{"type": "FeatureCollection", "features": [{"id": "10.1016/j.chemosphere.2024.143131", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:15:20Z", "type": "Journal Article", "created": "2024-08-19", "title": "Photoaging of polystyrene-based microplastics amplifies inflammatory response in macrophages", "description": "The continuous release of municipal and industrial products into the environment poses a growing concern for public health. Among environmental pollutants, polystyrene (PS) stands out as a primary constituent of environmental plastic waste, given its widespread use and high production rates owing to its durability and user-friendly properties. The detection of polystyrene microparticles (PS-MPs) in various living organisms has been well-documented, posing a serious threat due to their potential passage into the human ecosystem. In this manuscript, we aimed to study the toxicological effects of low concentrations of pristine and photoaged PS-MPs in a murine macrophage cell line. To this purpose, PS-MPs were photoaged by indoor exposure to visible light to simulate environmental weathering due to solar irradiation (PS-MPs3h). Physical characterization revealed that the irradiation treatment results in particle degradation and the possible release of nanoparticles. Monocultures of the RAW264.7\u00a0cell line were then exposed to PS-MPs and PS-MPs3h at concentrations comparable to experimental measurements from biological samples, to assess cytotoxicity, intracellular oxidative stress, primary genotoxicity, and inflammatory effects. Significant toxicity-related outcomes were observed in cells treated with both pristine PS-MPs and PS-MPs3h even at low concentrations (0,10\u00a0\u03bcg/ml and 1\u00a0\u03bcg/ml). PS-MPs3h exhibited greater adverse effects compared to PS-MPs, including reduced cell viability, increased ROS production, elevated DNA damage, and upregulation of IL-6 and NOS2 gene expression. Therefore, we can conclude that changes induced by environmental aging in the physicochemical composition of PS microplastics play a crucial role in the adverse health outcomes associated with microplastic exposure.", "keywords": ["Inflammation", "Mice", "Oxidative Stress", "RAW 264.7 Cells", "microplastics", " polystyrene", " macrophages", "Cell Survival", "Microplastics", "Macrophages", "Polystyrenes", "Animals", "Environmental Pollutants", "Reactive Oxygen Species", "DNA Damage"]}, "links": [{"href": "https://iris.cnr.it/bitstream/20.500.14243/493702/1/Aloi%20et%20al%20Chemospere%202024.pdf"}, {"href": "https://doi.org/10.1016/j.chemosphere.2024.143131"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Chemosphere", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.chemosphere.2024.143131", "name": "item", "description": "10.1016/j.chemosphere.2024.143131", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.chemosphere.2024.143131"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-01-01T00:00:00Z"}}, {"id": "10.1016/j.ijpddr.2024.100546", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:15:45Z", "type": "Journal Article", "created": "2024-05-05", "title": "Robenidine derivatives as potential antischistosomal drug candidates", "description": "Schistosomiasis caused by Schistosoma spp. is a disease that causes a considerable health burden to millions of people worldwide. The limited availability of effective drugs on the market and the increased risk of resistance development due to extensive usage, highlight the urgent need for new antischistosomal drugs. Recent studies have shown that robenidine derivatives, containing an aminoguanidine core, exhibit promising activities against Plasmodium falciparum, motivating further investigation into their efficacy against Schistosoma mansoni, due to their similar habitat and the resulting related cellular mechanisms like the heme detoxification pathway. The conducted phenotypic screening of robenidine and 80 derivatives against newly transformed schistosomula and adult Schistosoma mansoni yielded 11 candidates with low EC50 values for newly transformed schistosomula (1.12-4.63\u00a0\u03bcM) and adults (2.78-9.47\u00a0\u03bcM). The structure-activity relationship revealed that electron-withdrawing groups at the phenyl moiety, as well as the presence of methyl groups adjacent to the guanidine moiety, enhanced the activity of derivatives against both stages of Schistosoma mansoni. The two compounds 2,2'-Bis[(3-cyano-4-fluorophenyl)methylene] carbonimidic Dihydrazide Hydrochloride (1) and 2,2'-Bis[(4-difluoromethoxyphenyl) ethylidene] carbonimidic Dihydrazide Hydrochloride (19), were selected for an in vivo study in Schistosoma mansoni-infected mice based on their potency, cytotoxicity, pharmacokinetic-, and physicochemical properties, but failed to reduce the worm burden significantly (worm burden reduction <20%). Thus, robenidine derivatives require further refinements to obtain higher antischistosomal specificity and in vivo activity.", "keywords": ["Male", "0301 basic medicine", "0303 health sciences", "Drug discovery", "Infectious and parasitic diseases", "RC109-216", "Schistosoma mansoni", "Structure-activity relationship", "Guanidines", "Article", "Schistosomiasis mansoni", "3. Good health", "Mice", "Schistosomicides", "Structure-Activity Relationship", "03 medical and health sciences", "Aminoguanidine", "Animals", "Female", "Robenidine derivative"], "contacts": [{"organization": "Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1016/j.ijpddr.2024.100546"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/International%20Journal%20for%20Parasitology%3A%20Drugs%20and%20Drug%20Resistance", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.ijpddr.2024.100546", "name": "item", "description": "10.1016/j.ijpddr.2024.100546", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.ijpddr.2024.100546"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-01T00:00:00Z"}}, {"id": "10.1016/j.jinsphys.2016.03.003", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:15:52Z", "type": "Journal Article", "created": "2016-03-08", "title": "A novel approach to the measurement of surfactant parameters in arthropod digestive juices", "description": "In arthropods, the determination of two important parameters of digestive juices, i.e. the total surfactant concentration and the critical micelle concentration (CMC), is challenging due to small sample volumes and low surfactant concentrations. In this work, we report a successful implementation of potentiometric titrations using the surfactant ion-selective electrode (SISE) and the pyrene fluorescence method (PFM) for the determination of the total surfactant concentration and CMC in the digestive juice of terrestrial isopod crustaceans Porcellio scaber. Pooled digestive juice extracts of four (SISE) or two (PFM) animals were used per measurement run. In both cases, digestive juice extracts in 100 \u03bcL of deionized water were sufficient for one measurement run. The total surfactant concentration of P. scaber digestive juice was determined to be 9.2 \u00b1 3.5mM and the CMC was approximately 90 \u03bcM. Our work presents an important improvement towards easy CMC determination in small volume samples in comparison with the commonly used stalagmometric technique, where much larger sample volumes are usually needed. To date, the total surfactant concentration was not measured in the digestive juices of arthropods other than Homarus vulgaris, Astacus leptodactylus and Cancer pagurus, for which complex separation and analytical techniques were required. Our results obtained by SISE and PFM therefore present the first successful quantification of surfactants and their CMC in small volumes of arthropod digestive juice without prior separation or purification techniques.", "keywords": ["Male", "0301 basic medicine", "0303 health sciences", "critical micelle concentration", "surfactant", "pyrene fluorescence", "Slovenia", "info:eu-repo/classification/udc/595.373", "surfactant ion-selective electrode", "Surface-Active Agents", "03 medical and health sciences", "terrestrial isopod", "Animals", "Digestion", "Female", "14. Life underwater", "Digestive System", "Micelles", "Isopoda"]}, "links": [{"href": "https://doi.org/10.1016/j.jinsphys.2016.03.003"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Insect%20Physiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.jinsphys.2016.03.003", "name": "item", "description": "10.1016/j.jinsphys.2016.03.003", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.jinsphys.2016.03.003"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2016-05-01T00:00:00Z"}}, {"id": "10.1021/acs.est.9b02448", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:16:32Z", "type": "Journal Article", "created": "2019-07-29", "title": "In Vitro , in Vivo, and Spectroscopic Assessment of Lead Exposure Reduction via Ingestion and Inhalation Pathways Using Phosphate and Iron Amendments", "description": "This study compared lead (Pb) immobilization efficacies in mining/smelting impacted soil using phosphate and iron amendments via ingestion and inhalation pathways using in vitro and in vivo assays, in conjunction with investigating the dynamics of dust particles in the lungs and gastro-intestinal tract via X-ray fluorescence (XRF) microscopy. Phosphate amendments [phosphoric acid (PA), hydroxyapatite, monoammonium phosphate (MAP), triple super phosphate (TSP), and bone meal biochar] and hematite were applied at a molar ratio of Pb:Fe/P = 1:5. Pb phosphate formation was investigated in the soil/post-in vitro bioaccessibility (IVBA) residuals and in mouse lung via extended X-ray absorption fine structure (EXAFS) and X-ray absorption near edge structures (XANES) spectroscopy, respectively. EXAFS analysis revealed that anglesite was the dominant phase in the ingestible (<250 \u03bcm) and inhalable (<10 \u03bcm) particle fractions. Pb IVBA was significantly reduced (p < 0.05) by phosphate amendments in the <250 \u03bcm fraction (solubility bioaccessibility research consortium assay) and by PA, MAP, and TSP in the <10 \u03bcm fraction (inhalation-ingestion bioaccessibility assay). A 21.1% reduction in Pb RBA (<250 \u03bcm fraction) and 56.4% reduction in blood Pb concentration (<10 \u03bcm fraction) were observed via the ingestion and inhalation pathways, respectively. XRF microscopy detected Pb in the stomach within 4 h, presumably via mucociliary clearance.", "keywords": ["0301 basic medicine", "iron;", "soil;", "Iron", "animals;", "610", "Biological Availability", "mice;", "01 natural sciences", "Phosphates", "618", "X ray fluorescence", "phosphates;", "Mice", "Soil", "03 medical and health sciences", "biological availability;", "soil pollutants", "[SDE]Environmental Sciences", "Animals", "Soil Pollutants", "extended X ray absorption fine structure spectroscopy", "0105 earth and related environmental sciences"]}, "links": [{"href": "https://pubs.acs.org/doi/pdf/10.1021/acs.est.9b02448"}, {"href": "https://doi.org/10.1021/acs.est.9b02448"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Environmental%20Science%20%26amp%3B%20Technology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1021/acs.est.9b02448", "name": "item", "description": "10.1021/acs.est.9b02448", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1021/acs.est.9b02448"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-07-29T00:00:00Z"}}, {"id": "10.1038/nature02051", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:16:44Z", "type": "Journal Article", "created": "2003-10-29", "title": "Motor Neuron Columnar Fate Imposed By Sequential Phases Of Hox-C Activity", "description": "The organization of neurons into columns is a prominent feature of central nervous system structure and function. In many regions of the central nervous system the grouping of neurons into columns links cell-body position to axonal trajectory, thus contributing to the establishment of topographic neural maps. This link is prominent in the developing spinal cord, where columnar sets of motor neurons innervate distinct targets in the periphery. We show here that sequential phases of Hox-c protein expression and activity control the columnar differentiation of spinal motor neurons. Hox expression in neural progenitors is established by graded fibroblast growth factor signalling and translated into a distinct motor neuron Hox pattern. Motor neuron columnar fate then emerges through cell autonomous repressor and activator functions of Hox proteins. Hox proteins also direct the expression of genes that establish motor topographic projections, thus implicating Hox proteins as critical determinants of spinal motor neuron identity and organization.", "keywords": ["Homeodomain Proteins", "Motor Neurons", "0301 basic medicine", "0303 health sciences", "Fibroblast Growth Factor 8", "Stem Cells", "Gene Expression Regulation", " Developmental", "Mitosis", "Cell Differentiation", "Chick Embryo", "Neoplasm Proteins", "3. Good health", "DNA-Binding Proteins", "Fibroblast Growth Factors", "Mice", "03 medical and health sciences", "Spinal Cord", "Animals", "RNA", " Messenger", "Body Patterning", "Signal Transduction"], "contacts": [{"organization": "Thomas M. Jessell, Jeh-Ping Liu, Jeremy S. Dasen,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.1038/nature02051"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1038/nature02051", "name": "item", "description": "10.1038/nature02051", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1038/nature02051"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2003-10-01T00:00:00Z"}}, {"id": "10.1038/nature02052", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:16:44Z", "type": "Journal Article", "created": "2003-10-08", "title": "Loss Of Omi Mitochondrial Protease Activity Causes The Neuromuscular Disorder Of Mnd2 Mutant Mice", "description": "The mouse mutant mnd2 (motor neuron degeneration 2) exhibits muscle wasting, neurodegeneration, involution of the spleen and thymus, and death by 40 days of age. Degeneration of striatal neurons, with astrogliosis and microglia activation, begins at around 3 weeks of age, and other neurons are affected at later stages. Here we have identified the mnd2 mutation as the missense mutation Ser276Cys in the protease domain of the nuclear-encoded mitochondrial serine protease Omi (also known as HtrA2 or Prss25). Protease activity of Omi is greatly reduced in tissues of mnd2 mice but is restored in mice rescued by a bacterial artificial chromosome transgene containing the wild-type Omi gene. Deletion of the PDZ domain partially restores protease activity to the inactive recombinant Omi protein carrying the Ser276Cys mutation, suggesting that the mutation impairs substrate access or binding to the active site pocket. Loss of Omi protease activity increases the susceptibility of mitochondria to induction of the permeability transition, and increases the sensitivity of mouse embryonic fibroblasts to stress-induced cell death. The neurodegeneration and juvenile lethality in mnd2 mice result from this defect in mitochondrial Omi protease.", "keywords": ["Male", "0301 basic medicine", "0303 health sciences", "Binding Sites", "Cell Death", "Science", "Homozygote", "Molecular Sequence Data", "Caseins", "Chromosome Mapping", "Mice", " Transgenic", "High-Temperature Requirement A Serine Peptidase 2", "Mitochondria", "Mitochondrial Proteins", "Mice", "Mice", " Neurologic Mutants", "03 medical and health sciences", "Animals", "Humans", "Calcium", "Female", "Amino Acid Sequence", "Cells", " Cultured", "Crosses", " Genetic"]}, "links": [{"href": "https://doi.org/10.1038/nature02052"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1038/nature02052", "name": "item", "description": "10.1038/nature02052", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1038/nature02052"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2003-10-01T00:00:00Z"}}, {"id": "10.1038/s41467-022-31712-7", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:16:47Z", "type": "Journal Article", "created": "2022-07-11", "title": "Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis", "description": "Abstract<p>Diphthamide, a post-translationally modified histidine residue of eukaryotic TRANSLATION ELONGATION FACTOR2 (eEF2), is the human host cell-sensitizing target of diphtheria toxin. Diphthamide biosynthesis depends on the 4Fe-4S-cluster protein Dph1 catalyzing the first committed step, as well as Dph2 to Dph7, in yeast and mammals. Here we show that diphthamide modification of eEF2 is conserved inArabidopsis thalianaand requires AtDPH1. Ribosomal \uffe2\uff88\uff921 frameshifting-error rates are increased in Arabidopsisdph1mutants, similar to yeast and mice. Compared to the wild type, shorter roots and smaller rosettes ofdph1mutants result from fewer formed cells. TARGET OF RAPAMYCIN (TOR) kinase activity is attenuated, and autophagy is activated, indph1mutants. Under abiotic stress diphthamide-unmodified eEF2 accumulates in wild-type seedlings, most strongly upon heavy metal excess, which is conserved in human cells. In summary, our results suggest that diphthamide contributes to the functionality of the translational machinery monitored by plants to regulate growth.</p", "keywords": ["Mammals", "0301 basic medicine", "0303 health sciences", "Saccharomyces cerevisiae Proteins", "Science", "Q", "Arabidopsis", "Proteins", "Saccharomyces cerevisiae", "Article", "Mice", "03 medical and health sciences", "Animals", "Humans", "Histidine", "ddc:570"]}, "links": [{"href": "https://www.nature.com/articles/s41467-022-31712-7.pdf"}, {"href": "https://doi.org/10.1038/s41467-022-31712-7"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Communications", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1038/s41467-022-31712-7", "name": "item", "description": "10.1038/s41467-022-31712-7", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1038/s41467-022-31712-7"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-07-11T00:00:00Z"}}, {"id": "10.1101/688010", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:17:21Z", "type": "Journal Article", "created": "2019-07-02", "title": "High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation", "description": "ABSTRACT<p>By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 530 knockout mouse lines identified 140 monogenic \uffe2\uff80\uff9chits\uffe2\uff80\uff9d (&gt;25%), most of which had never hitherto been implicated in immunology. Furthermore, they were conspicuously enriched in genes for which humans show poor tolerance to loss-of-function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with one another and with specific physiologic traits. By limiting the freedom of individual immune parameters, such linkages impose genetically regulated \uffe2\uff80\uff9cimmunological structures\uffe2\uff80\uff9d, whose integrity was found to be associated with immunocompetence. Hence, our findings provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease.</p", "keywords": ["Male", "0301 basic medicine", "570", "SUSCEPTIBILITY LOCI", "Knockout", "Immunology", "610", "BACH2", "Inbred C57BL", "DISEASE", "Immunophenotyping", "Mice", "03 medical and health sciences", "AGE", "Citrobacter", "Models", "Salmonella", "EPIDEMIOLOGY", "Animals", "Humans", "RISK", "Mice", " Knockout", "IMMUNODEFICIENCY", "0303 health sciences", "Science & Technology", "IDENTIFICATION", "Animal", "GENOME-WIDE", "Enterobacteriaceae Infections", "Genetic Variation", "ASSOCIATION", "High-Throughput Screening Assays", "3. Good health", "Mice", " Inbred C57BL", "1107 Immunology", "Models", " Animal", "Salmonella Infections", "Female", "Life Sciences & Biomedicine"]}, "links": [{"href": "https://eprints.gla.ac.uk/207005/7/207005.pdf"}, {"href": "https://www.biorxiv.org/content/10.1101/688010v1.full.pdf"}, {"href": "https://doi.org/10.1101/688010"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Immunology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1101/688010", "name": "item", "description": "10.1101/688010", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1101/688010"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-07-02T00:00:00Z"}}, {"id": "10.1109/TMI.2017.2743819", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:17:22Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/10.1109/TMI.2017.2743819"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1109/TMI.2017.2743819", "name": "item", "description": "10.1109/TMI.2017.2743819", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1109/TMI.2017.2743819"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "10.1109/tmi.2017.2743819", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:17:23Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/10.1109/tmi.2017.2743819"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1109/tmi.2017.2743819", "name": "item", "description": "10.1109/tmi.2017.2743819", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1109/tmi.2017.2743819"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "10044/1/85999", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:21:36Z", "type": "Journal Article", "created": "2019-07-02", "title": "High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation", "description": "ABSTRACT<p>By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 530 knockout mouse lines identified 140 monogenic \uffe2\uff80\uff9chits\uffe2\uff80\uff9d (&gt;25%), most of which had never hitherto been implicated in immunology. Furthermore, they were conspicuously enriched in genes for which humans show poor tolerance to loss-of-function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with one another and with specific physiologic traits. By limiting the freedom of individual immune parameters, such linkages impose genetically regulated \uffe2\uff80\uff9cimmunological structures\uffe2\uff80\uff9d, whose integrity was found to be associated with immunocompetence. Hence, our findings provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease.</p", "keywords": ["Male", "0301 basic medicine", "570", "SUSCEPTIBILITY LOCI", "Knockout", "Immunology", "610", "BACH2", "Inbred C57BL", "DISEASE", "Immunophenotyping", "Mice", "03 medical and health sciences", "AGE", "Citrobacter", "Models", "Salmonella", "EPIDEMIOLOGY", "Animals", "Humans", "RISK", "Mice", " Knockout", "IMMUNODEFICIENCY", "0303 health sciences", "Science & Technology", "IDENTIFICATION", "Animal", "GENOME-WIDE", "Enterobacteriaceae Infections", "Genetic Variation", "ASSOCIATION", "High-Throughput Screening Assays", "3. Good health", "Mice", " Inbred C57BL", "1107 Immunology", "Models", " Animal", "Salmonella Infections", "Female", "Life Sciences & Biomedicine"]}, "links": [{"href": "https://eprints.gla.ac.uk/207005/7/207005.pdf"}, {"href": "https://www.biorxiv.org/content/10.1101/688010v1.full.pdf"}, {"href": "https://doi.org/10044/1/85999"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Immunology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10044/1/85999", "name": "item", "description": "10044/1/85999", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10044/1/85999"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-07-02T00:00:00Z"}}, {"id": "11877426", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:21:59Z", "type": "Journal Article", "created": "2002-07-26", "title": "Nerve Growth Factor-dependent Activation of the Small GTPase Rin", "description": "The Rit and Rin proteins comprise a distinct and evolutionarily conserved subfamily of Ras-related small GTPases. Although we have defined a role for Rit-mediated signal transduction in the regulation of cell proliferation and transformation, the function of Rin remains largely unknown. Because we demonstrate that Rin is developmentally regulated and expressed in adult neurons, we examined its role in neuronal signaling. In this study, we show that stimulation of PC6 cells with either epidermal growth factor or nerve growth factor (NGF) results in rapid activation of Rin. This activation correlates with the onset of Ras activation, and dominant-negative Ras completely inhibits Rin activation induced by NGF. Further examination of Ras-mediated Rin activation suggests that this process is dependent upon neuronally expressed regulatory factors. Expression of mutationally activated H-Ras fails to activate Rin in non-neuronal cells, but results in potent stimulation of Rin-GTP levels in a variety of neuronal cell lines. Furthermore, although constitutively activated Rin does not induce neurite outgrowth on its own, both NGF-induced and oncogenic Ras-induced neurite outgrowth were inhibited by the expression of dominant-negative Rin. Together, these studies indicate that Rin activation is a direct downstream effect of growth factor-dependent signaling in neuronal cells and suggest that Rin may function to transduce signals within the mature nervous system.", "keywords": ["0301 basic medicine", "Adrenal Gland Neoplasms", "3T3 Cells", "Pheochromocytoma", "Transfection", "PC12 Cells", "Rats", "Enzyme Activation", "Mice", "03 medical and health sciences", "Genes", " ras", "Culture Techniques", "Nerve Growth Factor", "Neurites", "ras Proteins", "Animals", "RNA", " Messenger", "Signal Transduction"], "contacts": [{"organization": "Michael L, Spencer, Haipeng, Shao, H Michael, Tucker, Douglas A, Andres,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/11877426"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Biological%20Chemistry", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11877426", "name": "item", "description": "11877426", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11877426"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2002-05-01T00:00:00Z"}}, {"id": "10115/29781", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:21:37Z", "type": "Journal Article", "created": "2022-07-11", "title": "Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis", "description": "Abstract<p>Diphthamide, a post-translationally modified histidine residue of eukaryotic TRANSLATION ELONGATION FACTOR2 (eEF2), is the human host cell-sensitizing target of diphtheria toxin. Diphthamide biosynthesis depends on the 4Fe-4S-cluster protein Dph1 catalyzing the first committed step, as well as Dph2 to Dph7, in yeast and mammals. Here we show that diphthamide modification of eEF2 is conserved inArabidopsis thalianaand requires AtDPH1. Ribosomal \uffe2\uff88\uff921 frameshifting-error rates are increased in Arabidopsisdph1mutants, similar to yeast and mice. Compared to the wild type, shorter roots and smaller rosettes ofdph1mutants result from fewer formed cells. TARGET OF RAPAMYCIN (TOR) kinase activity is attenuated, and autophagy is activated, indph1mutants. Under abiotic stress diphthamide-unmodified eEF2 accumulates in wild-type seedlings, most strongly upon heavy metal excess, which is conserved in human cells. In summary, our results suggest that diphthamide contributes to the functionality of the translational machinery monitored by plants to regulate growth.</p", "keywords": ["Mammals", "0301 basic medicine", "0303 health sciences", "Saccharomyces cerevisiae Proteins", "Science", "Q", "Arabidopsis", "Proteins", "Saccharomyces cerevisiae", "Article", "Mice", "03 medical and health sciences", "Animals", "Humans", "Histidine", "ddc:570"]}, "links": [{"href": "https://www.nature.com/articles/s41467-022-31712-7.pdf"}, {"href": "https://doi.org/10115/29781"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Nature%20Communications", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10115/29781", "name": "item", "description": "10115/29781", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10115/29781"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-07-11T00:00:00Z"}}, {"id": "10447/688224", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:21:47Z", "type": "Journal Article", "created": "2024-08-19", "title": "Photoaging of polystyrene-based microplastics amplifies inflammatory response in macrophages", "description": "The continuous release of municipal and industrial products into the environment poses a growing concern for public health. Among environmental pollutants, polystyrene (PS) stands out as a primary constituent of environmental plastic waste, given its widespread use and high production rates owing to its durability and user-friendly properties. The detection of polystyrene microparticles (PS-MPs) in various living organisms has been well-documented, posing a serious threat due to their potential passage into the human ecosystem. In this manuscript, we aimed to study the toxicological effects of low concentrations of pristine and photoaged PS-MPs in a murine macrophage cell line. To this purpose, PS-MPs were photoaged by indoor exposure to visible light to simulate environmental weathering due to solar irradiation (PS-MPs3h). Physical characterization revealed that the irradiation treatment results in particle degradation and the possible release of nanoparticles. Monocultures of the RAW264.7\u00a0cell line were then exposed to PS-MPs and PS-MPs3h at concentrations comparable to experimental measurements from biological samples, to assess cytotoxicity, intracellular oxidative stress, primary genotoxicity, and inflammatory effects. Significant toxicity-related outcomes were observed in cells treated with both pristine PS-MPs and PS-MPs3h even at low concentrations (0,10\u00a0\u03bcg/ml and 1\u00a0\u03bcg/ml). PS-MPs3h exhibited greater adverse effects compared to PS-MPs, including reduced cell viability, increased ROS production, elevated DNA damage, and upregulation of IL-6 and NOS2 gene expression. Therefore, we can conclude that changes induced by environmental aging in the physicochemical composition of PS microplastics play a crucial role in the adverse health outcomes associated with microplastic exposure.", "keywords": ["Inflammation", "microplastics", " polystyrene", " macrophages", "Cell Survival", "Microplastics", "Macrophages", "Mice", "Oxidative Stress", "RAW 264.7 Cells", "N/A", "Polystyrenes", "Animals", "Environmental Pollutants", "Reactive Oxygen Species", "DNA Damage"]}, "links": [{"href": "https://iris.cnr.it/bitstream/20.500.14243/493702/1/Aloi%20et%20al%20Chemospere%202024.pdf"}, {"href": "https://iris.unipa.it/bitstream/10447/688224/2/Aloi%20et%20al.%202024.pdf"}, {"href": "https://doi.org/10447/688224"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Chemosphere", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10447/688224", "name": "item", "description": "10447/688224", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10447/688224"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-01-01T00:00:00Z"}}, {"id": "11343/246714", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:21:54Z", "type": "Journal Article", "created": "2019-01-14", "title": "Exclusive dependence of IL-10R\u03b1 signalling on intestinal microbiota homeostasis and control of whipworm infection", "description": "The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory response elicited by the parasite while tunnelling through intestinal epithelial cells (IECs). The IL-10 family of receptors, comprising combinations of subunits IL-10R\u03b1, IL-10R\u03b2, IL-22R\u03b1 and IL-28R\u03b1, modulates intestinal inflammatory responses. Here we carefully dissected the role of these subunits in the resistance of mice to infection with T. muris, a mouse model of the human whipworm T. trichiura. Our findings demonstrate that whilst IL-22R\u03b1 and IL-28R\u03b1 are dispensable in the host response to whipworms, IL-10 signalling through IL-10R\u03b1 and IL-10R\u03b2 is essential to control caecal pathology, worm expulsion and survival during T. muris infections. We show that deficiency of IL-10, IL-10R\u03b1 and IL-10R\u03b2 results in dysbiosis of the caecal microbiota characterised by expanded populations of opportunistic bacteria of the families Enterococcaceae and Enterobacteriaceae. Moreover, breakdown of the epithelial barrier after whipworm infection in IL-10, IL-10R\u03b1 and IL-10R\u03b2-deficient mice, allows the translocation of these opportunistic pathogens or their excretory products to the liver causing organ failure and lethal disease. Importantly, bone marrow chimera experiments indicate that signalling through IL-10R\u03b1 and IL-10R\u03b2 in haematopoietic cells, but not IECs, is crucial to control worm expulsion and immunopathology. These findings are supported by worm expulsion upon infection of conditional mutant mice for the IL-10R\u03b1 on IECs. Our findings emphasize the pivotal and complex role of systemic IL-10R\u03b1 signalling on immune cells in promoting microbiota homeostasis and maintaining the intestinal epithelial barrier, thus preventing immunopathology during whipworm infections.", "keywords": ["0301 basic medicine", "Lydia Becker Institute", "QH301-705.5", "610", "Interleukin-22", "Mice", "03 medical and health sciences", "Animals", "Homeostasis", "Receptors", " Interleukin-10", "Trichuriasis", "Biology (General)", "Interleukins", "RC581-607", "Gastrointestinal Microbiome", "Interleukin-10", "3. Good health", "Intestines", "Mice", " Inbred C57BL", "Disease Models", " Animal", "Trichuris", "Cytokines", "Immunologic diseases. Allergy", "ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation; name=Lydia Becker Institute", "Research Article", "Signal Transduction"]}, "links": [{"href": "https://doi.org/11343/246714"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PLOS%20Pathogens", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11343/246714", "name": "item", "description": "11343/246714", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11343/246714"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-01-14T00:00:00Z"}}, {"id": "1887/73460", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:06Z", "type": "Journal Article", "created": "2018-01-31", "title": "Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies", "description": "The central CB2 receptor represents a promising target for the treatment of neuroinflammatory diseases as CB2 activation mediates anti-inflammatory effects. Recently, the F-18 labeled PET radiotracer [18F]7a was reported, which shows high CB2 affinity and high selectivity over the CB1 subtype but low metabolic stability due to hydrolysis of the amide group. Based on these findings twelve bioisosteres of 7a were synthesized containing a non-hydrolysable functional group instead of the amide group. The secondary amine 23a (Ki\u202f=\u202f7.9\u202fnM) and the ketone 26a (Ki\u202f=\u202f8.6\u202fnM) displayed high CB2 affinity and CB2:CB1 selectivity in in\u00a0vitro radioligand binding studies. Incubation of 7a, 23a and 26a with mouse liver microsomes and LC-quadrupole-MS analysis revealed a slightly higher metabolic stability of secondary amine 23a, but a remarkably higher stability of ketone 26a in comparison to amide 7a. Furthermore, a logD7.4 value of 5.56\u202f\u00b1\u202f0.08 was determined for ketone 26a by micro shake-flask method and LC-MS quantification.", "keywords": ["0301 basic medicine", "Amide bioisosteres", "Halogenation", "CB(2) receptor ligands", "Ligands", "Receptor", " Cannabinoid", " CB2", "Mice", "Structure-Activity Relationship", "03 medical and health sciences", "Animals", "Humans", "Identification of metabolites", "Amines", "2. Zero hunger", "0303 health sciences", "Dose-Response Relationship", " Drug", "Molecular Structure", "Fluorinated carbazole derivatives", "Ketones", "Amides", "3. Good health", "Metabolic stabilization", "PET", "Drug Design", "Positron-Emission Tomography", "Microsomes", " Liver", "Structure affinity relationships"]}, "links": [{"href": "https://doi.org/1887/73460"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/European%20Journal%20of%20Medicinal%20Chemistry", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "1887/73460", "name": "item", "description": "1887/73460", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/1887/73460"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-02-01T00:00:00Z"}}, {"id": "20.500.14243/493702", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:17Z", "type": "Journal Article", "created": "2024-08-19", "title": "Photoaging of polystyrene-based microplastics amplifies inflammatory response in macrophages", "description": "The continuous release of municipal and industrial products into the environment poses a growing concern for public health. Among environmental pollutants, polystyrene (PS) stands out as a primary constituent of environmental plastic waste, given its widespread use and high production rates owing to its durability and user-friendly properties. The detection of polystyrene microparticles (PS-MPs) in various living organisms has been well-documented, posing a serious threat due to their potential passage into the human ecosystem. In this manuscript, we aimed to study the toxicological effects of low concentrations of pristine and photoaged PS-MPs in a murine macrophage cell line. To this purpose, PS-MPs were photoaged by indoor exposure to visible light to simulate environmental weathering due to solar irradiation (PS-MPs3h). Physical characterization revealed that the irradiation treatment results in particle degradation and the possible release of nanoparticles. Monocultures of the RAW264.7\u00a0cell line were then exposed to PS-MPs and PS-MPs3h at concentrations comparable to experimental measurements from biological samples, to assess cytotoxicity, intracellular oxidative stress, primary genotoxicity, and inflammatory effects. Significant toxicity-related outcomes were observed in cells treated with both pristine PS-MPs and PS-MPs3h even at low concentrations (0,10\u00a0\u03bcg/ml and 1\u00a0\u03bcg/ml). PS-MPs3h exhibited greater adverse effects compared to PS-MPs, including reduced cell viability, increased ROS production, elevated DNA damage, and upregulation of IL-6 and NOS2 gene expression. Therefore, we can conclude that changes induced by environmental aging in the physicochemical composition of PS microplastics play a crucial role in the adverse health outcomes associated with microplastic exposure.", "keywords": ["Inflammation", "Mice", "Oxidative Stress", "RAW 264.7 Cells", "microplastics", " polystyrene", " macrophages", "Cell Survival", "Microplastics", "Macrophages", "Polystyrenes", "Animals", "Environmental Pollutants", "Reactive Oxygen Species", "DNA Damage"]}, "links": [{"href": "https://iris.cnr.it/bitstream/20.500.14243/493702/1/Aloi%20et%20al%20Chemospere%202024.pdf"}, {"href": "https://doi.org/20.500.14243/493702"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Chemosphere", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "20.500.14243/493702", "name": "item", "description": "20.500.14243/493702", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/20.500.14243/493702"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-01-01T00:00:00Z"}}, {"id": "2750197518", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:31Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"], "contacts": [{"organization": "Marko Pani\u0107, Jan Aelterman, Vladimir Crnojevi\u0107, Aleksandra Pi\u017eurica,", "roles": ["creator"]}]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/2750197518"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "2750197518", "name": "item", "description": "2750197518", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/2750197518"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "28858789", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:33Z", "type": "Journal Article", "created": "2017-08-24", "title": "Sparse Recovery in Magnetic Resonance Imaging With a Markov Random Field Prior", "description": "Recent research in compressed sensing of magnetic resonance imaging (CS-MRI) emphasizes the importance of modeling structured sparsity, either in the acquisition or in the reconstruction stages. Subband coefficients of typical images show certain structural patterns, which can be viewed in terms of fixed groups (like wavelet trees) or statistically (certain configurations are more likely than others). Wavelet tree models have already demonstrated excellent performance in MRI recovery from partial data. However, much less attention has been given in CS-MRI to modeling statistically spatial clustering of subband data, although the potentials of such models have been indicated. In this paper, we propose a practical CS-MRI reconstruction algorithm making use of a Markov random field prior model for spatial clustering of subband coefficients and an efficient optimization approach based on proximal splitting. The results demonstrate an improved reconstruction performance compared with both the standard CS-MRI methods and the recent related methods.", "keywords": ["Mice", "Image Processing", " Computer-Assisted", "0202 electrical engineering", " electronic engineering", " information engineering", "Animals", "Brain", "Humans", "02 engineering and technology", "Magnetic Resonance Imaging", "Algorithms", "Markov Chains"]}, "links": [{"href": "http://xplorestaging.ieee.org/ielx7/42/8053927/08016375.pdf?arnumber=8016375"}, {"href": "https://doi.org/28858789"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/IEEE%20Transactions%20on%20Medical%20Imaging", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "28858789", "name": "item", "description": "28858789", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/28858789"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2017-10-01T00:00:00Z"}}, {"id": "3167100", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:22:50Z", "type": "Journal Article", "created": "2003-04-07", "title": "In vitro drug delivery mediated by ecto-NAD+-glycohydrolase ligand-targeted liposomes", "description": "We have studied the growth-inhibitory potency of methotrexate and methotrexate-gamma-aspartate encapsulated in liposomes conjugated to ligands of ecto-NAD+-glycohydrolase (Salord, J. et al., Biochim. Biophys. Acta 886 (1986) 64-75). The ability of targeted liposomes to enhance growth inhibition, which amounted to a 4-fold reduction of the drug concentration required to inhibit cell growth by 50% as compared to nontargeted liposomes, was observed only with cells expressing this ecto-enzyme activity, i.e., Swiss 3T3 fibroblasts and RAJI, a Burkitt-type lymphoma cell line. Delivery of the encapsulated drugs was inhibited by NH4Cl and varied with the endocytic capacity of the cells. Only small unilamellar vesicles affected the growth of the lymphoma cells, whereas the fibroblasts were more sensitive to large unilamellar vesicles. With vesicles of appropriate size, there was a good correlation between the specific binding of the targeted liposomes to cells and drug delivery. Our results suggest that ecto-NAD+-glycohydrolase can provide a recognition site on target cells and mediate the internalization of targeted liposomes by a mechanism most probably related to adsorptive endocytosis.", "keywords": ["0301 basic medicine", "Drug Carriers", "0303 health sciences", "Antineoplastic Agents", "Fibroblasts", "NAD", "Burkitt Lymphoma", "Deoxyuridine", "Ammonium Chloride", "Cell Line", "3. Good health", "Kinetics", "Mice", "03 medical and health sciences", "Methotrexate", "NAD+ Nucleosidase", "Liposomes", "Tumor Cells", " Cultured", "Animals", "Humans", "Sulfhydryl Compounds", "N-Glycosyl Hydrolases", "Cell Division"], "contacts": [{"organization": "J, Salord, F, Schuber,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/3167100"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Biochimica%20et%20Biophysica%20Acta%20%28BBA%29%20-%20Molecular%20Cell%20Research", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "3167100", "name": "item", "description": "3167100", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3167100"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1988-09-01T00:00:00Z"}}, {"id": "3315c83b-cbf2-4941-902e-8962476d0a5f", "type": "Feature", "geometry": {"type": "Polygon", "coordinates": [[[28.68, 46.93], [28.68, 47.11], [29.0, 47.11], [29.0, 46.93], [28.68, 46.93]]]}, "properties": {"updated": "2023-12-20T12:00:58.332Z", "type": "Service", "created": "2022-01-02", "language": "rum", "title": "Seismic zones in Chisinau municipality (WMS)", "description": "Earthquakes are movements of the earth, which consist of vibrations generated in the internal areas of the Earth, propagated in the form of waves through rocks. These vibrations result from the movement of tectonic plates, often caused by volcanic activity.", "formats": [{"name": "OGC:WMS"}], "keywords": ["Soluri", "Utilizarea terenului", "Zone de risc natural", "zone de cutremur", "zone seismice", "Servicii de procesare geografic\u0103 \u2013 metadate", "Serviciu de gestionare a modelelor geografice/a informa\u021biilor", "Servicii de procesare geografic\u0103 \u2013 aspecte spa\u021biale"], "contacts": [{"name": "Nagorneac Constantin", "organization": "Direc\u0163ia General\u0103 Arhitectur\u0103, Urbanism \u015fi Rela\u0163ii Funciare (DGAURF) a Consilului Municipal Chi\u0219in\u0103u (CMC)", "position": "\u0218eful sec\u021biei topografie", "roles": ["owner"], "phones": [{"value": "+373 22 228 110"}], "emails": [{"value": "dgaurf@cmc.md"}], "addresses": [{"deliveryPoint": ["str. \u0218tefan cel Mare si Sf\u00e2nt, 83"], "city": "mun. Chi\u0219in\u0103u", "administrativeArea": null, "postalCode": "2012", "country": "Republica Moldova"}], "links": [{"href": null}]}], "themes": [{"concepts": [{"id": "Soluri"}, {"id": "Utilizarea terenului"}, {"id": "Zone de risc natural"}], "scheme": "http://inspire.ec.europa.eu/theme"}, {"concepts": [{"id": "Servicii de procesare geografic\u0103 \u2013 metadate"}, {"id": "Serviciu de gestionare a modelelor geografice/a informa\u021biilor"}, {"id": "Servicii de procesare geografic\u0103 \u2013 aspecte spa\u021biale"}], "scheme": "http://inspire.ec.europa.eu/metadata-codelist/SpatialDataServiceCategory"}]}, "links": [{"href": "https://gislocal.md/geoserver/apl/wms", "name": "s0100_seismic_zones", "description": "Zone Seismice mun. Chi\u0219in\u0103u", "protocol": "OGC:WMS", "rel": null}, {"href": "https://geoportalinds.gov.md/geonetwork/srv/api/records/3315c83b-cbf2-4941-902e-8962476d0a5f/attachments/WMS.jpg", "name": "preview", "description": "Web image thumbnail (URL)", "protocol": "WWW:LINK-1.0-http--image-thumbnail", "rel": "preview"}, {"rel": "self", "type": "application/geo+json", "title": "3315c83b-cbf2-4941-902e-8962476d0a5f", "name": "item", "description": "3315c83b-cbf2-4941-902e-8962476d0a5f", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3315c83b-cbf2-4941-902e-8962476d0a5f"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date-time": "2023-12-20T12:00:58Z"}}, {"id": "39731790", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:23:03Z", "type": "Journal Article", "created": "2024-12-19", "title": "Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation", "description": "For over three decades, praziquantel (PZQ) has been the mainstay chemotherapy for prevention and treatment of schistosomiasis. The excessive use of PZQ, coupled with the lack of advanced drug candidates in the current anti-schistosomiasis drug development pipeline, emphasizes the genuine need for new drugs. In the current work, we investigated the antischistosomal potential of a new series of compounds derived from the privileged benzimidazole scaffold, which exhibited low micromolar IC50 potency in the range of 1.0-2.7\u00a0\u03bcM against Schistosomamansoni adult worms, in vitro. However, representative compounds showed low in vivo activity. One compound (15) reduced worm burden by 51.9\u00a0%, although the reduction was not statistically significant. Furthermore, by invoking inhibition of hemozoin formation, an immutable drug target in Schistosoma adult worms, as a likely contributing mode of action, we observed that the most potent analogues were equally potent inhibitors of \u03b2-hematin (synthetic hemozoin) formation in a cell-free assay.", "keywords": ["Hemeproteins", "Anthelmintics", "Structure-Activity Relationship", "Mice", "Schistosomicides", "Molecular Structure", "Dose-Response Relationship", " Drug", "Parasitic Sensitivity Tests", "Animals", "Benzimidazoles", "Schistosoma mansoni", "Schistosomiasis mansoni"]}, "links": [{"href": "https://doi.org/39731790"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/European%20Journal%20of%20Medicinal%20Chemistry", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "39731790", "name": "item", "description": "39731790", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/39731790"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-02-01T00:00:00Z"}}, {"id": "PMC11101930", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:24:19Z", "type": "Journal Article", "created": "2024-05-05", "title": "Robenidine derivatives as potential antischistosomal drug candidates", "description": "Schistosomiasis caused by Schistosoma spp. is a disease that causes a considerable health burden to millions of people worldwide. The limited availability of effective drugs on the market and the increased risk of resistance development due to extensive usage, highlight the urgent need for new antischistosomal drugs. Recent studies have shown that robenidine derivatives, containing an aminoguanidine core, exhibit promising activities against Plasmodium falciparum, motivating further investigation into their efficacy against Schistosoma mansoni, due to their similar habitat and the resulting related cellular mechanisms like the heme detoxification pathway. The conducted phenotypic screening of robenidine and 80 derivatives against newly transformed schistosomula and adult Schistosoma mansoni yielded 11 candidates with low EC50 values for newly transformed schistosomula (1.12-4.63\u00a0\u03bcM) and adults (2.78-9.47\u00a0\u03bcM). The structure-activity relationship revealed that electron-withdrawing groups at the phenyl moiety, as well as the presence of methyl groups adjacent to the guanidine moiety, enhanced the activity of derivatives against both stages of Schistosoma mansoni. The two compounds 2,2'-Bis[(3-cyano-4-fluorophenyl)methylene] carbonimidic Dihydrazide Hydrochloride (1) and 2,2'-Bis[(4-difluoromethoxyphenyl) ethylidene] carbonimidic Dihydrazide Hydrochloride (19), were selected for an in vivo study in Schistosoma mansoni-infected mice based on their potency, cytotoxicity, pharmacokinetic-, and physicochemical properties, but failed to reduce the worm burden significantly (worm burden reduction <20%). Thus, robenidine derivatives require further refinements to obtain higher antischistosomal specificity and in vivo activity.", "keywords": ["Male", "0301 basic medicine", "0303 health sciences", "Drug discovery", "Infectious and parasitic diseases", "RC109-216", "Schistosoma mansoni", "Structure-activity relationship", "Guanidines", "Article", "Schistosomiasis mansoni", "3. Good health", "Mice", "Schistosomicides", "Structure-Activity Relationship", "03 medical and health sciences", "Aminoguanidine", "Animals", "Female", "Robenidine derivative"], "contacts": [{"organization": "Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/PMC11101930"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/International%20Journal%20for%20Parasitology%3A%20Drugs%20and%20Drug%20Resistance", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC11101930", "name": "item", "description": "PMC11101930", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC11101930"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-01T00:00:00Z"}}, {"id": "8009224", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:23:47Z", "type": "Journal Article", "created": "2006-10-06", "title": "Maternal Rescue of Transforming Growth Factor-\u03b2 1 Null Mice", "description": "<?xml version='1.0' encoding='UTF-8'?><article><p>Maternal sources of transforming growth factor-\u03b21 (TGF-\u03b21) are shown here to contribute to the normal appearance and perinatal survival of TGF-\u03b21 null newborn mice. Labeled TGF-\u03b21 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF\u03b2-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-\u03b21 null embryos and null newborn pups born to TGF-\u03b21 heterozygotes stained positive for TGF-\u03b21, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-\u03b21 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.</p></article>", "keywords": ["Heart Defects", " Congenital", "0301 basic medicine", "Heterozygote", "0303 health sciences", "Homozygote", "Embryonic and Fetal Development", "Mice", "03 medical and health sciences", "Fetus", "Milk", "Animals", " Newborn", "Pregnancy", "Transforming Growth Factor beta", "Animals", "Female", "Maternal-Fetal Exchange"], "contacts": [{"organization": "J J, Letterio, A G, Geiser, A B, Kulkarni, N S, Roche, M B, Sporn, A B, Roberts,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/8009224"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Science", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "8009224", "name": "item", "description": "8009224", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/8009224"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1994-06-24T00:00:00Z"}}, {"id": "8433705", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:23:50Z", "type": "Journal Article", "created": "2002-12-28", "title": "Interactions of cell-surface galactosyltransferase with immunoglobulins", "description": "Detection of the activity of beta-1,4-galactosyltransferase (beta-1,4-GT) in suspensions of viable mouse hepatocytes, the human hepatoma cell line Hep G2, the human colonic adenocarcinoma cell line HT-29, the monocyte-like cell line U937, and human splenic B and T lymphocytes suggested the presence of beta-1,4-GT, in an enzymatically active form, on plasma membranes. The presence of beta-1,4-GT on cell surfaces was also indicated from the effect of trypsinization of live cells, which significantly reduced cell surface beta-1,4-GT activity, but did not affect the activity associated with cytoplasmic membranes. Furthermore, the presence of beta-1,4-GT on the cell surface was demonstrated by indirect immunofluorescence staining of cells with anti-beta-1,4-GT antibody. The detection of radioactivity in immunoglobulins (Ig) and their component chains after incubation with suspensions of intact cells in the presence of Mn2+ and UDP-[3H]-galactose, indicated that Ig molecules were galactosylated. In the absence of UDP-[3H]-galactose, beta-1,4-GT on cell surfaces, or immobilized on Sepharose-4B, formed stable complexes with galactose acceptors, including Ig. The efficiency of binding decreased in the order: J chain > alpha chain > mu chain > polymeric IgA2 > monomeric/polymeric IgA1 > IgM > IgG. Thus, beta-1,4-GT could act as a cell-surface receptor for Ig through a cation-dependent, lectin-like association of the beta-1,4-GT with the carbohydrate moieties of the Ig. This was confirmed by indirect surface immunofluorescence and radiolabeled ligand binding assays. The binding was inhibitable by EDTA, alpha-lactalbumin (in the presence of glucose), GlcNAc, or uridine 3',5'dialdehyde. At 37 degrees C, the apparent affinity constants and association rate constants of interaction between cell surface beta-1,4-GT on glutaraldehyde-fixed HT-29 and U937 cells and alpha 2 chain or monomeric IgA1 were in the range from 7.1 x 10(7) to 4.6 x 10(8) M-1 and from 1 x 10(5) to 3 x 10(6) M-1 s-1, respectively. The dissociation rate constants and half time of dissociation calculated from these data were in the range from 2.1 x 10(-2) to 5.0 x 10(-4) s-1 and from 33 to 1380 s, respectively. The number of alpha 2 or IgA1 molecules bound per HT-29 and U937 cell were in the range from 1.9 x 10(5) to 1.3 x 10(6). The binding of IgA by the cell surface beta-1,4-GT was not associated with internalization or the catabolic degradation of the ligand.", "keywords": ["0301 basic medicine", "Mice", "0303 health sciences", "03 medical and health sciences", "Lectins", "Cell Membrane", "Animals", "Humans", "Immunoglobulins", "Galactosyltransferases", "Cell Line", "Immunoglobulin A", "3. Good health"], "contacts": [{"organization": "M, Tomana, J, Zikan, Z, Moldoveanu, R, Kulhavy, J C, Bennett, J, Mestecky,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/8433705"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Molecular%20Immunology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "8433705", "name": "item", "description": "8433705", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/8433705"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1993-02-01T00:00:00Z"}}, {"id": "bekele,1982", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:25:20Z", "type": "Journal Article", "description": "Serological relationships between new isolates of Trypanosoma cruzi from a single locality have been examined by direct agglutination and immunodiffusion, and compared with established strains. The strains were divided into three groups according to the absorption properties of their precipitinogens. The three groups were defined by the same characteristics as those in which strains of wide-ranging provenance and long laboratory history have been placed by previous workers. A lack of correspondence between the antigenic constitutions of the groups as described here and as described previously was demonstrated using reference strains. Relatedness values were calculated from agglutination titres, which indicated a complex heterogeneity of antigens, and from which a scheme of relationships was drawn.", "keywords": ["Male", "0301 basic medicine", "Agglutination", "Immunodiffusion", "Mice", "03 medical and health sciences", "0302 clinical medicine", "Trypanosoma cruzi", "Animals", "Chagas Disease", "Cross Reactions"], "contacts": [{"organization": "D, Ketteridge", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/bekele,1982"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Acta%20tropica", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "bekele,1982", "name": "item", "description": "bekele,1982", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/bekele,1982"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-01-01T00:00:00Z"}}, {"id": "bowes,1982", "type": "Feature", "geometry": null, "properties": {"updated": "2026-09-20T16:25:21Z", "type": "Journal Article", "description": "Serological relationships between new isolates of Trypanosoma cruzi from a single locality have been examined by direct agglutination and immunodiffusion, and compared with established strains. The strains were divided into three groups according to the absorption properties of their precipitinogens. The three groups were defined by the same characteristics as those in which strains of wide-ranging provenance and long laboratory history have been placed by previous workers. A lack of correspondence between the antigenic constitutions of the groups as described here and as described previously was demonstrated using reference strains. Relatedness values were calculated from agglutination titres, which indicated a complex heterogeneity of antigens, and from which a scheme of relationships was drawn.", "keywords": ["Male", "0301 basic medicine", "Agglutination", "Immunodiffusion", "Mice", "03 medical and health sciences", "0302 clinical medicine", "Trypanosoma cruzi", "Animals", "Chagas Disease", "Cross Reactions"], "contacts": [{"organization": "D, Ketteridge", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/bowes,1982"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Acta%20tropica", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "bowes,1982", "name": "item", "description": "bowes,1982", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/bowes,1982"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-01-01T00:00:00Z"}}, {"id": "e9941118-761a-4636-a6aa-ba2662bfa510", "type": "Feature", "geometry": {"type": "Polygon", "coordinates": [[[28.68, 46.93], [28.68, 47.11], [29.0, 47.11], [29.0, 46.93], [28.68, 46.93]]]}, "properties": {"updated": "2023-12-20T12:01:07.178Z", "type": "Service", "created": "2022-01-02", "language": "rum", "title": "Seismic zones Chisinau municipality (WFS)", "description": "Earthquakes are movements of the earth, which consist of vibrations generated in the internal areas of the Earth, propagated in the form of waves through rocks. 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The strains were divided into three groups according to the absorption properties of their precipitinogens. The three groups were defined by the same characteristics as those in which strains of wide-ranging provenance and long laboratory history have been placed by previous workers. A lack of correspondence between the antigenic constitutions of the groups as described here and as described previously was demonstrated using reference strains. Relatedness values were calculated from agglutination titres, which indicated a complex heterogeneity of antigens, and from which a scheme of relationships was drawn.", "keywords": ["Male", "0301 basic medicine", "Agglutination", "Immunodiffusion", "Mice", "03 medical and health sciences", "0302 clinical medicine", "Trypanosoma cruzi", "Animals", "Chagas Disease", "Cross Reactions"], "contacts": [{"organization": "D, Ketteridge", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/mckee,1982"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Acta%20tropica", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "mckee,1982", "name": "item", "description": "mckee,1982", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/mckee,1982"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1975-01-01T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Mice&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Mice&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Mice&", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Mice&offset=29", "hreflang": "en-US"}], "numberMatched": 29, "numberReturned": 29, "distributedFeatures": [], "timeStamp": "2026-09-21T09:50:52.107321Z"}