The World Health Organization \uffe2\uff80\uff98Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021\uffe2\uff80\uff932030\uffe2\uff80\uff99 outlines the targets for control and elimination of neglected tropical diseases (NTDs). New drugs are needed to achieve some of them. We are providing an overview of the pipeline for new anti-infective drugs for regulatory registration and steps to effective use for NTD control and elimination. Considering drugs approved for an NTD by at least one stringent regulatory authority: fexinidazole, included in WHO guidelines for Trypanosoma brucei gambiense African trypanosomiasis, is in development for Chagas disease. Moxidectin, registered in 2018 for treatment of individuals\uffe2\uff80\uff89\uffe2\uff89\uffa5\uffe2\uff80\uff8912\uffc2\uffa0years old with onchocerciasis, is undergoing studies to extend the indication to 4\uffe2\uff80\uff9311-year-old children and obtain additional data to inform WHO and endemic countries' decisions on moxidectin inclusion in guidelines and policies. Moxidectin is also being evaluated for other NTDs. Considering drugs in at least Phase 2 clinical development, a submission is being prepared for registration of acoziborole as an oral treatment for first and second stage T.b. gambiense African trypanosomiasis. Bedaquiline, registered for tuberculosis, is being evaluated for multibacillary leprosy. Phase 2 studies of emodepside and flubentylosin in O. volvulus-infected individuals are ongoing; studies for Trichuris trichuria and hookworm are planned. A trial of fosravuconazole in Madurella mycetomatis-infected patients is ongoing. JNJ-64281802 is undergoing Phase 2 trials for reducing dengue viral load. Studies are ongoing or planned to evaluate oxantel pamoate for onchocerciasis and soil-transmitted helminths, including Trichuris, and oxfendazole for onchocerciasis, Fasciola hepatica, Taenia solium cysticercosis, Echinococcus granulosus and soil-transmitted helminths, including Trichuris. Additional steps from first registration to effective use for NTD control and elimination include country registrations, possibly additional studies to inform WHO guidelines and country policies, and implementation research to address barriers to effective use of new drugs. Relative to the number of people suffering from NTDs, the pipeline is small. Close collaboration and exchange of experience among all stakeholders developing drugs for NTDs may increase the probability that the current pipeline will translate into new drugs effectively implemented in affected countries.
Graphical AbstractThis dataset corresponds to a datamart produced by the WP2 team of the Landmark H2020 project.
A specific request consists in the computation of a limited number of climate indicators for each grid cells and needed to run the dexi models. They are calculated for each year.
Those indicators was calculated for 2 periods:
This dataset corresponds to a datamart produced by the WP2 team of the Landmark H2020 project.
2 tables provided by France are available:
Both tables are connected with the same id attribute. To link soil data to management practices, yo", "keywords": ["2. Zero hunger", "Earth and Environmental Science", "Soils and soil sciences", "Agricultural Sciences", "Climate", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "15. Life on land", "Farming Systems", "Soil functions; soil; management; climate;", "Farming Systems and Practices", "Earth and Environmental Sciences", "Soil Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Soil functions soil management climate", "Environmental Research", "Natural Sciences", "Agriculture", " Forestry", " Horticulture", "Geosciences"], "contacts": [{"organization": "Saby, Nicolas P.A., Chenu, Jean-Philippe, Szergi, Tamas, Csorba, Adam, Bertuzzi, Patrick, Toutain, Beno\u00eet, Picaud, Calypso, Gay, Laura, Creamer, R.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.15454/aiq9ws"}, {"rel": "self", "type": "application/geo+json", "title": "10.15454/aiq9ws", "name": "item", "description": "10.15454/aiq9ws", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.15454/aiq9ws"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "10.15454/jtve46", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:19:42Z", "type": "Dataset", "title": "French SOERE soil monitoring dataset with related management practices data", "description": "Open AccessThis dataset corresponds to a datamart produced by the WP2 team of the Landmark H2020 project. The SOERE PRO is a French research observatory on organic residues recycling in agriculture. It is a network of long-term field experiments, including QualiAgro and PROspective devices, which has been created to evaluate benefits and risks associated with organic residue (OR) application in agriculture. It has been certified as SOERE PRO (a network of long-term experiments dedicated to the study of imp", "keywords": ["Earth and Environmental Science", "Climate", "6. Clean water", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Soil functions", "7. Clean energy", "12. Responsible consumption", "soil", "Farming Systems and Practices", "11. Sustainability", "13. Climate action", "climate", "Agriculture", " Forestry", " Horticulture", "2. Zero hunger", "Soils and soil sciences", "Agricultural Sciences", "Life Sciences", "15. Life on land", "soil functions", "Farming Systems", "Earth and Environmental Sciences", "Soil Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Environmental Research", "Natural Sciences", "Geosciences"], "contacts": [{"organization": "Gay, Laura, Saby, Nicolas P.A., Michaud, Aur\u00e9lia, Montenach, Denis, Resseguier Camille, Houot, Sabine, Szergi, Tamas, Csorba, Adam, Bertuzzi, Patrick, Toutain, Beno\u00eet, Picaud, Calypso, Creamer, Rachel,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.15454/jtve46"}, {"rel": "self", "type": "application/geo+json", "title": "10.15454/jtve46", "name": "item", "description": "10.15454/jtve46", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.15454/jtve46"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-01-01T00:00:00Z"}}, {"id": "10.15454/mutd4k", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:19:42Z", "type": "Dataset", "title": "Landmark H2020 dataset", "description": "Open AccessThis dataset corresponds to a list of attributes with metadata produced by the WP2 team of the Landmark H2020 project. This list was compiled based on the requirements of the diagnostic approach and the preferences of Work Package 3 for soil function modeling procedure.The list contains four categories of attributes: 5. \u201cSoil horizon attributes\u201d required to successfully derive diagnostic horizons/properties/materials and qualifiers;6. \u201cSoil attributes\u201d which contain physical/chemical/biological and other derived attributes;7. \u201cEnvironmental attributes\u201d which contain attributes needed to characterize of the surroundings of the soils (eg.: topography, climatic properties);8. \u201cManagement attributes\u201d which contain attributes regarding to management practices (eg.: irrigation, manuring, fertilization, pest control, weed management, grassland management, mechanization). The LANDMARK proposal builds on the concept that soils are a finite resource that provides a range of ecosystem services known as \u201csoil functions\u201d. Functions relating to agriculture include: primary productivity, water regulation purification, carbon-sequestration regulation, habitat for biodiversity and nutrient provision cycling. Tradeoffs between these functions may occur: for example, management aimed at maximising primary production may inadvertently affect the \u2018water purification\u2019 or \u2018habitat\u2019 functions. This has led to conflicting management recommendations and policy initiatives. There is now an urgent need to develop a coherent scientific and practical framework for the sustainable management of soils. LANDMARK will uniquely respond to the breadth of this challenge by delivering (through multi-actor development): 1. LOCAL SCALE: A toolkit for farmers with cost-effective, practical measures for sustainable (and context specific) soil management.2. REGIONAL SCALE - A blueprint for a soil monitoring scheme, using harmonised indicators: this will facilitate the assessment of soil functions for different soil types and land-uses for all major EU climatic zones.3. EU SCALE \u2013 An assessment of EU policy instruments for incentivising sustainable land management.", "keywords": ["Earth and Environmental Science", "Climate", "6. Clean water", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Soil functions", "12. Responsible consumption", "soil", "Farming Systems and Practices", "11. Sustainability", "13. Climate action", "climate", "Agriculture", " Forestry", " Horticulture", "2. Zero hunger", "Soils and soil sciences", "Agricultural Sciences", "Life Sciences", "15. Life on land", "Farming Systems", "Earth and Environmental Sciences", "Soil Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Environmental Research", "Natural Sciences", "management", "Geosciences"], "contacts": [{"organization": "Saby, Nicolas P.A., Micheli, Erika, Chenu, Jean-Philippe, Szergi, Tamas, Csorba, Adam, Bertuzzi, Patrick, Toutain, Beno\u00eet, Picaud, Calypso, Creamer, R.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.15454/mutd4k"}, {"rel": "self", "type": "application/geo+json", "title": "10.15454/mutd4k", "name": "item", "description": "10.15454/mutd4k", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.15454/mutd4k"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "10.3389/fvets.2021.706592", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:20:52Z", "type": "Journal Article", "created": "2021-09-07", "title": "Presence of adult companion goats favors the rumen microbial and functional development in artificially reared kids", "description": "
Newborn dairy ruminants are usually separated from their dams after birth and fed on milk replacer. This lack of contact with adult animals may hinder the rumen microbiological and physiological development. This study evaluates the effects of rearing newborn goat kids in contact with adult companions on the rumen development. Thirty-two newborn goat kids were randomly allocated to two experimental groups which were reared either in the absence (CTL) or in the presence of non-lactating adult goats (CMP) and weaned at 7 weeks of age. Blood and rumen samples were taken at 5, 7, and 9 weeks of age to evaluate blood metabolites and rumen microbial fermentation. Next-generation sequencing was carried out on rumen samples collected at 7 weeks of age. Results showed that CTL kids lacked rumen protozoa, whereas CMP kids had an abundant and complex protozoal community as well as higher methanogen abundance which positively correlated with the body weight and blood \uffce\uffb2-hydroxybutyrate as indicators of the physiological development. CMP kids also had a more diverse bacterial community (+132 ASVs) and a different structure of the bacterial and methanogen communities than CTL kids. The core rumen bacterial community in CMP animals had 53 more ASVs than that of CTL animals. Furthermore, the number of ASVs shared with the adult companions was over 4-fold higher in CMP kids than in CTL kids. Greater levels of early rumen colonizers Proteobacteria and Spirochaetes were found in CTL kids, while CMP kids had higher levels of Bacteroidetes and other less abundant taxa (Veillonellaceae, Cyanobacteria, and Selenomonas). These findings suggest that the presence of adult companions facilitated the rumen microbial development prior to weaning. This accelerated microbial development had no effect on the animal growth, but CMP animals presented higher rumen pH and butyrate (+45%) and ammonia concentrations than CTL kids, suggesting higher fibrolytic and proteolytic activities. CMP kids also had higher blood \uffce\uffb2-hydroxybutyrate (+79%) and lower blood glucose concentrations (-23%) at weaning, indicating an earlier metabolic development which could favor the transition from pre-ruminant to ruminant after the weaning process. Further research is needed to determine the effects of this intervention in more challenging farm conditions.
", "keywords": ["2. Zero hunger", "0301 basic medicine", "0303 health sciences", "Bacteria", "Methanogens", "rumen colonization", "weaning", "Veterinary medicine", "Weaning", "protozoa", "03 medical and health sciences", "SF600-1100", "Veterinary Science", "methanogens", "Rumen colonization", "Protozoa", "bacteria"]}, "links": [{"href": "https://doi.org/10.3389/fvets.2021.706592"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Frontiers%20in%20Veterinary%20Science", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3389/fvets.2021.706592", "name": "item", "description": "10.3389/fvets.2021.706592", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3389/fvets.2021.706592"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2021-09-07T00:00:00Z"}}, {"id": "10.3390/ani10040618", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:20:56Z", "type": "Journal Article", "created": "2020-04-07", "title": "Organic Livestock Production: A Bibliometric Review", "description": "Due to the increasing interest in organic farming, an overview of this research area is provided through a bibliometric analysis conducted between April and May 2019. A total of 320 documents were published up until 2018 on organic livestock farming, with an annual growth rate of 9.33% and a clear increase since 2005; 268 documents have been published in 111 journals. Germany is the country with the largest number of published papers (56 documents). Authors\uffe2\uff80\uff99 top keywords (excluding keywords used for running the search) included: animal welfare (29 times), animal health (22 times), cattle (15 times), grazing (10 times), and sheep (10 times). This could indicate that more research has been done on cattle because of the importance of this species in Germany. Moreover, the prevalence of the terms \uffe2\uff80\uff98animal welfare\uffe2\uff80\uff99 and \uffe2\uff80\uff98animal health\uffe2\uff80\uff99 may indicate that the research on organic livestock production has been focused on these two areas. The bibliometric analysis indicates that: (i) countries focused the organic livestock production research on their main production, and (ii) more research in species other than cattle and sheep is needed.
", "keywords": ["570", "sheep", "bibliometrix R; cattle; organic; poultry; sheep", "organic", "Veterinary medicine", "Review", "630", "Poultry", "03 medical and health sciences", "SF600-1100", "Dairy cattle", "'Organics' in general", "2. Zero hunger", "Organic", "Sheep", "poultry", "05 social sciences", "Beef cattle", "bibliometrix R", "Sheep and goats", "15. Life on land", "3. Good health", "Production systems", "Bibliometrix R", "QL1-991", "cattle", "Cattle", "Pigs", "0509 other social sciences", "0305 other medical science", "Zoology"]}, "links": [{"href": "https://www.iris.sssup.it/bitstream/11382/559815/1/animals_10_00618_pdf.pdf"}, {"href": "https://www.mdpi.com/2076-2615/10/4/618/pdf"}, {"href": "https://doi.org/10.3390/ani10040618"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Animals", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10.3390/ani10040618", "name": "item", "description": "10.3390/ani10040618", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.3390/ani10040618"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-04-03T00:00:00Z"}}, {"id": "10.34894/ZAXGXS", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:21:15Z", "type": "Dataset", "title": "Replication Data for: Relationship between home-field advantage of litter decomposition and priming of soil organic matter", "description": "In this study we investigated the relationship between HFA and PE by measuring litter- and SOM-derived carbon (C) fluxes after the addition of fresh plant litter. We reciprocally incubated three 13C labelled litter types (maize, bent and beech) in soils from ecosystems where these litters are abundantly produced (e.g., arable sites, grasslands and forests), with and without the addition of mineral nitrogen (N).", "keywords": ["Earth and Environmental Science", "Agricultural Sciences", "Earth and Environmental Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Verwerkte data", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Processed data", "15. Life on land", "Environmental Research", "Natural Sciences", "Geosciences"], "contacts": [{"organization": "Di Lonardo, Paolo", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.34894/ZAXGXS"}, {"rel": "self", "type": "application/geo+json", "title": "10.34894/ZAXGXS", "name": "item", "description": "10.34894/ZAXGXS", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.34894/ZAXGXS"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "10.57745/AKSR1A", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "Biogeographical patterns of the soil fungal:bacterial ratio across France", "description": "Data to perform the analyzes presented in the publication. See abstract below: Soils are one of the major reservoirs of biological diversity on our planet because they host a huge richness of microorganisms. The fungal:bacterial (F:B) ratio targets two major functional groups of organisms in soils and can improve our understanding of their importance and efficiency for soil functioning. To better decipher the variability of this ratio and rank the environmental parameters involved, we used the French Soil Quality Monitoring Network \u2013 one of the most extensive and a priori-free soil sampling surveys, based on a systematic 16 km x 16 km grid and including more than 2,100 samples. F:B ratios, measured by quantitative PCR targeting the 18S and 16S rDNA genes, turned out to be heterogenously distributed, and spatially structured in geographical patterns across France. These distribution patterns differed from bacterial or fungal densities taken separately, supporting the hypothesis that the F:B ratio is not the mere addition of each density, but rather results from the complex interactions of the two functional groups. The F:B ratios were mainly influenced by soil characteristics and land management. Among soil characteristics, the pH and to a lesser extent the organic carbon content and the C:N ratio were the main drivers. These results improved our understanding of soil microbial communities, and from an operational point of view, they suggested that the F:B ratio should be a useful new bioindicator of soil status. The resulting dataset can be considered as a first step toward building up a robust repository essential to any bioindicator and aimed at guiding and helping decision-making.", "keywords": ["2. Zero hunger", "Earth and Environmental Science", "Agricultural Sciences", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "15. Life on land", "Earth and Environmental Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "France", "fungal:bacterial ratio; soil; biogeographical", " RMQS", " France", "Environmental Research", "Natural Sciences", "RMQS", "fungal bacterial ratio soil biogeographical", "Agriculture", " Forestry", " Horticulture", "Geosciences"], "contacts": [{"organization": "Djemiel, Christophe", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/AKSR1A"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/AKSR1A", "name": "item", "description": "10.57745/AKSR1A", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/AKSR1A"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-01-01T00:00:00Z"}}, {"id": "10.57745/3QFT2T", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "French maps for the Global Soil Nutrient and Nutrient Budget Map (GSNmap)", "description": "This set of maps presents digital maps of soil properties on agricultural lands in France within the FAO framework \u201cGlobal Soil Nutrient and Nutrient Budgets maps\u201d. The spatial predictions of ten soil properties, namely Total N, available P, CEC, pH (water), Clay, Silt, Sand, Soil Organic Carbon, Bulk density and available K were generated with a 250 m spatial resolution. Random forest machine learning approach in combination with environmental variables was used for spatial distribution assessment of properties. Additionally, uncertainty maps expressed as the standard deviation of spatial predictions were produced. All maps are provided in a raster geotiff format. the identifier of the spatial reference system (srid) is 4326.", "keywords": ["Earth and Environmental Science", "bulk density", "cation exchange capacity", "available phosphorus content", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "sand", "cropland", "potassium content", "cation-exchange capacity", "Agriculture", " Forestry", " Horticulture", "2. Zero hunger", "silt", "Agricultural Sciences", "pH", "nutrient", "EAR soil sciences", "soil property", "Life Sciences", "clay", "15. Life on land", "6. Clean water", "soil organic carbon", "13. Climate action", "Earth and Environmental Sciences", "digital soil mapping", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Environmental Research", "Natural Sciences", "random forest", "Geosciences", "nitrogen content"], "contacts": [{"organization": "Suleymanov, Azamat, Saby, Nicolas, Bispo, Antonio,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/3QFT2T"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/3QFT2T", "name": "item", "description": "10.57745/3QFT2T", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/3QFT2T"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-01-01T00:00:00Z"}}, {"id": "10.57745/5TJJZA", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "Innovative cropping systems designed to reach both environmental and production targets: data set of biotic and abiotic variables from a twelve-year French field trial.", "description": "The data set describe variables collected from a French (N 48.84\u00b0, E 1.95\u00b0) field trial, over a twelve-year period (2009-2020), in which four innovative cropping systems designed to reach multiple environmental and production goals were assessed. Both biotic and abiotic variables were measured. In a previous data paper, we focused on nitrogen (N) fluxes collected from two systems, over eight years (2009-2016). In the present one, we enlarge the scope of the variables, including more crop descriptions and environmental indicators, from the all four systems, and over a longer period (2009-2020). The biotic data are: growth stages, aboveground plant N content and biomass collected at different growth stages according to the species, yield components of all the crops, yield harvested with a combine machine, crop sequences. No weed, crop disease, and pest\u2019s data are described. The abiotic data are soil physical and chemical properties (i.e. texture, calcareous content, pH, organic carbon (C) contents, and N contents) collected at different assessment periods. All agricultural practices and climate were regularly recorded, and the treatment frequency indexes and the energy consumptions were computed. The four innovative cropping systems were designed with new combinations of agricultural practices; they differed in terms of pesticide uses, N inputs, tillage practices, and crop sequences. These data could be used for benchmark to design low-input systems, to improve models for parameterization and validation, and to increase the predictive accuracy of models of growth and development for crops, specifically orphan species as linseed, faba bean of hemp, and soil C and soil N fluxes in original conditions.", "keywords": ["Crop biomass", "Yield", "Agricultural Sciences", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "cropping system", "Long-term field trial", "Agronomy", "Energy consumption", "Treatment frequency index", "Agricultural practices", "Crop growth", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Agricultural practices.", "Long term field trial", "Agriculture", " Forestry", " Horticulture"], "contacts": [{"organization": "Colnenne-David, Caroline", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/5TJJZA"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/5TJJZA", "name": "item", "description": "10.57745/5TJJZA", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/5TJJZA"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-01-01T00:00:00Z"}}, {"id": "10.57745/KAMGHR", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "The effects of earthworm species on organic matter transformations and soil microbial communities are only partially related to their bioturbation activity", "description": "This dataset was acquired to investigate the effects of earthworm species on soil bioturbation, biogeochemical transformations of soil organic matter, and soil microbial communities under controlled conditions. Six earthworm species (Lumbricus terrestris, Allolobophora chlorotica, Octolasion cyaneum, Octodrilus complanatus, Aporrectodea caliginosa meridionalis and Microscolex dubius) were incubated in soil cores with soil and alfalfa litter for 6 weeks, at 16 \u00b0C. The soil is a silty loam sampled in an agricultural plot in Estr\u00e9es-Mons, northern France. Two series of soil cores were performed, including controls (3 with litter and without earthworm, 3 without litter and without earthworm per series). At the end of the incubation period, the entire cores were scanned using a medical scanner for bioturbation measurements. All images were processed the same way to compute the number of macropores (set of connected voxels), the volume of burrows (sum of all the macropore volume), the vertical barycentre of the burrow system (the centre of mass of the burrow system when only the vertical dimension is taken into account), the diameter (assessed as the median of the diameter of all vertical pores with a circularity 0.8) and burrow system continuity (number of burrows whose vertical length was higher than 30% of the depth of the soil core). In cores with earthworms, the soil was sampled from three different compartments: surface casts, the drilosphere (i.e., soil surrounding burrows, up to 4 mm from the burrow walls), and surrounding bulk soil. In control cores without earthworms, the soil was sampled from three different depths: surface (0-2 cm from the soil surface), middle (8-12 cm) and bottom (18-22 cm). Biogeochemical measurements, performed on the different soil compartments, included : soil humidity, dissolved organic carbon (C), total C, total nitrogen (N), mineral N, organic N contents, C to N ratio, nitrate (NO3-) and ammonium (NH4+) contents at the time if sampling and after 8 days in incubation at 20\u00b0C, carbon dioxide (CO2) fluxes measured with Isotope-ratio mass spectrometry (IRMS) method after 46, 91, 136, and 181 hours of microcosm incubation at 20\u00b0C, CO2 fluxes measured with sodium hydroxide (NaOH) traps after 46, 94, 142, and 190 hours of microcosm incubation at 20\u00b0C. Microbiological measurements, performed on the different soil compartments, included: total DNA concentration in soil, 16S rRNA copy number, 18S rRNA copy number, bacterial operational taxonomic unit (OUT) composition, and Shannon index, calculated on bacterial OTU. This work was supported by the the AgroEcoSystem Division of INRAE through the funding of the \u201cGloWorms\u201d project.", "keywords": ["Earth and Environmental Science", "Decomposition", "Agricultural Sciences", "Nitrogen", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Carbon", "Soil", "Earth and Environmental Sciences", "Earthworm", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "mineralization", "Environmental Research", "Natural Sciences", "Agriculture", " Forestry", " Horticulture", "Geosciences"], "contacts": [{"organization": "Lashermes, Gwena\u00eblle, Vion-Guibert, Luna, Capowiez, Yvan, Alavoine, Gonzague, Delfosse, Olivier, Hedde, Micka\u00ebl, Marsden, Claire,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/KAMGHR"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/KAMGHR", "name": "item", "description": "10.57745/KAMGHR", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/KAMGHR"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2024-01-01T00:00:00Z"}}, {"id": "10.57745/MEQQIX", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "AMGv2 parameters", "description": "Parameters (for plant carbon inputs, exogenous organic matter carbon inputs and soil organic carbon mineralization) related to the AMGv2 model. These parameters are provided by the AMG Consortium (which includes INRAE, Agro-Transfert Ressources et Territoires, Arvalis Institut du V\u00e9g\u00e9tal and LDAR) and by Terres Inovia. They are applicable for average French arable crop conditions. A full description of the AMGv2 model can be found in Clivot et al. (2019): https://doi.org/10.1016/j.envsoft.2019.04.004", "keywords": ["2. Zero hunger", "modelling", "soil organic carbon", "13. Climate action", "Agricultural Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "15. Life on land", "Agriculture", " Forestry", " Horticulture"], "contacts": [{"organization": "Clivot, Hugues, Duparque, Annie, Ferchaud, Fabien, Lagrange, H\u00e9l\u00e8ne, Levavasseur, Florent, Levert, Maxime, Marsac, Sylvain, Mary, Bruno, Mouny, Jean-Christophe, Piquemal, Beno\u00eet, Sagot, St\u00e9phanie, Servain, Fran\u00e7ois, Trochard, Robert, Cadoux, St\u00e9phane, Perrin, Anne-Sophie,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/MEQQIX"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/MEQQIX", "name": "item", "description": "10.57745/MEQQIX", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/MEQQIX"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-01-01T00:00:00Z"}}, {"id": "10.57745/SEVWMQ", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "Data from: Conversion of arable land to perennial bioenergy crops increases soil organic carbon stocks on the long term", "description": "Perennial C4 bioenergy crops can combine high productivity and low input requirements. However, their impact on soil organic carbon (SOC) stocks remains uncertain. The aim of this study was to assess the long-term impact of converting arable land to perennial bioenergy crops on SOC stocks for two crop species (miscanthus and switchgrass) and several crop management practices (nitrogen fertilization, harvest date and irrigation). We analyzed two long-term experiments. Site 1 was located in Estr\u00e9es-Mons, northern France (49.872\u00b0N, 3.013\u00b0E), and corresponded to the INRAE long-term experiment called \u201cBiomass & Environment\u201d. Site 2 was located in Montgaillard-Lauragais, southern France (43.433\u00b0N, 1.679\u00b0E), and was managed by Arvalis. Both sites were sampled initially and after 12 (site 1) or 13 (site 2) years. SOC concentrations, \u03b413C values and bulk densities were measured in order do calculate SOC stocks at equivalent soil mass and changes in \u201cnew\u201d and \u201cold\u201d SOC stocks. The dataset is organised to calculate stocks at equivalent soil mass using the SimpleESM R script (https://github.com/fabienferchaud/SimpleESM).", "keywords": ["soil organic carbon", "Agricultural Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Miscanthus", "bioenergy", "carbon sequestration", "Agriculture", " Forestry", " Horticulture"], "contacts": [{"organization": "Ferchaud, Fabien, Marsac, Sylvain, Mary, Bruno,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/SEVWMQ"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/SEVWMQ", "name": "item", "description": "10.57745/SEVWMQ", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/SEVWMQ"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2025-01-01T00:00:00Z"}}, {"id": "10.57745/ykzdfi", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:24:15Z", "type": "Dataset", "title": "Etude 4pour1000 : BANCO simulation data for publication of the article \"A Marginal Abatement Cost Curve for Climate Change Mitigation by additional carbon storage in French agricultural land\"", "description": "input data and simulation outputs of the BANCO model : cost effective allocation of the net abatement effort. Simulations made for the article revision submited to JCP. (2022-07-25)", "keywords": ["Earth and Environmental Science", "Agricultural Sciences", "Economics", "Climate", "Social and Behavioural Sciences", "Social Sciences", "Life Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "7. Clean energy", "carbon sequestration", "Farming Systems", "modelling", "Farming Systems and Practices", "13. Climate action", "Earth and Environmental Sciences", "Soil Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Environmental Research", "Natural Sciences", "Agriculture", " Forestry", " Horticulture", "Geosciences"], "contacts": [{"organization": "Bami\u00e8re, Laure, Schiavo, Michele, Bellassen, Valentin, Delame, Nathalie, Letort, Elodie, Mosnier, Claire,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/10.57745/ykzdfi"}, {"rel": "self", "type": "application/geo+json", "title": "10.57745/ykzdfi", "name": "item", "description": "10.57745/ykzdfi", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10.57745/ykzdfi"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2022-01-01T00:00:00Z"}}, {"id": "11454/87069", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:25:03Z", "type": "Report", "title": "Civciv embriyolar\u0131nda sekonder n\u00f6rulasyon evrelerinin histolojik olarak incelenmesi", "description": "Embargo90 SUMMARY Neurulation is the process of the neural tube formation. It can be investigated in two categories as primary and secondary neurulation. Primary neurulation takes place by formation of neural plate that starts with the proliferation of ectoderm, folding of the neural plate lateral edges, and raising of these folds and approaching and joining of them in the middle zone. Secondary neurulation, on the other hand, takes place in the caudal of the embryo and starts with the formation of medullar cord via grouping and densification of mesenchyme cells in the tail bud. Earlier investigations have usually covered the primary neurulation. In this study, however, process of secondary neurulation that forms through canalization of a massive group of cells is investigated. Secondary neurulation is studied in stage 15 of 55-hour chick embryo based on the Hamburger-Hamilton stages. After the removal of embryos from the eggs, they were dissected from their membranes and put into proper fixatives. Paraffin procedure was applied to a group of embryos for the purpose of light microscopy and histochemical studies. P.A.S. and Hematoksilen Eozin staining were done to some 2- micron sections taken from the paraffin blocks. In order to achieve a better resolution under the light microscopy, some chick embryos were prepared according to the electron microscopy sample preparation procedures, and epon blocks were prepared accordingly. Some 1 -micron sections taken from the epon blocks were stained by toulin blue. Finally, embryos were studied under the light microscopy, and their photos were taken. It was found out that secondary neurulation was formed via cavitation of the medullar cord that developed from the tail bud in the caudal of the chick embryo. Different from the primary neurulation, secondary neurulation in chick embryos has four stages: First, formation of a massive group of cells identified as medullar cord91 via joining of dorsal cells of the tail bud. Second, appearance of the edges of the area of the cells grouped and differentiation of the cells as central and peripheral cells. Third, cavitation between the central and peripheral cells. Fourth, joining of all lumens and formation of one central canal. Apoptotic cells were identified according to the histologic criteria in the secondary neural tube and tail mesenchyme formed during the time period investigated. It was thought that these apoptotic cells were used in the normal development and control of the cell number. Neural tube defects still stay an important health problem, even though the understanding of the neurulation has advanced in the last years. Neural tube closure defects in humans may give rise to neural tube defects known as spina bifida, vertebrate defects, and in the extreme cases paralysis. In addition, defects that come to existence during the secondary neurulation are observed in clinical cases as terminal miyelosistosel and thick filum terminale syndrome. Although, mechanisms in the molecular and cellular level are now understood better, understanding of the cell behavior is important in preventing the congenital malformations. Finally, It was declared that secondary neurulation is very important in the process of neural tube formation as neural tube formation is very important in the development of a normal human. Molecular level studies can help cure neurulation pathologies.", "keywords": ["Morphology", "Veterinary Medicine", "Veteriner Hekimli\u011fi", "Eggs", "Croquet", "fatty acids", "Pearl mullet", "kroket", "Kroket", "eggs", "chemical composition", "Fatty acids", "Morfoloji", "croquets.", "amino acids", "Su \u00dcr\u00fcnleri", "Fishes", "ya\u011f asitleri", "\u0130nci kefali", "yumurta", "kimyasal kompozisyon", "Yumurtalar", "Aquatic Products", "Amino acids", "Amino asitler", "Bal\u0131klar", "amino asitler", "Ya\u011f asitleri", "Chalcalburnus tarichi"], "contacts": [{"organization": "Duyar, H\u00fcnkar Avni", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/11454/87069"}, {"rel": "self", "type": "application/geo+json", "title": "11454/87069", "name": "item", "description": "11454/87069", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11454/87069"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-12-29T00:00:00Z"}}, {"id": "3087185359", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:26:15Z", "type": "Dataset", "title": "Landmark H2020 dataset", "description": "Open AccessThis dataset corresponds to a list of attributes with metadata produced by the WP2 team of the Landmark H2020 project. This list was compiled based on the requirements of the diagnostic approach and the preferences of Work Package 3 for soil function modeling procedure.The list contains four categories of attributes: 5. \u201cSoil horizon attributes\u201d required to successfully derive diagnostic horizons/properties/materials and qualifiers;6. \u201cSoil attributes\u201d which contain physical/chemical/biological and other derived attributes;7. \u201cEnvironmental attributes\u201d which contain attributes needed to characterize of the surroundings of the soils (eg.: topography, climatic properties);8. \u201cManagement attributes\u201d which contain attributes regarding to management practices (eg.: irrigation, manuring, fertilization, pest control, weed management, grassland management, mechanization). The LANDMARK proposal builds on the concept that soils are a finite resource that provides a range of ecosystem services known as \u201csoil functions\u201d. Functions relating to agriculture include: primary productivity, water regulation purification, carbon-sequestration regulation, habitat for biodiversity and nutrient provision cycling. Tradeoffs between these functions may occur: for example, management aimed at maximising primary production may inadvertently affect the \u2018water purification\u2019 or \u2018habitat\u2019 functions. This has led to conflicting management recommendations and policy initiatives. There is now an urgent need to develop a coherent scientific and practical framework for the sustainable management of soils. LANDMARK will uniquely respond to the breadth of this challenge by delivering (through multi-actor development): 1. LOCAL SCALE: A toolkit for farmers with cost-effective, practical measures for sustainable (and context specific) soil management.2. REGIONAL SCALE - A blueprint for a soil monitoring scheme, using harmonised indicators: this will facilitate the assessment of soil functions for different soil types and land-uses for all major EU climatic zones.3. EU SCALE \u2013 An assessment of EU policy instruments for incentivising sustainable land management.", "keywords": ["Earth and Environmental Science", "Climate", "6. Clean water", "Agriculture", " Forestry", " Horticulture", " Aquaculture", "Soil functions", "12. Responsible consumption", "soil", "Farming Systems and Practices", "11. Sustainability", "13. Climate action", "climate", "Agriculture", " Forestry", " Horticulture", "2. Zero hunger", "Soils and soil sciences", "Agricultural Sciences", "Life Sciences", "15. Life on land", "Farming Systems", "Earth and Environmental Sciences", "Soil Sciences", "Agriculture", " Forestry", " Horticulture", " Aquaculture and Veterinary Medicine", "Environmental Research", "Natural Sciences", "management", "Geosciences"], "contacts": [{"organization": "Saby, Nicolas P.A., Micheli, Erika, Chenu, Jean-Philippe, Szergi, Tamas, Csorba, Adam, Bertuzzi, Patrick, Toutain, Beno\u00eet, Picaud, Calypso, Creamer, R.,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/3087185359"}, {"rel": "self", "type": "application/geo+json", "title": "3087185359", "name": "item", "description": "3087185359", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/3087185359"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "PMC9979492", "type": "Feature", "geometry": null, "properties": {"updated": "2026-07-25T16:28:15Z", "type": "Journal Article", "created": "2023-03-01", "title": "The pipeline for drugs for control and elimination of neglected tropical diseases: 1. Anti-infective drugs for regulatory registration", "description": "AbstractThe World Health Organization \uffe2\uff80\uff98Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021\uffe2\uff80\uff932030\uffe2\uff80\uff99 outlines the targets for control and elimination of neglected tropical diseases (NTDs). New drugs are needed to achieve some of them. We are providing an overview of the pipeline for new anti-infective drugs for regulatory registration and steps to effective use for NTD control and elimination. Considering drugs approved for an NTD by at least one stringent regulatory authority: fexinidazole, included in WHO guidelines for Trypanosoma brucei gambiense African trypanosomiasis, is in development for Chagas disease. Moxidectin, registered in 2018 for treatment of individuals\uffe2\uff80\uff89\uffe2\uff89\uffa5\uffe2\uff80\uff8912\uffc2\uffa0years old with onchocerciasis, is undergoing studies to extend the indication to 4\uffe2\uff80\uff9311-year-old children and obtain additional data to inform WHO and endemic countries' decisions on moxidectin inclusion in guidelines and policies. Moxidectin is also being evaluated for other NTDs. Considering drugs in at least Phase 2 clinical development, a submission is being prepared for registration of acoziborole as an oral treatment for first and second stage T.b. gambiense African trypanosomiasis. Bedaquiline, registered for tuberculosis, is being evaluated for multibacillary leprosy. Phase 2 studies of emodepside and flubentylosin in O. volvulus-infected individuals are ongoing; studies for Trichuris trichuria and hookworm are planned. A trial of fosravuconazole in Madurella mycetomatis-infected patients is ongoing. JNJ-64281802 is undergoing Phase 2 trials for reducing dengue viral load. Studies are ongoing or planned to evaluate oxantel pamoate for onchocerciasis and soil-transmitted helminths, including Trichuris, and oxfendazole for onchocerciasis, Fasciola hepatica, Taenia solium cysticercosis, Echinococcus granulosus and soil-transmitted helminths, including Trichuris. Additional steps from first registration to effective use for NTD control and elimination include country registrations, possibly additional studies to inform WHO guidelines and country policies, and implementation research to address barriers to effective use of new drugs. Relative to the number of people suffering from NTDs, the pipeline is small. Close collaboration and exchange of experience among all stakeholders developing drugs for NTDs may increase the probability that the current pipeline will translate into new drugs effectively implemented in affected countries.
Graphical Abstract