{"type": "FeatureCollection", "features": [{"id": "oai:idus.us.es:11441/146637", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:31:38Z", "type": "Report", "title": "The global distribution and environmental drivers of the soil antibiotic resistome", "description": "Atribuci\u00f3n 4.0 InternacionalGerman Research Foundation FZT 118", "keywords": ["Antibiotic resistance", "Mobile genetic elements", "Human health", "Global scale", "Global change"], "contacts": [{"organization": "Delgado Baquerizo, Manuel, Hu, Hang Wei, Maestre, Fernando T., Guerra, Carlos A., Eisenhauer, Nico, Eldridge, David J., Blanco-Pastor, Jos\u00e9 Luis, He, Ji Zheng,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/oai:idus.us.es:11441/146637"}, {"rel": "self", "type": "application/geo+json", "title": "oai:idus.us.es:11441/146637", "name": "item", "description": "oai:idus.us.es:11441/146637", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/oai:idus.us.es:11441/146637"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-01-01T00:00:00Z"}}, {"id": "10.1016/j.envpol.2021.118128", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:16:06Z", "type": "Journal Article", "created": "2021-09-09", "title": "Diagnosis of cadmium contamination in urban and suburban soils using visible-to-near-infrared spectroscopy", "description": "Previous studies have mostly focused on using visible-to-near-infrared spectral technique to quantitatively estimate soil cadmium (Cd) content, whereas little attention has been paid to identifying soil Cd contamination from a perspective of spectral classification. Here, we developed a framework to compare the potential of two spectral transformations (i.e., raw reflectance and continuum removal [CR]), three optimization strategies (i.e., full-spectrum, Boruta feature selection, and synthetic minority over-sampling technique [SMOTE]), and three classification algorithms (i.e., partial least squares discriminant analysis, random forest [RF], and support vector machine) for diagnosing soil Cd contamination. A total of 536 soil samples were collected from urban and suburban areas located in Wuhan City, China. Specifically, Boruta and SMOTE strategies were aimed at selecting the most informative predictors and obtaining balanced training datasets, respectively. Results indicated that soils contaminated by Cd induced decrease in spectral reflectance magnitude. Classification models developed after Boruta and SMOTE strategies out-performed to those from full-spectrum. A diagnose model combining CR preprocessing, SMOTE strategy, and RF algorithm achieved the highest validation accuracy for soil Cd (Kappa = 0.74). This study provides a theoretical reference for rapid identification of and monitoring of soil Cd contamination in urban and suburban areas.", "keywords": ["DIFFUSE-REFLECTANCE SPECTROSCOPY", "HUMAN HEALTH", "PREDICTION", "POTENTIALLY TOXIC ELEMENTS", "Boruta algorithm", "01 natural sciences", "Visible-to-near-infrared spectroscopy", "NIR SPECTROSCOPY", "Soil", "ORGANIC-CARBON", "Machine learning", "11. Sustainability", "Soil Pollutants", "Least-Squares Analysis", "0105 earth and related environmental sciences", "Spectroscopy", " Near-Infrared", "RANDOM FOREST", "Urban and suburban soil Cd contamination", "04 agricultural and veterinary sciences", "15. Life on land", "QUANTITATIVE-ANALYSIS", "6. Clean water", "RIVER DELTA", "13. Climate action", "Earth and Environmental Sciences", "Synthetic minority over-sampling technique", "0401 agriculture", " forestry", " and fisheries", "HEAVY-METAL CONCENTRATIONS", "Cadmium"]}, "links": [{"href": "https://doi.org/10.1016/j.envpol.2021.118128"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Environmental%20Pollution", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.envpol.2021.118128", "name": "item", "description": "10.1016/j.envpol.2021.118128", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.envpol.2021.118128"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-12-01T00:00:00Z"}}, {"id": "10.1007/s11104-006-9006-6", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:14:53Z", "type": "Journal Article", "created": "2006-06-23", "title": "Yields And Accumulations Of N And P In Farmer-Managed Intercrops Of Maize\u2013Pigeonpea In Semi-Arid Africa", "description": "Maize (Zea mays L.) is a major staple food in Sub-Saharan Africa but low soil fertility, limited resources and droughts keep yields low. Cultivation of maize intercropped with pigeonpea (Cajanus cajan L. Millsp.) is common in some areas of eastern and southern Africa. The objectives of this study were (1) to investigate dry matter, nitrogen (N) and phosphorus (P) accumulation in different plant components of maize\u2013pigeonpea intercropping systems and (2) to report the effects of the intercrops on soil fertility. Maize\u2013pigeonpea intercrops were compared to sole maize grown using farmers\u02019 practices. Intercropping maize and pigeonpea increased (P   0.11). Nitrate and ammonium levels in soil were still not affected by the treatments after the soils were incubated in anaerobic conditions for 8 days at 37\u00b0C (P > 0.11). However, pigeonpea added up to 60 kg of N ha\u22121 to the system and accumulated up to 6 kg of P ha\u22121 and only 25% of this N and P were exported in the grain. In conclusion, beside the added grain yield of pigeonpea in the intercropped systems, pigeonpea increased the recirculation of dry matter, N and P, which may have a long-term effect on soil fertility. Furthermore, the stems from pigeonpea contributed to household fuel wood consumption. The intercropped system thus had multiple benefits that gave significant increase in combined yield per unit area without additional labour requirements. The main requirement in order to up-scale the maize\u2013pigeonpea intercropping approach is sufficient supply of high-quality pigeonpea seeds.", "keywords": ["2. Zero hunger", "Food security", " food quality and human health", "Farm nutrient management", "0401 agriculture", " forestry", " and fisheries", "Recycling", " balancing and resource management", "04 agricultural and veterinary sciences", "15. Life on land"]}, "links": [{"href": "https://doi.org/10.1007/s11104-006-9006-6"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Plant%20and%20Soil", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1007/s11104-006-9006-6", "name": "item", "description": "10.1007/s11104-006-9006-6", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1007/s11104-006-9006-6"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2006-06-24T00:00:00Z"}}, {"id": "10.1016/j.foodres.2024.114342", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:16:10Z", "type": "Journal Article", "created": "2024-04-23", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract         <p>Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.</p", "keywords": ["Male", "11 Ciudades y comunidades sostenibles", "Economics", "Strategy and Management", "Microplastics", "Social Sciences", "Choice Behavior", "01 natural sciences", "Microplastics pollution", "Natural resource economics", "11. Sustainability", "11 Sustainable Cities and Communities", "Microeconomics", "Willingness to pay", "Business", "Chile", "Environmental resource management", "Marketing", "2. Zero hunger", "12 Producci\u00f3n y consumo responsable", "Ecology", "Middle Aged", "Microplastic Pollution in Marine and Terrestrial Environments", "Pollution", "Management", "3. Good health", "Economics", " Econometrics and Finance", "Mitigation technology", "Environmental health", "14 Vida submarina", "Physical Sciences", "Medicine", "Female", "Information treatment", "12 Responsible Consumption and Production", "Adult", "06 Clean Water and Sanitation", "Economics and Econometrics", "Certification", "06 Agua limpia y saneamiento", "330", "Environmental economics", "Discrete Choice Models in Economics and Health Care", "Food Contamination", "Business", " Management and Accounting", "12. Responsible consumption", "FOS: Economics and business", "Young Adult", "Humans", "Animals", "Conceptualizing the Circular Economy and Sustainable Supply Chains", "14. Life underwater", "Discrete Choice Experiment", "Biology", "0105 earth and related environmental sciences", "9. Industry and infrastructure", "Human health", "Valuation (finance)", "Consumer Behavior", "14 Life Below Water", "Purchasing", "Bivalvia", "Seafood", "13. Climate action", "FOS: Biological sciences", "Environmental Science", "Water Pollutants", " Chemical", "Finance"]}, "links": [{"href": "https://doi.org/10.1016/j.foodres.2024.114342"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Food%20Research%20International", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.foodres.2024.114342", "name": "item", "description": "10.1016/j.foodres.2024.114342", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.foodres.2024.114342"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-10-05T00:00:00Z"}}, {"id": "10.1186/s40168-022-01405-w", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:19:01Z", "type": "Journal Article", "created": "2022-12-12", "title": "The global distribution and environmental drivers of the soil antibiotic resistome", "description": "Abstract                 Background                 <p>Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth\uffe2\uff80\uff99s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.</p>                                Results                 <p>We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.</p>                                Conclusions                 <p>Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.</p>", "keywords": ["Ecolog\u00eda (Biolog\u00eda)", "0301 basic medicine", "SDG-03: Good health and well-being", "550", "Antibiotic resistance", "Edafolog\u00eda (Biolog\u00eda)", "Antibiotic resistance genes (ARGs)", "910", "http://metadata.un.org/sdg/3", "631.4", "Microbial ecology", "2417.14 Gen\u00e9tica Vegetal", "Soil", "03 medical and health sciences", "XXXXXX - Unknown", "Global scale", "Humans", "Global change", "SCALE", "Ensure healthy lives and promote well-being for all at all ages", "2. Zero hunger", "0303 health sciences", "Ecology", "Research", "QR100-130", "Human health", "15. Life on land", "Gen\u00e9tica", "Anti-Bacterial Agents", "3. Good health", "Phenotype", "Mobile genetic elements", "13. Climate action", "BACTERIA", "2511.02 Biolog\u00eda de Suelos", "RESISTANCE GENES"]}, "links": [{"href": "https://doi.org/10.1186/s40168-022-01405-w"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Microbiome", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1186/s40168-022-01405-w", "name": "item", "description": "10.1186/s40168-022-01405-w", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1186/s40168-022-01405-w"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-07-11T00:00:00Z"}}, {"id": "10.15454/2zqkir", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:19:15Z", "type": "Dataset", "title": "Science for policy 6: Urban planning: sealing the future of soil functions - datasets?", "description": "Open AccessThis dataset is part of Deliverable and 5.3 and produced by the WP4 team of the Landmark H2020 project. It contains the following shapefiles: PO6_BAU_NoZoning_50.shp PO6_BAU_NoZoning_100.shp PO6_BAU_Zoning_50.shp PO6_Sprawl_Zoning_50.shp PO6_BAU_NoZoning_50.shp PO6_Compact_Zoning_50.shp PO6_Compact_NoZoning_50.shp The metronamica Model was applied on six scenarios with combinations of business as usual, suburban sprawl or compact city development which build on the socio-economic projections and density assumptions of the ESPON-ET2050 project, and use the land use allocation parameters from the RECARE and SoilCare Integrated Assessment Models. Spatial development (zoning) was for some scenarios restricted in high productive fields. The model results give probabilities (0 \u2013 1) of urban development within the 1 km\u00b2 cells. Based on these probability percentages the different soil functions are reduced (100% of the probability and 50% of the probability) compared to the current soil functioning and, for the 50% scenarios, partly replaced by low productive grasslands as gardens and other public greenery. Z-scores are calculated from the spatial SF maps for each of the environmental zones. These environmental zones are derived from the Metzger et al. (2013). The z-scores give the signed fractional number of standard deviations by which SF means for an environmental zone are above or below the mean value and allow us indicate which areas have a higher or lower soil function performance compared to the mean value. Z-scores from the current SF maps and scenario maps were then compared to each other to calculate the change in z-scores. This change in z-scores is given in the shapefiles and describes the relative change in soil function performance. Positive values indicate an improvement in soil functioning compared to the current situation, negative values a decrease. More information regarding calculation and interpretation of both this dataset and the soil function maps used to calculate the z-scores can be found in: Vrebos D., F. Bampa, R. Creamer, A. Jones, E. Lugato, L. O\u2019Sullivan, P. Meire, R.P.O. Schulte, J. Schr\u00f6der and J. Staes (2018). Scenarios maps: visualizing optimized scenarios where supply of soil functions matches demands. LANDMARK Report 4.3. and Jones A. et al. (2019). An options document to propose future policy tools for functional soil management. LANDMARK 5.3. All available from www.landmark2020.eu.", "keywords": ["Water resources", "Food Safety", "Food Safety and Toxicology", "Nutritional Sciences", "Social Sciences", "7. Clean energy", "Pathology and Forensic Medicine", "Health and Life Sciences", "Farming Systems and Practices", "11. Sustainability", "13. Climate action", "Agriculture", " Forestry", " Horticulture", "Human Health and Pathology", "Soils and soil sciences", "Agricultural Sciences", "Life Sciences", "Hydrology and Hydrogeology", "15. Life on land", "Rural and Agricultural Sociology", "Human Nutrition and food security", "Farming Systems", "Medicine", " Health and Life Sciences", "Earth and Environmental Sciences", "Soil Sciences", "Medicine", "Geosciences"], "contacts": [{"organization": "Vrebos, Dirk, Bampa, Francesca, Schulte, Rogier, Creamer, Rachel, Jones, Arwyn, Staes, Jan, Zwetsloot Marie, Debernardini, Mariana, O\u2019Sullivan, Lilian,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.15454/2zqkir"}, {"rel": "self", "type": "application/geo+json", "title": "10.15454/2zqkir", "name": "item", "description": "10.15454/2zqkir", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.15454/2zqkir"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-01-01T00:00:00Z"}}, {"id": "10.5281/zenodo.7142483", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:22:51Z", "type": "Journal Article", "title": "Co-culture of human type I and type II pneumocyte cell lines as a model of alveolar epithelium", "description": "The epithelial tissues of the distal lung are continuously exposed to inhaled air, and are thus of research interest in<br> studying respiratory exposure to both therapeutic and hazardous materials. There is a need therefore to develop<br> sophisticated models of the human alveolar epithelium, which better represent the different cell types present in the<br> native lung and interactions between them. Our aim was to develop an air-liquid interface (ALI) model of the alveolar epithelium by incorporating human cell lines which bear features of type I (hAELVi) and type II (NCI-H441) epithelial cells. <br> Brookes et al (2021) PLoS ONE 16(9):e0248798. https://doi.org/10.1371/journal.pone.0248798<br>", "keywords": ["respiratory exposure", "microplastics", "epithelial tissues", "alveolar epithelium", "air-liquid interface", "human cell lines", "human health", "3. Good health", "nanoplastics"], "contacts": [{"organization": "Boland, Sonja, Brookes, Oliver, Kuen, Rene Lai, Miremont, Dorian, Eon-Bertho, Mawas, Safaa, Baeza-Squiban, Amelle,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.5281/zenodo.7142483"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/STCM%202022", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.5281/zenodo.7142483", "name": "item", "description": "10.5281/zenodo.7142483", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.5281/zenodo.7142483"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-01-01T00:00:00Z"}}, {"id": "11104/0369608", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:03Z", "type": "Journal Article", "created": "2025-09-01", "title": "Impacts of Climate Change Interventions on Biodiversity, Water, the Food System and Human Health and Well\u2010Being", "description": "ABSTRACT<p>Climate change threatens biodiversity, water, food and human health and well\uffe2\uff80\uff90being. Rapid, sustained mitigation and adaptation actions can benefit all these elements of the nexus. Key transitions in energy, land and marine ecosystems, urban areas, industry and society are essential for climate change mitigation, adaptation and sustainable development. These transitions require interdisciplinary research, policy support and societal engagement. Here we present an assessment of 69 response options, a subset of which (15) was used in the climate change chapter of the IPBES Nexus Assessment. We show that the majority of climate change response options for land, oceans and ecosystems, settlement and infrastructure, industrial and societal system transitions have broadly positive impacts across the nexus. However, energy system transitions show more apparent trade\uffe2\uff80\uff90offs. Most of these impacts result from energy infrastructure that would also be required for fossil fuel\uffe2\uff80\uff90based systems and should be compared to the far more damaging consequences of continued fossil fuel use. Transitioning to cleaner, renewable energy sources reduces these risks and offers significant improvements across the nexus by reducing climate change impacts. Of the 69 response options assessed, 59% have entirely positive effects, or at least no negative effects, across all nexus elements and can be considered as low\uffe2\uff80\uff90risk, immediately actionable options. The remaining 41% show either negative or variable impacts on at least one nexus element. However, this does not render them unviable; rather, their implementation must be carefully managed. Where impacts are variable, strategies should be tailored to ensure positive outcomes; where trade\uffe2\uff80\uff90offs are unavoidable, efforts should focus on minimising negative effects and maximising synergies. Our findings suggest that prioritising policies that address the interconnected challenges of climate change, biodiversity loss, land degradation, pollution, food insecurity, access to clean water, energy for all and sustainable development will deliver more effective and equitable climate action.</p", "keywords": ["Gcb Review", "food", "water", "synergy", "Biodiversity", "Trade\u2010off; water", "Synergy", "climate change", "Food", "human health and well-being", "Human health and well\u2010being", "Climate change", "IPBES", "biodiversity", "Nexus", "trade-off"]}, "links": [{"href": "https://doi.org/11104/0369608"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Global%20Change%20Biology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11104/0369608", "name": "item", "description": "11104/0369608", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11104/0369608"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-09-01T00:00:00Z"}}, {"id": "11441/146637", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:07Z", "type": "Report", "title": "The global distribution and environmental drivers of the soil antibiotic resistome", "description": "Open AccessGerman Research Foundation FZT 118", "keywords": ["Antibiotic resistance", "Mobile genetic elements", "Human health", "Global scale", "Global change"], "contacts": [{"organization": "Delgado Baquerizo, Manuel, Hu, Hang Wei, Maestre, Fernando T., Guerra, Carlos A., Eisenhauer, Nico, Eldridge, David J., Blanco-Pastor, Jos\u00e9 Luis, He, Ji Zheng,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/11441/146637"}, {"rel": "self", "type": "application/geo+json", "title": "11441/146637", "name": "item", "description": "11441/146637", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11441/146637"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-01-01T00:00:00Z"}}, {"id": "47e996b2-c60c-4cc8-9db3-20dab85ef478", "type": "Feature", "geometry": {"type": "Polygon", "coordinates": [[[2.54, 49.49], [2.54, 51.51], [6.41, 51.51], [6.41, 49.49], [2.54, 49.49]]]}, "properties": {"rights": "\u2022The custodian of the resource holds the rights of property (including the rights of intellectual property) to the geographic files \u2022The custodian grants the user the right to use the data for his internal use. \u2022Commercial use of the data under any form is strictly forbidden \u2022Custodian\u2019s name must be mentioned each time the data are being used publically.", "updated": "2024-01-19T10:41:54", "type": "Service", "language": "eng", "title": "Discovery Service - resources entered for the INSPIRE reporting", "description": "This is the discovery service for the metadata which are made available by the Belgian federal government. It only contains the resources which have been declared for the INSPIRE reporting, i.e. the resources which contain the keyword \u201creporting INSPIRE\u201d.", "formats": [{"name": "OGC:CSW"}], "keywords": ["Government and public sector", "National", "infoCatalogueService", "Buildings", "Addresses", "Elevation", "Meteorological geographical features", "Oceanographic geographical features", "Atmospheric conditions", "Geographical names", "Geology", "Habitats and biotopes", "Hydrography", "Agricultural and aquaculture facilities", "Environmental monitoring facilities", "Production and industrial facilities", "Land cover", "Orthoimagery", "Cadastral parcels", "Coordinate reference systems", "Bio-geographical regions", "Population distribution \u2014 demography", "Species distribution", "Human health and safety", "Utility and governmental services", "Soil", "Energy resources", "Protected sites", "Geographical grid systems", "Administrative units", "Mineral resources", "Statistical units", "Land use", "Area management/restriction/regulation zones and reporting units", "Transport networks", "Sea regions", "Natural risk zones", "Reporting INSPIRE", "federal government"], "contacts": [{"name": null, "organization": "National Geographic Institute", "position": null, "roles": ["custodian"], "phones": [{"value": null}], "emails": [{"value": "products@ngi.be"}], "addresses": [{"deliveryPoint": ["Kortenberglaan 115"], "city": "Brussels", "administrativeArea": null, "postalCode": "1000", "country": "Belgium"}], "links": [{"href": {"url": "http://www.ngi.be", "protocol": null, "protocol_url": "", "name": "http://www.ngi.be", "name_url": "", "description": null, "description_url": "", "applicationprofile": null, "applicationprofile_url": "", "function": null}}]}], "themes": [{"concepts": [{"id": "Government and public sector"}], "scheme": "http://vocab.belgif.be/auth/datatheme"}, {"concepts": [{"id": "National"}], "scheme": "http://inspire.ec.europa.eu/metadata-codelist/SpatialScope"}, {"concepts": [{"id": "infoCatalogueService"}], "scheme": "Commission Regulation (EC) No 1205/2008"}, {"concepts": [{"id": "Buildings"}, {"id": "Addresses"}, {"id": "Elevation"}, {"id": "Meteorological geographical features"}, {"id": "Oceanographic geographical features"}, {"id": "Atmospheric conditions"}, {"id": "Geographical names"}, {"id": "Geology"}, {"id": "Habitats and biotopes"}, {"id": "Hydrography"}, {"id": "Agricultural and aquaculture facilities"}, {"id": "Environmental monitoring facilities"}, {"id": "Production and industrial facilities"}, {"id": "Land cover"}, {"id": "Orthoimagery"}, {"id": "Cadastral parcels"}, {"id": "Coordinate reference systems"}, {"id": "Bio-geographical regions"}, {"id": "Population distribution \u2014 demography"}, {"id": "Species distribution"}, {"id": "Human health and safety"}, {"id": "Utility and governmental services"}, {"id": "Soil"}, {"id": "Energy resources"}, {"id": "Protected sites"}, {"id": "Geographical grid systems"}, {"id": "Administrative units"}, {"id": "Mineral resources"}, {"id": "Statistical units"}, {"id": "Land use"}, {"id": "Area management/restriction/regulation zones and reporting units"}, {"id": "Transport networks"}, {"id": "Sea regions"}, {"id": "Natural risk zones"}], "scheme": "http://inspire.ec.europa.eu/theme"}, {"concepts": [{"id": "federal government"}], "scheme": "https://www.eionet.europa.eu/gemet/en/themes/"}]}, "links": [{"href": "http://inspire.reporting.geo.be/eng/csw?request=GetCapabilities&service=CSW&version=2.0.2", "protocol": "OGC:CSW", "rel": null}, {"href": "https://inspire.reporting.geo.be/eng/csw?request=GetCapabilities&service=CSW&version=2.0.2", "protocol": "OGC:CSW"}, {"href": "https://www.geo.be/thumbs/metadata_discovery.png", "name": "preview", "description": "Web image thumbnail (URL)", "protocol": "WWW:LINK-1.0-http--image-thumbnail", "rel": "preview"}, {"rel": "self", "type": "application/geo+json", "title": "47e996b2-c60c-4cc8-9db3-20dab85ef478", "name": "item", "description": "47e996b2-c60c-4cc8-9db3-20dab85ef478", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/47e996b2-c60c-4cc8-9db3-20dab85ef478"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date-time": "2024-01-19T10:41:54Z"}}, {"id": "1854/LU-01KAB9KFWBCYFKX8433R94XMFK", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:18Z", "type": "Journal Article", "created": "2025-09-26", "title": "The Toxicity of Microplastics Explorer (ToMEx) 2.0", "description": "In 2021 the Toxicity of Microplastics Explorer (ToMEx, https://microplastics.sccwrp.org) was released as an open source, open access database and web application for microplastics toxicity. Since then, it has been utilized by the microplastic research community for the exploration, visualization, and analysis of toxicity data for both hazard characterization and risk assessment. The peer-reviewed literature has continued to grow exponentially, making ToMEx out-of-date. To ensure the continued utility of ToMEx, an international crowd-sourcing approach was utilized to update ToMEx by extracting data from additional studies published since the original release. Through this process, both the aquatic and human health ToMEx databases roughly doubled in size, and modest increases in data diversity (e.g., number of species represented, types of test particles) were observed in the aquatic organisms database. However, most trends (e.g., greater toxicities observed with smaller particle sizes, lack of dose-response data etc.) observed in the first iteration of ToMEx remained constant. A previously developed framework for deriving ecological health-based microplastic thresholds using species sensitivity distributions was reapplied to determine how thresholds and their associated uncertainty intervals would change following the database update. Twelve new studies passed minimum screening criteria and were deemed fit for the purpose of threshold derivation. The addition of new data allowed for the separation of freshwater and marine compartments which had previously been combined due to a lack of applicable toxicity data for freshwater species. When molecular and cellular level endpoints were included, freshwater thresholds were comparable or increased from values calculated using previous data (-5 to 2.5-fold change) whereas marine thresholds dramatically decreased (-5000 to -29-fold change). However, when endpoints were restricted to organism and above, marine and freshwater thresholds were comparable to those calculated previously (-20 to 14-fold change). Confidence intervals for both marine and freshwater thresholds remained wide. The doubling of the database increases the value of ToMEx for researchers, particularly those focused on characterizing hazards associated with microplastics. Its utility remains limited for environmental managers as 89% of studies in ToMEx 2.0 failed to meet minimum screening criteria for threshold derivation, highlighting the need to generate fit-for-purpose toxicity data for threshold development. However, ToMEx continues to be a useful research tool, and future iterations could become even more powerful through novel artificial intelligence applications to streamline data curation and even predict toxicological outcomes.", "keywords": ["Database", "Toxicity", "Aquatic organisms", "Earth and Environmental Sciences", "Research", "Microplastic", "Medicine and Health Sciences", "Human health", "Biology and Life Sciences"], "contacts": [{"organization": "Hampton, Leah M. Thornton, Wyler, Dana Briggs, Almroth, Bethanie Carney, Coffin, Scott, Cowger, Win, Doyle, Darragh, Hataley, Eden K., Hutton, Sara J., Mair, Magdalena M., Miller, Ezra L., Moncl\u00fas, Laura, Sharpe, Emma E., Samreen, Siddiqui, Ahmed, Kazi Towsif, Allamby, Quinn P. V., Vital, Ana L. Antonio, Asnicar, Davide, Bare, Jennifer L., Barrick, Andrew, Berreman, Katherine, Bertrand, Lidwina, Boone, Virginia, Bour, Agathe, Brehm, Julian, Carrasco-Navarro, Victor, Cook, Travis, Covernton, Garth A., Cubanski, Patricia, Da Silva, Pedro M. C., de Souza Leite, Luan, Gene, Sam M., Hermabessiere, Ludovic, Hooge, Asta, Iwasaki, Yuichi, Klasios, Natasha, Knauss, Christine M., Kardgar, Azora K\u00f6nig, Kropf, Philipp, Kudu, Isaac B., Kukkola, Anna, Laforsch, Christian, Kennedy, Stephanie B., Leusch, Frederic D. L., Li, Lucy Wei, Lu, Hsuan-Cheng, Mahan, Judd, Saif, Uddin Md, Mondellini, Simona, Norman, John P., Pandelides, Zacharias, Petersson, Tove, Philibert, Danielle A., Kvist, Elina, Ramsperger, Anja F. R. M., Rigutto, Gabrielle, Ritschar, Sven, Sandgaard, Monica H., Schmitt, Jona, Schott, Matthias, Schwarzer, Michael, Seabrook, Katryna J., Seifried, Teresa M., Sepahi, Rohan, Si\u00f1a, Mariella, Testoff, Alex N., Vercauteren, Maaike, Wardlaw, Colleen M., Yeh, Andrew, Zajac-Fay, Rachel, Mehinto, Alvine C.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/1854/LU-01KAB9KFWBCYFKX8433R94XMFK"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Microplastics%20and%20Nanoplastics", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1854/LU-01KAB9KFWBCYFKX8433R94XMFK", "name": "item", "description": "1854/LU-01KAB9KFWBCYFKX8433R94XMFK", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1854/LU-01KAB9KFWBCYFKX8433R94XMFK"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-09-26T00:00:00Z"}}, {"id": "1854/LU-8720112", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:18Z", "type": "Journal Article", "created": "2021-09-09", "title": "Diagnosis of cadmium contamination in urban and suburban soils using visible-to-near-infrared spectroscopy", "description": "Previous studies have mostly focused on using visible-to-near-infrared spectral technique to quantitatively estimate soil cadmium (Cd) content, whereas little attention has been paid to identifying soil Cd contamination from a perspective of spectral classification. Here, we developed a framework to compare the potential of two spectral transformations (i.e., raw reflectance and continuum removal [CR]), three optimization strategies (i.e., full-spectrum, Boruta feature selection, and synthetic minority over-sampling technique [SMOTE]), and three classification algorithms (i.e., partial least squares discriminant analysis, random forest [RF], and support vector machine) for diagnosing soil Cd contamination. A total of 536 soil samples were collected from urban and suburban areas located in Wuhan City, China. Specifically, Boruta and SMOTE strategies were aimed at selecting the most informative predictors and obtaining balanced training datasets, respectively. Results indicated that soils contaminated by Cd induced decrease in spectral reflectance magnitude. Classification models developed after Boruta and SMOTE strategies out-performed to those from full-spectrum. A diagnose model combining CR preprocessing, SMOTE strategy, and RF algorithm achieved the highest validation accuracy for soil Cd (Kappa = 0.74). This study provides a theoretical reference for rapid identification of and monitoring of soil Cd contamination in urban and suburban areas.", "keywords": ["DIFFUSE-REFLECTANCE SPECTROSCOPY", "HUMAN HEALTH", "PREDICTION", "POTENTIALLY TOXIC ELEMENTS", "Boruta algorithm", "01 natural sciences", "Visible-to-near-infrared spectroscopy", "NIR SPECTROSCOPY", "Soil", "ORGANIC-CARBON", "Machine learning", "11. Sustainability", "Soil Pollutants", "Least-Squares Analysis", "0105 earth and related environmental sciences", "Spectroscopy", " Near-Infrared", "RANDOM FOREST", "Urban and suburban soil Cd contamination", "04 agricultural and veterinary sciences", "15. Life on land", "QUANTITATIVE-ANALYSIS", "6. Clean water", "RIVER DELTA", "13. Climate action", "Earth and Environmental Sciences", "Synthetic minority over-sampling technique", "0401 agriculture", " forestry", " and fisheries", "HEAVY-METAL CONCENTRATIONS", "Cadmium"]}, "links": [{"href": "https://doi.org/1854/LU-8720112"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Environmental%20Pollution", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1854/LU-8720112", "name": "item", "description": "1854/LU-8720112", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1854/LU-8720112"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-12-01T00:00:00Z"}}, {"id": "1959.7/uws:76535", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:23Z", "type": "Journal Article", "created": "2022-12-11", "title": "The global distribution and environmental drivers of the soil antibiotic resistome", "description": "Abstract                                        Background                     <p>Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth\uffe2\uff80\uff99s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.</p>                                                           Results                     <p>We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.</p>                                                           Conclusions                     <p>Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.</p>", "keywords": ["Ecolog\u00eda (Biolog\u00eda)", "0301 basic medicine", "SDG-03: Good health and well-being", "550", "Antibiotic resistance", "Edafolog\u00eda (Biolog\u00eda)", "Antibiotic resistance genes (ARGs)", "910", "631.4", "Microbial ecology", "2417.14 Gen\u00e9tica Vegetal", "Soil", "03 medical and health sciences", "XXXXXX - Unknown", "Global scale", "Humans", "Global change", "SCALE", "2. Zero hunger", "0303 health sciences", "Ecology", "Research", "QR100-130", "Human health", "15. Life on land", "Gen\u00e9tica", "Anti-Bacterial Agents", "3. Good health", "Phenotype", "Mobile genetic elements", "13. Climate action", "BACTERIA", "2511.02 Biolog\u00eda de Suelos", "RESISTANCE GENES"]}, "links": [{"href": "https://doi.org/1959.7/uws:76535"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Microbiome", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1959.7/uws:76535", "name": "item", "description": "1959.7/uws:76535", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1959.7/uws:76535"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-07-11T00:00:00Z"}}, {"id": "1e653c62e5737fecd5d1bfcda54efca7", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:24:26Z", "type": "Report", "title": "Noninvasive oxgenation strategies in immunocompromised patients with acute hypoxemic respiratory failure.", "description": "Open AccessL\u2019insuffisance respiratoire aigu\u00eb est la premi\u00e8re cause d\u2019admission en R\u00e9animation des patients immunod\u00e9prim\u00e9s. Malgr\u00e9 les progr\u00e8s th\u00e9rapeutiques, leur mortalit\u00e9 reste tr\u00e8s \u00e9lev\u00e9e en cas de recours \u00e0 la ventilation m\u00e9canique invasive. La ventilation non invasive (VNI) est recommand\u00e9e comme traitement de premi\u00e8re ligne en raison de la diminution de mortalit\u00e9 rapport\u00e9e dans les \u00e9tudes randomis\u00e9es anciennes. R\u00e9cemment, ces b\u00e9n\u00e9fices ont \u00e9t\u00e9 remis en cause par des essais de plus grande ampleur. Toutefois, il est possible que les r\u00e9glages de la VNI n\u2019aient pas \u00e9t\u00e9 optimaux dans ces \u00e9tudes, diminuant ainsi son efficacit\u00e9. Par ailleurs, l\u2019oxyg\u00e9noth\u00e9rapie nasale \u00e0 haut d\u00e9bit (OHD) est une technique d\u2019oxyg\u00e9nation r\u00e9cente avec des r\u00e9sultats prometteurs dans de nombreuses situations cliniques. L\u2019objectif final de ce projet \u00e9tait de conduire une \u00e9tude prospective randomis\u00e9e multicentrique comparant la VNI avec des r\u00e9glages optimis\u00e9s \u00e0 l\u2019OHD chez les patients immunod\u00e9prim\u00e9s admis en R\u00e9animation pour une insuffisance respiratoire aigu\u00eb. Nous avons tout d\u2019abord valid\u00e9 l\u2019hypoth\u00e8se de recherche du projet, son objectif principal, les calculs d\u2019effectif et le taux de recrutement au moyen d\u2019une \u00e9tude pilote r\u00e9trospective. Puis nous avons \u00e9labor\u00e9 le protocole de VNI \u00e0 partir d\u2019une revue syst\u00e9matique de la litt\u00e9rature comparant l\u2019efficacit\u00e9 des diff\u00e9rents protocoles de VNI publi\u00e9s. Ensuite, nous avons analys\u00e9 les facteurs de risque d\u2019\u00e9chec de la VNI chez les patients hypox\u00e9miques afin d\u2019identifier les param\u00e8tres physiologiques respiratoires \u00e0 surveiller chez les patients trait\u00e9s par VNI. En outre, nous avons identifi\u00e9 les m\u00e9canismes responsables des effets physiologiques de l\u2019OHD au moyen d\u2019une \u00e9tude sur banc puis chez des volontaires sains. Enfin, nous avons s\u00e9lectionn\u00e9 la m\u00e9thode d\u2019estimation de la fraction inspir\u00e9e en dioxyg\u00e8ne mesur\u00e9e au masque la plus fiable en comparant les diff\u00e9rentes m\u00e9thodes existantes dans le but d\u2019affiner les crit\u00e8res d\u2019inclusion du projet. Ces cinq \u00e9tudes pr\u00e9liminaires nous ont permis de conduire une \u00e9tude prospective randomis\u00e9e dans 30 centres en France et en Italie dans le but de comparer les effets de l\u2019OHD seule d\u00e9livr\u00e9e \u00e0 60 L/min \u00e0 son association \u00e0 la VNI intensive (administr\u00e9e au moins 12 heures par jour avec une pression expiratoire positive d\u2019au moins 8 cmH2O et un volume courant expir\u00e9 inf\u00e9rieur \u00e0 8 ml/kg de poids pr\u00e9dit) sur la mortalit\u00e9 \u00e0 28 jours chez 300 patients immunod\u00e9prim\u00e9s admis en R\u00e9animation pour une insuffisance respiratoire aigu\u00eb.", "keywords": ["Clinical study", "Immunod\u00e9pression", "[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology", "High-Flow nasal cannula oxygen therapy", "Ventilation non invasive", "\u00c9tude clinique", "[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract", "Insuffisance respiratoire aigu\u00eb", "Oxyg\u00e9noth\u00e9rapie nasale \u00e0 haut d\u00e9bit", "Acute respiratory failure", "Noninvasive ventilation", "Immunosuppression"], "contacts": [{"organization": "Coudroy, R\u00e9mi", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/1e653c62e5737fecd5d1bfcda54efca7"}, {"rel": "self", "type": "application/geo+json", "title": "1e653c62e5737fecd5d1bfcda54efca7", "name": "item", "description": "1e653c62e5737fecd5d1bfcda54efca7", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1e653c62e5737fecd5d1bfcda54efca7"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-01-01T00:00:00Z"}}, {"id": "3114970092", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:25:10Z", "type": "Dataset", "title": "Science for policy 6: Urban planning: sealing the future of soil functions - datasets?", "description": "Open AccessThis dataset is part of Deliverable and 5.3 and produced by the WP4 team of the Landmark H2020 project. It contains the following shapefiles: PO6_BAU_NoZoning_50.shp PO6_BAU_NoZoning_100.shp PO6_BAU_Zoning_50.shp PO6_Sprawl_Zoning_50.shp PO6_BAU_NoZoning_50.shp PO6_Compact_Zoning_50.shp PO6_Compact_NoZoning_50.shp The metronamica Model was applied on six scenarios with combinations of business as usual, suburban sprawl or compact city development which build on the socio-economic projections and density assumptions of the ESPON-ET2050 project, and use the land use allocation parameters from the RECARE and SoilCare Integrated Assessment Models. Spatial development (zoning) was for some scenarios restricted in high productive fields. The model results give probabilities (0 \u2013 1) of urban development within the 1 km\u00b2 cells. Based on these probability percentages the different soil functions are reduced (100% of the probability and 50% of the probability) compared to the current soil functioning and, for the 50% scenarios, partly replaced by low productive grasslands as gardens and other public greenery. Z-scores are calculated from the spatial SF maps for each of the environmental zones. These environmental zones are derived from the Metzger et al. (2013). The z-scores give the signed fractional number of standard deviations by which SF means for an environmental zone are above or below the mean value and allow us indicate which areas have a higher or lower soil function performance compared to the mean value. Z-scores from the current SF maps and scenario maps were then compared to each other to calculate the change in z-scores. This change in z-scores is given in the shapefiles and describes the relative change in soil function performance. Positive values indicate an improvement in soil functioning compared to the current situation, negative values a decrease. More information regarding calculation and interpretation of both this dataset and the soil function maps used to calculate the z-scores can be found in: Vrebos D., F. Bampa, R. Creamer, A. Jones, E. Lugato, L. O\u2019Sullivan, P. Meire, R.P.O. Schulte, J. Schr\u00f6der and J. Staes (2018). Scenarios maps: visualizing optimized scenarios where supply of soil functions matches demands. LANDMARK Report 4.3. and Jones A. et al. (2019). An options document to propose future policy tools for functional soil management. LANDMARK 5.3. All available from www.landmark2020.eu.", "keywords": ["Water resources", "Food Safety", "Food Safety and Toxicology", "Nutritional Sciences", "Social Sciences", "7. Clean energy", "Pathology and Forensic Medicine", "Health and Life Sciences", "Farming Systems and Practices", "11. Sustainability", "13. Climate action", "Agriculture", " Forestry", " Horticulture", "Human Health and Pathology", "Soils and soil sciences", "Agricultural Sciences", "Life Sciences", "Hydrology and Hydrogeology", "15. 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We hypothesized that breaking advanced glycation end product (AGE) cross-links could improve remodeling in mesenteric resistance arteries in Zucker diabetic fatty (ZDF) rats compared with lean Zucker (LZ) rats. Arteries, exposed to high (HF) or normal (NF) blood flow after alternate arterial ligation in vivo, were collected after 2 weeks. In LZ rats, HF artery diameter was larger than for NF vessels, but this was not the case in ZDF rats. Endothelium-mediated dilation in ZDF rats, which was lower than in LZ rats, was further decreased in HF arteries. Treatment of rats with the AGE-breaker 4,5-dimethyl-3-phenacylthiazolium chloride (ALT-711) (3 mg/kg/day; 3 weeks) reversed diabetes-induced impairment of HF-dependent remodeling. ALT-711 also improved endothelium nitric oxide-dependent relaxation in mesenteric resistance arteries. Reactive oxygen species reduction restored relaxation in ZDF rats but not in LZ or ALT-711-treated rats. AGEs were reduced in ALT-711-treated ZDF rats compared with ZDF rats. Metalloproteinase activity, necessary for HF-dependent remodeling, was reduced in ZDF rats compared with LZ rats and restored by ALT-711. Thus, targeting AGE cross-links may provide a therapeutic potential for overcoming microvascular complications in ischemic disorders occurring in diabetes.", "keywords": ["[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system"], "contacts": [{"organization": "Freidja, Mohamed, Tarhouni, Kahena, Toutain, Bertrand, Fassot, C\u00e9line, Loufrani, Laurent, Henrion, Daniel,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/a7e3fe76872a58bceb6ba68fea80dda3"}, {"rel": "self", "type": "application/geo+json", "title": "a7e3fe76872a58bceb6ba68fea80dda3", "name": "item", "description": "a7e3fe76872a58bceb6ba68fea80dda3", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/a7e3fe76872a58bceb6ba68fea80dda3"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2012-01-01T00:00:00Z"}}, {"id": "aac6ae47d0f5fcd32e3687c113d7560c", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-24T16:27:46Z", "type": "Report", "title": "Breech presentation: Clinical practice guidelines from the French College of Gynaecologists and Obstetricians (CNGOF)", "description": "Objective: To determine the optimal management of singleton fetuses in breech presentation. 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