{"type": "FeatureCollection", "features": [{"id": "2965037", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:28:19Z", "type": "Journal Article", "created": "2002-12-28", "title": "Suppressive characteristics of the cultured umbilical cord blood lymphocytes: Enhanced suppression of non specific MLR by short term cultured peripheral blood and rosetted lymphocytes", "description": "We have used the mixed leukocyte reaction assay (MLR) to compare the non-specific suppressor activity of fresh and short-term cultured peripheral blood rosetted lymphocytes from human umbilical cord blood. To a one way MLR between adult responders and irradiated adult stimulator cells, we added adult or cord blood mononuclear cells. Cord-blood derived mononuclear cells were more potent suppressors of the MLR than the adult peripheral blood mononuclear cells. When the fresh cord blood T cell fraction was separated from non-T cells by rosetting, the frequency and capacity of suppression fell, suggesting a role of non-T cells in this phenomenon. However, short-term culture (up to nine days) of cord blood derived T cells in the absence of mitogen resulted in a significant increase in their suppressive characteristics. Maternal cells were not used in any of these assays and the suppression was non specific. There was no HLA restriction to the response. The cord blood lymphocytes responded poorly to alloantigen when compared to the adult lymphocytes. In addition, there was a correlation between the allogeneic proliferative response and the suppressive capacity of the cord blood cells. Such a correlation was not found with the adult peripheral blood lymphocytes.", "keywords": ["Adult", "0301 basic medicine", "Rosette Formation", "Infant", " Newborn", "In Vitro Techniques", "Fetal Blood", "Lymphocyte Activation", "T-Lymphocytes", " Regulatory", "Kinetics", "03 medical and health sciences", "0302 clinical medicine", "Humans", "Lymphocyte Culture Test", " Mixed", "Cells", " Cultured"], "contacts": [{"organization": "L M, Noh, M M, Khan, K L, Melmon,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/2965037"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Developmental%20%26amp%3B%20Comparative%20Immunology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "2965037", "name": "item", "description": "2965037", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/2965037"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1988-01-01T00:00:00Z"}}, {"id": "PMC5857245", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:31:03Z", "type": "Journal Article", "created": "2018-01-31", "title": "The association between early-life relative telomere length and childhood neurodevelopment", "description": "To examine the association between telomere length and neurodevelopment in children.We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates.Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (\u03b2\u202f=\u202f4.01; 95% confidence interval (CI)\u202f=\u202f0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (\u03b2\u202f=\u202f2.88; CI\u202f=\u202f1.21-4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (\u03b2\u202f=\u202f2.83; CI\u202f=\u202f0.69, 4.97); the psychomotor developmental index did not (\u03b2\u202f=\u202f3.62; CI\u202f=\u202f-1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL.Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.", "keywords": ["Male", "0301 basic medicine", "0303 health sciences", "Infant", " Newborn", "Infant", "Telomere Homeostasis", "Neuropsychological Tests", "Telomere", "Fetal Blood", "03 medical and health sciences", "Child Development", "Child", " Preschool", "Humans", "Female"]}, "links": [{"href": "https://doi.org/PMC5857245"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/NeuroToxicology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC5857245", "name": "item", "description": "PMC5857245", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC5857245"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-03-01T00:00:00Z"}}, {"id": "chen,2012", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:32:52Z", "type": "Journal Article", "created": "2016-12-24", "description": "Using a combined special glass electrode it is possible to monitor pH ratios and pH variation in the subcutaneous tissue of the infant scalp continuously. Tests on a normal sample of newborn babies immediately after birth showed a significant correlation between tissue pH and capillary blood pH, with the trend of pH variation being broadly similar in both measurement media.", "keywords": ["03 medical and health sciences", "Scalp", "0302 clinical medicine", "Infant", " Newborn", "Humans", "Glass", "Hydrogen-Ion Concentration", "Fetal Blood", "Electrodes", "Monitoring", " Physiologic"], "contacts": [{"organization": "Urs Latscha, Otto Stamm, Aldo Campana, Paul Janecek,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/chen,2012"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Obstetrics%20and%20Gynecology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "chen,2012", "name": "item", "description": "chen,2012", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/chen,2012"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "chen,y.,2012", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:32:52Z", "type": "Journal Article", "created": "2016-12-24", "description": "Using a combined special glass electrode it is possible to monitor pH ratios and pH variation in the subcutaneous tissue of the infant scalp continuously. 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Tests on a normal sample of newborn babies immediately after birth showed a significant correlation between tissue pH and capillary blood pH, with the trend of pH variation being broadly similar in both measurement media.", "keywords": ["03 medical and health sciences", "Scalp", "0302 clinical medicine", "Infant", " Newborn", "Humans", "Glass", "Hydrogen-Ion Concentration", "Fetal Blood", "Electrodes", "Monitoring", " Physiologic"], "contacts": [{"organization": "Urs Latscha, Otto Stamm, Aldo Campana, Paul Janecek,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/e,2012"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Obstetrics%20and%20Gynecology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "e,2012", "name": "item", "description": "e,2012", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/e,2012"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "evans,2012", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:24Z", "type": "Journal Article", "created": "2016-12-24", "description": "Using a combined special glass electrode it is possible to monitor pH ratios and pH variation in the subcutaneous tissue of the infant scalp continuously. 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