{"type": "FeatureCollection", "features": [{"id": "10.1016/j.foodres.2024.114342", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T06:57:01Z", "type": "Journal Article", "created": "2024-04-23", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.The World Health Organization recommends the use of the microscopy-based Kato-Katz thick smear for diagnosing soil-transmitted helminth (STH) infections. Despite its simplicity and cost-effectiveness, the Kato-Katz method faces challenges, including reader subjectivity and reduced sensitivity. Real-time polymerase chain reaction (qPCR) technology offers standardized readouts and higher sensitivity, making it suitable for STH diagnosis and monitoring the treatment efficacy of emodepside within the framework of randomized controlled trials.

Methodology/Principal findings

We evaluated the performance of Kato-Katz versus qPCR for assessing treatment efficacy in terms of cure rates, of single doses of 5, 10, 15, 20, 25 and 30\uffe2\uff80\uff89mg of emodepside compared to 400\uffe2\uff80\uff89mg albendazole. Spearman\uffe2\uff80\uff99s rank correlation coefficient examined the correlation between STH eggs per gram in stool samples and qPCR Ct values. Diagnostic sensitivity of qPCR was calculated using a Bayesian latent class modelling approach with data from Ascaris lumbricoides infections. Agreement between Kato-Katz and qPCR at baseline was 93.57% for Trichuris trichiura, and 73.49% for both hookworm and A. lumbricoides. For the latter helminth qPCR demonstrated higher sensitivity (85.00% vs. 47.70%) and slightly lower specificity (93.40% vs. 99.40%) compared to Kato-Katz. We observed a fair to moderate agreement with negative correlation between Ct values and Kato-Katz egg counts. Treatment efficacy, as assessed by qPCR, was lower for all doses of emodepside and albendazole compared to Kato-Katz. Nonetheless, emodepside demonstrated higher cure rates against T. trichiura and A. lumbricoides infections compared to albendazole.

Conclusion/ Significance

Our study confirmed that qPCR is a sensitive diagnostic method for diagnosing STH infections compared to Kato-Katz and serves as a valuable tool for determining treatment efficacy in clinical trials. Furthermore, qPCR confirmed the better treatment efficacy of emodepside compared to albendazole, despite indicating lower cure rates than Kato-Katz.

The Food and Drug Administration (FDA) can regulate the introduction of new tobacco products and some changes to existing products. Cigarette packs have been used as a marketing tool to target specific groups and priority populations. Research has shown that sexual and gender minority (SGM) adults are substantially more likely to use tobacco products than their straight and cisgender counterparts. However, research to inform the FDA\u2019s regulatory decisions regarding cigarette packs targeting priority populations is nascent. To fill this gap, we conducted an online experiment in 2018, randomizing U.S. adults who reported current smoking ( N = 954, 52% were SGM) to view one of three cigarette packs. A graphic designer developed \u201cGlacier\u201d branded packs with three levels of SGM imagery: (1) no targeting, (2) subtle targeting, and (3) a rainbow \u201cpride edition.\u201d Participants viewed and rated the pack using cognitive, affective, and behavioral measures informed by theory. We used a linear model framework to compare the two SGM-targeted packs with the not targeted version and tested interactions between pack and SGM identity for the dependent variables. We stratified results by SGM status. SGM status was a significant moderator of the relationship between the pack and ratings of appeal, positive affect, feeling shocked, and intent to try with a coupon. Findings from this study revealed that packs designed for SGM populations can disproportionately change cognitive, affective, and behavioral intention responses for SGM smokers. Products entering the market should be assessed by FDA for the appeal of their packs to vulnerable populations.

", "keywords": ["Adult", "Male", "Marketing", "Adolescent", "Vaping", "Tobacco Products", "Electronic Nicotine Delivery Systems", "Risk Assessment", "Transgender Persons", "United States", "3. Good health", "Sexual and Gender Minorities", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Socioeconomic Factors", "Surveys and Questionnaires", "Humans", "Female", "10. No inequality", "Designed for LGBT", "Cigarette Packs", "Potential Impact", "Minority Groups"]}, "links": [{"href": "https://doi.org/10342/9526"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Health%20Promotion%20Practice", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "10342/9526", "name": "item", "description": "10342/9526", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/10342/9526"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2020-01-01T00:00:00Z"}}, {"id": "11577/3480910", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:05:33Z", "type": "Journal Article", "created": "2014-09-20", "title": "The representativeness of a European multi-center network for influenza-like-illness participatory surveillance", "description": "The Internet is becoming more commonly used as a tool for disease surveillance. Similarly to other surveillance systems and to studies using online data collection, Internet-based surveillance will have biases in participation, affecting the generalizability of the results. Here we quantify the participation biases of Influenzanet, an ongoing European-wide network of Internet-based participatory surveillance systems for influenza-like-illness.In 2011/2012 Influenzanet launched a standardized common framework for data collection applied to seven European countries. Influenzanet participants were compared to the general population of the participating countries to assess the representativeness of the sample in terms of a set of demographic, geographic, socio-economic and health indicators.More than 30,000 European residents registered to the system in the 2011/2012 season, and a subset of 25,481 participants were selected for this study. All age classes (10\u00a0years brackets) were represented in the cohort, including under 10 and over 70\u00a0years old. The Influenzanet population was not representative of the general population in terms of age distribution, underrepresenting the youngest and oldest age classes. The gender imbalance differed between countries. A counterbalance between gender-specific information-seeking behavior (more prominent in women) and Internet usage (with higher rates in male populations) may be at the origin of this difference. Once adjusted by demographic indicators, a similar propensity to commute was observed for each country, and the same top three transportation modes were used for six countries out of seven. Smokers were underrepresented in the majority of countries, as were individuals with diabetes; the representativeness of asthma prevalence and vaccination coverage for 65+ individuals in two successive seasons (2010/2011 and 2011/2012) varied between countries.Existing demographic and national datasets allowed the quantification of the participation biases of a large cohort for influenza-like-illness surveillance in the general population. Significant differences were found between Influenzanet participants and the general population. The quantified biases need to be taken into account in the analysis of Influenzanet epidemiological studies and provide indications on populations groups that should be targeted in recruitment efforts.", "keywords": ["Influenza; Internet data collection; Participation bias; Representativeness; Selection bias; Surveillance", "Adult", "Male", "0301 basic medicine", "Adolescent", "Health Status", "Young Adult", "03 medical and health sciences", "Age Distribution", "0302 clinical medicine", "Influenza", " Human", "11. Sustainability", "Prevalence", "Humans", "Child", "Representativeness", "Aged", "Selection bias", "Internet", "Surveillance", "Internet data collection", "Public Health", " Environmental and Occupational Health", "Infant", " Newborn", "Participation bias", "Infant", "Middle Aged", "16. Peace & justice", "Influenza", "3. Good health", "Europe", "Socioeconomic Factors", "[SDV.SPEE] Life Sciences [q-bio]/Sant\u00e9 publique et \u00e9pid\u00e9miologie", "13. Climate action", "Child", " Preschool", "Population Surveillance", "Female", "Research Article"]}, "links": [{"href": "https://researchonline.lshtm.ac.uk/id/eprint/2017934/1/12889_2014_7121_MOESM2_ESM.pdf"}, {"href": "https://air.unimi.it/bitstream/2434/240039/2/cantarelli-colizza.pdf"}, {"href": "https://www.research.unipd.it/bitstream/11577/3480910/1/Cantarelli_BMC-PubHealth_2014.pdf"}, {"href": "https://doi.org/11577/3480910"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/BMC%20Public%20Health", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "11577/3480910", "name": "item", "description": "11577/3480910", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/11577/3480910"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2014-09-20T00:00:00Z"}}, {"id": "20440493", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:06:02Z", "type": "Journal Article", "created": "2010-05-03", "title": "Mechanotransduction: The Missing Link in the Facial Aging Puzzle?", "description": "Craniofacial bony remodeling has been recognized as an important contributor to the facial aging process. Multiple studies have demonstrated significant craniofacial skeletal changes with age. However, no review has assembled this information in a concise, cogent fashion. Furthermore, the etiology of these skeletal changes has not been elucidated. This information is important for understanding the mechanisms of facial aging and for further development of facial rejuvenation.A literature review of all articles discussing remodeling of the craniofacial skeleton with age was performed. Studies that used objective measurements of craniofacial skeletal parameters for different age groups were collected and analyzed.The studies demonstrated consistent morphologic changes in the craniofacial skeleton with age. These changes included trends toward increased facial bony width in women; contour changes of the orbit, anterior maxilla, and mandibular body; and decreased dimensions of the glabellar, pyriform, and maxillary angles.The craniofacial skeleton remodels with aging. Many of the observed changes in soft tissue contour and position reflect these skeletal changes. Changes in facial muscle function through the process of mechanotransduction may be responsible for these skeletal changes.", "keywords": ["Adult", "Aged", " 80 and over", "Male", "Aging", "Adolescent", "Skull", "Middle Aged", "Biophysical Phenomena", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Face", "Humans", "Female", "Aged"], "contacts": [{"organization": "Safa E, Sharabi, Daniel A, Hatef, John C, Koshy, Larry H, Hollier, Michael J, Yaremchuk,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/20440493"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Aesthetic%20Plastic%20Surgery", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "20440493", "name": "item", "description": "20440493", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/20440493"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2010-05-04T00:00:00Z"}}, {"id": "26072915", "type": "Feature", "geometry": null, "properties": {"license": "Open Access", "updated": "2026-05-31T07:06:17Z", "type": "Journal Article", "created": "2015-06-11", "title": "Augmented Carbohydrate Oxidation under Moderate Hypobaric Hypoxia Equivalent to Simulated Altitude of 2500 m", "description": "Hypoxia itself stimulates glucose uptake mediated by a mechanism independent of insulin. However, whether moderate hypoxia causes similar metabolic effect in humans remains unclear. The present study aimed to determine glycemic regulation following glucose load at a simulated moderate altitude of 2,500 m. Eight healthy young males (mean \u00b1 standard error: 24 \u00b1 1 years; 171.3 \u00b1 1.6 cm; 66.9 \u00b1 3.7 kg; 22.8 \u00b1 1.0 kg/m(2)) consumed 75 g of glucose solution under either hypobaric condition (560 mmHg) or normobaric condition (745 mmHg). In the hypobaric chamber, the oxygen partial pressure is proportionally reduced with a reduction of atmospheric pressure, consequently leading to the hypoxic condition. Plasma glucose and serum insulin concentrations increased significantly following glucose load in both conditions (P < 0.05). However, no significant interaction (condition \u00d7 time) or main effect for condition was observed. There were no significant differences in serum glycerol, plasma epinephrine, or plasma norepinephrine concentrations between the two conditions. No significant differences between the conditions were observed in changes in VO2 or VCO2. However, the hypobaric condition showed significantly higher respiratory exchange ratio (VCO2/VO2) at 90 and 120 min following glucose load (P < 0.05 vs. normobaric condition), suggesting that carbohydrate oxidation following glucose load was enhanced in moderate hypobaric hypoxia. In conclusion, acute exposure to moderate hypobaric hypoxia significantly augmented carbohydrate oxidation following the glucose load, without affecting glucose or insulin responses. Thus, a short-time exposure to moderate hypobaric hypoxia may be beneficial for people with impaired glucose tolerance.", "keywords": ["Blood Glucose", "Glycerol", "Male", "2. Zero hunger", "Analysis of Variance", "Epinephrine", "Altitude", "Carbon Dioxide", "3. Good health", "Oxygen", "Norepinephrine", "Young Adult", "03 medical and health sciences", "Atmospheric Pressure", "Glucose", "0302 clinical medicine", "Humans", "Insulin", "Hypoxia", "Pulmonary Ventilation"]}, "links": [{"href": "https://doi.org/26072915"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/The%20Tohoku%20Journal%20of%20Experimental%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "26072915", "name": "item", "description": "26072915", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/26072915"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2015-01-01T00:00:00Z"}}, {"id": "30932950", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:06:39Z", "type": "Journal Article", "created": "2019-03-29", "title": "Longitudinally Measured Changes in Somnolence Severity With a Visual Analog Scale in a Randomized Lithium Versus Quetiapine-IR Study in Bipolar Disorder", "description": "Abstract Objective

The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder.

Methods

A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measured with a VAS from 0 to 100 (VAS based), and somnolence frequency was recorded according to incident report (incidence based) at each visit. The rates of VAS-based and incidence-based somnolence and changes in somnolence severity from baseline to the end of study were compared between the lithium and quetiapine groups. Longitudinal changes in somnolence severity were analyzed with linear regression analysis.

Results

Of 42 patients randomized, only 3 scored 0 on the VAS at baseline. The rates of incidence-based and VAS-based somnolence were similar in the lithium and quetiapine-IR groups. The VAS change scores from baseline to each visit varied in both groups with significant decreases at weeks 6 and 12 in the quetiapine-IR group only. The decrease at week 6 in the quetiapine-IR group was significantly different from that in the lithium group. Patterns of changes in somnolence severity were inconsistent in both groups. A significant interaction between time course and the decrease in VAS scores was observed in the quetiapine-IR group, but not in the lithium group.

Conclusions

Baseline somnolence was highly prevalent in patients with bipolar disorder. The change in somnolence severity was different between lithium-treated and quetiapine-treated patients. Quantifying somnolence longitudinally is important in clinical trials and practice.

", "keywords": ["Adult", "Male", "Bipolar Disorder", "Sleepiness", "Visual Analog Scale", "Middle Aged", "Severity of Illness Index", "Quetiapine Fumarate", "Young Adult", "03 medical and health sciences", "0302 clinical medicine", "Antimanic Agents", "Lithium Compounds", "Humans", "Female", "Longitudinal Studies", "Antipsychotic Agents"], "contacts": [{"organization": "Keming, Gao, Meilei, Su, Stephen J, Ganocy, Toyomi, Goto, Chengmei, Yuan, Fang, Fang, Carla, Conroy, Brittany, Brownrigg, Mary Beth, Serrano, Joseph R, Calabrese,", "roles": ["creator"]}]}, "links": [{"href": "https://doi.org/30932950"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/Journal%20of%20Clinical%20Psychopharmacology", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "30932950", "name": "item", "description": "30932950", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/30932950"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2019-05-01T00:00:00Z"}}, {"id": "37195942", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:07:00Z", "type": "Journal Article", "created": "2023-05-17", "title": "Emodepside for Trichuris trichiura and Hookworm Infection", "description": "Current treatments for soil-transmitted helminth infections in humans have low efficacy against Trichuris trichiura. Emodepside - a drug in veterinary use and under development for the treatment of onchocerciasis in humans - is a leading therapeutic candidate for soil-transmitted helminth infection.We conducted two phase 2a, dose-ranging, randomized, controlled trials to evaluate the efficacy and safety of emodepside against T. trichiura and hookworm infections. We randomly assigned, in equal numbers, adults 18 to 45 years of age in whom T. trichiura or hookworm eggs had been detected in stool samples to receive emodepside, at a single oral dose of 5, 10, 15, 20, 25, or 30 mg; albendazole, at a single oral dose of 400 mg; or placebo. The primary outcome was the percentage of participants who were cured of T. trichiura or hookworm infection (the cure rate) with emodepside 14 to 21 days after treatment, determined with the use of the Kato-Katz thick-smear technique. Safety was assessed 3, 24, and 48 hours after the receipt of treatment or placebo.A total of 266 persons were enrolled in the T. trichiura trial and 176 in the hookworm trial. The predicted cure rate against T. trichiura in the 5-mg emodepside group (85% [95% confidence interval {CI}, 69 to 93]; 25 of 30 participants) was higher than the predicted cure rate in the placebo group (10% [95% CI, 3 to 26]; 3 of 31 participants) and the observed cure rate in the albendazole group (17% [95% CI, 6 to 35]; 5 of 30 participants). A dose-dependent relationship was shown in participants with hookworm: the observed cure rate was 32% (95% CI, 13 to 57; 6 of 19 participants) in the 5-mg emodepside group and 95% (95% CI, 74 to 99.9; 18 of 19 participants) in the 30-mg emodepside group; the observed cure rates were 14% (95% CI, 3 to 36; 3 of 21 participants) in the placebo group and 70% (95% CI, 46 to 88; 14 of 20 participants) in the albendazole group. In the emodepside groups, headache, blurred vision, and dizziness were the most commonly reported adverse events 3 and 24 hours after treatment; the incidence of events generally increased in a dose-dependent fashion. Most adverse events were mild in severity and were self-limited; there were few moderate and no serious adverse events.Emodepside showed activity against T. trichiura and hookworm infections. (Funded by the European Research Council; ClinicalTrials.gov number, NCT05017194.).", "keywords": ["Adult", "Dose-Response Relationship", " Drug", "Antinematodal Agents", "Administration", " Oral", "Middle Aged", "Albendazole", "16. Peace & justice", "3. Good health", "03 medical and health sciences", "Feces", "Hookworm Infections", "Soil", "Young Adult", "0302 clinical medicine", "Trichuris", "Depsipeptides", "Animals", "Humans", "Trichuriasis"]}, "links": [{"href": "https://doi.org/37195942"}, {"rel": "related", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/New%20England%20Journal%20of%20Medicine", "name": "related record", "description": "related record", "type": "application/json"}, {"rel": "self", "type": "application/geo+json", "title": "37195942", "name": "item", "description": "37195942", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main/items/37195942"}, {"rel": "collection", "type": "application/json", "title": "Collection", "name": "collection", "description": "Collection", "href": "https://repository.soilwise-he.eu/cat/collections/metadata:main"}], "time": {"date": "2023-05-18T00:00:00Z"}}, {"id": "38763635", "type": "Feature", "geometry": null, "properties": {"updated": "2026-05-31T07:07:02Z", "type": "Journal Article", "created": "2024-04-22", "title": "Microplastics in seafood: Consumer preferences and valuation for mitigation technologies", "description": "Abstract

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employs a discrete choice experiment to investigate Chilean consumers' preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers\uffe2\uff80\uff99 willingness to pay for them. Specifically, consumers\uffe2\uff80\uff99 willingness to pay for mussels with a 90% depuration efficiency certification is around US$ 4. The provision of health impact information increased the price premium by 56%, while the provision of environmental information increased it by 21%. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8% and the risk perception of microplastics for human health by 5.8%. These results emphasize the critical role of information in shaping consumer preferences and provide evidence for validating investment in research and development related to microplastic pollution mitigation measures.