{"type": "FeatureCollection", "features": [{"id": "sun,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sun,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sun,2007", "name": "item", "description": "sun,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sun,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "10.1056/nejm199703063361004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:58Z", "type": "Journal Article", "created": "2002-07-27", "title": "Sympathetic Cardioneuropathy in Dysautonomias", "description": "The classification of dysautonomias has been confusing, and the pathophysiology obscure. We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and assessments of the entry rate of the sympathetic neurotransmitter norepinephrine into the cardiac venous drainage (cardiac norepinephrine spillover). We related the laboratory findings to signs of sympathetic neurocirculatory failure (orthostatic hypotension and abnormal blood-pressure responses associated with the Valsalva maneuver), central neural degeneration, and responsiveness to treatment with levodopa-carbidopa (Sinemet).Cardiac scans were obtained after intravenous administration of 6-[18F]fluorodopamine in 26 patients with dysautonomia. Fourteen had sympathetic neurocirculatory failure--three with no signs of central neurodegeneration (pure autonomic failure), two with parkinsonism responsive to treatment with levodopa-carbidopa, and nine with central neurodegeneration unresponsive to treatment with levodopa-carbidopa (the Shy-Drager syndrome). The rates of cardiac norepinephrine spillover were estimated on the basis of concentrations of intravenously infused [3H]norepinephrine during catheterization of the right side of the heart.Patients with pure autonomic failure or parkinsonism and sympathetic neurocirculatory failure had no myocardial 6-[18F]fluorodopamine-derived radioactivity or cardiac norepinephrine spillover, indicating loss of myocardial sympathetic-nerve terminals, whereas patients with the Shy-Drager syndrome had increased levels of 6-[18F]fluorodopamine-derived radioactivity, indicating intact sympathetic terminals and absent nerve traffic. Patients with dysautonomia who did not have sympathetic neurocirculatory failure had normal levels of 6-[18F]fluorodopamine-derived radioactivity in myocardium and normal rates of cardiac norepinephrine spillover.The results of 6-[18F]fluorodopamine positron-emission tomography and neurochemical analyses support a new clinical pathophysiologic classification of dysautonomias, based on the occurrence of sympathetic neurocirculatory failure, signs of central neurodegeneration, and responsiveness to levodopa-carbidopa.", "keywords": ["Adult", "Aged", " 80 and over", "Fluorine Radioisotopes", "Nitrogen Radioisotopes", "Sympathetic Nervous System", "Epinephrine", "Dopamine", "Myocardium", "Shy-Drager Syndrome", "Heart", "Parkinson Disease", "Middle Aged", "3. Good health", "Diagnosis", " Differential", "Levodopa", "Norepinephrine", "Autonomic Nervous System Diseases", "Ammonia", "Parasympathetic Nervous System", "Reference Values", "Coronary Circulation", "Humans", "Aged", "Tomography", " Emission-Computed"], "contacts": [{"organization": "Graeme Eisenhofer, Richard O. Cannon, Irwin J. Kopin, Courtney Holmes, David S. Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1056/nejm199703063361004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1056/nejm199703063361004", "name": "item", "description": "10.1056/nejm199703063361004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1056/nejm199703063361004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1997-01-01T00:00:00Z"}}, {"id": "10.3390/bios14050215", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:22:28Z", "type": "Journal Article", "created": "2024-04-26", "title": "Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Graphene-based materials are actively being investigated as sensing elements for the detection of different analytes. Both graphene grown by chemical vapor deposition (CVD) and graphene oxide (GO) produced by the modified Hummers\u2019 method are actively used in the development of biosensors. The production costs of CVD graphene- and GO-based sensors are similar; however, the question remains regarding the most efficient graphene-based material for the construction of point-of-care diagnostic devices. To this end, in this work, we compare CVD graphene aptasensors with the aptasensors based on reduced GO (rGO) for their capabilities in the detection of NT-proBNP, which serves as the gold standard biomarker for heart failure. Both types of aptasensors were developed using commercial gold interdigitated electrodes (IDEs) with either CVD graphene or GO formed on top as a channel of liquid-gated field-effect transistor (FET), yielding GFET and rGO-FET sensors, respectively. The functional properties of the two types of aptasensors were compared. Both demonstrate good dynamic range from 10 fg/mL to 100 pg/mL. The limit of detection for NT-proBNP in artificial saliva was 100 fg/mL and 1 pg/mL for rGO-FET- and GFET-based aptasensors, respectively. While CVD GFET demonstrates less variations in parameters, higher sensitivity was demonstrated by the rGO-FET due to its higher roughness and larger bandgap. The demonstrated low cost and scalability of technology for both types of graphene-based aptasensors may be applicable for the development of different graphene-based biosensors for rapid, stable, on-site, and highly sensitive detection of diverse biochemical markers.</p></article>", "keywords": ["Transistors", " Electronic", "graphene", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "01 natural sciences", "point-of-care diagnostic", "Article", "Peptide Fragments", "0104 chemical sciences", "Limit of Detection", "Natriuretic Peptide", " Brain", "graphene oxide", "Humans", "Graphite", "Gold", "0210 nano-technology", "Electrodes", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/5/215/pdf"}, {"href": "https://doi.org/10.3390/bios14050215"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/bios14050215", "name": "item", "description": "10.3390/bios14050215", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/bios14050215"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-04-26T00:00:00Z"}}, {"id": "10.3390/bios12121071", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:22:28Z", "type": "Journal Article", "created": "2022-11-24", "title": "One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>A novel photochemical technological route for one-step functionalization of a graphene surface with an azide-modified DNA aptamer for biomarkers is developed. The methodology is demonstrated for the functionalization of a DNA aptamer for an N-terminal B-type natriuretic peptide (NT-proBNP) heart failure biomarker on the surface of a graphene channel within a system based on a liquid-gated graphene field effect transistor (GFET). The limit of detection (LOD) of the aptamer-functionalized sensor is 0.01 pg/mL with short response time (75 s) for clinically relevant concentrations of the cardiac biomarker, which could be of relevance for point-of-care (POC) applications. The novel methodology could be applicable for the development of different graphene-based biosensors for fast, stable, real-time, and highly sensitive detection of disease markers.</p></article>", "keywords": ["azide modification", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "point-of-care diagnostic", "Article", "Peptide Fragments", "graphene biosensor; heart failure; field-effect transistor; point-of-care diagnostic; aptamer; azide modification; photochemistry", "Natriuretic Peptide", " Brain", "graphene biosensor", "Graphite", "0210 nano-technology", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "http://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://doi.org/10.3390/bios12121071"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/bios12121071", "name": "item", "description": "10.3390/bios12121071", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/bios12121071"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-11-23T00:00:00Z"}}, {"id": "11573/1419330", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:13Z", "type": "Journal Article", "created": "2020-06-05", "title": "Variability in pulmonary diffusing capacity in heart failure", "description": "As pulmonary diffusing capacity is related to mortality risk and prognosis in patients with heart failure (HF), it is measured frequently. As such, it would be essential to know the week-to-week variability (reproducibility) of pulmonary diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). This variability would let clinicians understand what a clinically measurable change in DLCO and DLNO would be in these patients.On three different days spanning over ten weeks, 40\u2009H\u2009F patients underwent testing for DLCO and DLNO. DLCO was determined after a 4\u2009s and 10\u2009s breath-hold maneuver, while DLNO was determined after a 4\u2009s breath-hold maneuver.Forty heart failure patients (66\u2009\u00b1\u200910 years; BMI\u2009=\u200928.4\u2009\u00b1\u20094.6\u2009kg\u2219m-2; 28 males), that were referred to our clinic were able to complete the protocol. DLCO (4\u2009s breath-hold) and DLNO (4\u2009s breath-hold) were 79\u2009\u00b1\u200919 % and 59\u2009\u00b1\u200914 % predicted, respectively. Fifty percent of patients (n\u2009=\u200920) were below the lower limit of normal (LLN, below the 5th percentile) for predicted DLCO (4\u2009s), while 78 % of patients (n\u2009=\u200931) were below the LLN for predicted DLNO. All 16 patients that were below the LLN for DLCO were also below the LLN for DLNO. Over a ten week period, the reproducibility of DLNO (4\u2009s) DLCO (4\u2009s) and DLCO (10\u2009s) was 18.9, 8.2, and 5.9\u2009mL\u2009min\u2009mmHg-1, respectively.The week-to-week fluctuation in DLNO (4\u2009s), as a percentage, is less than DLCO (4\u2009s) in patients with HF. The reproducibility of DLNO in patients with HF is like that of healthy subjects.", "keywords": ["Male", "DLCO; DLNO; lung function; heart failure; reproducibility", "Physiology (science-metrix)", "Heart Disease (rcdc)", "Pulmonary Diffusing Capacity (mesh)", "3208 Medical physiology (for-2020)", "Heart failure", "Nitric Oxide", "Lung (rcdc)", "DLCO", "DLCO; DLNO; Heart failure; Lung function; Reproducibility;", "Clinical Research (rcdc)", "03 medical and health sciences", "0302 clinical medicine", "1102 Cardiorespiratory Medicine and Haematology (for)", "Middle Aged (mesh)", "Reproducibility of Results (mesh)", "Humans", "32 Biomedical and Clinical Sciences (for-2020)", "Male (mesh)", "3202 Clinical Sciences (for-2020)", "Carbon Monoxide (mesh)", "Aged", "DLNO", "Heart Failure", "Humans (mesh)", "Carbon Monoxide", "Cardiovascular (hrcs-hc)", "Aged (mesh)", "3201 Cardiovascular medicine and haematology (for-2020)", "Reproducibility of Results", "Heart Failure (mesh)", "Middle Aged", "1109 Neurosciences (for)", "Lung function", "Reproducibility", "3. Good health", "1116 Medical Physiology (for)", "4.2 Evaluation of markers and technologies (hrcs-rac)", "Female (mesh)", "Nitric Oxide (mesh)", "Pulmonary Diffusing Capacity", "Cardiovascular (rcdc)", "Female"]}, "links": [{"href": "https://air.unimi.it/bitstream/2434/743296/2/agostoni%203.pdf"}, {"href": "https://doi.org/11573/1419330"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Respiratory%20Physiology%20%26amp%3B%20Neurobiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11573/1419330", "name": "item", "description": "11573/1419330", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11573/1419330"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-09-01T00:00:00Z"}}, {"id": "17190727", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:23Z", "type": "Journal Article", "created": "2006-12-27", "title": "Long-Acting Calcium Channel Blocker, Azelnidipine, Increases Endothelial Nitric Oxide Synthase in the Brain and Inhibits Sympathetic Nerve Activity", "description": "Nitric oxide (NO) in the central nervous system inhibits sympathetic nerve activity, thereby decreasing blood pressure. It is unknown, however, whether orally administered antihypertensive treatment alters NO synthase (NOS) expression, particularly in the brain, and how changes in NOS expression affects sympathetic nerve activity. Azelnidipine, a recently developed long-acting dihydropyridine calcium channel blocker, does not cause baroreflex-induced tachycardia. The aim of the present study was to determine whether antihypertensive treatment with azelnidipine alters endothelial NOS (eNOS), neuronal NOS (nNOS), or inducible NOS (iNOS) expression in the brain, and how changes in NOS affect sympathetic nerve activity. Azelnidipine (20 mg/kg/day) or hydralazine (20 mg/kg/day) was orally administered for 30 days in stroke-prone spontaneously hypertensive rats (SHRSP). Blood pressure and heart rate were measured by the tail cuff method. Urinary norepinephrine excretion was measured as a marker of sympathetic nerve activity. Western blot analysis was performed to examine eNOS, nNOS, or iNOS expression levels in the brain (cortex, cerebellum, hypothalamus, and the brain stem), heart, and aorta. The extent of blood pressure reduction was similar between the two groups. Heart rate increased in the hydralazine-treated group but did not change in the azelnidipine-treated group. Urinary norepinephrine excretion was significantly increased only in the hydralazine-treated group. Treatment with azelnidipine significantly increased eNOS expression levels in the brain, heart, and aorta, but did not alter nNOS or iNOS expression levels. Treatment with hydralazine did not change any of the NOS expression levels. These results suggest that antihypertensive treatment with azelnidipine attenuates reflex-induced sympathetic activation and enhances eNOS expression levels in the brain as well as in the heart and aorta.", "keywords": ["Male", "Dihydropyridines", "Sympathetic Nervous System", "Nitric Oxide Synthase Type III", "Myocardium", "Brain", "Nitric Oxide Synthase Type II", "Blood Pressure", "Rats", " Inbred Strains", "Nitric Oxide Synthase Type I", "Calcium Channel Blockers", "Rats", "3. Good health", "Enzyme Activation", "Norepinephrine", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Rats", " Inbred SHR", "Animals", "Azetidinecarboxylic Acid", "Aorta"], "contacts": [{"organization": "Yoshikuni, Kimura, Yoshitaka, Hirooka, Yoji, Sagara, Kenji, Sunagawa,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/17190727"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Clinical%20and%20Experimental%20Hypertension", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "17190727", "name": "item", "description": "17190727", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/17190727"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2007-01-01T00:00:00Z"}}, {"id": "19462205", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:30Z", "type": "Journal Article", "created": "2009-05-21", "title": "Modifiable surgical and anesthesiologic risk factors for the development of cardiac and pulmonary complications after laparoscopic colorectal surgery", "description": "In contrast to patient-related risk factors, which are difficult to influence, factors relating to surgery and anesthesia that can be influenced have hardly been investigated. This study aimed to identify such risk factors.Pre- and intraoperative surgical and anesthesiologic factors of 388 colonic and 112 rectal procedures performed by a single surgeon within 50 months were recorded and analyzed for correlations with postoperative complications requiring treatment.Higher American Society of Anesthesiology (ASA) emergency interventions and intraoperative factors (bleeding, long operating time) had an elevated risk for general complications. Furthermore, patients benefited from the clinical experience of the anesthesiologist, especially in terms of emergency procedures, hemorrhagic complications, and a longer operating time.Standardization of the surgical technique, 'bloodless' surgery, standardization of intraoperative monitoring, and the use of board-certified anesthesiologists for high-risk cases, emergency procedures, and patients with high ASA stages are able to reduce postoperative morbidity.", "keywords": ["Adult", "Aged", " 80 and over", "Lung Diseases", "Male", "Intraoperative Care", "Adolescent", "Heart Diseases", "Middle Aged", "3. Good health", "Colonic Diseases", "03 medical and health sciences", "Postoperative Complications", "0302 clinical medicine", "Anesthesiology", "Preoperative Care", "Humans", "Female", "Laparoscopy", "Clinical Competence", "Prospective Studies", "Emergencies", "Anesthesia", " Inhalation", "Aged"], "contacts": [{"organization": "Th C, B\u00f6ttger, S, Hermeneit, M, M\u00fcller, A, Terzic, A, Rodehorst, L, Elad, M, Schamberger,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/19462205"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Surgical%20Endoscopy", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "19462205", "name": "item", "description": "19462205", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/19462205"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2009-05-22T00:00:00Z"}}, {"id": "1985394658", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:34Z", "type": "Journal Article", "created": "2002-07-27", "title": "Sympathetic Cardioneuropathy in Dysautonomias", "description": "The classification of dysautonomias has been confusing, and the pathophysiology obscure. We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and assessments of the entry rate of the sympathetic neurotransmitter norepinephrine into the cardiac venous drainage (cardiac norepinephrine spillover). We related the laboratory findings to signs of sympathetic neurocirculatory failure (orthostatic hypotension and abnormal blood-pressure responses associated with the Valsalva maneuver), central neural degeneration, and responsiveness to treatment with levodopa-carbidopa (Sinemet).Cardiac scans were obtained after intravenous administration of 6-[18F]fluorodopamine in 26 patients with dysautonomia. Fourteen had sympathetic neurocirculatory failure--three with no signs of central neurodegeneration (pure autonomic failure), two with parkinsonism responsive to treatment with levodopa-carbidopa, and nine with central neurodegeneration unresponsive to treatment with levodopa-carbidopa (the Shy-Drager syndrome). The rates of cardiac norepinephrine spillover were estimated on the basis of concentrations of intravenously infused [3H]norepinephrine during catheterization of the right side of the heart.Patients with pure autonomic failure or parkinsonism and sympathetic neurocirculatory failure had no myocardial 6-[18F]fluorodopamine-derived radioactivity or cardiac norepinephrine spillover, indicating loss of myocardial sympathetic-nerve terminals, whereas patients with the Shy-Drager syndrome had increased levels of 6-[18F]fluorodopamine-derived radioactivity, indicating intact sympathetic terminals and absent nerve traffic. Patients with dysautonomia who did not have sympathetic neurocirculatory failure had normal levels of 6-[18F]fluorodopamine-derived radioactivity in myocardium and normal rates of cardiac norepinephrine spillover.The results of 6-[18F]fluorodopamine positron-emission tomography and neurochemical analyses support a new clinical pathophysiologic classification of dysautonomias, based on the occurrence of sympathetic neurocirculatory failure, signs of central neurodegeneration, and responsiveness to levodopa-carbidopa.", "keywords": ["Adult", "Aged", " 80 and over", "Fluorine Radioisotopes", "Nitrogen Radioisotopes", "Sympathetic Nervous System", "Epinephrine", "Dopamine", "Myocardium", "Shy-Drager Syndrome", "Heart", "Parkinson Disease", "Middle Aged", "3. Good health", "Diagnosis", " Differential", "Levodopa", "Norepinephrine", "Autonomic Nervous System Diseases", "Ammonia", "Parasympathetic Nervous System", "Reference Values", "Coronary Circulation", "Humans", "Aged", "Tomography", " Emission-Computed"], "contacts": [{"organization": "Graeme Eisenhofer, Richard O. Cannon, Irwin J. Kopin, Courtney Holmes, David S. Goldstein,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/1985394658"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1985394658", "name": "item", "description": "1985394658", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1985394658"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1997-01-01T00:00:00Z"}}, {"id": "3c573e29a77be4dc6c8b5e88fa64191f", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-04-03T16:29:04Z", "type": "Report", "title": "Resting heart rate is associated with an increased prevalence of nonproliferative and proliferative/laser treated retinopathy in normoalbuminuric type 1 diabetic patients", "description": "Identification of the determinants of the onset of early diabetic retinopathy is essential for reducing the morbidity and mortality associated with diabetes. Many study have identified poor glycemic control, duration of diabetes and blood pressure as most important risk factors for development of retinopathy. The aim of this study was to evaluate the associations of clinical and metabolic parameters with nonproliferative (NPR) and proliferative/laser tretaed retinopathy (PR)in normoalbuminuric T1DM. Study included 333 (198 without retinopathy, 135 with NPR and PR) normoalbuminuric T1DM with normal or mildly decreased renal function (estimated glomerular filtration rate over 60ml/min), before any internevtiions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula. Microalbumin was measured spectrophotometrically by turbidimetric immuno-inhibition. Diagnosis of retinopathy was made by fundoscopy after pupillary dilatation. Resting heart rate was determined using a standard 12-lead ECG after a resting period of 10 minutes and expressed in beats per minute. Only resting HR was associated with NPR and PR in our normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function.", "keywords": ["heart rate; retinopathy; type 1 diabetes", "3. Good health"], "contacts": [{"organization": "Bulum, Tomislav, Prka\u010din, Ingrid, Blaslov, Kristina, Zibar, Karin, Duvnjak, Lea,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/3c573e29a77be4dc6c8b5e88fa64191f"}, {"rel": "self", "type": "application/geo+json", "title": "3c573e29a77be4dc6c8b5e88fa64191f", "name": "item", "description": "3c573e29a77be4dc6c8b5e88fa64191f", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3c573e29a77be4dc6c8b5e88fa64191f"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-01-01T00:00:00Z"}}, {"id": "8009224", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:30:11Z", "type": "Journal Article", "created": "2006-10-06", "title": "Maternal Rescue of Transforming Growth Factor-\u03b2 1 Null Mice", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Maternal sources of transforming growth factor-\u03b21 (TGF-\u03b21) are shown here to contribute to the normal appearance and perinatal survival of TGF-\u03b21 null newborn mice. Labeled TGF-\u03b21 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF\u03b2-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-\u03b21 null embryos and null newborn pups born to TGF-\u03b21 heterozygotes stained positive for TGF-\u03b21, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-\u03b21 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.</p></article>", "keywords": ["Heart Defects", " Congenital", "0301 basic medicine", "Heterozygote", "0303 health sciences", "Homozygote", "Embryonic and Fetal Development", "Mice", "03 medical and health sciences", "Fetus", "Milk", "Animals", " Newborn", "Pregnancy", "Transforming Growth Factor beta", "Animals", "Female", "Maternal-Fetal Exchange"], "contacts": [{"organization": "J J, Letterio, A G, Geiser, A B, Kulkarni, N S, Roche, M B, Sporn, A B, Roberts,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/8009224"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Science", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "8009224", "name": "item", "description": "8009224", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/8009224"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1994-06-24T00:00:00Z"}}, {"id": "PMC11117807", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:31:00Z", "type": "Journal Article", "created": "2024-04-26", "title": "Comparative Study of Field-Effect Transistors Based on Graphene Oxide and CVD Graphene in Highly Sensitive NT-proBNP Aptasensors", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Graphene-based materials are actively being investigated as sensing elements for the detection of different analytes. Both graphene grown by chemical vapor deposition (CVD) and graphene oxide (GO) produced by the modified Hummers\u2019 method are actively used in the development of biosensors. The production costs of CVD graphene- and GO-based sensors are similar; however, the question remains regarding the most efficient graphene-based material for the construction of point-of-care diagnostic devices. To this end, in this work, we compare CVD graphene aptasensors with the aptasensors based on reduced GO (rGO) for their capabilities in the detection of NT-proBNP, which serves as the gold standard biomarker for heart failure. Both types of aptasensors were developed using commercial gold interdigitated electrodes (IDEs) with either CVD graphene or GO formed on top as a channel of liquid-gated field-effect transistor (FET), yielding GFET and rGO-FET sensors, respectively. The functional properties of the two types of aptasensors were compared. Both demonstrate good dynamic range from 10 fg/mL to 100 pg/mL. The limit of detection for NT-proBNP in artificial saliva was 100 fg/mL and 1 pg/mL for rGO-FET- and GFET-based aptasensors, respectively. While CVD GFET demonstrates less variations in parameters, higher sensitivity was demonstrated by the rGO-FET due to its higher roughness and larger bandgap. The demonstrated low cost and scalability of technology for both types of graphene-based aptasensors may be applicable for the development of different graphene-based biosensors for rapid, stable, on-site, and highly sensitive detection of diverse biochemical markers.</p></article>", "keywords": ["Transistors", " Electronic", "graphene", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "01 natural sciences", "point-of-care diagnostic", "Article", "Peptide Fragments", "0104 chemical sciences", "Limit of Detection", "Natriuretic Peptide", " Brain", "graphene oxide", "Humans", "Graphite", "Gold", "0210 nano-technology", "Electrodes", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "https://www.mdpi.com/2079-6374/14/5/215/pdf"}, {"href": "https://doi.org/PMC11117807"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11117807", "name": "item", "description": "PMC11117807", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11117807"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-04-26T00:00:00Z"}}, {"id": "PMC9775241", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:31:10Z", "type": "Journal Article", "created": "2022-11-24", "title": "One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>A novel photochemical technological route for one-step functionalization of a graphene surface with an azide-modified DNA aptamer for biomarkers is developed. The methodology is demonstrated for the functionalization of a DNA aptamer for an N-terminal B-type natriuretic peptide (NT-proBNP) heart failure biomarker on the surface of a graphene channel within a system based on a liquid-gated graphene field effect transistor (GFET). The limit of detection (LOD) of the aptamer-functionalized sensor is 0.01 pg/mL with short response time (75 s) for clinically relevant concentrations of the cardiac biomarker, which could be of relevance for point-of-care (POC) applications. The novel methodology could be applicable for the development of different graphene-based biosensors for fast, stable, real-time, and highly sensitive detection of disease markers.</p></article>", "keywords": ["azide modification", "field-effect transistor", "heart failure", "aptamer", "Biosensing Techniques", "02 engineering and technology", "Aptamers", " Nucleotide", "point-of-care diagnostic", "Article", "Peptide Fragments", "graphene biosensor; heart failure; field-effect transistor; point-of-care diagnostic; aptamer; azide modification; photochemistry", "Natriuretic Peptide", " Brain", "graphene biosensor", "Graphite", "0210 nano-technology", "TP248.13-248.65", "Biomarkers", "Biotechnology"]}, "links": [{"href": "http://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://www.mdpi.com/2079-6374/12/12/1071/pdf"}, {"href": "https://doi.org/PMC9775241"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biosensors", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC9775241", "name": "item", "description": "PMC9775241", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC9775241"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-11-23T00:00:00Z"}}, {"id": "baieta.,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:32:31Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. Haddy,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/baieta.,2017"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "baieta.,2017", "name": "item", "description": "baieta.,2017", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/baieta.,2017"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "colberg,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:32:53Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/colberg,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "colberg,2007", "name": "item", "description": "colberg,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/colberg,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "deng,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:06Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/deng,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "deng,2004", "name": "item", "description": "deng,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/deng,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}, {"id": "fan,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:33Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/fan,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "fan,2007", "name": "item", "description": "fan,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/fan,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "garciaolmos,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:43Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/garciaolmos,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "garciaolmos,2007", "name": "item", "description": "garciaolmos,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/garciaolmos,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "han,s.,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:45Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/han,s.,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "han,s.,2014", "name": "item", "description": "han,s.,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/han,s.,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "lu,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:26Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/lu,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "lu,2007", "name": "item", "description": "lu,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/lu,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "ji,x.,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:21Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/ji,x.,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "ji,x.,2007", "name": "item", "description": "ji,x.,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ji,x.,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "jiang,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:21Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. 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The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/jin,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "jin,2014", "name": "item", "description": "jin,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/jin,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "kahle,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:24Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. 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The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/li,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "li,2014", "name": "item", "description": "li,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/li,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "li,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:25Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. 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Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. 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Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/nrcaf,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "nrcaf,2007", "name": "item", "description": "nrcaf,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/nrcaf,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "sharrowandismail,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:03Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sharrowandismail,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sharrowandismail,2004", "name": "item", "description": "sharrowandismail,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sharrowandismail,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}, {"id": "su,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/su,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "su,2014", "name": "item", "description": "su,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/su,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "vonreis,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:10Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/vonreis,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "vonreis,2014", "name": "item", "description": "vonreis,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/vonreis,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "wang,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:11Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/wang,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "wang,2007", "name": "item", "description": "wang,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/wang,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "wang,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:11Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/wang,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "wang,2014", "name": "item", "description": "wang,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/wang,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "wang,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:11Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. Haddy,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/wang,2017"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "wang,2017", "name": "item", "description": "wang,2017", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/wang,2017"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "xuan,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/xuan,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "xuan,2014", "name": "item", "description": "xuan,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/xuan,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "yan,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. Haddy,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/yan,2017"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "yan,2017", "name": "item", "description": "yan,2017", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/yan,2017"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "yang,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/yang,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "yang,2007", "name": "item", "description": "yang,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/yang,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "yu,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/yu,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "yu,2014", "name": "item", "description": "yu,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/yu,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "yue,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:12Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/yue,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "yue,2007", "name": "item", "description": "yue,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/yue,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "zhao,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhao,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhao,2014", "name": "item", "description": "zhao,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhao,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zheng,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zheng,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zheng,2007", "name": "item", "description": "zheng,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zheng,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "zhou,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhou,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhou,2007", "name": "item", "description": "zhou,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhou,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "zhangw.,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhangw.,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhangw.,2007", "name": "item", "description": "zhangw.,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhangw.,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "zhou,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. Haddy,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhou,2017"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhou,2017", "name": "item", "description": "zhou,2017", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhou,2017"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zhouandwang,2014", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+. </p>", "keywords": ["Male", "0301 basic medicine", "Epinephrine", "Myocardium", "Sodium", "Heart", "Hydrogen-Ion Concentration", "In Vitro Techniques", "Propranolol", "Rats", "Ion Exchange", "Perfusion", "03 medical and health sciences", "0302 clinical medicine", "Potassium", "Animals", "Acidosis", " Respiratory", "Rabbits", "Acidosis", "Alkalosis", " Respiratory"], "contacts": [{"organization": "PA Poole-Wilson, GA Langer,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhouandwang,2014"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/American%20Journal%20of%20Physiology-Legacy%20Content", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhouandwang,2014", "name": "item", "description": "zhouandwang,2014", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhouandwang,2014"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-09-01T00:00:00Z"}}, {"id": "zimmerman,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. 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