochemistry", "Natriuretic Peptide", " Brain", "graphene biosensor", "Graphite", "0210 nano-technology", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "http://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://doi.org/PMC9775241"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC9775241", "name": "item", "description": "PMC9775241", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC9775241"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-11-23T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Brain&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Brain&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Brain&", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Brain&offset=13", "hreflang": "en-US"}], "numberMatched": 13, "numberReturned": 13, "distributedFeatures": [], "timeStamp": "2026-09-21T09:52:12.668778Z"}