{"type": "FeatureCollection", "features": [{"id": "10.1007/s00018-021-04080-6", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-23T16:14:20Z", "type": "Journal Article", "created": "2022-01-19", "title": "Outlook on next\u2010generation probiotics from the human gut", "description": "Probiotics currently available on the market generally belong to a narrow range of microbial species. However, recent studies about the importance of the gut microbial commensals on human health highlighted that the gut microbiome is an unexplored reservoir of potentially beneficial microbes. For this reason, academic and industrial research is focused on identifying and testing novel microbial strains of gut origin for the development of next-generation probiotics. Although several of these are promising for the prevention and treatment of many chronic diseases, studies on human subjects are still scarce and approval from regulatory agencies is, therefore, rare. In addition, some issues need to be overcome before implementing their wide application on the market, such as the best methods for cultivation and storage of these oxygen-sensitive taxa. This review summarizes the most recent evidence related to NGPs and provides an outlook to the main issues that still limit their wide employment.", "keywords": ["0301 basic medicine", "Gut microbiome", "Clostridiales", "0303 health sciences", "Bacteria", "Faecalibacterium prausnitzii", "Probiotics", "Next-generation probiotics", "Prevotella", "Akkermansia", "Bacterial Physiological Phenomena", "Gastrointestinal Microbiome", "3. Good health", "03 medical and health sciences", "Akkermansia muciniphila; Faecalibacterium prausnitzii; Gut microbiome; Live biotherapeutics; Next-generation probiotics; Prevotella copri", "Live biotherapeutics", "Dysbiosis", "Humans", "Prevotella copri", "Akkermansia muciniphila"], "contacts": [{"organization": "De Filippis F., Esposito A., Ercolini D.,", "roles": ["creator"]}]}, "links": [{"href": "https://www.iris.unina.it/bitstream/11588/868940/2/CMLS%2c2022_NGP.pdf"}, {"href": "https://link.springer.com/content/pdf/10.1007/s00018-021-04080-6.pdf"}, {"href": "https://doi.org/10.1007/s00018-021-04080-6"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Cellular%20and%20Molecular%20Life%20Sciences", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s00018-021-04080-6", "name": "item", "description": "10.1007/s00018-021-04080-6", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s00018-021-04080-6"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-01-19T00:00:00Z"}}, {"id": "10.1186/s12916-021-01913-w", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-23T16:19:10Z", "type": "Journal Article", "created": "2021-02-11", "title": "High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome", "description": "Abstract Background

Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.

Methods

Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts.

Results

Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q\uffe2\uff80\uff89<\uffe2\uff80\uff890.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet.

Conclusion

A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella.

Trial registration

The ClinicalTrials.gov registration identifier is NCT03479866.

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