{"type": "FeatureCollection", "features": [{"id": "10.1007/s40265-021-01505-1", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-21T16:15:03Z", "type": "Journal Article", "created": "2021-04-30", "title": "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review", "description": "Soil-transmitted helminths (Ascaris lumbricoides, hookworm and Trichuris trichiura) infect about one-fifth of the world's population. The currently available drugs are all highly efficacious against A. lumbricoides. However, they are only moderately efficacious against hookworm and poorly efficacious against T. trichiura. Oxantel, a tetrahydropyrimidine derivative discovered in the 1970s, has recently been brought back to our attention given its high efficacy against T. trichiura infections (estimated 76% cure rate and 85% egg reduction rate at a 20 mg/kg dose). This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. Oxantel pamoate acts locally in the human gastrointestinal tract and binds to the parasite's nicotinic acetylcholine receptor (nAChR), leading to a spastic paralysis of the worm and subsequent expulsion. The drug is metabolically stable, shows low permeability and low systemic bioavailability after oral use. Oxantel pamoate was found to be safe in humans, with only a few mild adverse events reported. Several clinical trials have investigated the efficacy of this drug against T. trichiura\u00a0and suggest that oxantel pamoate is more efficacious against T. trichiura than the currently recommended drugs, which makes it a strong asset to the depleted drug armamentarium and could help delay or even prevent the development of resistance to existing drugs. We highlight existing data to support the use of oxantel pamoate against T. trichiura infections.", "keywords": ["Hookworm Infections", "03 medical and health sciences", "Trichuris", "0302 clinical medicine", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Pyrantel Pamoate", "Animals", "Humans", "Drug Interactions", "Review Article", "3. Good health"]}, "links": [{"href": "https://link.springer.com/content/pdf/10.1007/s40265-021-01505-1.pdf"}, {"href": "https://doi.org/10.1007/s40265-021-01505-1"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Drugs", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s40265-021-01505-1", "name": "item", "description": "10.1007/s40265-021-01505-1", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s40265-021-01505-1"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-04-30T00:00:00Z"}}, {"id": "10.1007/s11356-013-2321-6", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-21T16:14:57Z", "type": "Journal Article", "created": "2013-12-02", "title": "Interactive Effects Of Different Inorganic As And Se Species On Their Uptake And Translocation By Rice (Oryza Sativa L.) Seedlings", "description": "There is a lack of information on the interactive relationship of absorption and transformation between two inorganic arsenic (As) species and two inorganic selenium (Se) species in rice grown under hydroponic condition. Interactive effects of inorganic As (As(III)) and (As(V)) and Se (Se(IV)and Se(VI)) species on their uptake, accumulation, and translocation in rice (Oryza sativa L.) seedlings were investigated in hydroponic culture. The results clearly showed the interactive effects of inorganic As and Se on their uptake by rice. The presence of Se reduced the sum of As species in the rice shoots regardless of Se speciation. If Se is present as Se(IV), then is it is accompanied by a corresponding increase of the sum of As species, but if Se is present as Se(VI), then there is no change in the sum of As species in rice roots. These effects are observed regardless of initial As speciation. When the rice plants are exposed to Se(IV), the presence of As increases the sum of Se species in the roots, and decreases the sum of Se species in the corresponding shoots. This effect is more pronounced for As(III) than for As(V). There is no effect on Se during exposure to Se(VI). Co-existence of As also increased SeMet in rice roots.", "keywords": ["0106 biological sciences", "Oryza", "04 agricultural and veterinary sciences", "Plant Roots", "01 natural sciences", "Arsenic", "Selenium", "Hydroponics", "Seedlings", "13. Climate action", "0401 agriculture", " forestry", " and fisheries", "Drug Interactions", "Environmental Pollutants", "Plant Shoots"], "contacts": [{"organization": "Yi-Zong Huang, Gui-Lan Duan, Yunxia Liu, Ying Hu, Guo-Xin Sun,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1007/s11356-013-2321-6"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Environmental%20Science%20and%20Pollution%20Research", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s11356-013-2321-6", "name": "item", "description": "10.1007/s11356-013-2321-6", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s11356-013-2321-6"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2013-12-03T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Drug+Interactions&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Drug+Interactions&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Drug+Interactions&", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Drug+Interactions&offset=2", "hreflang": "en-US"}], "numberMatched": 2, "numberReturned": 2, "distributedFeatures": [], "timeStamp": "2026-09-22T09:51:32.814522Z"}