{"type": "FeatureCollection", "features": [{"id": "10.1016/j.xgen.2024.100639", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:17:24Z", "type": "Journal Article", "created": "2024-08-30", "title": "ONCOLINER: A new solution for monitoring, improving, and harmonizing somatic variant calling across genomic oncology centers", "description": "The characterization of somatic genomic variation associated with the biology of tumors is fundamental for cancer research and personalized medicine, as it guides the reliability and impact of cancer studies and genomic-based decisions in clinical oncology. However, the quality and scope of tumor genome analysis across cancer research centers and hospitals are currently highly heterogeneous, limiting the consistency of tumor diagnoses across hospitals and the possibilities of data sharing and data integration across studies. With the aim of providing users with actionable and personalized recommendations for the overall enhancement and harmonization of somatic variant identification across research and clinical environments, we have developed ONCOLINER. Using specifically designed mosaic and tumorized genomes for the analysis of recall and precision across somatic SNVs, insertions or deletions (indels), and structural variants (SVs), we demonstrate that ONCOLINER is capable of improving and harmonizing genome analysis across three state-of-the-art variant discovery pipelines in genomic oncology.", "keywords": ["330", "Bioinformatics", "Genome", " Human", "610", "Genomics", "Medical Oncology", "Somatic variant calling", "Polymorphism", " Single Nucleotide", "Article", "Benchmarking", "Oncology", "INDEL Mutation", "\u00c0rees tem\u00e0tiques de la UPC::Inform\u00e0tica::Aplicacions de la inform\u00e0tica::Bioinform\u00e0tica", "Neoplasms", "Cancer genomics", "Humans", "Benchmarking data", "Precision Medicine", "Software"]}, "links": [{"href": "https://doi.org/10.1016/j.xgen.2024.100639"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cell%20Genomics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.xgen.2024.100639", "name": "item", "description": "10.1016/j.xgen.2024.100639", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.xgen.2024.100639"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-09-01T00:00:00Z"}}, {"id": "10.17632/2hgj8935fr.1", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-07-25T16:19:57Z", "type": "Dataset", "title": "International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening Recommendations Detect Most Malignancies in Dermatomyositis Patients: Retrospective Performance in a Tertiary-Care Center Cohort", "description": "Supplemental Material (Methods, Results, Discussion, Figures, Tables)", "keywords": ["Rheumatology", "Medical Dermatology", "Dermatomyositis", "Cancer"], "contacts": [{"organization": "Fernandez, Anthony, Flatley, Elizabeth, Cassard, Lydia,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.17632/2hgj8935fr.1"}, {"rel": "self", "type": "application/geo+json", "title": "10.17632/2hgj8935fr.1", "name": "item", "description": "10.17632/2hgj8935fr.1", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.17632/2hgj8935fr.1"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-04-08T00:00:00Z"}}, {"id": "10.15167/2421-4248/jpmh2019.60.3s1", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:19:40Z", "type": "Journal Article", "title": "I cambiamenti climatici e la coltivazione del pomodoro: la valutazione dell\u2019impatto ambientale nel progetto TOMRES", "description": "Atti del 52\u00b0 Congresso Nazionale Societ\u00e0 Italiana di Igiene, Medicina Preventiva e Sanit\u00e0 Pubblica (SItI) Perugia 16-19 ottobre 2019", "keywords": ["03 medical and health sciences", "0302 clinical medicine", "/", "WAT_CHALLENGE; acque reflue; saggi biologici; cancerogenesi; mutagensi", "promozione della salute", " salutogenesi", "0305 other medical science", "Mycobacterium chimaera", " Heater Cooler Units (HCU)", "3. Good health"]}, "links": [{"href": "https://iris.cnr.it/bitstream/20.500.14243/477031/1/8.2_2019_Sieroprevalenza%20HAV_Siti%20Perugia%2016_19%20Ott_2019.pdf"}, {"href": "https://iris.unimore.it/bitstream/11380/1188860/1/MV_196_SITI-Perugia_metodologia-risk-assessment_2019.pdf"}, {"href": "https://iris.unito.it/bitstream/2318/1803227/1/Atti_SItI.pdf"}, {"href": "https://doi.org/10.15167/2421-4248/jpmh2019.60.3s1"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20preventive%20Medicine%20and%20Hygiene", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.15167/2421-4248/jpmh2019.60.3s1", "name": "item", "description": "10.15167/2421-4248/jpmh2019.60.3s1", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.15167/2421-4248/jpmh2019.60.3s1"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-01-01T00:00:00Z"}}, {"id": "10.17632/c4hdzzdpc5.2", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:19:57Z", "type": "Dataset", "title": "Data for: Perceived stress moderates the effects of a randomized trial of dance movement therapy on diurnal cortisol slopes in breast cancer patients", "keywords": ["Moderation", "Breast Cancer", "Dance Therapy", "Mediation", "Stress", "Cortisol", "3. Good health"], "contacts": [{"organization": "Ho, Rainbow Tin Hung", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.17632/c4hdzzdpc5.2"}, {"rel": "self", "type": "application/geo+json", "title": "10.17632/c4hdzzdpc5.2", "name": "item", "description": "10.17632/c4hdzzdpc5.2", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.17632/c4hdzzdpc5.2"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-01-01T00:00:00Z"}}, {"id": "10.3389/fbioe.2022.1070851", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:20:45Z", "type": "Journal Article", "created": "2023-01-04", "title": "Modification of bacterial cells for in vivo remotely guided systems", "description": "

It was shown recently that bacterial strains, which can act specifically against malignant cells, can be used efficiently in cancer therapy. Many appropriate bacterial strains are either pathogenic or invasive and there is a substantial shortage of methods with which to monitor in vivo the distribution of bacteria used in this way. Here, it is proposed to use a Layer-by-Layer (LbL) approach that can encapsulate individual bacterial cells with fluorescently labeled polyelectrolytes (PE)s and magnetite nanoparticles (NP)s. The NP enable remote direction in vivo to the site in question and the labeled shells in the far-red emission spectra allow non-invasive monitoring of the distribution of bacteria in the body. The magnetic entrapment of the modified bacteria causes the local concentration of the bacteria to increase by a factor of at least 5. The PEs create a strong barrier, and it has been shown in vitro experiments that the division time of bacterial cells coated in this way can be regulated, resulting in control of their invasion into tissues. That animals used in the study survived and did not suffer septic shock, which can be attributed to PE capsules that prevent release of endotoxins from bacterial cells.

Mesoporous silica nanoparticles (MSNs) exhibit highly beneficial characteristics for devising efficient biosensors for different analytes. Their unique properties, such as capabilities for stable covalent binding to recognition groups (e.g., antibodies or aptamers) and sensing surfaces, open a plethora of opportunities for biosensor construction. In addition, their structured porosity offers capabilities for entrapping signaling molecules (dyes or electroactive species), which could be released efficiently in response to a desired analyte for effective optical or electrochemical detection. This work offers an overview of recent research studies (in the last five years) that contain MSNs in their optical and electrochemical sensing platforms for the detection of cancer biomarkers, classified by cancer type. In addition, this study provides an overview of cancer biomarkers, as well as electrochemical and optical detection methods in general.

", "keywords": ["MSNs", "cancer biomarkers", "Review", "Biosensing Techniques", "Electrochemical Techniques", "02 engineering and technology", "biosensors", "optical detection", "Silicon Dioxide", "01 natural sciences", "0104 chemical sciences", "3. Good health", "Neoplasms", "electrochemical detection", "Biomarkers", " Tumor", "Nanoparticles", "Humans", "0210 nano-technology", "Porosity", "TP248.13-248.65", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/7/326/pdf"}, {"href": "https://doi.org/10.3390/bios14070326"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/bios14070326", "name": "item", "description": "10.3390/bios14070326", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/bios14070326"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-06-30T00:00:00Z"}}, {"id": "10.3390/cancers15072162", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:20:57Z", "type": "Journal Article", "created": "2023-04-06", "title": "Raman Spectroscopic Imaging of Human Bladder Resectates towards Intraoperative Cancer Assessment", "description": "

Raman spectroscopy offers label-free assessment of bladder tissue for in vivo and ex vivo intraoperative applications. In a retrospective study, control and cancer specimens were prepared from ten human bladder resectates. Raman microspectroscopic images were collected from whole tissue samples in a closed chamber at 785 nm laser excitation using a 20\u00d7 objective lens and 250 \u00b5m step size. Without further preprocessing, Raman images were decomposed by the hyperspectral unmixing algorithm vertex component analysis into endmember spectra and their abundancies. Hierarchical cluster analysis distinguished endmember Raman spectra that were assigned to normal bladder, bladder cancer, necrosis, epithelium and lipid inclusions. Interestingly, Raman spectra of microplastic particles, pigments or carotenoids were detected in 13 out of 20 specimens inside tissue and near tissue margins and their identity was confirmed by spectral library surveys. Hypotheses about the origin of these foreign materials are discussed. In conclusion, our Raman workflow and data processing protocol with minimal user interference offers advantages for future clinical translation such as intraoperative tumor detection and label-free material identification in complex matrices.

", "keywords": ["Raman spectroscopy; bladder cancer; hyperspectral unmixing; microplastic; pigment", "610", "Article", "3. Good health"]}, "links": [{"href": "http://www.mdpi.com/2072-6694/15/7/2162/pdf"}, {"href": "https://doi.org/10.3390/cancers15072162"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cancers", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/cancers15072162", "name": "item", "description": "10.3390/cancers15072162", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/cancers15072162"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-04-05T00:00:00Z"}}, {"id": "10.3390/pharmaceutics13040460", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:21:04Z", "type": "Journal Article", "created": "2021-03-29", "title": "pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers", "description": "

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

", "keywords": ["Ruthenium-based anti-cancer drugs", "ruthenium-based anticancer drugs", "PH-responsive drug delivery", "Mesoporous silica nanoparticles", "pH-responsive drug delivery", "02 engineering and technology", "controlled drug delivery", "01 natural sciences", "Article", "cancer treatment", "ddc:", "3. Good health", "0104 chemical sciences", "RS1-441", "Pharmacy and materia medica", "Cancer treatment", "mesoporous silica nanoparticles", "0210 nano-technology", "Controlled drug delivery"]}, "links": [{"href": "http://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://doi.org/10.3390/pharmaceutics13040460"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Pharmaceutics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/pharmaceutics13040460", "name": "item", "description": "10.3390/pharmaceutics13040460", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/pharmaceutics13040460"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-03-28T00:00:00Z"}}, {"id": "10.5281/zenodo.4655380", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-07-25T16:23:28Z", "type": "Journal Article", "created": "2021-03-29", "title": "pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers.", "description": "

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

", "keywords": ["Ruthenium-based anti-cancer drugs", "ruthenium-based anticancer drugs", "PH-responsive drug delivery", "Mesoporous silica nanoparticles", "pH-responsive drug delivery", "02 engineering and technology", "controlled drug delivery", "01 natural sciences", "Article", "cancer treatment", "ddc:", "3. Good health", "0104 chemical sciences", "RS1-441", "Pharmacy and materia medica", "Cancer treatment", "mesoporous silica nanoparticles", "0210 nano-technology", "Controlled drug delivery"]}, "links": [{"href": "http://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://doi.org/10.5281/zenodo.4655380"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Pharmaceutics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.5281/zenodo.4655380", "name": "item", "description": "10.5281/zenodo.4655380", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.5281/zenodo.4655380"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-03-28T00:00:00Z"}}, {"id": "10044/1/97038", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:35Z", "type": "Journal Article", "created": "2022-04-01", "title": "Terahertz Metastructures for Noninvasive Biomedical Sensing and Characterization in Future Health Care [Bioelectromagnetics]", "description": "According to a recent report [1] from the Cancer Research Agency of the World Health Organization, cancer is a dominant cause of mortality worldwide, leading to 10 million deaths in 2020 alone. Diagnosing a patient from the early stages tremendously raises the chance of survival. Current clinical cancer detection approaches including X-ray, magnetic resonance imaging (MRI), and biomarker analysis not only fail to provide a precise border of the malignant tissue, especially in the early stages of cancer, but also can be invasive and lead to tissue damage. Recent progress in EM biosensor technologies has the potential to deliver a point-of-care diagnosis and surpass conventional methods regarding accuracy, time, and cost.", "keywords": ["Technology", "Organizations", "Science & Technology", "Sensors", "Tissue damage", "610", "Engineering", " Electrical & Electronic", "02 engineering and technology", "Cancer detection", "Costs", "Point of care", "ARRAYS", "3. Good health", "0906 Electrical and Electronic Engineering", "Engineering", "Magnetic resonance imaging", "CELLS", "Telecommunications", "PLASMONS", "1005 Communications Technologies", "0202 electrical engineering", " electronic engineering", " information engineering", "Electrical & Electronic", "Networking & Telecommunications"]}, "links": [{"href": "https://eprints.gla.ac.uk/263337/1/263337.pdf"}, {"href": "http://xplorestaging.ieee.org/ielx7/74/9747968/09748039.pdf?arnumber=9748039"}, {"href": "https://doi.org/10044/1/97038"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Antennas%20and%20Propagation%20Magazine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10044/1/97038", "name": "item", "description": "10044/1/97038", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10044/1/97038"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-04-01T00:00:00Z"}}, {"id": "20.500.12511/12365", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:25:32Z", "type": "Journal Article", "created": "2023-04-21", "title": "Impact of adding pertuzumab to trastuzumab plus chemotherapy in neoadjuvant treatment of HER2 positive breast cancer patients: a multicenter real-life HER2PATH study", "description": "To investigate the pathological complete response (pCR) achieved after neoadjuvant therapy with versus without adding pertuzumab (P) to trastuzumab (H) plus neoadjuvant chemotherapy (NCT) in HER2+ breast cancer (BC) patients in a real-life setting.A total of 1528 female HER2+ BC patients who received NCT plus H with or without P were included in this retrospective real-life study. Primary endpoint was pCR rate (ypT0/Tis ypN0). Clinicopathological characteristics, event-free survival (EFS) time, and relapse rates were evaluated with respect to HER2 blockade (NCT-H vs. NCT-HP) and pCR.Overall, 62.2% of patients received NCT-H and 37.8% received NCT-HP. NCT-HP was associated with a significantly higher pCR rate (66.4 vs. 56.8%, p\u2009<\u20090.001) and lower relapse (4.5 vs. 12.2%, p\u2009<\u20090.001) in comparison to NCT-H. Patients with pCR had a significantly lower relapse (5.6 vs. 14.9%, p\u2009<\u20090.001) and longer EFS time (mean(SE) 111.2(1.9) vs. 93.9(2.7) months, p\u2009<\u20090.001) compared to patients with non-pCR. Patients in the NCT-HP group were more likely to receive docetaxel (75.0 vs. 40.6%, p\u2009<\u20090.001), while those with pCR were more likely to receive paclitaxel (50.2 vs. 40.7%, p\u2009<\u20090.001) and NCT-HP (41.5 vs. 32.1%, p\u2009<\u20090.001). Hormone receptor status and breast conservation rates were similar in NCT-HP vs. NCT-H groups and in patients with vs. without pCR. Invasive ductal carcinoma (OR, 2.669, 95% CI 1.596 to 4.464, p\u2009<\u20090.001), lower histological grade of the tumor (OR, 4.052, 95% CI 2.446 to 6.713, p\u2009<\u20090.001 for grade 2 and OR, 3.496, 95% CI 2.020 to 6.053, p\u2009<\u20090.001 for grade 3), lower T stage (OR, 1.959, 95% CI 1.411 to 2.720, p\u2009<\u20090.001) and paclitaxel (vs. docetaxel, OR, 1.571, 95% CI 1.127 to 2.190, p\u2009=\u20090.008) significantly predicted the pCR.This real-life study indicates that adding P to NCT-H enables higher pCR than NCT-H in HER2+ BC, while pCR was associated with lower relapse and better EFS time.", "keywords": ["neoadjuvant treatment", "Pathological Complete Response", "Efficacy", "Paclitaxel", "Receptor", " ErbB-2", "HER2 protein positive", "Breast Neoplasms", "event-free survival", "Docetaxel", "Neosphere", "breast cancer", "pertuzumab", "Breast Cancer", "Antineoplastic Combined Chemotherapy Protocols", "Humans", "Relapse", "Neoadjuvant Treatment", "Retrospective Studies", "relapse", "Pertuzumab", "real-word evidence", "HER2 Protein Positive", "Cardiac Safety", "Controlled Superiority Trial", "Real-Wordevidence", "Trastuzumab", "Adjuvant Trastuzumab", "Her2 Protein Positive", "Neoadjuvant Therapy", "3. Good health", "trastuzumab", "Event-Freesurvival", "Female", "Real-Word Evidence", "Open-Label", "Neoplasm Recurrence", " Local", "Event-Free Survival", "Regimens"]}, "links": [{"href": "https://doi.org/20.500.12511/12365"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Acta%20Oncologica", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "20.500.12511/12365", "name": "item", "description": "20.500.12511/12365", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/20.500.12511/12365"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-04-03T00:00:00Z"}}, {"id": "21.15107/rcub_cer_4573", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-07-25T16:25:39Z", "type": "Dataset", "title": "Supplementary material to: \"Ph-responsive release of ruthenium metallotherapeutics from mesoporous silica-based nanocarriers\"", "description": "Open AccessPublished version of the article: [https://cer.ihtm.bg.ac.rs/handle/123456789/4572]", "keywords": ["Ruthenium-based anti-cancer drugs", "PH-responsive drug delivery", "Cancer treatment", "Mesoporous silica nanoparticles", "Controlled drug delivery"], "contacts": [{"organization": "Mladenovi\u0107, Minja, Morgan, Ibrahim, Ili\u0107, Neboj\u0161a, Saoud, Mohamad, Pergal, Marija, Kalu\u0111erovi\u0107, Goran N., Kne\u017eevi\u0107, Nikola \u017d.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/21.15107/rcub_cer_4573"}, {"rel": "self", "type": "application/geo+json", "title": "21.15107/rcub_cer_4573", "name": "item", "description": "21.15107/rcub_cer_4573", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/21.15107/rcub_cer_4573"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-01-01T00:00:00Z"}}, {"id": "2117/418477", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:25:40Z", "type": "Journal Article", "created": "2024-08-30", "title": "ONCOLINER: A new solution for monitoring, improving, and harmonizing somatic variant calling across genomic oncology centers", "description": "The characterization of somatic genomic variation associated with the biology of tumors is fundamental for cancer research and personalized medicine, as it guides the reliability and impact of cancer studies and genomic-based decisions in clinical oncology. However, the quality and scope of tumor genome analysis across cancer research centers and hospitals are currently highly heterogeneous, limiting the consistency of tumor diagnoses across hospitals and the possibilities of data sharing and data integration across studies. With the aim of providing users with actionable and personalized recommendations for the overall enhancement and harmonization of somatic variant identification across research and clinical environments, we have developed ONCOLINER. Using specifically designed mosaic and tumorized genomes for the analysis of recall and precision across somatic SNVs, insertions or deletions (indels), and structural variants (SVs), we demonstrate that ONCOLINER is capable of improving and harmonizing genome analysis across three state-of-the-art variant discovery pipelines in genomic oncology.", "keywords": ["330", "Bioinformatics", "Genome", " Human", "610", "Genomics", "Medical Oncology", "Somatic variant calling", "Polymorphism", " Single Nucleotide", "Article", "Benchmarking", "Oncology", "INDEL Mutation", "\u00c0rees tem\u00e0tiques de la UPC::Inform\u00e0tica::Aplicacions de la inform\u00e0tica::Bioinform\u00e0tica", "Neoplasms", "Cancer genomics", "Humans", "Benchmarking data", "Precision Medicine", "Software"]}, "links": [{"href": "https://doi.org/2117/418477"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cell%20Genomics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "2117/418477", "name": "item", "description": "2117/418477", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/2117/418477"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-09-01T00:00:00Z"}}, {"id": "3149801252", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:26:20Z", "type": "Journal Article", "created": "2021-03-29", "title": "pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers", "description": "

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

", "keywords": ["Ruthenium-based anti-cancer drugs", "ruthenium-based anticancer drugs", "PH-responsive drug delivery", "Mesoporous silica nanoparticles", "pH-responsive drug delivery", "02 engineering and technology", "controlled drug delivery", "01 natural sciences", "Article", "cancer treatment", "ddc:", "3. Good health", "0104 chemical sciences", "RS1-441", "Pharmacy and materia medica", "Cancer treatment", "mesoporous silica nanoparticles", "0210 nano-technology", "Controlled drug delivery"]}, "links": [{"href": "http://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://doi.org/3149801252"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Pharmaceutics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "3149801252", "name": "item", "description": "3149801252", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3149801252"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-03-28T00:00:00Z"}}, {"id": "3187469060", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-07-25T16:26:23Z", "type": "Report", "created": "2021-08-07", "title": "In vivo capture of bacterial cells by remote guiding", "description": "

Recently, it has been shown that several bacterial strains can be very efficient in cancer treatment since they possess many important properties such as self-targeting, ease of detection, sensing and toxicity against tumors. However, there are only a few relevant \uffe2\uff80\uff9ccandidates\uffe2\uff80\uff9d for such an approach, as targeting and detection one of the biggest challenges as well as there are many limitations in the use of genetic approaches. Here, it is proposed the solution that enables surface modification of alive bacterial cells without interfering with their genetic material and potentially reduces their toxic side effect. By the electrostatic interaction fluorescently labeled polyelectrolytes (PEs) and magnetite nanoparticles (NPs) were deposited on the bacterial cell surface to control the cell growth, distribution and detection of bacteria. According to the results obtained in vivo, by the magnet entrapment of the modified bacteria the local concentration of the cells was increased more than 5 times, keeping the high concentrations even when the magnet is removed. Since the PEs create a strong barrier, in vitro it was shown that the division time of the cells can be regulated for better immune presentation.

Raman spectroscopy offers label-free assessment of bladder tissue for in vivo and ex vivo intraoperative applications. In a retrospective study, control and cancer specimens were prepared from ten human bladder resectates. Raman microspectroscopic images were collected from whole tissue samples in a closed chamber at 785 nm laser excitation using a 20\u00d7 objective lens and 250 \u00b5m step size. Without further preprocessing, Raman images were decomposed by the hyperspectral unmixing algorithm vertex component analysis into endmember spectra and their abundancies. Hierarchical cluster analysis distinguished endmember Raman spectra that were assigned to normal bladder, bladder cancer, necrosis, epithelium and lipid inclusions. Interestingly, Raman spectra of microplastic particles, pigments or carotenoids were detected in 13 out of 20 specimens inside tissue and near tissue margins and their identity was confirmed by spectral library surveys. Hypotheses about the origin of these foreign materials are discussed. In conclusion, our Raman workflow and data processing protocol with minimal user interference offers advantages for future clinical translation such as intraoperative tumor detection and label-free material identification in complex matrices.

", "keywords": ["Raman spectroscopy; bladder cancer; hyperspectral unmixing; microplastic; pigment", "610", "Article", "3. Good health"]}, "links": [{"href": "http://www.mdpi.com/2072-6694/15/7/2162/pdf"}, {"href": "https://doi.org/PMC10093366"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cancers", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC10093366", "name": "item", "description": "PMC10093366", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC10093366"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-04-05T00:00:00Z"}}, {"id": "PMC11274377", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:28:07Z", "type": "Journal Article", "created": "2024-07-01", "title": "Biosensors for Cancer Biomarkers Based on Mesoporous Silica Nanoparticles", "description": "

Mesoporous silica nanoparticles (MSNs) exhibit highly beneficial characteristics for devising efficient biosensors for different analytes. Their unique properties, such as capabilities for stable covalent binding to recognition groups (e.g., antibodies or aptamers) and sensing surfaces, open a plethora of opportunities for biosensor construction. In addition, their structured porosity offers capabilities for entrapping signaling molecules (dyes or electroactive species), which could be released efficiently in response to a desired analyte for effective optical or electrochemical detection. This work offers an overview of recent research studies (in the last five years) that contain MSNs in their optical and electrochemical sensing platforms for the detection of cancer biomarkers, classified by cancer type. In addition, this study provides an overview of cancer biomarkers, as well as electrochemical and optical detection methods in general.

", "keywords": ["MSNs", "cancer biomarkers", "Review", "Biosensing Techniques", "Electrochemical Techniques", "02 engineering and technology", "biosensors", "optical detection", "Silicon Dioxide", "01 natural sciences", "3. Good health", "0104 chemical sciences", "Neoplasms", "electrochemical detection", "Biomarkers", " Tumor", "Nanoparticles", "Humans", "0210 nano-technology", "Porosity", "TP248.13-248.65", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/7/326/pdf"}, {"href": "https://doi.org/PMC11274377"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11274377", "name": "item", "description": "PMC11274377", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11274377"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-06-30T00:00:00Z"}}, {"id": "PMC5679399", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:28:10Z", "type": "Journal Article", "created": "2017-11-01", "title": "NDEx 2.0: A Clearinghouse for Research on Cancer Pathways", "description": "Abstract

We present NDEx 2.0, the latest release of the Network Data Exchange (NDEx) online data commons (www.ndexbio.org) and the ways in which it can be used to (i) improve the quality and abundance of biological networks relevant to the cancer research community; (ii) provide a medium for collaboration involving networks; and (iii) facilitate the review and dissemination of networks. We describe innovations addressing the challenges of an online data commons: scalability, data integration, data standardization, control of content and format by authors, and decentralized mechanisms for review. The practical use of NDEx is presented in the context of a novel strategy to foster network-oriented communities of interest in cancer research by adapting methods from academic publishing and social media. Cancer Res; 77(21); e58\uffe2\uff80\uff9361. \uffc2\uffa92017 AACR.There is an ongoing debate on the possible association between infections in early childhood and subsequent cancer risk, but it remains unclear if a hospital admission for infection is associated with risk of childhood cancer diagnosis. We examined if a hospital-based diagnosis of pneumonia was a clinical marker of the three most common childhood cancers.

Design

Population-based cohort study.

Setting

Denmark, hospital diagnoses, 1994\uffe2\uff80\uff932013.

Methods

Using national health registries, we compared the observed incidence of leukaemia, lymphoma and brain cancer among 83\uffe2\uff80\uff89935 children with a hospital-based pneumonia diagnosis with that expected among children in the general population. We calculated absolute cancer risks and standardised incidence ratios (SIRs) as a measure of relative risk.

Results

The cancer SIRs were substantially increased during the first 6 months of follow-up; lymphoid leukaemia: 6.2 (95% CI 3.5 to 10.3); myeloid leukaemia: 14.8 (95% CI 6.0 to 30.6); Hodgkin\uffe2\uff80\uff99s lymphoma: 60.8 (95% CI 26.2 to 120), non-Hodgkin\uffe2\uff80\uff99s lymphoma: 15.9 (95% CI 5.2 to 37.2) and brain cancer: 4.4 (95% CI 1.9 to 8.7). The 6-month absolute risks of leukaemia, lymphoma and brain cancer were all low, reaching 0.05% when combined. An increased risk persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the 5-year absolute cancer risk was 0.14%.

Conclusions

The short-term incidence of leukaemia, lymphoma and brain cancer was higher than expected and persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the absolute cancer risk was low.Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeutic development is the cancer's ability to develop resistance. It has been hypothesized that cancer stem cells are the cause for this resistance, and targeting them will lead to tumor regression. A pentaspan transmembrane glycoprotein, CD133 has been suggested to mark cancer stem cells in various tumor types, however, the accuracy of CD133 as a cancer stem cell biomarker has been highly controversial. There are numerous speculations for this, including differences in cell culture conditions, poor in vivo assays, and the inability of current antibodies to detect CD133 variants and deglycosylated epitopes. This review summarizes the most recent and relevant research regarding the controversies surrounding CD133 as a normal stem cell and cancer stem cell biomarker. Additionally, it aims to establish the overall clinical significance of CD133 in cancer. Recent clinical studies have shown that high expression of CD133 in tumors has been indicated as a prognostic marker of disease progression. As such, a spectrum of immunotherapeutic strategies have been developed to target these CD133pos cells with the goal of translation into the clinic. This review compiles the current therapeutic strategies targeting CD133 and discusses their prognostic potential in various cancer subtypes.

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

", "keywords": ["Ruthenium-based anti-cancer drugs", "ruthenium-based anticancer drugs", "PH-responsive drug delivery", "Mesoporous silica nanoparticles", "pH-responsive drug delivery", "02 engineering and technology", "controlled drug delivery", "01 natural sciences", "Article", "cancer treatment", "ddc:", "0104 chemical sciences", "3. Good health", "RS1-441", "Pharmacy and materia medica", "Cancer treatment", "mesoporous silica nanoparticles", "0210 nano-technology", "Controlled drug delivery"]}, "links": [{"href": "http://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://www.mdpi.com/1999-4923/13/4/460/pdf"}, {"href": "https://doi.org/PMC8067187"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Pharmaceutics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC8067187", "name": "item", "description": "PMC8067187", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC8067187"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-03-28T00:00:00Z"}}, {"id": "PMC9845715", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:28:15Z", "type": "Journal Article", "created": "2023-01-04", "title": "Modification of bacterial cells for in vivo remotely guided systems", "description": "

It was shown recently that bacterial strains, which can act specifically against malignant cells, can be used efficiently in cancer therapy. Many appropriate bacterial strains are either pathogenic or invasive and there is a substantial shortage of methods with which to monitor in vivo the distribution of bacteria used in this way. Here, it is proposed to use a Layer-by-Layer (LbL) approach that can encapsulate individual bacterial cells with fluorescently labeled polyelectrolytes (PE)s and magnetite nanoparticles (NP)s. The NP enable remote direction in vivo to the site in question and the labeled shells in the far-red emission spectra allow non-invasive monitoring of the distribution of bacteria in the body. The magnetic entrapment of the modified bacteria causes the local concentration of the bacteria to increase by a factor of at least 5. The PEs create a strong barrier, and it has been shown in vitro experiments that the division time of bacterial cells coated in this way can be regulated, resulting in control of their invasion into tissues. That animals used in the study survived and did not suffer septic shock, which can be attributed to PE capsules that prevent release of endotoxins from bacterial cells.