{"type": "FeatureCollection", "features": [{"id": "10.1016/j.jhazmat.2020.122438", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-09-22T16:16:14Z", "type": "Journal Article", "created": "2020-03-02", "title": "Degradation and transformation on nitrated nonylphenol isomers in activated sludge under nitrifying and heterotrophic conditions", "description": "Nitrated nonylphenols (2-nitro-nonylphenols, NNPs) are metabolites of the endocrine-disrupter nonylphenols (NPs). While they have been detected in the environment, their fate in activated sludge has yet to be determined. In this study, we used synthesized NNP isomers and a 14C-tracer technique to study the degradation and transformation of four NNP isomers (NNP111, NNP112, NNP38, and NNP65) in nitrifying activated sludge (NAS) and heterotrophic bacteria-enhanced activated sludge (HAS). Our results showed that the degradation of NNPs in both NAS and HAS was isomer-specific. The half-lives of the NNPs decreased in the order: NNP111 > NNP112 > NNP38 > NNP65. After 36 days of incubation, 9.48 % and 4.01 % of the 14C-NNP111 was mineralized in NAS and HAS, respectively. In addition to mineralization, five metabolites of NNPs containing hydroxyl, carbonyl, and carboxyl substituents on the alkyl chains were formed in NAS but not in HAS. The transformation of NNPs differed in NAS and HAS, mainly due to the differences in their microbial communities and the activities thereof in NAS and HAS. This is the first study of the isomer-specific fate of NNP isomers in activated sludge. Future studies should assess the toxicity, stability and potential risks of NNP metabolites in the environment.", "keywords": ["Biodegradation", " Environmental", "Isomerism", "Phenols", "Sewage", "11. Sustainability", "0211 other engineering and technologies", "02 engineering and technology", "Endocrine Disruptors", "Nitrification", "01 natural sciences", "Water Pollutants", " Chemical", "6. 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Initially, a set of 45 PFAS was tested using TTR-TR\u03b2-CALUX bioassay, which was subsequently employed to develop a classification model, distinguishing active and inactive PFAS. The model fulfills all good practices for QSAR model validation and can predict whether a given PFAS can disrupt plasma transport of the thyroid hormone (T4). Subsequently, active compounds were used to develop two regression approaches: (i) multiple linear regression MLR, and (ii) second approach aimed at identifying multiple valid QSAR models based on different data-splitting strategies. Finally, a comprehensive virtual screening of a large PFAS dataset was conducted to assess their potency in disrupting thyroid hormone transport. The predictions indicated that more than 7500 compounds were active with over 100 PFAS potentially causing even greater adverse effects than PFOA. These findings highlight the critical role of integrating New Approach Methodologies (NAM)-based in vitro toxicity testing with multifaceted molecular modeling in assessing the risks associated with PFAS contamination in environmental matrices.", "keywords": ["Fluorocarbons", "Thyroid Hormones", "PFAS CALUX", "PFAS", "H2020", "Quantitative Structure-Activity Relationship", "Humans", "Computer Simulation", "Biological Transport", "Environmental Pollutants", "Endocrine Disruptors", "PROMISCES"]}, "links": [{"href": "https://doi.org/10.1016/j.jhazmat.2025.137949"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Hazardous%20Materials", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.jhazmat.2025.137949", "name": "item", "description": "10.1016/j.jhazmat.2025.137949", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.jhazmat.2025.137949"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-07-01T00:00:00Z"}}, {"id": "39694292", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-09-22T16:23:19Z", "type": "Journal Article", "created": "2024-12-20", "title": "PFAS (per- and polyfluorinated alkyl substances) as EDCs (endocrine-disrupting chemicals) - Identification of compounds with high potential to bind to selected terpenoids NHRs (nuclear hormone receptors)", "description": "The file contains a publication entitled \u2018PFAS (per- and polyfluorinated alkyl substances) as EDCs (endocrine-disrupting chemicals) - Identification of compounds with high potential to bind to selected terpenoids NHRs (nuclear hormone receptors)\u2019 by Natalia Bulawska, Anita Sosnowska, Dominika Kowalska, Maciej St\u0119pnik, Tomasz Puzyn with Supplementary Materials.", "keywords": ["Molecular Docking Simulation", "Fluorocarbons", "Hydrocarbons", " Fluorinated", "Quantitative Structure-Activity Relationship", "Receptors", " Cytoplasmic and Nuclear", "Humans", "Endocrine Disruptors"]}, "links": [{"href": "https://doi.org/39694292"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Chemosphere", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "39694292", "name": "item", "description": "39694292", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/39694292"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-02-01T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Endocrine+Disruptors&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Endocrine+Disruptors&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Endocrine+Disruptors&", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Endocrine+Disruptors&offset=3", "hreflang": "en-US"}], "numberMatched": 3, "numberReturned": 3, "distributedFeatures": [], "timeStamp": "2026-09-22T20:50:14.737011Z"}