{"type": "FeatureCollection", "features": [{"id": "10.1186/s12916-021-01913-w", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:00:08Z", "type": "Journal Article", "created": "2021-02-11", "title": "High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome", "description": "Abstract Background

Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.

Methods

Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts.

Results

Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q\uffe2\uff80\uff89<\uffe2\uff80\uff890.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet.

Conclusion

A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella.

Trial registration

The ClinicalTrials.gov registration identifier is NCT03479866.

", "keywords": ["Adult", "Male", "0301 basic medicine", "610", "Leukocyte Count", "03 medical and health sciences", "RNA", " Ribosomal", " 16S", "Leukocytes", "Humans", "Lymphocyte Count", "White blood cell", " Gut microbiome", " Diet", " Vegetable intake", " Chronic inflammation", "White blood cell", "Clostridium", "2. Zero hunger", "Gut microbiome", "Clostridiales", "0303 health sciences", "Mediation Analysis", "Interleukin-6", "R", "COVID-19", "Chronic inflammation; Diet; Gut microbiome; Vegetable intake; White blood cell", "Chronic inflammation", "General Medicine", "Fasting", "Middle Aged", "Diet", "Gastrointestinal Microbiome", "3. Good health", "Actinobacteria", "Vegetable intake", "Fruit", "Medicine", "Female", "Biomarkers", "Research Article"]}, "links": [{"href": "https://air.unimi.it/bitstream/2434/1101012/2/s12916-021-01913-w.pdf"}, {"href": "https://iris.unitn.it/bitstream/11572/329112/1/s12916-021-01913-w.pdf"}, {"href": "http://link.springer.com/content/pdf/10.1186/s12916-021-01913-w.pdf"}, {"href": "https://doi.org/10.1186/s12916-021-01913-w"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1186/s12916-021-01913-w", "name": "item", "description": "10.1186/s12916-021-01913-w", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1186/s12916-021-01913-w"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-02-11T00:00:00Z"}}, {"id": "10.1016/j.cub.2020.09.063", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T06:56:45Z", "type": "Journal Article", "created": "2020-10-15", "title": "Newly explored\u00a0Faecalibacterium\u00a0diversity is connected to age, lifestyle, geography, and disease.", "description": "Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.", "keywords": ["Adult", "0301 basic medicine", "pangenome", "Adolescent", "gut microbiome", "Datasets as Topic", "General Biochemistry", " Genetics and Molecular Biology", "Innovation action", "Feces", "03 medical and health sciences", "Animals", "Humans", "biotherapeutics", "European Commission", "Child", "Life Style", "Faecalibacterium", "Aged", "Aurora Universities Network", "Horizon 2020", "0303 health sciences", "EC", "Geography", "Faecalibacterium prausnitzii", "H2020", "Age Factors", "Infant", "Middle Aged", "Gastrointestinal Microbiome", "Faecalibacterium prausnitzii", " gut microbiome", " strain diversity", " pangenome", " novel probiotics", " biotherapeutics", "Child", " Preschool", "novel probiotics", "Dysbiosis", "Macaca", "Metagenome", "strain diversity", "Metagenomics", "General Agricultural and Biological Sciences"]}, "links": [{"href": "https://www.iris.unina.it/bitstream/11588/819607/1/PIIS0960982220314330.pdf"}, {"href": "https://doi.org/10.1016/j.cub.2020.09.063"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Current%20Biology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.1016/j.cub.2020.09.063", "name": "item", "description": "10.1016/j.cub.2020.09.063", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.1016/j.cub.2020.09.063"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-12-01T00:00:00Z"}}, {"id": "10.1016/j.foodres.2024.114342", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T06:57:01Z", "type": "Journal Article", "created": "2024-04-23", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.3\u00a0months duration met the inclusion criteria and were evaluated to obtain a sample of 261 patients, 109 women and 152 men, with an average age of 48.39. Three intra-articular injections of autologous PRGF were administered at 2-week intervals in outpatient surgery. The process of obtaining PRGF was carried out following the Anitua Technique. Participants were asked to fill out a questionnaire with personal data and the following assessment instruments: VAS, SF-36, WOMAC Index and Lequesne Index before the first infiltration of PRGF and 6\u00a0months after the last infiltration.Statistically significant differences (P\u00a0<\u00a00.0001) between pre-treatment and follow-up values were found for pain, stiffness and functional capacity in the WOMAC Index; pain and total score, distance and daily life activities in the Lequesne Index; the VAS pain score; and the SF-36 physical health domain. There were no adverse effects related to PRGF infiltration.At 6\u00a0months following intra-articular infiltration of PRGF in patients with OA of the knee, improvements in function and quality of life were documented by OA-specific and general clinical assessment instruments. These favourable findings point to consider PRGF as a therapy for OA.", "keywords": ["Male", "Platelet-Derived Growth Factor", "Platelet-Rich Plasma", "Recovery of Function", "Middle Aged", "Osteoarthritis", " Knee", "Magnetic Resonance Imaging", "Statistics", " Nonparametric", "Injections", " Intra-Articular", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Surveys and Questionnaires", "Quality of Life", "Humans", "Female", "Longitudinal Studies", "Prospective Studies"]}, "links": [{"href": "https://doi.org/20714903"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Archives%20of%20Orthopaedic%20and%20Trauma%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "20714903", "name": "item", "description": "20714903", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/20714903"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2010-08-17T00:00:00Z"}}, {"id": "23892191", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:06:13Z", "type": "Journal Article", "created": "2013-07-24", "title": "The Efficacy of the T-Shunt Procedure and Intracavernous Tunneling (Snake Maneuver) for Refractory Ischemic Priapism", "description": "The current management of ischemic priapism that is refractory to conventional medical therapy is a form of shunt procedure that diverts blood away from the corpus cavernosum. We assessed the outcome of the T-shunt and intracavernous tunneling for the management of ischemic priapism.During a 36-month period 45 patients presented with prolonged ischemic priapism. Patients were divided into subgroups according to the duration of priapism. All patients had an unsuccessful primary treatment, and underwent a T-shunt and intracavernous tunneling with cavernous muscle biopsies. All patients completed an IIEF-5 (International Index of Erectile Function-5) questionnaire preoperatively and 6 months postoperatively.Resolution of the priapism using a T-shunt and snake maneuver occurred in all patients with a priapism duration of less than 24 hours and in only 30% of those with priapism lasting more than 48 hours. After a 6-month median followup the IIEF-5 score was significantly reduced from a mean of 24 (range 23 to 25) preoperatively to 7.7 (range 5 to 24), which was related to the duration of the priapism (p <0.0005). All patients with priapism for more than 48 hours had necrotic cavernous smooth muscle on biopsy and had severe erectile dysfunction requiring the insertion of a penile prosthesis. Those patients with moderate and mild erectile dysfunction were treated with phosphodiesterase type 5 inhibitors.The success of the T-shunt with snake tunneling is dependent on the duration of priapism. When it is less than 24 hours the results are favorable, although erectile dysfunction is still present in 50% of patients. In those with a priapism duration greater than 48 hours the technique usually fails to resolve the priapism and all patients end up with erectile dysfunction due to smooth muscle necrosis.", "keywords": ["Adult", "Male", "03 medical and health sciences", "Time Factors", "Treatment Outcome", "0302 clinical medicine", "Ischemia", "Humans", "Middle Aged", "Priapism", "Aged", "Penis", "3. Good health"], "contacts": [{"organization": "Zacharakis, E., Raheem, A.A., Freeman, A., Skolarikos, A., Garaffa, G., Christopher, A.N., Muneer, A., Ralph, D.J.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/23892191"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Urology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "23892191", "name": "item", "description": "23892191", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/23892191"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-01-01T00:00:00Z"}}, {"id": "28107603", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-05-31T07:06:22Z", "type": "Journal Article", "created": "2017-01-20", "title": "Desmopressin (Octostim\u00ae) before a native kidney biopsy can reduce the risk for biopsy complications in patients with impaired renal function: A pilot study", "description": "AbstractAim

To evaluate whether the administration of desmopressin alters the risk for renal biopsy complications.

Methods

A multicenter registry containing 576 native kidney biopsies (NKb) with a serum creatinine above 150\uffc2\uffa0\uffce\uffbcmol/L in 527 patients (372 men and 155 women, median age 61\uffc2\uffa0years) was used. Most of the data were prospective. At one of the hospitals all biopsies with creatinine above 150\uffc2\uffa0\uffce\uffbcmol/L received desmopressin before biopsies (NKb 204). These were compared to outcome of biopsy complications against other centres where desmopressin was not given (NKb 372). Fisher's exact test, \uffcf\uff872 analyses, univariate and multiple binary logistic regression were used. Data were given as odds ratio (OR) and confidence interval (CI). A two sided P\uffe2\uff80\uff90value of <0.05 was considered significant.

Results

In NKb with creatinine >150\uffc2\uffa0\uffce\uffbcmol/L, those with desmopressin had less overall (3.4% vs 8.4%, OR 0.39, CI 0.17\uffe2\uff80\uff930.90) whereas major or minor complications were not different. While desmopressin did not exhibit difference in complications in men, women received less major (0% vs 8.6%, P\uffc2\uffa0=\uffc2\uffa00.03) and overall complications (0% vs 12.1%, P\uffc2\uffa0=\uffc2\uffa00.006). A multiple logistic regression revealed that, after adjusting for BMI, age and sex, prophylaxis with desmopressin showed less major (OR 0.38, CI 0.15\uffe2\uff80\uff930.96) and overall complications (OR 0.36, CI 0.15\uffe2\uff80\uff930.85).

Conclusion

Desmopressin given before a native kidney biopsy in patients with impaired renal function can reduce the risk for complications.The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder.

Methods

A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measured with a VAS from 0 to 100 (VAS based), and somnolence frequency was recorded according to incident report (incidence based) at each visit. The rates of VAS-based and incidence-based somnolence and changes in somnolence severity from baseline to the end of study were compared between the lithium and quetiapine groups. Longitudinal changes in somnolence severity were analyzed with linear regression analysis.

Results

Of 42 patients randomized, only 3 scored 0 on the VAS at baseline. The rates of incidence-based and VAS-based somnolence were similar in the lithium and quetiapine-IR groups. The VAS change scores from baseline to each visit varied in both groups with significant decreases at weeks 6 and 12 in the quetiapine-IR group only. The decrease at week 6 in the quetiapine-IR group was significantly different from that in the lithium group. Patterns of changes in somnolence severity were inconsistent in both groups. A significant interaction between time course and the decrease in VAS scores was observed in the quetiapine-IR group, but not in the lithium group.

Conclusions

Baseline somnolence was highly prevalent in patients with bipolar disorder. The change in somnolence severity was different between lithium-treated and quetiapine-treated patients. Quantifying somnolence longitudinally is important in clinical trials and practice.

", "keywords": ["Adult", "Male", "Bipolar Disorder", "Sleepiness", "Visual Analog Scale", "Middle Aged", "Severity of Illness Index", "Quetiapine Fumarate", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Antimanic Agents", "Lithium Compounds", "Humans", "Female", "Longitudinal Studies", "Antipsychotic Agents"], "contacts": [{"organization": "Keming, Gao, Meilei, Su, Stephen J, Ganocy, Toyomi, Goto, Chengmei, Yuan, Fang, Fang, Carla, Conroy, Brittany, Brownrigg, Mary Beth, Serrano, Joseph R, Calabrese,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/30932950"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Clinical%20Psychopharmacology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "30932950", "name": "item", "description": "30932950", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/30932950"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-05-01T00:00:00Z"}}, {"id": "37195942", "type": "Feature", "geometry": null, "properties": {"license": "Closed Access", "updated": "2026-05-31T07:07:00Z", "type": "Journal Article", "created": "2023-05-17", "title": "Emodepside for Trichuris trichiura and Hookworm Infection", "description": "Current treatments for soil-transmitted helminth infections in humans have low efficacy against Trichuris trichiura. Emodepside - a drug in veterinary use and under development for the treatment of onchocerciasis in humans - is a leading therapeutic candidate for soil-transmitted helminth infection.We conducted two phase 2a, dose-ranging, randomized, controlled trials to evaluate the efficacy and safety of emodepside against T. trichiura and hookworm infections. We randomly assigned, in equal numbers, adults 18 to 45 years of age in whom T. trichiura or hookworm eggs had been detected in stool samples to receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo. The primary outcome was the percentage of participants who were cured of T. trichiura or hookworm infection (the cure rate) with emodepside 14 to 21 days after treatment, determined with the use of the Kato-Katz thick-smear technique. Safety was assessed 3, 24, and 48 hours after the receipt of treatment or placebo.A total of 266 persons were enrolled in the T. trichiura trial and 176 in the hookworm trial. The predicted cure rate against T. trichiura in the 5-mg emodepside group (85% [95% confidence interval {CI}, 69 to 93]; 25 of 30 participants) was higher than the predicted cure rate in the placebo group (10% [95% CI, 3 to 26]; 3 of 31 participants) and the observed cure rate in the albendazole group (17% [95% CI, 6 to 35]; 5 of 30 participants). A dose-dependent relationship was shown in participants with hookworm: the observed cure rate was 32% (95% CI, 13 to 57; 6 of 19 participants) in the 5-mg emodepside group and 95% (95% CI, 74 to 99.9; 18 of 19 participants) in the 30-mg emodepside group; the observed cure rates were 14% (95% CI, 3 to 36; 3 of 21 participants) in the placebo group and 70% (95% CI, 46 to 88; 14 of 20 participants) in the albendazole group. In the emodepside groups, headache, blurred vision, and dizziness were the most commonly reported adverse events 3 and 24 hours after treatment; the incidence of events generally increased in a dose-dependent fashion. Most adverse events were mild in severity and were self-limited; there were few moderate and no serious adverse events.Emodepside showed activity against T. trichiura and hookworm infections. (Funded by the European Research Council; ClinicalTrials.gov number, NCT05017194.).", "keywords": ["Adult", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Administration", " Oral", "Middle Aged", "Albendazole", "16. Peace & justice", "3. Good health", "03 medical and health sciences", "Feces", "Hookworm Infections", "Soil", "Young Adult", "0302 clinical medicine", "Trichuris", "Depsipeptides", "Animals", "Humans", "Trichuriasis"]}, "links": [{"href": "https://doi.org/37195942"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "37195942", "name": "item", "description": "37195942", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/37195942"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-05-18T00:00:00Z"}}, {"id": "38763635", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:07:02Z", "type": "Journal Article", "created": "2024-04-22", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.To assess the association of Life's Essential 8 (LE8) and the presence of abdominal aortic calcification (AAC) with mortality among middle\uffe2\uff80\uff90aged and older individuals.

Methods

Participants aged older than 40\uffe2\uff80\uff89years were enrolled from the National Health and Nutrition Examination Survey 2013\uffe2\uff80\uff902014. AAC was assessed using dual\uffe2\uff80\uff90energy X\uffe2\uff80\uff90ray absorptiometry. Mortality data were ascertained through linkage with the National Death Index until 31 December 2019. The LE8 score incorporates eight components: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose and blood pressure. The total LE8 score, an unweighted average of all components, was categorized into low (0\uffe2\uff80\uff9049), medium (50\uffe2\uff80\uff9079) and high (80\uffe2\uff80\uff90100) scores.

Results

This study included 2567 individuals, with a mean LE8 score of 67.28\uffe2\uff80\uff89\uffc2\uffb1\uffe2\uff80\uff890.48 and an AAC prevalence of 28.28%. Participants with low LE8 scores showed a significantly higher prevalence of AAC (odds ratio\uffe2\uff80\uff89=\uffe2\uff80\uff892.12 [1.12\uffe2\uff80\uff904.19]) compared with those with high LE8 scores. Over a median 6\uffe2\uff80\uff90year follow\uffe2\uff80\uff90up, there were 222 all\uffe2\uff80\uff90cause deaths, and 55 cardiovascular deaths occurred. Participants with AAC had an increased risk of all\uffe2\uff80\uff90cause (hazard ratio [HR]\uffe2\uff80\uff89=\uffe2\uff80\uff892.17 [1.60\uffe2\uff80\uff902.95]) and cardiovascular (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.35 [1.40\uffe2\uff80\uff903.93]) mortality. Moreover, individuals with AAC and low or medium LE8 scores exhibited a 137% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.37 [1.58\uffe2\uff80\uff903.54]) and 119% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.19 [1.61\uffe2\uff80\uff902.99]) higher risk of all\uffe2\uff80\uff90cause mortality, as well as a 224% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff893.24 [1.73\uffe2\uff80\uff906.04]) and 125% (HR\uffe2\uff80\uff89=\uffe2\uff80\uff892.25 [1.24\uffe2\uff80\uff904.09]) increased risk of cardiovascular mortality, respectively.

Conclusions

The LE8 score correlates with AAC prevalence in middle\uffe2\uff80\uff90aged and older individuals and serves as a valuable tool for evaluating the risk of all\uffe2\uff80\uff90cause and cardiovascular mortality in individuals with AAC.

", "keywords": ["Male", "Adult", "Aged", " 80 and over", "2. Zero hunger", "Aortic Diseases", "Middle Aged", "Nutrition Surveys", "United States", "Body Mass Index", "Diet", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Risk Factors", "Prevalence", "Humans", "Female", "Aorta", " Abdominal", "Mortality", "Vascular Calcification", "Exercise", "Aged"]}, "links": [{"href": "https://doi.org/39165042"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Diabetes%2C%20Obesity%20and%20Metabolism", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "39165042", "name": "item", "description": "39165042", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/39165042"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-08-20T00:00:00Z"}}, {"id": "PMC4416083", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:08:47Z", "type": "Journal Article", "created": "2014-10-14", "title": "Clinical characteristics of RA patients with secondary SS and association with joint damage", "description": "Secondary SS (sSS) is a common extra-articular manifestation of RA. There are conflicting data regarding the association of sSS with worse joint damage. This study aims to characterize sSS patients in an RA cohort and study the association between sSS and joint damage.We conducted a cross-sectional study of RA patients with \u22651 year of follow-up at a large academic centre. Subjects with co-morbid diseases that can also result in sicca symptoms were excluded from the analysis. Subjects were considered to have sSS if they were reported as having sSS by their rheumatologist at recruitment into the cohort and had the diagnosis confirmed by chart review. The primary outcome was Sharp score using bilateral hand radiographs at recruitment. We constructed a linear regression model to determine the association of sSS status and Sharp score adjusted by age, gender, disease duration and ACPA and RF status.We studied 829 RA subjects, mean age 57 years, 83% female, mean RA duration 13 years, 74% seropositive; 85 subjects (10.3%) had sSS. We observed a female predominance (95.3%), longer mean disease duration (16.9 years) and higher frequency of RF or ACPA positive among patients with sSS and RA. Having sSS at baseline was associated with higher Sharp scores (P = 0.03), independent of age, gender, RA disease duration and seropositive disease.In our RA cohort, RA subjects with sSS had worse joint damage, suggesting that sSS is a marker of more aggressive disease.", "keywords": ["Adult", "Male", "2. Zero hunger", "Comorbidity", "Middle Aged", "Severity of Illness Index", "Antibodies", "Arthritis", " Rheumatoid", "03 medical and health sciences", "Cross-Sectional Studies", "Sjogren's Syndrome", "0302 clinical medicine", "Rheumatoid Factor", "Disease Progression", "Linear Models", "Humans", "Female", "Joints", "Arthrography", "10. No inequality", "Aged", "Follow-Up Studies"], "contacts": [{"organization": "Lindsay E, Brown, Michelle L, Frits, Christine K, Iannaccone, Michael E, Weinblatt, Nancy A, Shadick, Katherine P, Liao,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/PMC4416083"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Rheumatology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC4416083", "name": "item", "description": "PMC4416083", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC4416083"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-10-13T00:00:00Z"}}, {"id": "PMC6090968", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:08:48Z", "type": "Journal Article", "created": "2018-08-02", "title": "Amoxicillin/clavulanic acid-induced pancreatitis: case report", "description": "Acute pancreatitis is an acute inflammation of the pancreas that varies in severity from mild to life threatening usually requiring hospitalization. The true incidence of drug-induced pancreatitis (DIP) is indeterminate due to the inadequate documentation of case reports of DIP. Here we present the case of amoxicillin/clavulanic acid-induced pancreatitis in a previously healthy male after excluding all other causes of pancreatitis.A 58-year-old Caucasian man presenting for acute sharp abdominal pain with associated nausea and heaves. Pain was non-radiating and worsening with movement. Patient had no constitutional symptoms. The only medication he received prior to presentation was amoxicillin/clavulanic acid as prophylaxis for a dental procedure with his symptoms starting on day 9th of therapy. Laboratory studies revealed mild leukocytosis, increased levels of serum lipase, amylase, and C-reactive protein (CRP). Abdominal computed tomography (CT) was notable for acute pancreatitis with no pseudocyst formation. Hence, patient was diagnosed with mild acute pancreatitis that was treated with aggressive intravenous (IV) hydration and pain management with bowel rest of 2\u00a0days duration and significant improvement being noticed within 72\u00a0h. On further questioning, patient recalled that several years ago he had similar abdominal pain that developed after taking amoxicillin/clavulanic acid but did not seek medical attention at that time and the pain resolved within few days while abstaining from food intake. All other causes of pancreatitis were ruled out in this patient who is non-alcoholic, non-smoker, and never had gallstones. Abdominal ultrasound and magnetic resonance cholangiopancreatography (MRCP) eliminated out the possibility of gallstones, biliary ductal dilatation, or choledocholithiasis. Patient had no hypertriglyceridemia nor hypercalcemia, never had endoscopic retrograde cholangiopancreatography (ERCP), never took steroids, has no known malignancy, infection, trauma, or exposure to scorpions.This case describes a patient with DIP after the intake of amoxicillin/clavulanic acid and when all other common causes of acute pancreatitis were excluded. Only two other case reports were available through literature review regarding amoxicillin/clavulanic acid- induced pancreatitis. We again stress on the importance of identifying and reporting cases of DIP to raise awareness among physicians and clinicians.", "keywords": ["Male", "Amoxicillin/clavulanic acid", "Cholangiopancreatography", " Magnetic Resonance", "Vomiting", "Amoxicillin", "Case Report", "Nausea", "RC799-869", "Drug-induced pancreatitis", "Diseases of the digestive system. Gastroenterology", "Middle Aged", "Amoxicillin-Potassium Clavulanate Combination", "Abdominal Pain", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Pancreatitis", "Humans", "Tomography", " X-Ray Computed", "beta-Lactamase Inhibitors", "Ultrasonography"], "contacts": [{"organization": "Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar, Vesna Tegeltija,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/PMC6090968"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Gastroenterology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC6090968", "name": "item", "description": "PMC6090968", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC6090968"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2018-08-02T00:00:00Z"}}, {"id": "PMC4698961", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:08:47Z", "type": "Journal Article", "created": "2015-06-14", "title": "Validation of the Written Administration of the Short Literacy Survey", "description": "Most health literacy assessments are time consuming and administered verbally. Written self-administration of measures may facilitate more widespread assessment of health literacy. This study aimed to determine the intermethod reliability and concurrent validity of the written administration of the 3 subjective health literacy questions of the Short Literacy Survey (SLS). The Rapid Estimate of Adult Literacy in Medicine (REALM) and the shortened test of Functional Health Literacy in Adults (S-TOFHLA) were the reference measures of health literacy. Two hundred ninety-nine participants completed the written and verbal administrations of the SLS from June to December 2012. Intermethod reliability was demonstrated when (a) the written and verbal SLS score did not differ and (b) written and verbal scores were highly correlated. The written items were internally consistent (Cronbach's \u03b1\u00a0=\u00a0.733). The written total score successfully identified persons with sixth-grade equivalency or less for literacy on the REALM (AUROC\u00a0=\u00a00.753) and inadequate literacy on the S-TOFHLA (AUROC\u00a0=\u00a00. 869). The written administration of the SLS is reliable, valid, and is effective in identifying persons with limited health literacy.", "keywords": ["Adult", "Male", "Writing", "4. Education", "Reproducibility of Results", "Middle Aged", "Health Literacy", "3. Good health", "03 medical and health sciences", "0302 clinical medicine", "Surveys and Questionnaires", "Humans", "Female", "0305 other medical science", "Aged"]}, "links": [{"href": "https://doi.org/PMC4698961"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Health%20Communication", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "PMC4698961", "name": "item", "description": "PMC4698961", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/PMC4698961"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2015-06-14T00:00:00Z"}}, {"id": "deng,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:10:38Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/deng,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "deng,2004", "name": "item", "description": "deng,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/deng,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}, {"id": "kahle,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:13:34Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/kahle,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "kahle,2004", "name": "item", "description": "kahle,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/kahle,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}, {"id": "kaho,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:13:34Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/kaho,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "kaho,2004", "name": "item", "description": "kaho,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/kaho,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}, {"id": "sharrowandismail,2004", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:14:06Z", "type": "Journal Article", "created": "2004-04-20", "description": "Eight patients had cardiac manifestations that were life-threatening in five while taking psychotropic drugs, either phenothiazines or tricyclic antidepressants. Although most patients were receiving several drugs, Mellaril (thioridazine) appeared to be responsible for five cases of ventricular tachycardia, one of which was fatal in a 35 year old woman. Supraventricular tachycardia developed in one patient receiving Thorazine (chlorpromazine). Aventyl (nortriptyline) and Elavil (amitriptyline) each produced left bundle branch block in a 73 year old woman. Electrocardiographic T and U wave abnormalities were present in most patients. The ventricular arrhythmias responded to intravenous administration of lidocaine and to direct current electric shock; ventricular pacing was required in some instances and intravenous administration of propranolol combined with ventricular pacing in one. The tachyarrhythmias generally subsided within 48 hours after administration of the drugs was stopped. Five of the eight patients were 50 years of age or younger; only one clearly had antecedent heart disease. Major cardiac arrhythmias are a potential hazard in patients without heart disease who are receiving customary therapeutic doses of psychotropic drugs. A prospective clinical trial is suggested to quantify the risk of cardiac complications to patients receiving phenothiazines or tricyclic antidepressant drugs.", "keywords": ["Adult", "Heart Failure", "Male", "Psychotropic Drugs", "Chlorpromazine", "Digitalis Glycosides", "Lidocaine", "Arrhythmias", " Cardiac", "Antidepressive Agents", " Tricyclic", "Middle Aged", "Adrenergic Agonists", "Cardiovascular System", "3. Good health", "Electrocardiography", "03 medical and health sciences", "0302 clinical medicine", "Phenothiazines", "Humans", "Female", "Mesoridazine", "Hypotension", "Diuretics", "Aged"], "contacts": [{"organization": "Irwin B. Hanenson, David McCall, Noble O. Fowler, John C. Holmes, Te Chuan Chou,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/sharrowandismail,2004"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20American%20Journal%20of%20Cardiology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "sharrowandismail,2004", "name": "item", "description": "sharrowandismail,2004", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/sharrowandismail,2004"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "1976-02-01T00:00:00Z"}}], "links": [{"rel": "self", "type": "application/geo+json", "title": "This document as GeoJSON", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Middle+Aged&f=json", "hreflang": "en-US"}, {"rel": "alternate", "type": "text/html", "title": "This document as HTML", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Middle+Aged&f=html", "hreflang": "en-US"}, {"rel": "collection", "type": "application/json", "title": "Collection URL", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main", "hreflang": "en-US"}, {"type": "application/geo+json", "rel": "first", "title": "items (first)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Middle+Aged&", "hreflang": "en-US"}, {"rel": "last", "type": "application/geo+json", "title": "items (last)", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items?keywords=Middle+Aged&offset=25", "hreflang": "en-US"}], "numberMatched": 25, "numberReturned": 25, "distributedFeatures": [], "timeStamp": "2026-05-31T09:04:17.709869Z"}