{"type": "FeatureCollection", "features": [{"id": "10.1002/cbic.202000051", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:14:06Z", "type": "Journal Article", "created": "2020-01-31", "title": "An Engineered E.\u2005coli Strain for Direct in Vivo Fluorination", "description": "Abstract<p>Selectively fluorinated compounds are found frequently in pharmaceutical and agrochemical products where currently 25\uffe2\uff80\uff9330\uffe2\uff80\uff89% of optimised compounds emerge from development containing at least one fluorine atom. There are many methods for the site\uffe2\uff80\uff90specific introduction of fluorine, but all are chemical and they often use environmentally challenging reagents. Biochemical processes for C\uffe2\uff88\uff92F bond formation are attractive, but they are extremely rare. In this work, the fluorinase enzyme, originally identified from the actinomycete bacterium Streptomyces cattleya, is engineered into Escherichia coli in such a manner that the organism is able to produce 5\uffe2\uff80\uffb2\uffe2\uff80\uff90fluorodeoxyadenosine (5\uffe2\uff80\uffb2\uffe2\uff80\uff90FDA) from S\uffe2\uff80\uff90adenosyl\uffe2\uff80\uff90l\uffe2\uff80\uff90methionine (SAM) and fluoride in live E.\uffe2\uff80\uff85coli cells. Success required the introduction of a SAM transporter and deletion of the endogenous fluoride efflux capacity in order to generate an E.\uffe2\uff80\uff85coli host that has the potential for future engineering of more elaborate fluorometabolites.</p>", "keywords": ["SAM transporters", "0301 basic medicine", "570", "S-Adenosylmethionine", "0303 health sciences", "Deoxyadenosines", "Halogenation", "DAS", "Fluorine", "Halogenations", "540", "QD Chemistry", "Streptomyces", "3. Good health", "03 medical and health sciences", "Bacterial Proteins", "Isomerism", "Escherichia coli", "QD", "Fluoride channels", "Genetic Engineering", "Oxidoreductases", "Fluorinases"]}, "links": [{"href": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202000051"}, {"href": "https://doi.org/10.1002/cbic.202000051"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ChemBioChem", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1002/cbic.202000051", "name": "item", "description": "10.1002/cbic.202000051", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1002/cbic.202000051"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-03-03T00:00:00Z"}}, {"id": "10.1016/j.scitotenv.2024.172589", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:17:10Z", "type": "Journal Article", "created": "2024-04-22", "title": "Determination of organic fluorinated compounds content in complex samples through combustion ion chromatography methods: a way to define a \u201cTotal Per- and Polyfluoroalkyl Substances (PFAS)\u201d parameter?", "description": "Emerging contaminants are a growing concern for scientists and public authorities. The group of per-polyfluoroalkyl substances (PFAS), known as 'forever chemicals', in complex environmental liquid and solid matrices was analysed in this study. The development of global analytical methods based on combustion ion chromatography (CIC) is expected to provide accurate picture of the overall PFAS contamination level via the determination of extractable organic fluorine (EOF) and adsorbable organic fluorine (AOF). The obtained results may be put into perspective with other methods such as targeted analyses (LC-MS/MS). The impact of pH, the presence of dissolved organic carbon and suspended particles on AOF measurements were explored. The effectiveness of the washing step to remove adsorbed inorganic fluorine (IF) has been proven for samples containing up to 8 mgF.L-1. CIC-based methods showed good repeatability and reproducibility for the complex matrices studied. Environmental applications of these methods have been tested. AOF and EOF analyses could explain between 1\u00a0% and 23\u00a0% and 0.1\u00a0% to 2\u00a0% of total organic fluorine (TOF), respectively. The sum of PFAS compounds expressed as fluorine could explain from 0.2\u00a0% to 11\u00a0% and from 0.003\u00a0% to 5\u00a0% for AOF and EOF, respectively. These results also suggest that some fluorinated compounds are not adsorbed or extractable and/or lost by volatilisation during the application of AOF and EOF analytical procedure. These findings highlight that AOF and EOF are not entirely efficient as proxy to assess 'total PFAS' for assessing environmental contamination by PFAS. However, these methods could still be applied to gain a better understanding of the sources and fate of PFAS in the environment.", "keywords": ["Combustion ion chromatography", "13. Climate action", "Organic fluorine", "chemical analysis", "PFAS", "[SDU.STU] Sciences of the Universe [physics]/Earth Sciences", "H2020", "Environment", "PROMISCES", "Analysis"]}, "links": [{"href": "https://doi.org/10.1016/j.scitotenv.2024.172589"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Science%20of%20The%20Total%20Environment", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.scitotenv.2024.172589", "name": "item", "description": "10.1016/j.scitotenv.2024.172589", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.scitotenv.2024.172589"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-07-01T00:00:00Z"}}, {"id": "10.1056/nejm199703063361004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:18:30Z", "type": "Journal Article", "created": "2002-07-27", "title": "Sympathetic Cardioneuropathy in Dysautonomias", "description": "The classification of dysautonomias has been confusing, and the pathophysiology obscure. We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and assessments of the entry rate of the sympathetic neurotransmitter norepinephrine into the cardiac venous drainage (cardiac norepinephrine spillover). We related the laboratory findings to signs of sympathetic neurocirculatory failure (orthostatic hypotension and abnormal blood-pressure responses associated with the Valsalva maneuver), central neural degeneration, and responsiveness to treatment with levodopa-carbidopa (Sinemet).Cardiac scans were obtained after intravenous administration of 6-[18F]fluorodopamine in 26 patients with dysautonomia. Fourteen had sympathetic neurocirculatory failure--three with no signs of central neurodegeneration (pure autonomic failure), two with parkinsonism responsive to treatment with levodopa-carbidopa, and nine with central neurodegeneration unresponsive to treatment with levodopa-carbidopa (the Shy-Drager syndrome). The rates of cardiac norepinephrine spillover were estimated on the basis of concentrations of intravenously infused [3H]norepinephrine during catheterization of the right side of the heart.Patients with pure autonomic failure or parkinsonism and sympathetic neurocirculatory failure had no myocardial 6-[18F]fluorodopamine-derived radioactivity or cardiac norepinephrine spillover, indicating loss of myocardial sympathetic-nerve terminals, whereas patients with the Shy-Drager syndrome had increased levels of 6-[18F]fluorodopamine-derived radioactivity, indicating intact sympathetic terminals and absent nerve traffic. Patients with dysautonomia who did not have sympathetic neurocirculatory failure had normal levels of 6-[18F]fluorodopamine-derived radioactivity in myocardium and normal rates of cardiac norepinephrine spillover.The results of 6-[18F]fluorodopamine positron-emission tomography and neurochemical analyses support a new clinical pathophysiologic classification of dysautonomias, based on the occurrence of sympathetic neurocirculatory failure, signs of central neurodegeneration, and responsiveness to levodopa-carbidopa.", "keywords": ["Adult", "Aged", " 80 and over", "Fluorine Radioisotopes", "Nitrogen Radioisotopes", "Sympathetic Nervous System", "Epinephrine", "Dopamine", "Myocardium", "Shy-Drager Syndrome", "Heart", "Parkinson Disease", "Middle Aged", "3. Good health", "Diagnosis", " Differential", "Levodopa", "Norepinephrine", "Autonomic Nervous System Diseases", "Ammonia", "Parasympathetic Nervous System", "Reference Values", "Coronary Circulation", "Humans", "Aged", "Tomography", " Emission-Computed"], "contacts": [{"organization": "Graeme Eisenhofer, Richard O. Cannon, Irwin J. Kopin, Courtney Holmes, David S. Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1056/nejm199703063361004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1056/nejm199703063361004", "name": "item", "description": "10.1056/nejm199703063361004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1056/nejm199703063361004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1997-01-01T00:00:00Z"}}, {"id": "10.17169/refubium-47723", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:20:38Z", "type": "Journal Article", "created": "2025-06-13", "title": "Effect of Hydrophobic Cross-Linkers in Strong Base Gel-Type Resins on the Adsorption Kinetics and Capacity for Perfluoroalkyl Substances", "description": "The persistence and water mobility of per- and polyfluoroalkyl substances (PFAS) have led authorities worldwide to lower regulatory limits to prevent adverse health effects. Removal via adsorption on activated carbon can be inefficient due to the unspecific surface interaction, while ion exchange resins with positive charges and hydrophobic chains can offer faster kinetics and improved removal. In here, novel cationic resins were synthesized by cross-linking polyethylenimine, followed by methylation. To obtain cross-linked particles and introduce hydrophobic interacting moieties in one single synthetic step, aliphatic, fluorous, and silicone-based oligoethers were used as cross-linkers. These cationic adsorbents were compared with two state-of-the-art strong base gel-type ion exchange resins and granular activated carbon in isotherm and kinetic studies. The newly developed adsorbents showed significantly faster removals of all tested long- and short-chain PFAS. The fluorous cationic adsorbent achieved equilibrium loadings that were comparable to those of the state-of-the-art adsorbents for all PFAS with five or more perfluorinated carbon atoms.", "keywords": ["siloxane", "Chemie und zugeordnete Wissenschaften", "fluorine\u2212fluorine interactions", "water treatment", "540", "PFAS adsorption", "Article", "ion exchange resins", "polyethylenimine"]}, "links": [{"href": "https://doi.org/10.17169/refubium-47723"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ACS%20ES%26amp%3BT%20Water", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.17169/refubium-47723", "name": "item", "description": "10.17169/refubium-47723", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.17169/refubium-47723"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-06-13T00:00:00Z"}}, {"id": "1985394658", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:26:41Z", "type": "Journal Article", "created": "2002-07-27", "title": "Sympathetic Cardioneuropathy in Dysautonomias", "description": "The classification of dysautonomias has been confusing, and the pathophysiology obscure. We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and assessments of the entry rate of the sympathetic neurotransmitter norepinephrine into the cardiac venous drainage (cardiac norepinephrine spillover). We related the laboratory findings to signs of sympathetic neurocirculatory failure (orthostatic hypotension and abnormal blood-pressure responses associated with the Valsalva maneuver), central neural degeneration, and responsiveness to treatment with levodopa-carbidopa (Sinemet).Cardiac scans were obtained after intravenous administration of 6-[18F]fluorodopamine in 26 patients with dysautonomia. Fourteen had sympathetic neurocirculatory failure--three with no signs of central neurodegeneration (pure autonomic failure), two with parkinsonism responsive to treatment with levodopa-carbidopa, and nine with central neurodegeneration unresponsive to treatment with levodopa-carbidopa (the Shy-Drager syndrome). The rates of cardiac norepinephrine spillover were estimated on the basis of concentrations of intravenously infused [3H]norepinephrine during catheterization of the right side of the heart.Patients with pure autonomic failure or parkinsonism and sympathetic neurocirculatory failure had no myocardial 6-[18F]fluorodopamine-derived radioactivity or cardiac norepinephrine spillover, indicating loss of myocardial sympathetic-nerve terminals, whereas patients with the Shy-Drager syndrome had increased levels of 6-[18F]fluorodopamine-derived radioactivity, indicating intact sympathetic terminals and absent nerve traffic. Patients with dysautonomia who did not have sympathetic neurocirculatory failure had normal levels of 6-[18F]fluorodopamine-derived radioactivity in myocardium and normal rates of cardiac norepinephrine spillover.The results of 6-[18F]fluorodopamine positron-emission tomography and neurochemical analyses support a new clinical pathophysiologic classification of dysautonomias, based on the occurrence of sympathetic neurocirculatory failure, signs of central neurodegeneration, and responsiveness to levodopa-carbidopa.", "keywords": ["Adult", "Aged", " 80 and over", "Fluorine Radioisotopes", "Nitrogen Radioisotopes", "Sympathetic Nervous System", "Epinephrine", "Dopamine", "Myocardium", "Shy-Drager Syndrome", "Heart", "Parkinson Disease", "Middle Aged", "3. Good health", "Diagnosis", " Differential", "Levodopa", "Norepinephrine", "Autonomic Nervous System Diseases", "Ammonia", "Parasympathetic Nervous System", "Reference Values", "Coronary Circulation", "Humans", "Aged", "Tomography", " Emission-Computed"], "contacts": [{"organization": "Graeme Eisenhofer, Richard O. Cannon, Irwin J. Kopin, Courtney Holmes, David S. Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/1985394658"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1985394658", "name": "item", "description": "1985394658", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1985394658"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1997-01-01T00:00:00Z"}}, {"id": "38657803", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-13T16:28:03Z", "type": "Journal Article", "created": "2024-04-22", "title": "Determination of organic fluorinated compounds content in complex samples through combustion ion chromatography methods: a way to define a \u201cTotal Per- and Polyfluoroalkyl Substances (PFAS)\u201d parameter?", "description": "Emerging contaminants are a growing concern for scientists and public authorities. The group of per-polyfluoroalkyl substances (PFAS), known as 'forever chemicals', in complex environmental liquid and solid matrices was analysed in this study. The development of global analytical methods based on combustion ion chromatography (CIC) is expected to provide accurate picture of the overall PFAS contamination level via the determination of extractable organic fluorine (EOF) and adsorbable organic fluorine (AOF). The obtained results may be put into perspective with other methods such as targeted analyses (LC-MS/MS). The impact of pH, the presence of dissolved organic carbon and suspended particles on AOF measurements were explored. The effectiveness of the washing step to remove adsorbed inorganic fluorine (IF) has been proven for samples containing up to 8 mgF.L-1. CIC-based methods showed good repeatability and reproducibility for the complex matrices studied. Environmental applications of these methods have been tested. AOF and EOF analyses could explain between 1\u00a0% and 23\u00a0% and 0.1\u00a0% to 2\u00a0% of total organic fluorine (TOF), respectively. The sum of PFAS compounds expressed as fluorine could explain from 0.2\u00a0% to 11\u00a0% and from 0.003\u00a0% to 5\u00a0% for AOF and EOF, respectively. These results also suggest that some fluorinated compounds are not adsorbed or extractable and/or lost by volatilisation during the application of AOF and EOF analytical procedure. These findings highlight that AOF and EOF are not entirely efficient as proxy to assess 'total PFAS' for assessing environmental contamination by PFAS. However, these methods could still be applied to gain a better understanding of the sources and fate of PFAS in the environment.", "keywords": ["Combustion ion chromatography", "13. 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