{"type": "FeatureCollection", "features": [{"id": "sun,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:07Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sun,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sun,2007", "name": "item", "description": "sun,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sun,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "17190727", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:23Z", "type": "Journal Article", "created": "2006-12-27", "title": "Long-Acting Calcium Channel Blocker, Azelnidipine, Increases Endothelial Nitric Oxide Synthase in the Brain and Inhibits Sympathetic Nerve Activity", "description": "Nitric oxide (NO) in the central nervous system inhibits sympathetic nerve activity, thereby decreasing blood pressure. It is unknown, however, whether orally administered antihypertensive treatment alters NO synthase (NOS) expression, particularly in the brain, and how changes in NOS expression affects sympathetic nerve activity. Azelnidipine, a recently developed long-acting dihydropyridine calcium channel blocker, does not cause baroreflex-induced tachycardia. The aim of the present study was to determine whether antihypertensive treatment with azelnidipine alters endothelial NOS (eNOS), neuronal NOS (nNOS), or inducible NOS (iNOS) expression in the brain, and how changes in NOS affect sympathetic nerve activity. Azelnidipine (20 mg/kg/day) or hydralazine (20 mg/kg/day) was orally administered for 30 days in stroke-prone spontaneously hypertensive rats (SHRSP). Blood pressure and heart rate were measured by the tail cuff method. Urinary norepinephrine excretion was measured as a marker of sympathetic nerve activity. Western blot analysis was performed to examine eNOS, nNOS, or iNOS expression levels in the brain (cortex, cerebellum, hypothalamus, and the brain stem), heart, and aorta. The extent of blood pressure reduction was similar between the two groups. Heart rate increased in the hydralazine-treated group but did not change in the azelnidipine-treated group. Urinary norepinephrine excretion was significantly increased only in the hydralazine-treated group. Treatment with azelnidipine significantly increased eNOS expression levels in the brain, heart, and aorta, but did not alter nNOS or iNOS expression levels. Treatment with hydralazine did not change any of the NOS expression levels. These results suggest that antihypertensive treatment with azelnidipine attenuates reflex-induced sympathetic activation and enhances eNOS expression levels in the brain as well as in the heart and aorta.", "keywords": ["Male", "Dihydropyridines", "Sympathetic Nervous System", "Nitric Oxide Synthase Type III", "Myocardium", "Brain", "Nitric Oxide Synthase Type II", "Blood Pressure", "Rats", " Inbred Strains", "Nitric Oxide Synthase Type I", "Calcium Channel Blockers", "Rats", "3. Good health", "Enzyme Activation", "Norepinephrine", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Rats", " Inbred SHR", "Animals", "Azetidinecarboxylic Acid", "Aorta"], "contacts": [{"organization": "Yoshikuni, Kimura, Yoshitaka, Hirooka, Yoji, Sagara, Kenji, Sunagawa,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/17190727"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Clinical%20and%20Experimental%20Hypertension", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "17190727", "name": "item", "description": "17190727", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/17190727"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2007-01-01T00:00:00Z"}}, {"id": "3c573e29a77be4dc6c8b5e88fa64191f", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-04-03T16:29:04Z", "type": "Report", "title": "Resting heart rate is associated with an increased prevalence of nonproliferative and proliferative/laser treated retinopathy in normoalbuminuric type 1 diabetic patients", "description": "Identification of the determinants of the onset of early diabetic retinopathy is essential for reducing the morbidity and mortality associated with diabetes. Many study have identified poor glycemic control, duration of diabetes and blood pressure as most important risk factors for development of retinopathy. The aim of this study was to evaluate the associations of clinical and metabolic parameters with nonproliferative (NPR) and proliferative/laser tretaed retinopathy (PR)in normoalbuminuric T1DM. Study included 333 (198 without retinopathy, 135 with NPR and PR) normoalbuminuric T1DM with normal or mildly decreased renal function (estimated glomerular filtration rate over 60ml/min), before any internevtiions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) formula. Microalbumin was measured spectrophotometrically by turbidimetric immuno-inhibition. Diagnosis of retinopathy was made by fundoscopy after pupillary dilatation. Resting heart rate was determined using a standard 12-lead ECG after a resting period of 10 minutes and expressed in beats per minute. Only resting HR was associated with NPR and PR in our normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function.", "keywords": ["heart rate; retinopathy; type 1 diabetes", "3. Good health"], "contacts": [{"organization": "Bulum, Tomislav, Prka\u010din, Ingrid, Blaslov, Kristina, Zibar, Karin, Duvnjak, Lea,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/3c573e29a77be4dc6c8b5e88fa64191f"}, {"rel": "self", "type": "application/geo+json", "title": "3c573e29a77be4dc6c8b5e88fa64191f", "name": "item", "description": "3c573e29a77be4dc6c8b5e88fa64191f", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3c573e29a77be4dc6c8b5e88fa64191f"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-01-01T00:00:00Z"}}, {"id": "baieta.,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:32:31Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. 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Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. 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Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/fan,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "fan,2007", "name": "item", "description": "fan,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/fan,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "garciaolmos,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:33:43Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/garciaolmos,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "garciaolmos,2007", "name": "item", "description": "garciaolmos,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/garciaolmos,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "lu,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:26Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/lu,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "lu,2007", "name": "item", "description": "lu,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/lu,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "ji,x.,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:21Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/ji,x.,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "ji,x.,2007", "name": "item", "description": "ji,x.,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/ji,x.,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "jiang,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:21Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/jiang,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "jiang,2007", "name": "item", "description": "jiang,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/jiang,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "zhangp.,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:37:13Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/zhangp.,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "zhangp.,2007", "name": "item", "description": "zhangp.,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/zhangp.,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "hu,2007", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:19Z", "type": "Journal Article", "created": "2011-11-29", "description": "Thirty-four patients with life-threatening childhood status asthmaticus were treated with intravenous isoproterenol infusions. Twenty-seven responded favorably; seven failed to respond and underwent mechanical ventilation. Intravenously administered isoporterenol was a useful therapeutic adjunct in the treatment of these severe attacks. Complications in these cases were rare, but cardiac arrhythmia, rebound bronchospasm, and acute mobilization of secretions need to be considered. Further evaluation of the efficacy of intravenous infusions of isoproterenol in status asthmaticus would be valuable.", "keywords": ["Male", "Colorado", "Adolescent", "Isoproterenol", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Asthma", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Heart Rate", "Humans", "Female", "Infusions", " Parenteral", "Blood Gas Analysis", "Child"], "contacts": [{"organization": "Ernest K. Cotton, William H. Parry, Frank Martorano,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/hu,2007"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Pediatrics%20%26amp%3B%20Adolescent%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "hu,2007", "name": "item", "description": "hu,2007", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/hu,2007"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-01-01T00:00:00Z"}}, {"id": "li,2017", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:36:25Z", "type": "Journal Article", "created": "2017-12-22", "description": "<p> Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood. </p>", "keywords": ["Male", "0301 basic medicine", "Carotid Body", "Blood Pressure", "Heart", "Carbon Dioxide", "Hydrogen-Ion Concentration", "Vagotomy", "Chemoreceptor Cells", "Oxygen", "Perfusion", "03 medical and health sciences", "Carotid Sinus", "Dogs", "0302 clinical medicine", "Heart Rate", "Coronary Circulation", "Pressure", "Animals", "Ventricular Function", "Female", "Vascular Resistance"], "contacts": [{"organization": "J. M. Dabney, PE Parker, Ehrhart Ic, Jerry B. Scott, Weidner Wj, Francis J. 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