The PRISMA satellite is equipped with an advanced hyperspectral Earth observation technology capable of improving the accuracy of quantitative estimation of bio-geophysical variables in various Earth Science Applications and in particular for soil science. The purpose of this research was to evaluate the ability of the PRISMA hyperspectral imager to estimate topsoil properties (i.e., organic carbon, clay, sand, silt), in comparison with current satellite multispectral sensors. To investigate this expectation, a test was carried out using topsoil data collected in Italy following two approaches. Firstly, PRISMA, Sentinel-2 and Landsat 8 spectral simulated datasets were obtained from the spectral resampling of a laboratory soil library. Subsequently, bare soil reflectance data were obtained from two experimental areas in Italy, using real satellites images, at dates close to each other. The estimation models of soil properties were calibrated employing both Partial Least Square Regression and Cubist Regression algorithms. The results of the study revealed that the best accuracies in retrieving topsoil properties were obtained by PRISMA data, using both laboratory and real datasets. Indeed, the resampled spectra of the hyperspectral imager provided the best Ratio of Performance to Inter-Quartile distance (RPIQ) for clay (4.87), sand (3.80), and organic carbon (2.59) estimation, for the spectral soil library datasets. For the bare soil reflectance obtained from real satellite imagery, a higher level of prediction accuracy was obtained from PRISMA data, with RPIQ \u00b1 SE values of 2.32 \u00b1 0.07 for clay, 3.85 \u00b1 0.19 for silt, and 3.51 \u00b1 0.16 for soil organic carbon. The results for the PRISMA hyperspectral satellite imagery with the Cubist Regression provided the best performance in the prediction of silt, sand, clay and SOC. The same variables were better estimated using PLSR models in the case of the resampled hyperspectral data. The statistical accuracy in the retrieval of SOC from real and resampled PRISMA data revealed the potential of the actual hyperspectral satellite. The results supported the expected good ability of the PRISMA imager to estimate topsoil properties.