{"type": "FeatureCollection", "features": [{"id": "10.1016/j.cub.2020.09.063", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:16:26Z", "type": "Journal Article", "created": "2020-10-15", "title": "Newly explored\u00a0Faecalibacterium\u00a0diversity is connected to age, lifestyle, geography, and disease.", "description": "Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.", "keywords": ["Adult", "0301 basic medicine", "pangenome", "Adolescent", "gut microbiome", "Datasets as Topic", "General Biochemistry", " Genetics and Molecular Biology", "Innovation action", "Feces", "03 medical and health sciences", "Animals", "Humans", "biotherapeutics", "European Commission", "Child", "Life Style", "Faecalibacterium", "Aged", "Aurora Universities Network", "Horizon 2020", "0303 health sciences", "EC", "Geography", "Faecalibacterium prausnitzii", "H2020", "Age Factors", "Infant", "Middle Aged", "Gastrointestinal Microbiome", "Faecalibacterium prausnitzii", " gut microbiome", " strain diversity", " pangenome", " novel probiotics", " biotherapeutics", "Child", " Preschool", "novel probiotics", "Dysbiosis", "Macaca", "Metagenome", "strain diversity", "Metagenomics", "General Agricultural and Biological Sciences"]}, "links": [{"href": "https://www.iris.unina.it/bitstream/11588/819607/1/PIIS0960982220314330.pdf"}, {"href": "https://doi.org/10.1016/j.cub.2020.09.063"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Current%20Biology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.cub.2020.09.063", "name": "item", "description": "10.1016/j.cub.2020.09.063", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.cub.2020.09.063"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-12-01T00:00:00Z"}}, {"id": "10.1038/s41467-024-51398-3", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:18:39Z", "type": "Journal Article", "created": "2024-08-13", "title": "Insights into the ecology of the infant gut plasmidome", "description": "Plasmids are small DNA molecules that enable bacteria to share beneficial traits, influencing microbial communities. However, their role within the human gut microbiome remains largely unknown. In this study, we investigate the gut microbiomes of 34 mother-child cohorts, employing a plasmid analysis workflow to understand the impact of plasmids on the gut microbiome. We create a plasmid phylogenetic tree, devise a method for assigning plasmid hosts, and examine potential plasmid transfer networks. Our research discovers a wide variety of previously unidentified plasmid sequences, indicating that current databases do not fully represent the gut plasmidome. Interestingly, infants display greater plasmid diversity compared to mothers and other healthy adults. We find that Bacteroidota, a major bacterial phylum, serves as the primary host for gut plasmids and plays a dominant role in gut plasmid transfer events. Additionally, plasmids broaden the genetic capabilities of bacteria, with their influence on bacterial function becoming more apparent as children's gut microbiomes develop. This study sheds light on the role of plasmids in the infant gut microbiome, making a significant contribution to our understanding of plasmid biology.", "keywords": ["Adult", "Male", "0301 basic medicine", "0303 health sciences", "Bacteria", "Bacteroidetes", "Science", "Q", "Infant", " Newborn", "Infant", "Article", "Gastrointestinal Microbiome", "Feces", "03 medical and health sciences", "Humans", "Female", "Phylogeny", "Plasmids"]}, "links": [{"href": "https://doi.org/10.1038/s41467-024-51398-3"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Communications", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1038/s41467-024-51398-3", "name": "item", "description": "10.1038/s41467-024-51398-3", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1038/s41467-024-51398-3"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-13T00:00:00Z"}}, {"id": "11577/3480910", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:27:14Z", "type": "Journal Article", "created": "2014-09-20", "title": "The representativeness of a European multi-center network for influenza-like-illness participatory surveillance", "description": "The Internet is becoming more commonly used as a tool for disease surveillance. Similarly to other surveillance systems and to studies using online data collection, Internet-based surveillance will have biases in participation, affecting the generalizability of the results. Here we quantify the participation biases of Influenzanet, an ongoing European-wide network of Internet-based participatory surveillance systems for influenza-like-illness.In 2011/2012 Influenzanet launched a standardized common framework for data collection applied to seven European countries. Influenzanet participants were compared to the general population of the participating countries to assess the representativeness of the sample in terms of a set of demographic, geographic, socio-economic and health indicators.More than 30,000 European residents registered to the system in the 2011/2012 season, and a subset of 25,481 participants were selected for this study. All age classes (10\u00a0years brackets) were represented in the cohort, including under 10 and over 70\u00a0years old. The Influenzanet population was not representative of the general population in terms of age distribution, underrepresenting the youngest and oldest age classes. The gender imbalance differed between countries. A counterbalance between gender-specific information-seeking behavior (more prominent in women) and Internet usage (with higher rates in male populations) may be at the origin of this difference. Once adjusted by demographic indicators, a similar propensity to commute was observed for each country, and the same top three transportation modes were used for six countries out of seven. Smokers were underrepresented in the majority of countries, as were individuals with diabetes; the representativeness of asthma prevalence and vaccination coverage for 65+ individuals in two successive seasons (2010/2011 and 2011/2012) varied between countries.Existing demographic and national datasets allowed the quantification of the participation biases of a large cohort for influenza-like-illness surveillance in the general population. Significant differences were found between Influenzanet participants and the general population. The quantified biases need to be taken into account in the analysis of Influenzanet epidemiological studies and provide indications on populations groups that should be targeted in recruitment efforts.", "keywords": ["Influenza; Internet data collection; Participation bias; Representativeness; Selection bias; Surveillance", "Adult", "Male", "0301 basic medicine", "Adolescent", "Health Status", "Young Adult", "03 medical and health sciences", "Age Distribution", "0302 clinical medicine", "Influenza", " Human", "11. Sustainability", "Prevalence", "Humans", "Child", "Representativeness", "Aged", "Selection bias", "Internet", "Surveillance", "Internet data collection", "Public Health", " Environmental and Occupational Health", "Infant", " Newborn", "Participation bias", "Infant", "Middle Aged", "16. Peace & justice", "Influenza", "3. Good health", "Europe", "Socioeconomic Factors", "[SDV.SPEE] Life Sciences [q-bio]/Sant\u00e9 publique et \u00e9pid\u00e9miologie", "13. Climate action", "Child", " Preschool", "Population Surveillance", "Female", "Research Article"]}, "links": [{"href": "https://researchonline.lshtm.ac.uk/id/eprint/2017934/1/12889_2014_7121_MOESM2_ESM.pdf"}, {"href": "https://air.unimi.it/bitstream/2434/240039/2/cantarelli-colizza.pdf"}, {"href": "https://www.research.unipd.it/bitstream/11577/3480910/1/Cantarelli_BMC-PubHealth_2014.pdf"}, {"href": "https://doi.org/11577/3480910"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Public%20Health", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11577/3480910", "name": "item", "description": "11577/3480910", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11577/3480910"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-09-20T00:00:00Z"}}, {"id": "25031029", "type": "Feature", "geometry": null, "properties": {"updated": "2026-04-03T16:28:05Z", "type": "Journal Article", "created": "2014-07-17", "title": "Maternal Reported Indicators and Causes of Insufficient Milk Supply", "description": "Background:

Although the breastfeeding initiation rate is high in China, exclusivity is low. Not having enough breast milk has been frequently reported as a reason for supplementing and weaning.

Objective:

The objective was to explore maternal perception of indicators and causes of self-reported insufficient milk supply (IMS) among a sample of southwestern Chinese mothers.

Methods:

This was a cross-sectional study, conducted in a hospital in Chengdu, China.

Results:

The majority of mothers were of Han ethnicity and primiparous. Most initiated breastfeeding (n = 325, 95.3%). Among mothers who had weaned by the time of questionnaire completion, more than half (n = 52) reported IMS as a reason, and 53.8% of these mothers reported this occurring during the first 2 days postpartum. Mothers often identified IMS by using less sensitive indicators of adequate intake such as receiving a hungry look from the infant after nursing (34.6%) and not feeling the presence of milk (28.8%). More sensitive indicators of adequate intake, such as the number of wet/soiled diapers, were not reported. More than a third of mothers (39.2%) could not express a reason for the occurrence of IMS. Among those who identified reasons, nearly one-fourth of mothers attributed IMS, at least partially, to dietary factors such as poor appetite (23.5%).

Conclusion:

Self-reported IMS appears to be a common barrier to breastfeeding continuation among this sample of Chinese mothers. Culturally appropriate intervention, designed to inform mothers how to correctly identify and address IMS, might be an effective strategy to support optimal infant-feeding behaviors in China. There is an ongoing debate on the possible association between infections in early childhood and subsequent cancer risk, but it remains unclear if a hospital admission for infection is associated with risk of childhood cancer diagnosis. We examined if a hospital-based diagnosis of pneumonia was a clinical marker of the three most common childhood cancers.

Design

Population-based cohort study.

Setting

Denmark, hospital diagnoses, 1994\uffe2\uff80\uff932013.

Methods

Using national health registries, we compared the observed incidence of leukaemia, lymphoma and brain cancer among 83\uffe2\uff80\uff89935 children with a hospital-based pneumonia diagnosis with that expected among children in the general population. We calculated absolute cancer risks and standardised incidence ratios (SIRs) as a measure of relative risk.

Results

The cancer SIRs were substantially increased during the first 6 months of follow-up; lymphoid leukaemia: 6.2 (95% CI 3.5 to 10.3); myeloid leukaemia: 14.8 (95% CI 6.0 to 30.6); Hodgkin\uffe2\uff80\uff99s lymphoma: 60.8 (95% CI 26.2 to 120), non-Hodgkin\uffe2\uff80\uff99s lymphoma: 15.9 (95% CI 5.2 to 37.2) and brain cancer: 4.4 (95% CI 1.9 to 8.7). The 6-month absolute risks of leukaemia, lymphoma and brain cancer were all low, reaching 0.05% when combined. An increased risk persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the 5-year absolute cancer risk was 0.14%.

Conclusions

The short-term incidence of leukaemia, lymphoma and brain cancer was higher than expected and persisted beyond 5 years for non-Hodgkin\uffe2\uff80\uff99s lymphoma and brain cancer. However, the absolute cancer risk was low.